Should topical opioid analgesics be regarded as effective and safe when applied to chronic cutaneous lesions?

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Chronic Morphine Administration Delays Wound Healing by Inhibiting Immune Cell Recruitment to the Wound Site

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Prolonged Use of High-Dose Morphine Impairs Angiogenesis and Mobilization of Endothelial Progenitor Cells in Mice

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(2009) Jerri M. Rook et al.   ANESTHESIOLOGY

Morphine-induced early delays in wound closure: Involvement of sensory neuropeptides and modification of neurokinin receptor expression

(2009) Jerri M. Rook et al.   BIOCHEMICAL PHARMACOLOGY

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(2009) Christoph Stein et al.   BRAIN RESEARCH REVIEWS

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Influences of opioids and nanoparticles on in vitro wound healing models

(2009) Nadine B. Wolf et al.   EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS

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Potential Utility of Peripherally Applied Loperamide in Oral Chronic Graft-versus-host Disease Related Pain

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