Review
Pharmacology & Pharmacy
Nupur Vasdev, Nakshatra Chaudhari, Suryanarayana Polaka, Kuldeep Rajpoot, Piyush Gondaliya, Adil Ali Sayyed, Pinaki Sengupta, Rakesh Kumar Tekade
Summary: Ophthalmic formulations are widely used in treating eye disorders and maintaining sterility is crucial. However, preservatives in these formulations can cause side effects, leading to the development of preservative-free ophthalmic formulations (PFOFs). This review discusses the current research and development status of PFOFs, their market positioning, regulatory implications, and the areas where they are finding applications.
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
(2023)
Article
Pharmacology & Pharmacy
Benjamin A. Kuzma, Sharareh Senemar, Tannaz Ramezanli, Priyanka Ghosh, Sam G. Raney, Grazia Stagni
Summary: This study investigates the effect of dose-duration on dermal exposure of metronidazole-containing drug products and characterizes metronidazole dermal elimination using a retrodialysis/microdialysis approach. The results suggest that truncating dose-duration can reduce experimental duration, but careful selection of dose-duration is necessary to discriminate between formulations.
EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS
(2022)
Article
Biochemistry & Molecular Biology
Stefania Cometa, Carla Zannella, Francesco Busto, Anna De Filippis, Gianluigi Franci, Massimiliano Galdiero, Elvira De Giglio
Summary: The study revealed that a hydroxytyrosol-rich Olea europaea L. fruit extract had strong inhibitory effects against HSV-1, with the hydrogel formulation showing the highest antiviral activity. While the ability to convey active ingredients to the skin slightly varied among the three formulations, both the OFE and the formulations were found to be non-toxic to cells.
Article
Plant Sciences
Danielle Twilley, Deveshnee Moodley, Heidi Rolfes, Indres Moodley, Lyndy J. McGaw, Balungile Madikizela, Beverley Summers, Lee-ann Raaff, Marlize Lategan, Lebogang Kgatuke, Ephraim C. Mabena, Namrita Lall
Summary: This study evaluated the biological activity of two South African plant extracts and successfully incorporated them into sunscreen formulations to protect the skin. The extracts showed antioxidant activity, mutagenic potential, and antiproliferative activity against human dermal fibroblasts, while not affecting the stability or photoprotective effect of the sunscreen formulations.
SOUTH AFRICAN JOURNAL OF BOTANY
(2021)
Article
Ophthalmology
Samuel Kyei, Nana Yaw Abaka Dadzie, Ebenezer Zaabaar, Kwasi Antwi Asamoah Dwomoh, Kofi Asiedu
Summary: The study found that the duration of anesthetic effect and corneal touch threshold following the administration of 0.5% topical ophthalmic proparacaine and tetracaine hydrochlorides varied based on sex and age. Females had shorter duration of effect, while elderly participants had the longest duration of maximal effect of the two ophthalmic preparations (5 minutes). Sex and age showed significant influences on corneal touch threshold following application of the two anesthetics.
JOURNAL OF OPHTHALMOLOGY
(2021)
Article
Agriculture, Dairy & Animal Science
William Antonio Sagastegui-Guarniz, Carmen R. Silva-Correa, Victor E. Villarreal-La Torre, Maria Gonzalez-Blas, Walter O. Sagastegui-Guarniz, Abhel A. Calderon-Pena, Cinthya L. Aspajo-Villalaz, Jose L. Cruzado-Razco, Julio Hilario-Vargas
Summary: Momordica charantia gel and cream formulations demonstrated wound healing activity on induced wounds in mice, with 1% cream formulation showing the most effective treatment as indicated by higher wound closure percentage and histopathological analysis with the presence of fibroblasts and abundant collagen and elastic fibers in the skin samples.
