Article
Biochemistry & Molecular Biology
Hsiu-Man Lien, Yu-Yen Wang, Mei-Zi Huang, Hui-Yu Wu, Chao-Lu Huang, Chia-Chi Chen, Shao-Wen Hung, Chia-Chang Chen, Cheng-Hsun Chiu, Chih-Ho Lai
Summary: A. indica could be developed as an effective therapeutic agent for gastroprotective purposes, as it has a protective effect on aspirin-induced gastric ulcers.
Article
Pharmacology & Pharmacy
Jose L. R. Martins, Dayane M. Silva, Emerson H. Gomes, Samuel A. Fava, Murilo F. Carvalho, Isaac Y. L. Macedo, Eric S. Gil, Paulo C. Ghedini, Fabio F. Rocha, Osmar N. Silva, James O. Fajemiroye, Emerith M. H. Pinto, Elson A. Costa
Summary: This study demonstrates the gastroprotective activity of linoleic acid (LA) in different types of gastric mucosal damage. The observed gastroprotection may occur through an increase in mucosal defensive factors.
CURRENT PHARMACEUTICAL DESIGN
(2022)
Article
Integrative & Complementary Medicine
Shih-Cheng Huang, Wen-Jun Wu, Yi-Ju Lee, Ming-Shiun Tsai, Xiang-Zhe Yan, Hsiao-Chun Lin, Pin-Yen Lai, Kun-Teng Wang, Jiunn-Wang Liao, Jen-Chieh Tsai, Sue-Hong Wang
Summary: The study found that Machilus zuihoensis Hayata bark (MZ) has protective effects against acidic ethanol-induced gastric ulcer. The mechanisms involved mucus secretion, antioxidative, anti-inflammatory, and anti-apoptotic effects, as well as inhibition of NF-kB and MAPK signaling pathways.
JOURNAL OF TRADITIONAL AND COMPLEMENTARY MEDICINE
(2023)
Article
Chemistry, Medicinal
Kamila Lopes de Lira, Flavia Danniele Frota Machado, Ana Flavia Seraine Custodio Viana, Irisdalva Sousa Oliveira, Francilene Vieira da Silva, Helio de Barros Fernandes, Jackson Roberto Guedes da Silva Almeida, Francisco de Assis Oliveira, Alexsandro Branco, Rita De Cassia Meneses Oliveira
Summary: Neoglaziovia variegata (Arruda) Mez has shown promising gastroprotective activity, potentially involving nitric oxide, prostaglandins, mucus, sulfhydryl groups, and K-ATP channels.
JOURNAL OF MEDICINAL FOOD
(2021)
Article
Food Science & Technology
Hanan A. Ogaly, Muhammad A. Alsherbiny, Shymaa A. El Badawy, Reham M. Abd-Elsalam, Chun Guang Li, Asmaa A. Azouz
Summary: Vitex agnus castus L. extract (VACE) demonstrated gastroprotective properties in rats by ameliorating gastric juice acidity, preserving beneficial contents, decreasing harmful contents, and regulating molecular mechanisms related to inflammation, oxidative stress, and apoptosis.
JOURNAL OF FUNCTIONAL FOODS
(2021)
Article
Medicine, Research & Experimental
Munaf Aal-Aaboda, Atheer Majid Rashid Al-Juhaishi, Abbas M. Khalil, Nameera Ghazi Abdulkareem
Summary: This study evaluated the gastroprotective potential of zafirlukast against indomethacin-induced gastric ulcers in rats. The results showed that zafirlukast improved the morphology of gastric tissues, increased PGE2 levels, and reduced IL-1 beta expression and TBARS concentrations, indicating its potential gastroprotective, anti-inflammatory, and anti-oxidant properties.
IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES
(2023)
Article
Plant Sciences
Joao Francisco Camara Neto, Matheus da Silva Campelo, Gilberto Santos Cerqueira, Joao Antonio Leal de Miranda, Jhonyson Arruda Carvalho Guedes, Raimundo Rafael de Almeida, Sandra de Aguiar Soares, Nilce Viana Gramosa, Guilherme Juliao Zocolo, Icaro Gusmao Pinto Vieira, Nagila Maria Pontes Silva Ricardo, Maria Elenir Nobre Pinho Ribeiro
Summary: This study aimed to characterize the chemical profile of Agaricus blazei Murill extract and evaluate its gastroprotective effect. The results showed that the extract had antioxidant activity and could protect the gastric mucosa.
JOURNAL OF ETHNOPHARMACOLOGY
(2022)
Article
Integrative & Complementary Medicine
Nurul 'Ain Abu Bakar, Muhammad Nazrul Hakim Abdullah, Vuanghao Lim, Yoke Keong Yong
Summary: This study demonstrated the gastroprotective effect of polypeptide K (PPK) on gastric ulcers. Results showed that PPK effectively reduced the ulcer area, preserved the architecture of gastric tissues, and enhanced gastric wall mucus secretion. This may contribute to the decreased total acidity in the stomach.
EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE
(2022)
Article
Biotechnology & Applied Microbiology
Juan Luo, Jie Hu, Meiling Zhang, Yue Zhang, Jiashu Wu, Jinjun Cheng, Huihua Qu, Hui Kong, Yan Zhao
Summary: Nelumbinis Rhizomatis Nodus carbon dots (NRN-CDs) show significant gastroprotective effects on ethanol-induced gastric ulcers in rats, potentially through the regulation of oxidative stress and inflammatory factors. NRN-CDs could be developed as a promising drug for the treatment of gastric ulcers.
Article
Medicine, Research & Experimental
Ibrahim Abdel Aziz Ibrahim, Abbas I. Hussein, Mahmoud S. Muter, Abdulalah T. Mohammed, Morteta H. Al-Medhtiy, Suhayla Hamad Shareef, Peshawa Yunis Aziz, Nabaz Fisal Shakir Agha, Mahmood Ameen Abdulla
Summary: The study confirms that silver nanoparticles can protect the gastric mucosa from ethanol-induced damage. They exert their effects through antioxidant activity, increased mucus secretion, and modulation of relevant protein expression.
BIOMEDICINE & PHARMACOTHERAPY
(2022)
Article
Environmental Sciences
Mohsen Foadoddini, Hossein Javdani, Ali Farahi, Mehran Hosseini
Summary: The study demonstrated that the ethanolic extract of Ferula foetida (Bunge) Regel umbel has potential in promoting healing of gastric ulcers in rats by mediating NF-kappa B and VEGF/PGE(2) pathways. This was evidenced by a reduction in ulcer area, accelerated epithelialization, increased levels of VEGF and PGE(2) in tissues, and inhibition of NF-kappa B p65 expression.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2022)
Article
Plant Sciences
Yanzhen Mai, Siyuan Xu, Ru Shen, Bairu Feng, Hong He, Yifei Xu
Summary: The water extract of A. rugosum (WEA) has been found to have gastroprotective effects, reducing the size of gastric ulcers and exhibiting anti-inflammatory properties. Pre-treatment with WEA decreased the concentration of inflammatory factors in the stomach and did not have a significant impact on gastric acid and mucus secretion.
PHARMACEUTICAL BIOLOGY
(2022)
Article
Medicine, Research & Experimental
Yizi Zhang, Lingli Sun, Xingfei Lai, Xingjia Peng, Shuai Wen, Zhenbiao Zhang, Yinzheng Xie, Qiuhua Li, Ruohong Chen, Xi Zheng, Kun Zhang, Shili Sun, Dongli Li
Summary: The study found that flower extracts of Jasminum grandiflorum could alleviate gastric ulcers in mice by increasing PGE2 production, enhancing antioxidant enzyme activity, and suppressing ROS, lipid peroxidation, apoptosis-related proteins, pro-inflammatory cytokines, and NO production.
BIOMEDICINE & PHARMACOTHERAPY
(2021)
Article
Biochemistry & Molecular Biology
Xiao-Yin Wang, Miao Wang, Jun-Yi Yin, Ye-Hao Song, Yu-Xiao Wang, Shao-Ping Nie, Ming-Yong Xie
Summary: This study demonstrates that Hericium erinaceus polysaccharide has gastroprotective activity and can be used for the treatment of gastric ulcers. It also successfully screens the bioactive fractions that have cytoprotective effects.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2022)
Article
Engineering, Chemical
Ahmed Aj Jabbar, Fuad O. Abdullah, Kamaran Abdoulrahman, Yaseen Galali, Ibrahim Abdel Aziz Ibrahim, Abdullah R. Alzahrani, Rawaz Rizgar Hassan
Summary: This study investigates the gastroprotective effects of P. decaisnei on ethanol-induced ulcers, showing its potential as a protective and therapeutic agent for gastric ulcers and stomach lesions.
Article
Chemistry, Applied
Beatriz Sepulveda, Derin Benites, Laura Albornoz, Mario Simirgiotis, Olivio Castro, Olimpo Garcia-Beltran, Carlos Areche
Summary: This study reports a green extraction method for lichen substances from Hypotrachyna cirrhata using ethyl lactate and high power ultrasounds. The results showed that ethyl lactate can be a sustainable alternative to toxic solvents like methanol, and also demonstrated higher antioxidant activity.
NATURAL PRODUCT RESEARCH
(2023)
Article
Plant Sciences
Monika Kujawska, Guillermo Schmeda-Hirschmann
Summary: The study on the use of medicinal plants by Paraguayan mestizo migrants in Provincia de Misiones, Argentina, highlights the continuity and change in the herbal pharmacopoeia, with a blend of native plants from different regions. The ongoing search for new medicinal plants to address modern health challenges is evident, although there is limited evidence on their effectiveness in pharmacological literature.
JOURNAL OF ETHNOPHARMACOLOGY
(2022)
Article
Plant Sciences
Jazmin Alarcon-Esposito, Nelida Nina, Cristina Theoduloz, Alberto Burgos-Edwards, Hernan Paillan, Guillermo Schmeda-Hirschmann
Summary: In this study, the MeOH:H2O (7:3) extracts of leaves from Chilean bean landraces were evaluated for their antioxidant activity and inhibition of enzymes associated with metabolic syndrome. The results showed that these extracts exhibited high antioxidant activity and strong inhibition against alpha-glucosidase. Caffeoylmalic acid and flavonol glycosides were identified as the main active compounds. The leaf extracts of Chilean beans have the potential to be a source of bioactive compounds.
PLANT FOODS FOR HUMAN NUTRITION
(2022)
Article
Biochemistry & Molecular Biology
Carmen Cortes, Diego A. Gonzalez-Cabrera, Ruth Barrientos, Claudio Parra, Javier Romero-Parra, Mariano Walter Pertino, Carlos Areche, Beatriz Sepulveda, Jorge Borquez, Alfredo Torres-Benitez, Mario J. Simirgiotis
Summary: In this study, the chemical composition and biological activity of Ovidia pillopillo, an endemic species of the Valdivian Forest in Chile, were investigated for the first time. The plant was found to contain various flavonoids and coumarins, and exhibited strong antioxidant and enzyme inhibition activities. These findings suggest that Ovidia pillopillo has potential as a source of new medicines.
Article
Biochemistry & Molecular Biology
Laura Albornoz, Alfredo Torres-Benitez, Miguel Moreno-Palacios, Mario J. Simirgiotis, Saul A. Montoya-Serrano, Beatriz Sepulveda, Elena Stashenko, Olimpo Garcia-Beltran, Carlos Areche
Summary: In this study, hyphenated liquid chromatography with high-resolution mass spectrometry was used to analyze the metabolomes of eleven species of Sticta lichens. Chemical markers for fast identification of Sticta lichens were identified for the first time. The study also compared chemical compounds and traditional morphological traits in the study of ancestor-descendant relationships in the genus, and found inconsistencies between the two methods.
Article
Chemistry, Analytical
Beatriz Sepulveda, Alberto Cornejo, Daniela Barcenas-Perez, Jose Cheel, Carlos Areche
Summary: Lichens are symbiotic organisms that produce secondary compounds. Using hyphenated techniques, 25 compounds were detected from Antarctic lichen, including two new compounds and 10 phenolic compounds that were found for the first time in the Cladonia genus.
Article
Plant Sciences
Guillermo Schmeda-Hirschmann, Alberto Burgos-Edwards, Antonieta Rojas de Arias, Camila Lopez-Torres, Charlotte Palominos, Sebastian Fuentes-Retamal, Yarela Herrera, Karen Dubois-Camacho, Felix A. Urra
Summary: This study analyzed a traditional recipe used by the Mbya culture in Paraguay to treat cancer with the native toad Rhinella schneideri. The composition of the recipe was determined and its effects on human breast cancer cells were evaluated. The results showed that the recipe contains various metabolites, including alkaloids and bufadienolide derivatives. The recipe did not have cytotoxic effects on breast cancer cells, but it increased mitochondrial bioenergetics and inhibited cell migration.
JOURNAL OF ETHNOPHARMACOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Jaqueline Cornejo-Campos, Yenny Adriana Gomez-Aguirre, Jose Rodolfo Velazquez-Martinez, Oscar Javier Ramos-Herrera, Carolina Estefania Chavez-Murillo, Francisco Cruz-Sosa, Carlos Areche, Emmanuel Cabanas-Garcia
Summary: This study analyzed the phytochemical profile, total phenolic content, and antioxidant activity of Acanthocereus tetragonus. It was found that some metabolites remained intact after cooking, indicating the functional contribution of A. tetragonus to human metabolism.
Article
Biochemistry & Molecular Biology
Carlos Areche, Javier Romero Parra, Beatriz Sepulveda, Olimpo Garcia-Beltran, Mario J. Simirgiotis
Summary: In this study, the metabolite fingerprinting, antioxidant, and enzyme inhibitory potential of Himantormia lugubris, a small lichen shrub native to Chile and growing in the Antarctica region, were investigated for the first time. The results showed that this species is a rich source of bioactive compounds with good inhibition activity against cholinesterase and tyrosinase enzymes, as well as potential antioxidant activity.
Article
Chemistry, Applied
Grover Castaneta, Beatriz Sepulveda, Reinaldo Vargas, Olimpo Garcia-Beltran, Mario Simirgiotis, Carlos Areche
Summary: This study isolated and purified lichen substances from Usnea cornuta using conventional solvents, green solvents, and green technologies. By using UHPLC/ESI/MS/MS, several lichen compounds were identified, and the quantification of usnic acid, diffractaic acid, and galbinic acid was performed. The extraction properties and antioxidant capacities of limonene, ethyl lactate, and methanol were compared, and the results showed that ethyl lactate could replace methanol as a more sustainable green chemistry method with similar antioxidant capacity.
NATURAL PRODUCT RESEARCH
(2023)
Article
Chemistry, Analytical
Grover Castaneta, Nicolas Cifuentes, Beatriz Sepulveda, Daniela Barcenas-Perez, Jose Cheel, Carlos Areche
Summary: Salvia rosmarinus is a plant with various biological activities, and its leaves are traditionally used for cooking. This study investigated the chemical composition of a green extract obtained by maceration with ethyl lactate, identifying numerous compounds including organic acids, flavonoids, and terpenoids.
Article
Food Science & Technology
Nelida Nina, Cristina Theoduloz, Hernan Paillan, Felipe Jimenez-Aspee, Katherine Marquez, Katharina Schuster, Laura Becker, Claudia Oellig, Jan Frank, Guillermo Schmeda-Hirschmann
Summary: This study aimed to analyze the chemical composition, antioxidant capacity, and enzyme inhibition effect of secondary metabolites-enriched extracts (SMEE) of thirteen Chilean bean landraces before and after boiling. HPLC-DAD-MS/MS was used to determine the SMEE composition, and various compounds including procyanidins, flavonoids, phenylpropanoids, and saponins were identified. Cooking decreased the total phenolics and saponins content, but certain individual compounds like ferulic acid and soyasaponins Ba and Bb increased. Total phenolics showed a significant correlation with antioxidant activity, and some saponins exhibited a correlation with α-glucosidase inhibition. The findings suggest that bean components may have local activity in the intestine, preventing oxidation of other nutrients and modulating gastrointestinal enzymes.
JOURNAL OF FUNCTIONAL FOODS
(2023)
Article
Food Science & Technology
Javier Antileo-Laurie, Cristina Theoduloz, Alberto Burgos-Edwards, Felipe Jimenez-Aspee, Katherine Marquez, Marlene Fischer, Guillermo Schmeda-Hirschmann
Summary: This study investigated the phenolic content, antioxidant capacity, and inhibitory effects on enzymes related to metabolic syndrome of the peumo fruits consumed by Mapuche Amerindians in Chile. The results showed that peumo fruits contained beneficial compounds and had significant effects on enzyme activity and antioxidant capacity. Furthermore, significant differences were observed in the fruit parts and processing methods.
FOOD RESEARCH INTERNATIONAL
(2023)
Article
Horticulture
Nelida Nina, Cristina Theoduloz, Gerardo Tapia, Felipe Jimenez-Aspee, Katherine Marquez, Guillermo Schmeda-Hirschmann
Summary: The aim of this study was to assess the impact of hydric stress on the phenolic composition, antioxidant capacity, and inhibition of enzymes associated with metabolic syndrome, in nine bean landraces cultivated in the Mediterranean zone of Chile. Results showed that under restricted watering, all phenolic compounds increased in Pinto beans and decreased in other accessions. Best effect towards alpha-glucosidase was observed for Negro Argel, Bayote, and Enriqueta with IC50 between 0.006 μg/mL and 0.820 μg/mL. Water stress has a significant effect on polyphenols composition and consequently on the antioxidant activity and inhibition of enzymes.
SCIENTIA HORTICULTURAE
(2023)
Article
Multidisciplinary Sciences
Mabel Duarte Alves Gomides, Astridia Marilia de Souza Fontes, Amanda Oliveira Soares Monteiro Silveira, Daniel Chadud Matoso, Anderson Luiz Ferreira, Geraldo Sadoyama
Summary: This study emphasizes the importance of active surveillance for carbapenem-resistant Enterobacterales (CRE) and evaluates the prevalence of invasive infections, risk factors, and mortality risk in CRE-colonized patients. The results reveal that early detection of CRE colonization through screening testing is a vital tool for controlling CRE spread, but there is ineffective control of colonization and infection. The study highlights the significance of implementing preventive measures and improving teamwork.
