Article
Plant Sciences
Thi Phuong Linh Le, Jin Woo Lee, Jun Gu Kim, Jae Sang Han, Haeun Kwon, Dongho Lee, Mi Kyeong Lee, Bang Yeon Hwang
Summary: Two new tetrahydroprotoberberine N-oxides were isolated from Chelidonium majus, along with fourteen known compounds. Their structures were determined using various spectroscopic methods, and their inhibitory effects on nitric oxide production were evaluated, with some compounds showing significant effects.
PHYTOCHEMISTRY LETTERS
(2021)
Article
Plant Sciences
Valerija Krizhanovska, Inga Sile, Arta Kronberga, Ilva Nakurte, Ieva Mezaka, Maija Dambrova, Osvalds Pugovics, Solveiga Grinberga
Summary: The study found significant differences in the phytochemical composition and cytotoxic activity of Chelidonium majus extracts between wild-grown and organically cultivated specimens. Cultivation resulted in a significant increase in alkaloid content and enhanced cytotoxicity of the extracts.
Review
Infectious Diseases
Elham Zarenezhad, Hussein T. Abdulabbas, Mahrokh Marzi, Esraa Ghazy, Mohammad Ekrahi, Babak Pezeshki, Abdolmajid Ghasemian, Amira A. Moawad
Summary: Methicillin-resistant Staphylococcus aureus (MRSA) has developed extensive antibiotic resistance and contains virulence factors for severe infections. Nickel nanoparticles (NiNPs) have shown potential as a cheap prognostic and therapeutic agent, exerting antibacterial effects through disrupting cell membranes, deforming proteins, and inhibiting DNA replication.
Article
Chemistry, Medicinal
Tanveer Ali, Abdul Basit, Asad Mustafa Karim, Jung-Hun Lee, Jeong-Ho Jeon, Shafiq ur Rehman, Sang-Hee Lee
Summary: This study investigates the diversity and role of missense mutations of PBP2a in the antibiotic resistance mechanism in Staphylococcus aureus. The results show that the E239R mutation in the allosteric site of PBP2a induces conformational changes in the active site, hindering its interaction with cefoxitin and leading to high-level resistance.
Article
Pharmacology & Pharmacy
Preeyaporn M. Sreepian, Panthip Rattanasinganchan, Apichai Sreepian
Summary: Citrus hystrix essential oil (CHEO) has been found to have broad-spectrum antibacterial activity and can be used in combination with gentamicin to inhibit the growth of methicillin-resistant S. aureus (MRSA) and reduce the emergence of resistant bacteria.
SAUDI PHARMACEUTICAL JOURNAL
(2023)
Article
Microbiology
Jiun-Liang Chen, Tsung-Yu Huang, Wei-Bin Hsu, Chiang-Wen Lee, Yao-Chang Chiang, Pey-Jium Chang, Kuo-Ti Peng
Summary: This study investigated the genotypic and phenotypic characteristics of MRSA clones isolated from PJI patients in a hospital in Taiwan. The findings showed that ST239 MRSA isolates were highly resistant to multiple antibiotics, had a high biofilm formation ability, and infected patients typically exhibited fever and inflammation. Additionally, knee infections were mainly attributed to ST59 MRSA, and there was an increasing trend of infections caused by ST8 and other MRSA genotypes in PJI patients.
Article
Microbiology
Ryota Miyazawa, So Shimoda, Keiichi Matsuda, Ryuta Tobe, Tasuke Ando, Hiroshi Yoneyama
Summary: Staphylococcus aureus is a major pathogen in humans and livestock, causing serious issues such as bovine mastitis. This study monitored cases of intramammary infection caused by S. aureus in the Miyagi Prefecture, Japan, and analyzed the strains obtained from dairy farms. The study found recurrent cases of infection and identified a Methicillin-Sensitive SA (MSSA) ST398 strain isolated from mastitis-containing cows, which is the first confirmed case in Japan. The results highlight the importance of nationwide surveillance to manage the distribution of ST398 strains in dairy farms for human and animal health.
Article
Immunology
Xinyi Wang, Huilin Zhao, Bingjie Wang, Ying Zhou, Yanlei Xu, Lulin Rao, Wenxiu Ai, Yinjuan Guo, Xiaocui Wu, Jingyi Yu, Longhua Hu, Lizhong Han, Shuying Chen, Liang Chen, Fangyou Yu
Summary: This study characterized six ST8 strains collected from three tertiary hospitals in China, and found that two MRSA strains exhibited similar virulence potential as the epidemic USA300 strain. These findings highlight the need for enhanced surveillance of these highly virulent MRSA strains in China.
EMERGING MICROBES & INFECTIONS
(2022)
Article
Microbiology
Tanis C. Dingle, Dulini Gamage, Sara Gomez-Villegas, Blake M. Hanson, Jinnethe Reyes, April Abbott, Carey-Ann D. Burnham, Jennifer Dien Bard, Stephanie Fritz, William R. Miller, Lars F. Westblade, Barbara Zimmer, Cesar A. Arias, Susan Butler-Wu
Summary: This multicenter study evaluated the prevalence of the cefazolin inoculum effect (CzIE) in North American methicillin-susceptible Staphylococcus aureus (MSSA) isolates. The study found that the CzIE was present in 18.6% of MSSA isolates, with varying prevalence across different study sites. Furthermore, more CzIE-positive isolates had a cefazolin MIC of 1.0 μg/mL, while more CzIE-negative isolates had a MIC of 0.25 μg/mL.
JOURNAL OF CLINICAL MICROBIOLOGY
(2022)
Article
Chemistry, Medicinal
Dingyi Shen, Songpo Duan, Yuhan Hu, Jintong Liang, Youzhi Tang
Summary: This study found that the phloroglucinol derivative TPG and 2-nitrophloroglucinol exhibited potent synergistic antibacterial activity with penicillin or bacitracin against MRSA. The combination disrupted the MRSA cell membrane and inhibited the expression of related proteins, effectively inhibiting MRSA growth.
PHYTOTHERAPY RESEARCH
(2023)
Article
Microbiology
Mohamad Hamad, Farah Al-Marzooq, Vunnam Srinivasulu, Hany A. Omar, Ashna Sulaiman, Dana M. Zaher, Gorka Orive, Taleb H. Al-Tel
Summary: We report the discovery of a new class of potent antimicrobial compounds effective against Gram-positive bacteria, including MRSA. These compounds exhibit low minimum inhibitory concentrations and rapid killing ability, without inducing bacterial resistance. Furthermore, they show minimal toxicity to human red blood cells. The study suggests that these small molecules hold promise as new antibacterial agents against MRSA infections.
FRONTIERS IN MICROBIOLOGY
(2022)
Article
Veterinary Sciences
Hester Rynhoud, Brian M. Forde, Scott A. Beatson, Sam Abraham, Erika Meler, Ricardo J. Soares Magalhaes, Justine S. Gibson
Summary: This study investigated the molecular epidemiology of MRSA and MRSP isolates in dogs and cats, revealing significant differences in resistance and virulence factors between different sequence types. However, there were no differences in individual and clinical factors between predominant sequence types. The majority of isolates showed high levels of antimicrobial resistance, posing a potential threat to human and veterinary health. The phylogenetic clustering of isolates suggests potential importation of clones from countries with high volume of pet movements, warranting further investigation.
FRONTIERS IN VETERINARY SCIENCE
(2021)
Article
Microbiology
Yinjuan Guo, Linling Xu, Bingjie Wang, Lulin Rao, Yanlei Xu, Xinyi Wang, Huilin Zhao, Jingyi Yu, Ying Zhou, Fangyou Yu
Summary: Mupirocin is an important antimicrobial agent in the eradication of MRSA colonization. Mupirocin-resistant MR-MRSA isolates with different molecular characteristics were analyzed, and it was found that they carried different SCCmec types, spa types, and virulence genes. Most of the MR-MRSA isolates were also resistant to other antibiotics, especially erythromycin and clindamycin. The study identified a novel high-level mupirocin-resistant MR-MRSA strain, which poses a therapeutic challenge for MRSA infections.
MICROBIOLOGY SPECTRUM
(2023)
Article
Biochemistry & Molecular Biology
Zhen Zhang, Zhujun Luo, Ying Sun, Duanyu Deng, Kaize Su, Jinxuan Li, Zhenping Yan, Xu Wang, Jifan Cao, Wende Zheng, Song Ang, Yanxian Feng, Kun Zhang, Hang Ma, Panpan Wu
Summary: This study designed and synthesized a series of novel CBD derivatives, among which derivative 21f showed enhanced antibacterial activity against MRSA without cytotoxic effect. Mechanistic studies further revealed that 21f inhibited biofilm formation, induced reactive oxygen species, and reduced bacterial metabolism, leading to accelerated bacterial death.
BIOORGANIC CHEMISTRY
(2023)
Article
Food Science & Technology
Basavaprabhu Haranahalli Nataraj, Chette Ramesh, Rashmi Hogarehalli Mallappa
Summary: Metabolites of lactic acid bacteria have potential as postbiotics to inhibit the growth of undesirable microorganisms in food and pharmaceutical industries. The biosurfactants extracted from Lactobacillus acidophilus NCFM and Lacticaseibacillus rhamnosus GG showed promising antimicrobial and antibiofilm activities against staphylococcal isolates, indicating their potential as candidates for further technology intervention.
LWT-FOOD SCIENCE AND TECHNOLOGY
(2021)
