Article
Endocrinology & Metabolism
Ravi Prakash, Tripti Mishra, Kapil Dev, Kriti Sharma, Jitendra Kuldeep, Aijaz Ahmad John, Alok Tripathi, Chetan Sharma, Kamal Ram Arya, Brijesh Kumar, Mohd Imran Siddiqi, Narender Tadigoppula, Divya Singh
Summary: This study investigated the mechanism by which coelogin stimulates osteoblastogenesis and its effects on osteoprotection and bone regeneration. Results showed that coelogin treatment led to increased osteoblast proliferation, survival, differentiation, and mineralization in osteoblast cells, and promoted new bone formation and prevented bone deterioration in osteopenic mice. Signaling studies revealed that coelogin activates the ER-Erk and Akt-dependent pathways to stimulate osteoblastogenesis.
CALCIFIED TISSUE INTERNATIONAL
(2021)
Article
Peripheral Vascular Disease
Mohammad Shafid, Kumaravelu Jagavelu, Hina Iqbal, Pankaj Yadav, Debabrata Chanda, Neeraj Kumar Verma, Jimut Kanti Ghosh, Matthias Gaestel, Kashif Hanif
Summary: MK2 plays a significant role in pulmonary hypertension, and its inhibition may be a novel target for PH treatment. Inhibition of MK2 alleviated right ventricle pressure and hypertrophy in PH rats, improved cardiac function, reversed pulmonary vascular remodeling, and enhanced pulmonary vascular relaxation.
Article
Biochemistry & Molecular Biology
Dabin Jeong, Wan-Kyu Ko, Seong-Jun Kim, Gong-Ho Han, Daye Lee, Seung-Hun Sheen, Seil Sohn
Summary: LOBE significantly reduces NO production and pro-inflammatory gene expression in LPS-induced BMDMs, potentially through inhibition of the MAPK signaling pathway by reducing phosphorylation levels of ERK and JNK.
Article
Biochemistry & Molecular Biology
Qianqian Xu, Peiyu Zhang, Xiaoyan Han, Huwei Ren, Weiyue Yu, Wei Hao, Bowen Luo, Muhammad Imran Khan, Ni Chen
Summary: This study investigates the pivotal role of Nuclear factor-erythroid 2-related factor 2 (NRF2) in the activation of DNA damage repair in lung cancer cells after x-rays exposure. The study shows that NRF2 knockdown disrupts damaged DNA repair and homologous recombination, and NRF2 activation mediates DNA damage response via the MAPK pathway. These findings suggest that NRF2 plays a critical role in the development of radioresistance, which is of great significance for the development of radiotherapies.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Agriculture, Dairy & Animal Science
Fuqing Huang, Kunling Teng, Yayong Liu, Tianwei Wang, Tianqi Xia, Fangfei Yun, Jin Zhong
Summary: Nisin Z has potential anti-inflammatory effects on mastitis by inhibiting the activation of the ERK1/2 and p38 MAPK signaling pathway and promoting the blood-milk barrier.
JOURNAL OF DAIRY SCIENCE
(2022)
Review
Oncology
Sunil Kumar Singh, Ruchi Roy, Sandeep Kumar, Piush Srivastava, Saket Jha, Basabi Rana, Ajay Rana
Summary: MAP4K4, a member of the MAPK signaling pathway, plays a crucial role in various non-malignant and malignant diseases. It has been implicated in metabolic and inflammatory diseases as well as glioblastoma, colon, prostate, and pancreatic cancers. Since MAP4K4 plays a significant role in inflammatory and malignant diseases, it can be targeted for therapeutic intervention.
Article
Biochemistry & Molecular Biology
Chuwei Lin, Aneirin Alan Lott, Wei Zhu, Craig P. Dufresne, Sixue Chen
Summary: This study used metabolomics and proteomics to investigate the metabolites and protein profiles of the mpk4 mutant and the wild type plants. It revealed the involvement of MPK4 in polyamine synthesis and photosynthesis, providing insights into the metabolic networks potentially regulated by MPK4.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Jin-Kyu Kang, Hyun-Kyu Kang, Chang-Gu Hyun
Summary: Spiramycin has anti-inflammatory effects by inhibiting the production of pro-inflammatory mediators and cytokines in macrophages, suggesting its potential as a candidate for topical anti-inflammatory agents.
Article
Cell Biology
Chunxia Li, Jun Dai, Chuanbin Liu, Guanjun Dong, Xin Zhang, Junfeng Zhang, Fenglian Yan, Hui Zhang, Changying Wang, Mingsheng Zhao, Zhaochen Ning, Qun Ma, Hui Shi, Zhihua Li, Huabao Xiong
Summary: This study reveals that PDK2 is involved in the regulation of TLR-mediated inflammation and plays a role in the activation of TLR4 signaling pathway and production of proinflammatory cytokines. Inhibition of PDK2 can significantly reduce the occurrence and pathological damage of endotoxin shock and suppress the production of inflammatory factors. Therefore, PDK2 may be a potential target for the treatment of septic shock.
Article
Medicine, Research & Experimental
Enkhtuya Radnaa, Lauren Richardson, Brett Goldman, Jared K. Burks, Tuvshintugs Baljinnyam, Natasha Vora, Hui-Juan Zhang, Elizabeth A. Bonney, Arum Han, Ramkumar Menon
Summary: This study investigated the impact of oxidative stress on p38 MAPK signaling and cell fate, using amnion epithelial cells. The results showed that excessive activation of p38 can have adverse effects on cell behavior and tissue homeostasis.
Article
Food Science & Technology
Li Yuan, Qian Chu, Bei Yang, Wei Zhang, Quancai Sun, Ruichang Gao
Summary: This study identified five peptide sequences derived from sturgeon cartilage, four of which were newly discovered. These peptides exhibited potential anti-inflammatory activity by reducing the production of nitric oxide and interleukin-6 while increasing interleukin-10 excretion. The results suggested that these peptides acted by inhibiting the MAPK and IL-17 signaling pathways.
FOOD SCIENCE AND HUMAN WELLNESS
(2023)
Article
Orthopedics
Xiangchao Meng, Wei Zhang, Zhuocheng Lyu, Teng Long, You Wang
Summary: This study demonstrates that zinc oxide nanoparticles (ZnO NPs) can attenuate inflammation induced by polymer wear particles by regulating the MEK-ERK-COX-2 axis, thus preventing inflammatory osteolysis in bone tissue.
JOURNAL OF ORTHOPAEDIC TRANSLATION
(2022)
Article
Cell Biology
Chang-Ning Fu, Jia-Wen Song, Zhi-Peng Song, Qian-Wen Wang, Wen-Wu Bai, Tao Guo, Peng Li, Chao Liu, Shuang-Xi Wang, Bo Dong
Summary: Statin-induced skeletal injury is mediated by the excessive expression of miR-1a, leading to decreased MAP3K1 gene expression and subsequent apoptosis of skeletal muscle cells.
Article
Pharmacology & Pharmacy
Meiyu Zhang, Taro Miura, Shunsuke Suzuki, Masako Chiyotanda, Sachiko Tanaka, Kentaro Sugiyama, Hisashi Kawashima, Toshihiko Hirano
Summary: Vitamin K2 is suggested to have a suppressive effect on the peripheral blood mononuclear cells (PBMCs) of pediatric atopic dermatitis patients, potentially by reducing the immune response through inhibiting specific signaling pathways.
BIOLOGICAL & PHARMACEUTICAL BULLETIN
(2021)
Review
Pharmacology & Pharmacy
Xin-Fang Leong, Ker Woon Choy, Aspalilah Alias
Summary: Atherosclerosis poses serious health problems and requires long-term medication for prevention. Thymoquinone, a bioactive compound from Nigella sativa L., shows potential anti-inflammatory effects in atherosclerosis, but further studies are needed to determine its effectiveness and safety.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Dentistry, Oral Surgery & Medicine
Thamiris Cirelli, Rafael Nepomuceno, Silvana R. P. Orrico, Carlos Rossa, Joni A. Cirelli, Kari E. North, Mariaelisa Graff, Silvana P. Barros, Raquel M. Scarel-Caminaga
Summary: Genetic markers of susceptibility to periodontitis were validated in a Brazilian population, with SNPs in the NPY, IL37, and NCR2 genes associated with moderate or severe periodontitis, and the TLR9 marker associated with lower risk of severe periodontitis in men. Sex- and smoking-specific effects were observed for these SNPs, highlighting the genetic predisposition to periodontitis.
JOURNAL OF PERIODONTOLOGY
(2021)
Article
Dentistry, Oral Surgery & Medicine
K. H. Kwack, L. Zhang, J. Sohn, V Maglaras, R. Thiyagarajan, K. L. Kirkwood
Summary: The study suggests that expansion of myeloid-derived suppressor cells (MDSCs) in obese mice may contribute to the formation of osteoclasts during periodontitis, leading to increased alveolar bone destruction. This provides a more detailed mechanistic understanding of the interplay between obesity and periodontitis.
JOURNAL OF DENTAL RESEARCH
(2022)
Article
Dentistry, Oral Surgery & Medicine
Yanchun Li, Zhongyang Lu, Lixia Zhang, Cameron L. Kirkwood, Keith L. Kirkwood, Maria F. Lopes-Virella, Yan Huang
Summary: Imipramine, as an inhibitor of aSMase, abolishes the synergy between MetS and periodontitis on alveolar bone loss in animal model and inhibits pro-inflammatory and pro-osteoclastogenic gene expression in macrophages in vitro. This study suggests that aSMase could be a potential therapeutic target for MetS-exacerbated periodontitis.
JOURNAL OF PERIODONTAL RESEARCH
(2022)
Article
Dentistry, Oral Surgery & Medicine
Jiho Sohn, Lu Li, Lixia Zhang, Rajendra P. Settem, Kiyonobu Honma, Ashu Sharma, Karen L. Falkner, Jan M. Novak, Yijun Sun, Keith L. Kirkwood
Summary: Recent epidemiological studies have shown that inflammatory bowel disease is associated with periodontal disease. This study reveals the mechanism behind P. gingivalis-mediated intestinal inflammation and identifies the alteration in gut microbiota as a key factor in causing intestinal inflammation.
MOLECULAR ORAL MICROBIOLOGY
(2022)
Article
Cell Biology
Vinicius de Paiva Goncalves, Joao Paulo Steffens, Carlos Rossa Junior, Luis Carlos Spolidorio
Summary: This study aimed to evaluate the effects of testosterone depletion and supraphysiological testosterone supplementation on early phase wound healing in animals. The results showed that supraphysiological testosterone supplementation improved wound healing by enhancing angiogenesis and reducing wound contraction.
INFLAMMATION RESEARCH
(2022)
Article
Oncology
Marcell Costa de Medeiros, Min Liu, Rajat Banerjee, Emily Bellile, Nisha J. D'Silva, Carlos Rossa Jr
Summary: The study found that galanin secreted by head and neck squamous cell carcinoma (HNSCC) cells exhibits immune-suppressive and pro-tumoral effects. Galanin decreases cell proliferation and expression of pro-inflammatory cytokines, while increasing apoptosis and expression of pro-tumoral cytokines/growth factors. It also suppresses T cell activation and anti-tumoral phenotypes. High expression of galanin is associated with reduced overall survival in HNSCC patients.
Article
Biochemistry & Molecular Biology
Subin Surendran, Usama Aboelkheir, Andrew A. Tu, William J. Magner, S. Lynn Sigurdson, Mihai Merzianu, Wesley L. Hicks, Amritha Suresh, Keith L. Kirkwood, Moni A. Kuriakose
Summary: This study identified T regulatory cells (Treg) infiltrating oral dysplastic lesions, suggesting their association with disease progression. CD8(+) effector T cells and immune checkpoint markers PD-1 and PD-L1 were also associated with oral cancer progression, indicating the presence of an adaptive immune response and T-cell exhaustion.
Article
Pharmacology & Pharmacy
Cindy Grace Perez-Pacheco, Natalie Aparecida Rodrigues Fernandes, Angelo Constantino Camilli, Danilo Paschoal Ferrarezi, Amanda Favoreto Silva, Mayara Cristina Zunareli, Camila Fernanda Amantino, Fernando Lucas Primo, Morgana Rodrigues Guimaraes-Stabilli, Carlos Rossa Junior
Summary: The aim of this study was to assess the influence of local application of curcumin-loaded nanoparticles on periodontal repair. The results demonstrate that local administration of curcumin-loaded nanoparticles enhanced tissue repair in an experimental model of periodontal repair, promoting bone repair and increasing collagen content.
NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Laura Andrea Gonzalez Maldonado, Camyla Rodrigues Nascimento, Natalie Aparecida Rodrigues Fernandes, Ana Lidia Pinheiro Silva, Nisha J. D'Silva, Carlos Rossa Jr
Summary: In oral squamous cell carcinoma, macrophages in the tumor microenvironment play a significant role in prognosis and disease survival. This study focuses on the effects of tumor cell-secreted TGF-beta on macrophage phenotype and macrophage-facilitated tumor invasion. The results show that blocking the effects of TGF-beta can affect macrophage phenotype and impact tumor cell invasion and chemotaxis differently.
INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY
(2022)
Article
Oncology
Mauricio Rocha Dourado, Amr Elseragy, Bruno Cesar da Costa, Fabio Haach Teo, Gustavo Narvaes Guimaraes, Renato Assis Machado, Maija Risteli, Wafa Wahbi, Clarissa Araujo Gurgel Rocha, Livia Maris Ribeiro Paranaiba, Wilfredo Alejandro Gonzalez-Arriagada, Sabrina Daniela da Silva, Ana Lucia Carrinho Ayroza Rangel, Marcelo Rocha Marques, Carlos Rossa Junior, Tuula Salo, Ricardo D. Coletta
Summary: In this study, the expression and impact of stress induced phosphoprotein 1 (STIP1) in oral squamous cell carcinoma (OSCC) were investigated. It was found that STIP1 was highly expressed in OSCC, and its overexpression was associated with shorter survival and higher risk of recurrence. Knockdown of STIP1 reduced proliferation, migration, and invasion of tumor cells, and decreased the number of metastases in a zebrafish model. Furthermore, STIP1 was inversely expressed with miR-218-5p, and transfection of miR-218-5p mimics decreased STIP1 levels and inhibited tumor cell proliferation, migration, and invasion.
FRONTIERS IN ONCOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Camyla Rodrigues Nascimento, Natalie Ap Rodrigues Fernandes, Laura Andrea Gonzalez Maldonado, Carlos Rossa Junior
Summary: Understanding macrophage biology is important for understanding various biological processes and developing new immunomodulatory strategies. This study compared the response of macrophages derived from THP-1 and U937 cells to different polarizing conditions, and found that they have different tendencies towards M1 and M2 phenotypes, with THP-1-derived macrophages being more responsive to M1 stimuli.
BIOCHEMISTRY AND BIOPHYSICS REPORTS
(2022)
Article
Biochemistry & Molecular Biology
Iolanda Augusta Fernandes de Matos, Natalie Aparecida Rodrigues Fernandes, Giovani Cirelli, Mariely Araujo de Godoi, Leticia Ribeiro de Assis, Luis Octavio Regasini, Carlos Rossa Junior, Morgana Rodrigues Guimaraes-Stabili
Summary: In this in vitro study, a newly synthesized chalcone T4 was found to inhibit osteoclast differentiation and activity and stimulate osteogenesis, indicating a promising therapeutic potential in osteolytic diseases.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Dentistry, Oral Surgery & Medicine
Yanchun Li, Zhongyang Lu, Cameron L. Kirkwood, Keith L. Kirkwood, Stephen A. Wank, Ai-Jun Li, Maria F. Lopes-Virella, Yan Huang
Summary: GPR40 deficiency worsens alveolar bone loss and periodontal inflammation in patients with periodontitis and MetS, indicating a beneficial role of GPR40 in MetS-associated periodontitis. Furthermore, GPR40 deficiency or inhibition in macrophages further upregulates proinflammatory and pro-osteoclastogenic genes induced by LPS and palmitic acid, suggesting that GPR40 has anti-inflammatory and anti-osteoclastogenic properties.
JOURNAL OF PERIODONTAL RESEARCH
(2023)
Article
Dentistry, Oral Surgery & Medicine
L. Li, Y. Hayashi-Okada, K. L. Falkner, S. Cervi, S. Andrusz, Y. Shimizu, J. J. Zambon, K. L. Kirkwood, R. E. Schifferle, P. I. Diaz
Summary: This study aimed to evaluate the effects of an intensive, at-home, chemical, and mechanical antiplaque regimen as an adjunct to scaling and root planing (SRP) for the treatment of periodontitis. The results showed that intensive antiplaque measures can improve periodontal therapy outcomes, particularly in subjects with diabetes.
JDR CLINICAL & TRANSLATIONAL RESEARCH
(2023)
Article
Dentistry, Oral Surgery & Medicine
Elisandra Marcia Rodrigues, Kennia Scapin Viola, Laura Gonzalez Maldonado, Carlos Rossa-Junior, Juliane Maria Guerreiro-Tanomaru, Mario Tanomaru-Filho
Summary: Modified formulations of calcium silicate repair materials with additives have been developed to enhance handling, consistency, biocompatibility, and bioactivity. In this study, the effects of these modified materials on human osteoblastic cells were evaluated. The results showed that the modified cements did not have cytotoxic effects and promoted cell viability, gene expression, and mineralization processes.
BRAZILIAN ORAL RESEARCH
(2022)