History of the G Protein–Coupled Receptor (GPCR) Assays From Traditional to a State-of-the-Art Biosensor Assay

AKAP79, PKC, PKA and PDE4 participate in a Gq-linked muscarinic receptor and adenylate cyclase 2 cAMP signalling complex

(2013) Jia X. Shen et al.   BIOCHEMICAL JOURNAL

G-protein-Coupled Receptors and Their (Bio) Chemical Significance Win 2012 Nobel Prize in Chemistry

(2013) Hsi-Hsien Lin   Biomedical Journal

An update of novel screening methods for GPCR in drug discovery

(2012) Linjie Chen et al.   Expert Opinion on Drug Discovery

Optimization of a GCaMP Calcium Indicator for Neural Activity Imaging

(2012) J. Akerboom et al.   JOURNAL OF NEUROSCIENCE

Comparing Label-Free Biosensors for Pharmacological Screening With Cell-Based Functional Assays

(2010) Matthew F. Peters et al.   ASSAY AND DRUG DEVELOPMENT TECHNOLOGIES

Use of the GTPγS ([35S]GTPγS and Eu-GTPγS) binding assay for analysis of ligand potency and efficacy at G protein-coupled receptors

(2010) Philip G. Strange   BRITISH JOURNAL OF PHARMACOLOGY

Label-free whole-cell assays: expanding the scope of GPCR screening

(2010) Clay W Scott et al.   DRUG DISCOVERY TODAY

Derived (Mutated)–Types of TRPV6 Channels Elicit Greater Ca2+ Influx Into the Cells Than Ancestral-Types of TRPV6: Evidence From Xenopus Oocytes and Mammalian Cell Expression System

(2010) Yuka Sudo et al.   JOURNAL OF PHARMACOLOGICAL SCIENCES

Noradrenaline Induces Clock Gene Per1 mRNA Expression in C6 Glioma Cells Through β2-Adrenergic Receptor Coupled With Protein Kinase A – cAMP Response Element Binding Protein (PKA–CREB) and Src-Tyrosine Kinase – Glycogen Synthase Kinase-3β (Src–GSK-3β)

(2010) Norimitsu Morioka et al.   JOURNAL OF PHARMACOLOGICAL SCIENCES

Therapeutic potential of β-arrestin- and G protein-biased agonists

(2010) Erin J. Whalen et al.   TRENDS IN MOLECULAR MEDICINE

A perspective on more effective GPCR-targeted drug discovery efforts

(2008) Annette Gilchrist   Expert Opinion on Drug Discovery

M3 Muscarinic Acetylcholine Receptor-Mediated Signaling Is Regulated by Distinct Mechanisms

(2008) J. Luo et al.   MOLECULAR PHARMACOLOGY