AT-406, an IAP Inhibitor, Activates Apoptosis and Induces Radiosensitization of Normoxic and Hypoxic Cervical Cancer Cells

Embelin Induces Apoptosis in Human Glioma Cells Through Inactivating NF-κB

(2013) Sang-Yoon Park et al.   JOURNAL OF PHARMACOLOGICAL SCIENCES

Anti-tumor activity of the X-linked inhibitor of apoptosis (XIAP) inhibitor embelin in gastric cancer cells

(2013) Da-Guang Wang et al.   MOLECULAR AND CELLULAR BIOCHEMISTRY

Smac mimetic compound LCL161 sensitizes esophageal carcinoma cells to radiotherapy by inhibiting the expression of inhibitor of apoptosis protein

(2013) Qin Qin et al.   TUMOR BIOLOGY

AT-406, an orally active antagonist of multiple inhibitor of apoptosis proteins, inhibits progression of human ovarian cancer

(2012) Melissa K. Brunckhorst et al.   CANCER BIOLOGY & THERAPY

Inhibitor of Apoptosis (IAP) proteins as therapeutic targets for radiosensitization of human cancers

(2012) Simone Fulda   CANCER TREATMENT REVIEWS

Targeting IAP proteins for therapeutic intervention in cancer

(2012) Simone Fulda et al.   NATURE REVIEWS DRUG DISCOVERY

Smac-mimetic compound SM-164 induces radiosensitization in breast cancer cells through activation of caspases and induction of apoptosis

(2011) Dong Yang et al.   BREAST CANCER RESEARCH AND TREATMENT

Global cancer statistics

(2011) Ahmedin Jemal et al.   CA-A CANCER JOURNAL FOR CLINICIANS

Embelin suppresses STAT3 signaling, proliferation, and survival of multiple myeloma via the protein tyrosine phosphatase PTEN

(2011) Ji Young Heo et al.   CANCER LETTERS

Use of the γ-H2AX assay to monitor DNA damage and repair in translational cancer research

(2011) Alesia Ivashkevich et al.   CANCER LETTERS

Heterotrimeric stimulatory GTP-binding proteins inhibit cisplatin-induced apoptosis by increasing X-linked inhibitor of apoptosis protein expression in cervical cancer cells

(2011) Eun-Ah Cho et al.   CANCER SCIENCE

A Potent and Orally Active Antagonist (SM-406/AT-406) of Multiple Inhibitor of Apoptosis Proteins (IAPs) in Clinical Development for Cancer Treatment

(2011) Qian Cai et al.   JOURNAL OF MEDICINAL CHEMISTRY

BV6, an IAP Antagonist, Activates Apoptosis and Enhances Radiosensitization of Non-small Cell Lung Carcinoma In Vitro

(2011) Wenyan Li et al.   Journal of Thoracic Oncology

Radiosensitization of Head and Neck Squamous Cell Carcinoma by a SMAC-Mimetic Compound, SM-164, Requires Activation of Caspases

(2011) J. Yang et al.   MOLECULAR CANCER THERAPEUTICS

Ubiquitylation in apoptosis: a post-translational modification at the edge of life and death

(2011) Domagoj Vucic et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

IAP antagonists: promising candidates for cancer therapy

(2010) Raimund Mannhold et al.   DRUG DISCOVERY TODAY

Targeting mitochondria for cancer therapy

(2010) Simone Fulda et al.   NATURE REVIEWS DRUG DISCOVERY

In vitro and in vivo radiosensitization of colorectal cancer HT-29 cells by the smac mimetic JP-1201

(2010) Sergio Huerta et al.   SURGERY

Peroxisome Proliferator-Activated Receptor-  Contributes to the Inhibitory Effects of Embelin on Colon Carcinogenesis

(2009) Y. Dai et al.   CANCER RESEARCH

Molecularly Targeted Radiosensitization of Human Prostate Cancer by Modulating Inhibitor of Apoptosis

(2008) Y. Dai et al.   CLINICAL CANCER RESEARCH