Article
Immunology
Xiaoqi Sun, Xiaotian Wang, Qianqian He, Muqing Zhang, Li Chu, Yang Zhao, Yongchao Wu, Jianping Zhang, Xue Han, Xi Chu, Zhonglin Wu, Shengjiang Guan
Summary: The study demonstrated that Baicalin alleviates arsenic trioxide-induced cardiac toxicity by inhibiting oxidative stress, apoptosis, and inflammation, potentially through the inhibition of the TLR4/NF-cB signaling pathway.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Farzan Mozaffarian, Mohammad Amin Dehghani, Atefeh Raesi Vanani, Masoud Mahdavinia
Summary: The study explored the protective effect of alpha lipoic acid (ALA) against arsenic-induced liver toxicity in rat mitochondria. Results showed that pre-treatment with ALA improved mitochondrial function and reduced oxidative stress and mitochondrial membrane damage.
BIOLOGICAL TRACE ELEMENT RESEARCH
(2022)
Article
Pharmacology & Pharmacy
Ming Yuan, Hiroe Sano, Takaaki Nishino, Hongbin Chen, Ren-shi Li, Yuki Matsuo, Kyoko Nishida, Takayuki Koga, Tomoki Takeda, Yoshitaka Tanaka, Yuji Ishii
Summary: Maternal exposure to TCDD can cause developmental and reproductive disorders in pups due to reduced LH production. However, administration of LA to TCDD-exposed pregnant rats can reverse the LH reduction and alleviate reproductive disorders in offspring. LA supplementation restores sexually dimorphic behavior in male and female offspring, suggesting its potential use as a protective measure against dioxin toxicity.
BIOCHEMICAL PHARMACOLOGY
(2023)
Review
Nutrition & Dietetics
Ruey-Yu Hsieh, I-Chen Huang, Chiehfeng Chen, Jia-Ying Sung
Summary: Alpha-lipoic acid (ALA) improves symptoms in patients with diabetic sensorimotor peripheral neuropathy (DSPN) by reducing oxidative stress and improving microcirculation. A meta-analysis of randomized controlled trials (RCTs) evaluated the effects of orally-administered ALA versus placebo in patients with DSPN, finding that ALA treatment had favorable effects on sensory symptoms, total symptoms' score (TSS), neurological disability score (NDS), and global satisfaction. However, it did not produce favorable results for vibration perception, nerve conduction, and neuropathy impairment.
Article
Biochemistry & Molecular Biology
Kaio Murilo Monteiro Espindola, Everton Luiz Pompeu Varela, Rosyana de Fatima Vieira de Albuquerque, Rosiane Araujo Figueiredo, Savio Monteiro dos Santos, Nivea Silva Malcher, Pamela Suelen da S. Seabra, Andreia do Nascimento Fonseca, Karla Marcely de Azevedo Sousa, Susan Beatriz Batista de Oliveira, Agnaldo da Silva Carneiro, Michael D. Coleman, Marta Chagas Monteiro
Summary: This study evaluated the protective effect of racemic alpha lipoic acid (ALA) and its enantiomers on methemoglobin induction caused by Dapsone (DDS) therapy. The results showed that ALA could effectively inhibit the formation of methemoglobin induced by DDS-NOH and reduce DNA damage. This study suggests that ALA could be used as a treatment in patients who chronically use DDS, including leprosy patients.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Pharmacology & Pharmacy
Kavitha N. Chilaka, Ramanachary Namoju
Summary: This study investigates the protective role of alpha-lipoic acid (ALA) against prenatal Cytarabine (CYT)-induced reproductive impairment in male rats. The results show that ALA supplementation alleviates CYT-induced disruptions in oxidative balance, steroidogenesis, spermatogenesis, and testicular histological aberrations.
NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY
(2023)
Article
Clinical Neurology
Dayong Han, Lei Teng, Xiaoxiong Wang, Yunbo Zhen, Xiaofeng Chen, Mingchun Yang, Ming Gao, Guang Yang, Mingyang Han, Ligang Wang, Jiajun Xu, Yue Li, Alina Shumadalova, Shiguang Zhao
Summary: Arsenic trioxide demonstrated good safety and tolerability in glioma patients, with a recommended dose of 1.5 mg for a phase II trial.
FRONTIERS IN NEUROLOGY
(2022)
Article
Pharmacology & Pharmacy
Vijay Bhasker Reddy, Lakmal Boteju, Asela Boteju, Li Shen, Kelem Kassahun, Nageshwar Reddy, Adrian Sheldon, Sanjeev Luther, Ke Hu
Summary: This study highlights the clearance mechanism of CPI-613 via beta-oxidation, species differences in their ability to carry out beta-oxidation, and subsequent elimination routes. Structural limitations for completion of terminal cycle of beta-oxidation is discussed against the backdrop of its endogenous counterpart lipoic acid.
DRUG METABOLISM AND DISPOSITION
(2022)
Article
Engineering, Chemical
Hongbin Ling, Annelies Malfliet, Bart Blanpain, Muxing Guo
Summary: The study successfully removed arsenic from crude antimony trioxide using a nitric acid leaching method, achieving high selectivity for arsenic removal and antimony recovery. The arsenic removal ratio reached 86%, while the antimony leaching ratio was only 0.3%, with successful conversion to antimony oxide suitable for commercial production.
SEPARATION AND PURIFICATION TECHNOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Aaron Priester, Richard Waters, Ashleigh Abbott, Krista Hilmas, Klaus Woelk, Hunter A. Miller, Aria W. Tarudji, Connor C. Gee, Brandon McDonald, Forrest M. Kievit, Anthony J. Convertine
Summary: This study designed a material that can rapidly bind and neutralize reactive oxygen species (ROS) and lipid peroxidation product (LPOx) after traumatic brain injury (TBI). These neuroprotective copolymers (NPCs) showed promise for improved target engagement of multiple biochemical derangements and reduction of post-traumatic oxidative stress, potentially leading to improved TBI therapeutic outcomes.
Article
Biochemistry & Molecular Biology
Ilenia Martinelli, Daniele Tomassoni, Proshanta Roy, Lorenzo Di Cesare Mannelli, Francesco Amenta, Seyed Khosrow Tayebati
Summary: Hypertension leads to organ damage through oxidative stress, which can be reduced by antioxidant supplementation such as (+)-ALA. In spontaneously hypertensive rats, (+)-ALA showed greater effectiveness in reducing oxidative stress, cardiac, and renal damages compared to (+/-)-ALA. Therefore, (+)-ALA is proposed as a more appropriate antioxidant to prevent renal and cardiac alterations associated with hypertension.
Article
Nutrition & Dietetics
Katarzyna Hodun, Klaudia Sztolsztener, Adrian Chabowski
Summary: In this study, chronic administration of antioxidants NAC and ALA significantly reduced ceramide accumulation in the heart, while increasing myocardial sphingosine-1-phosphate levels. This led to an improvement in the intracellular insulin transduction pathway, suggesting a potential therapeutic strategy for obesity-related cardiovascular insulin resistance.
Article
Environmental Sciences
Abiodun O. Oluyomi, Aaron P. Thrift, Adegboyega Olayode, Elaine Symanski, Hemant Roy, Hashem B. El-Serag
Summary: Texas has the highest rates of hepatocellular carcinoma (HCC) in the United States, potentially related to exposure to toxicants like arsenic. The study found significant associations between arsenic exposure levels and HCC incidence in certain racial/ethnic groups.
ENVIRONMENTAL RESEARCH
(2024)
Article
Cardiac & Cardiovascular Systems
Cheng Shen, Xueheng Chen, Yong Cao, Yanyan Du, Xuan Xu, Qingjing Wu, Lizhi Lin, Yiran Qin, Runqi Meng, Lijun Gan, Jinguo Zhang
Summary: Chronic alcohol intake leads to cardiac hypertrophy, dysfunction, and mitochondrial dysfunction, while alpha-LA protects cardiac cells against alcohol-induced damage by activating aldehyde dehydrogenase 2 and inhibiting mitophagy.
JOURNAL OF CARDIOVASCULAR PHARMACOLOGY
(2023)
Review
Immunology
Sahar Sheikholeslami, Shaghayegh Khodaverdian, Masoumeh Dorri-Giv, Seyyed Mohammad Hosseini, Shokoufeh Souri, Razzagh Abedi-Firouzjah, Hamed Zamani, Leila Dastranj, Bagher Farhood
Summary: This study reviewed the potential role of alpha-lipoic acid in alleviating radiation-induced toxicities in healthy cells/tissues. Experimental results showed that this radio-protective agent could alleviate radiation-induced toxicities through mechanisms such as anti-oxidant, antiapoptosis, and anti-inflammatory effects. Co-treatment of alpha-lipoic acid with radiotherapy could ameliorate the radiation-induced toxicities in healthy cells/tissues.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2021)
Article
Pharmacology & Pharmacy
Toshinori Hirai, Ryosuke Yamaga, Motoki Kei, Keiko Hosohata, Toshimasa Itoh
Summary: This study investigates the relationship between acute kidney injury and hypokalemia in patients using Yokukansan preparation. The results show that patients with acute kidney injury are at higher risk for hypokalemia, which occurs later compared to patients without acute kidney injury. High systolic blood pressure and mean arterial pressure were identified as clinical predictors for acute kidney injury.
BIOLOGICAL & PHARMACEUTICAL BULLETIN
(2021)
Article
Pharmacology & Pharmacy
Toshinori Hirai, Keiko Hosohata, Yukari Ogawa, Takuya Iwamoto
Summary: This meta-analysis examined the relationship between clinical characteristics and nephrotoxicity associated with Teicoplanin, finding that patients over 65 years old had a higher trend of nephrotoxicity and hypoalbuminemia was negatively correlated with nephrotoxicity associated with Teicoplanin.
BASIC & CLINICAL PHARMACOLOGY & TOXICOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Keiko Hosohata, Denan Jin, Shinji Takai
Summary: In this study, the protective effect of Glaucocalxin A (GLA) on acute kidney injury (AKI) was investigated. GLA improved cell viability, suppressed reactive oxygen species (ROS) production, elevated superoxide dismutase activity, and prevented cell death in HK-2 human renal tubular epithelial cells exposed to hypoxia/reoxygenation (H/R). GLA also ameliorated the activation of the Akt/Nrf2/HO-1 signaling pathway. These findings suggest that GLA may serve as a promising therapeutic drug for AKI.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Hematology
Etsuko Kumagai, Keiko Hosohata, Kazuhiro Furumachi, Shinji Takai
Summary: TTR levels serve as independent and sensitive predictors of mortality in hemodialysis patients. TTR <20 mg/dl is a risk factor for 1-year mortality in Japanese hemodialysis patients.
THERAPEUTIC APHERESIS AND DIALYSIS
(2022)
Article
Oncology
Mayako Uchida, Saeko Murata, Hanae Morikawa, Hiroko Yonemitsu, Shigeru Ishida, Kimitaka Suetsugu, Toshikazu Tsuji, Hiroyuki Watanabe, Takehiro Kawashiri, Koji Kato, Keiko Hosohata, Toshihiro Miyamoto, Nobuaki Egashira, Tsutomu Nakamura, Koichi Akashi, Ichiro Ieiri
Summary: This study investigated the usefulness of a medication guidance sheet (MGS) in monitoring chemotherapy-related adverse events (AEs) in non-Hodgkin's lymphoma patients. The accuracy of the MGS was greatly improved after modification of the AEs duration, with a prediction accuracy of 84%.
ANTICANCER RESEARCH
(2022)
Article
Biochemistry & Molecular Biology
Hiroki Yoneyama, Keiko Hosohata, Denan Jin, Iroha Yoshida, Miyui Toyoda, Ikuko Kitamura, Shinji Takai, Yoshihide Usami
Summary: By designing and synthesizing novel vanin-1 inhibitors, researchers discovered that one compound, OMP-7, exhibited potent inhibitory activity that was 20 times stronger than the mother compound RR6. The in vivo assay showed that OMP-7 had stronger inhibitory activity against both serum and renal vanin-1 compared to RR6. These findings suggest that OMP-7 has potential as a new drug for treating related diseases.
BIOORGANIC & MEDICINAL CHEMISTRY
(2022)
Article
Pharmacology & Pharmacy
Iku Niinomi, Saki Oyama, Ayaka Inada, Tomohito Wakabayashi, Toshinori Hirai, Hiroko Kambara, Tatsuya Iida, Mayako Uchida, Yukako Sano, Keiko Hosohata
Summary: This study analyzed the frequency and safety profiles of adverse events caused by drugs used in the treatment of juvenile idiopathic arthritis (JIA) using a spontaneous reporting system database. The study found that prednisolone and tocilizumab were the most frequently reported drugs for JIA treatment. Prednisolone was significantly associated with hematophagic histiocytosis, while tocilizumab was associated with pneumonia, decreased neutrophil count, and lymphadenitis.
INTERNATIONAL JOURNAL OF CLINICAL PHARMACOLOGY AND THERAPEUTICS
(2022)
Review
Biochemistry & Molecular Biology
Keiko Hosohata, Tanisorn Harnsirikarn, Susama Chokesuwattanaskul
Summary: This review summarizes the involvement and importance of ferroptosis in acute kidney injury through oxidative stress.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Health Care Sciences & Services
Takeo Hata, Atsushi Hirata, Ryosuke Ota, Keiko Hosohata, Masami Nishihara, Masashi Neo, Takahiro Katsumata
Summary: This study investigated the patterns of prescribing biologic disease-modifying anti-rheumatic drugs (bDMARDs) for moderate-to-severe juvenile idiopathic arthritis (JIA) in Japan. The study found increasing trends for adalimumab and tocilizumab and a decreasing trend for methotrexate. Differences in medication use were also observed between systemic JIA and non-systemic JIA patients, in line with national and international guidelines.
THERAPEUTICS AND CLINICAL RISK MANAGEMENT
(2022)
Review
Biochemistry & Molecular Biology
Masanori Ono, Hitoshi Ando, Takiko Daikoku, Tomoko Fujiwara, Michihiro Mieda, Yasunari Mizumoto, Takashi Iizuka, Kyosuke Kagami, Takashi Hosono, Satoshi Nomura, Natsumi Toyoda, Naomi Sekizuka-Kagami, Yoshiko Maida, Naoaki Kuji, Hirotaka Nishi, Hiroshi Fujiwara
Summary: The circadian rhythm, controlled by clock genes, is crucial for reproduction. In the mouse uterus, the oscillation of circadian clock gene has been observed. CLOCK-BMAL1 heterodimer promotes the transcription of Per1/2 and Cry1/2 genes by binding to their promoters' E-box sequences. The endometrial clock plays an important role in pregnancy, and disruptions in the uterine clock can lead to complications.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Chemistry, Medicinal
Hironao Okubo, Hitoshi Ando, Yusuke Takasaki, Eisuke Nakadera, Yuka Fukuo, Shuichiro Shiina, Kenichi Ikejima
Summary: This study investigated the impact of cabozantinib exposure on proteinuria and muscle toxicity in Japanese patients with unresectable hepatocellular carcinoma. The findings suggest that cabozantinib treatment can lead to proteinuria and muscle toxicity, which can be predicted by measuring serum creatine kinase and aldolase levels.
Article
Pharmacology & Pharmacy
Tomohito Wakabayashi, Takahiro Nakatsuji, Hiroko Kambara, Iku Niinomi, Saki Oyama, Ayaka Inada, Sayaka Ueno, Mayako Uchida, Kazunori Iwanaga, Tatsuya Iida, Keiko Hosohata
Summary: This study used a spontaneous reporting system database to clarify drugs associated with abnormal behavior in a real-world setting. The results showed that neuraminidase inhibitors, acetaminophen, and montelukast were associated with abnormal behavior. These findings can help raise awareness among physicians regarding these drugs.
CURRENT REVIEWS IN CLINICAL AND EXPERIMENTAL PHARMACOLOGY
(2022)
Article
Medicine, Research & Experimental
Mayako Uchida, Rika Kawai, Rie Hisamitsu, Sayaka Mai, Shigeru Ishida, Hiroyuki Watanabe, Takehiro Kawashiri, Koji Kato, Keiko Hosohata, Toshihiro Miyamoto, Nobuaki Egashira, Tsutomu Nakamura, Koichi Akashi, Ichiro Ieiri
Summary: This study developed a medication instruction sheet (MIS) for patients receiving R-CHOP therapy and evaluated its usefulness in monitoring adverse drug reactions (ADRs) in non-Hodgkin's lymphoma (NHL) patients. The results showed that the MIS accurately predicted the occurrence of ADRs in terms of grade and timing, except for patients with thrombocytopenia.
Review
Medicine, General & Internal
Naoto Nagata, Guanliang Chen, Liang Xu, Hitoshi Ando
Summary: Nonalcoholic fatty liver disease (NAFLD) is a common chronic liver disease, and hepatic inflammation plays a crucial role in its development. Chemokines, especially CCL2 and CCL5, are important in inducing insulin resistance, steatosis, inflammation, and fibrosis in NAFLD. Cenicriviroc (CVC), a dual antagonist of chemokine receptors, has shown potential as a therapeutic approach for NASH-associated liver fibrosis.
MEDICINA-LITHUANIA
(2022)
Article
Medicine, General & Internal
Nazmul Hasan, Koki Sugimoto, Koki Yamada, Jun-ichi Morishige, Kentaro Ushijima, Akio Fujimura, Naoto Nagata, Hitoshi Ando
Summary: This study investigated whether chronic treatment with the antidiabetic agent metformin impairs circadian clocks, especially if given at an inappropriate time. The results showed that chronic treatment with metformin does not disrupt circadian clock gene expression in peripheral tissues and affects hepatic AMPK activation rhythm in diabetic mice.
MEDICINA-LITHUANIA
(2022)
