Journal
JOURNAL OF PHARMACOLOGICAL SCIENCES
Volume 113, Issue 4, Pages 414-417Publisher
JAPANESE PHARMACOLOGICAL SOC
DOI: 10.1254/jphs.10058SC
Keywords
chemoattractant lectin; Karatoxin; Hypodytes rubrinnis
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Funding
- University of Tokushima
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A chemoattractant lectin from the dorsal spines of the redfin velvetfish, Hypodytes rubripinnis, was isolated using a combination of affinity chromatography techniques. The glycoprotein, with a molecular mass of 110 kDa, is named Karatoxin. Karatoxin caused agglutination of rabbit erythrocytes. This agglutination was effectively inhibited by D-mannose. In addition, Karatoxin exhibited not only mitogenic activity in the presence of murine splenocytes, but also chemotactic activity in the presence of guinea-pig neutrophils and macrophages. Thus, Karatoxin appears to be a novel chemoattractant lectin. These results suggest that the redfin velvetfish Hypodytes rubripinnis may be a novel source of biologically active substances.
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