Article
Peripheral Vascular Disease
Vadym Buncha, Alena Cherezova, Sati Alexander, Irina Baranovskaya, Kathleen A. Coleman, Mary Cherian-Shaw, Michael W. Brands, Jennifer C. Sullivan, Paul M. O'Connor, Mykola Mamenko
Summary: In female rats, the MR-ENaC axis plays a crucial role in determining AngII-dependent hypertension, while its effects are limited in males.
Article
Medicine, General & Internal
Kazumichi Fujioka, Ruka Nakasone, Kosuke Nishida, Mariko Ashina, Itsuko Sato, Kandai Nozu
Summary: Pseudohypoaldosteronism type 1 (PHA-1) is a disorder characterized by sodium regulation problems due to renal tubular resistance to aldosterone. This study conducted a nationwide surveillance of neonatal PHA-1 in Japan, revealing its higher prevalence among preterm infants without male predominance and immediate onset after birth in cases without genetic or renal complications.
JOURNAL OF CLINICAL MEDICINE
(2022)
Review
Behavioral Sciences
Claire L. Pince, Kimberly E. Whiting, Tammy Wang, Andras H. Leko, Lisa A. Farinelli, Diane Cooper, Mehdi Farokhnia, Leandro F. Vendruscolo, Lorenzo Leggio
Summary: This scoping review summarizes the role of aldosterone and mineralocorticoid receptor (MR) in addiction and the potential effects of pharmacological manipulations of MR on addiction-related outcomes. The findings suggest that dysregulations of aldosterone and MR occur in both peripheral and central systems and are influenced by drug exposure patterns and genetic factors. Antagonism of MR holds promise as a potential target for the treatment of addiction, but further research is needed.
NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS
(2023)
Review
Endocrinology & Metabolism
Konstantinos Papadopoulos, Alexandra Papadopoulou, Tar-Choon Aw
Summary: Type 2 diabetes is a lifelong disease that requires innovative pharmacological interventions. Understanding the role of miRNA, particularly miR-155, is crucial in the pathogenesis of T2DM. Reduced levels of miR-155 in aging, obesity, and T2DM contribute to insulin resistance and glucose dysregulation. Restoring miR-155 levels through various treatments may be a potential therapeutic option.
WORLD JOURNAL OF DIABETES
(2023)
Article
Cell Biology
Krysten E. Ferraino, Natalie Cora, Celina M. Pollard, Anastasiya Sizova, Jennifer Maning, Anastasios Lymperopoulos
Summary: Angiotensin II (AngII) utilizes AT1R and AT2R G protein-coupled receptors to exert physiological effects, particularly impacting cardiovascular homeostasis. AT1R signaling mobilizes multiple signal transducers inside cells, with Gq/11 proteins and ?-arrestins specifically activated to promote aldosterone synthesis and secretion in the adrenal cortex. "Biased" signaling refers to preferential activation of one signaling pathway over others downstream of the same receptor, with therapeutic relevance in selectively promoting beneficial effects over detrimental consequences.
CELLULAR SIGNALLING
(2021)
Article
Cardiac & Cardiovascular Systems
Brett W. Sperry, Mazen Hanna, Sanjiv J. Shah, Wael A. Jaber, John A. Spertus
Summary: The study investigated an enriched cohort of HFpEF patients with cardiac amyloidosis phenotype in TOPCAT, finding that these patients had the worst prognosis but benefitted similarly from spironolactone therapy.
JACC-HEART FAILURE
(2021)
Review
Pharmacology & Pharmacy
Gregory L. Hundemer, Manish M. Sood
Summary: RAAS inhibitors are evidence-based treatments for various conditions, but can lead to hyperkalemia, which increases the risk for cardiovascular events. Managing hyperkalemia while maintaining the benefits of RAAS inhibitors is essential to prevent adverse outcomes.
PHARMACOLOGICAL RESEARCH
(2021)
Review
Biochemistry & Molecular Biology
Michael Crompton, Laura J. Skinner, Simon C. Satchell, Matthew J. Butler
Summary: The renin angiotensin aldosterone system plays a crucial role in blood pressure regulation. Excessive stimulation of mineralocorticoid receptors by aldosterone can lead to various pathological effects in the heart, kidney, and endothelial cells. In this article, we discussed the association between hyperaldosteronism and fibrosis, cardiac dysfunction, maladaptive hypertrophy, proteinuria, and fibrosis. We also reviewed how aldosterone exposure damages the endothelial glycocalyx and suggested that preventing glycocalyx remodeling may offer a novel strategy for limiting endothelial damage.
Article
Physiology
Julia Schrankl, Michaela Fuchs, Katharina Broeker, Christoph Daniel, Armin Kurtz, Charlotte Wagner
Summary: This study investigated the cell-specific localization of AT(1) receptor expression in rodent and human kidneys, revealing conserved AT(1) receptor mRNA expression sites in the (juxta)glomerular areas and tubulointerstitium across species, potentially serving as main target sites for ANG II in adult kidneys.
AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY
(2021)
Article
Cardiac & Cardiovascular Systems
Tlili Barhoumi, Fatmah A. Mansour, Maroua Jalouli, Hassan S. Alamri, Rizwan Ali, Abdel Halim Harrath, Maha Aljumaa, Mohamed Boudjelal
Summary: Angiotensin II (Ang II) is a key component of the renin-angiotensin-aldosterone system and is associated with cardiopathology. High levels of Ang II have been linked to inflammatory conditions such as coronary heart disease, obesity, and type 2 diabetes. This study evaluated the cellular effects of Ang II on THP-1-derived macrophages, showing that it stimulates differentiation markers and proinflammatory markers while decreasing an M2 marker. Ang II also induces calcium overload, increases reactive oxygen species, and arrests cells in the G1 phase, primarily through the angiotensin II type 1 receptor (AT1R).
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2023)
Article
Biochemistry & Molecular Biology
Xiaomeng Gao, Jingyue Chang, Yi Chang, Lili Fan, Ziqian Liu, Cuijuan Zhang, Tatsuo Shimosawa, Fan Yang, Qingyou Xu
Summary: Renal fibrosis, a common process in chronic kidney disease (CKD), is influenced by angiogenesis. Vascular endothelial cells contribute to renal fibrosis through phenotypic transformation and extracellular matrix secretion. Aldosterone, an inflammatory mediator, stimulates angiogenesis via mineralocorticoid receptor (MR) activation. Clinical evidence suggests that MR blockers (MRBs) protect damaged kidneys possibly by inhibiting angiogenesis. In this study, aldosterone infusion in mice induced angiogenesis and endothelial-mesenchymal transition (EndMT), highlighting their involvement in renal fibrosis. Aldosterone induced inflammation and macrophages secreted vascular endothelial growth factor (VEGF)-A to regulate angiogenesis through MR activation, while EndMT occurred in response to transforming growth factor (TGF)-β1 induction, contributing to renal fibrosis. These effects were counteracted by the MRB esaxerenone. These findings suggest that reducing angiogenesis may be an effective strategy for treating renal fibrosis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Nutrition & Dietetics
Daniela Jezova, Peter Karailiev, Lucia Karailievova, Agnesa Puhova, Harald Murck
Summary: The study introduced the concept that Glycyrrhiza glabra extract might reduce the entry point for SARS-CoV-2, ACE2. Results showed a significant decrease in ACE2 gene and protein expression in the small intestine of rats fed with the extract, suggesting a potential therapeutic target for COVID-19 prevention.
Review
Immunology
Felicitas E. Hengel, Jean-Pierre Benitah, Ulrich O. Wenzel
Summary: The mosaic theory proposes that hypertension is a result of interactions among various causes, and recent research highlights the role of inflammation and salt intake in this process. Inflammation plays a crucial role in the pathophysiology of hypertension, and high-salt intake can modulate inflammatory responses, ultimately affecting the development of hypertension.
CELLULAR & MOLECULAR IMMUNOLOGY
(2022)
Article
Urology & Nephrology
Daniel E. Leisman, Tiago D. Fernandes, Vanesa Bijol, Mabel N. Abraham, Jake R. Lehman, Matthew D. Taylor, Christine Capone, Omar Yaipan, Rinaldo Bellomo, Clifford S. Deutschman
Summary: The study found that sepsis reduces the expression of renal angiotensin II receptors, leading to changes in kidney blood flow and creatinine levels. Both mouse models and clinical observations suggest that angiotensin II prevents these functional changes, while AT1R blockade exacerbates them.
KIDNEY INTERNATIONAL
(2021)
Article
Endocrinology & Metabolism
Johannes J. Kovarik, Christopher C. Kaltenecker, Oliver Domenig, Marlies Antlanger, Marko Poglitsch, Chantal Kopecky, Marcus D. Saemann
Summary: In this study, the effects of combined MRA eplerenone and ACEi therapy on key RAAS effectors in CKD patients were examined. The results showed that eplerenone treatment led to global RAAS activation while significantly increasing the alternative RAAS effector Ang-(1-7).
Editorial Material
Gastroenterology & Hepatology
Naoya Tada, Hideki Kobara, Noriko Nishiyama, Ken Ishimura, Kunihisa Uchita, Akira Nishiyama, Tsutomu Masaki
Review
Peripheral Vascular Disease
Ningning Wan, Asadur Rahman, Akira Nishiyama
Summary: Esaxerenone, a novel nonsteroidal mineralocorticoid receptor blocker, has shown efficacy and good tolerability in treating hypertensive patients in Japan. In addition to lowering blood pressure, esaxerenone also demonstrates renoprotective effects. Clinical trials have indicated the potential clinical application of esaxerenone in treating renal diseases.
JOURNAL OF HUMAN HYPERTENSION
(2021)
Article
Surgery
Naoya Tada, Hideki Kobara, Noriko Nishiyama, Shintaro Fujihara, Tadayuki Takata, Kazuhiro Kozuka, Takanori Matsui, Nobuya Kobayashi, Taiga Chiyo, Koji Fujita, Joji Tani, Tatsuo Yachida, Akihito Tsuji, Keiichi Okano, Yasuyuki Suzuki, Daisuke Nakano, Akira Nishiyama, Tsutomu Masaki
Summary: This study concludes that the guidewire-assisted OTSC delivery (GOD) method is a feasible and safe technique for delivering OTSC to the small and proximal large intestine.
MINIMALLY INVASIVE THERAPY & ALLIED TECHNOLOGIES
(2022)
Article
Urology & Nephrology
Adriana Marton, Tatsuroh Kaneko, Jean-Paul Kovalik, Atsutaka Yasui, Akira Nishiyama, Kento Kitada, Jens Titze
Summary: SGLT2 inhibitors induce metabolic adaptations similar to aestivation, helping patients adapt to reduced energy availability and conserve water. These metabolic adjustments may contribute to the favorable cardiovascular and renal outcomes of SGLT2 inhibitor therapy.
NATURE REVIEWS NEPHROLOGY
(2021)
Review
Peripheral Vascular Disease
Satoshi Kidoguchi, Naoki Sugano, Gorou Tokudome, Takashi Yokoo, Yuichiro Yano, Kiyohiko Hatake, Akira Nishiyama
Summary: Due to aging populations, the prevalence of hypertension, cardiovascular events, and cancer is increasing globally. Small-molecule inhibitors used in cancer therapy have a positive impact on prognosis and survival of cancer patients, leading to a rapid increase in cancer survivors with hypertension. However, there is a lack of evidence on optimal blood pressure control for cancer patients with hypertension, highlighting the need for further research on the concept of onco-hypertension.
Article
Surgery
Nobuya Kobayashi, Hideki Kobara, Noriko Nishiyama, Shintaro Fujihara, Kazuhiro Kozuka, Naoya Tada, Takanori Matsui, Taiga Chiyo, Tadayuki Takata, Koji Fujita, Joji Tani, Tatsuo Yachida, Keiichi Okano, Daisuke Nakano, Akira Nishiyama, Hirohito Mori, Tsutomu Masaki
Summary: The study demonstrated that the WaRP method has a high technical success rate and safety in reducing post-ESD bleeding after gastric ESD, making it a simple and reliable approach.
MINIMALLY INVASIVE THERAPY & ALLIED TECHNOLOGIES
(2022)
Article
Surgery
Yasuhiro Goda, Hideki Kobara, Nobuya Kobayashi, Noriko Nishiyama, Shintaro Fujihara, Naoya Tada, Kazuhiro Kozuka, Takanori Matsui, Taiga Chiyo, Tingting Shi, Koji Fujita, Joji Tani, Tatsuo Yachida, Masashi Takata, Keiichi Okano, Daisuke Nakano, Akira Nishiyama, Hirohito Mori, Tsutomu Masaki
Summary: This study examined the clinical outcomes and long-term characteristics of patients treated with Over-The-Scope Clip (OTSC). The results showed a 100% clinical success rate and a 2.9% complication rate during the observation period. OTSC remains effective in the long-term.
MINIMALLY INVASIVE THERAPY & ALLIED TECHNOLOGIES
(2022)
Article
Physiology
Johannes Kovarik, Norihiko Morisawa, Johannes Wild, Adriana Marton, Kaoru Takase-Minegishi, Shintaro Minegishi, Steffen Daub, Jeff M. Sands, Janet D. Klein, James L. Bailey, Jean-Paul Kovalik, Manfred Rauh, Susanne Karbach, Karl F. Hilgers, Friedrich Luft, Akira Nishiyama, Daisuke Nakano, Kento Kitada, Jens Titze
Summary: Our study found that rats with 5/6 nephrectomy showed polyuria due to the inability of their kidneys to concentrate urine, but they were able to adapt physiologically by mobilizing nitrogen and energy from muscle, increasing norepinephrine and copeptin levels, and reducing skin blood flow to compensate for transepidermal water loss. This complex physiologic-metabolic adjustment across multiple organs allowed the rats to stabilize their body water content despite persisting renal water loss, although it led to hypertension and muscle catabolism.
Article
Hematology
Eri Muso, Soichi Sakai, Youske Ogura, Susumu Yukawa, Yoshiki Nishizawa, Noriaki Yorioka, Takao Saito, Masatoshi Mune, Satoshi Sugiyama, Yasuhiko Iino, Tsutomu Hirano, Motoshi Hattori, Tsuyoshi Watanabe, Hitoshi Yokoyama, Hiroshi Sato, Shunya Uchida, Takashi Wada, Tetsuo Shoji, Hiroaki Oda, Kiyoshi Mori, Hideki Kimura, Osamu Ito, Akira Nishiyama, Shoichi Maruyama, Reiko Inagi, Shoichi Fujimoto, Tatsuo Tsukamoto, Yusuke Suzuki, Hirokazu Honda, Tetsuya Babazono, Kazuhiko Tsuruya, Yukio Yuzawa
Summary: Many reports have demonstrated the therapeutic efficacy of LDL-Apheresis in improving heavy proteinuria and severely impaired renal function in cases of drug-resistant nephrotic syndrome. A post hoc analysis of the POLARIS study showed significant improvements in proteinuria and renal function in cases with normal and moderately impaired renal function, and a trend for improvement in severely impaired renal function. Most cases did not progress to end-stage renal disease within 2 years after LDL-A treatment.
THERAPEUTIC APHERESIS AND DIALYSIS
(2022)
Article
Health Care Sciences & Services
Tadashi Sofue, Taiga Hara, Yoko Nishijima, Satoshi Nishioka, Hiroyuki Watatani, Masahito Yamanaka, Norihiro Takahashi, Akira Nishiyama, Tetsuo Minamino
Summary: After the implementation of the NHI special health checkup and chronic kidney disease (CKD) initiative in Kagawa prefecture, there was an increase in the prevalence of CKD and the coverage rate of NHI health checkups.
JOURNAL OF PERSONALIZED MEDICINE
(2021)
Article
Biochemistry & Molecular Biology
Mai Hattori, Asadur Rahman, Satoshi Kidoguchi, Nourin Jahan, Yoshihide Fujisawa, Norihiko Morisawa, Hiroyuki Ohsaki, Hideki Kobara, Tsutomu Masaki, Akram Hossain, Akumwami Steeve, Akira Nishiyama
Summary: This study investigated the effects of the nonsteroidal mineralocorticoid receptor blocker esaxerenone on blood pressure and renal health in salt-loaded conditions. The results showed that esaxerenone significantly reduced blood pressure and attenuated renal damage induced by high salt intake. These effects were associated with the modulation of sodium homeostasis by esaxerenone.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Jose A. Godoy-Lugo, Max A. Thorwald, Dora A. Mendez, Ruben Rodriguez, Daisuke Nakano, Akira Nishiyama, Rudy M. Ortiz
Summary: This study found that long-term AT1 blockade can increase nuclear Nrf2 content and reduce the expression of antioxidant enzymes, thereby promoting the development of NAFLD. The angiotensin receptor blocker can alleviate the impact of hyperglycemia on Nrf2, suggesting its role in antioxidant defense.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Biochemistry & Molecular Biology
Asadur Rahman, Nourin Jahan, Md Tanvir Rahman, Akira Nishiyama
Summary: Inappropriate mineralocorticoid receptor (MR) activation in cardiovascular cells has negative effects on cardiac remodeling and function. MR inhibition is an important strategy to overcome cardiovascular dysfunction, but the clinical application of steroidal MR antagonists is limited due to adverse effects. Newer non-steroidal MR antagonists show promise for clinical use, particularly in patients with type 2 diabetes and chronic kidney disease. Pre-clinical and clinical evidence supports the use of non-steroidal MR antagonists in treating cardiovascular disease.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Editorial Material
Biochemistry & Molecular Biology
Rudy M. Ortiz, Ryousuke Satou, Jia L. Zhuo, Akira Nishiyama
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Chemistry, Analytical
Kosuke Nogo, Kou Ikejima, Wei Qi, Natsumi Kawashima, Tomoya Kitazaki, Satoru Adachi, Kenji Wada, Akira Nishiyama, Ichiro Ishimaru
Summary: This study developed a palm-sized LWIR hyperspectral camera for imaging-type two-dimensional Fourier spectroscopy, which could record the absorbance of black microplastics more quickly and effectively than traditional FPA-FT-IR systems, making it easier to use in the field or on a research vessel.
ANALYTICAL METHODS
(2021)