Journal
JOURNAL OF PHARMACOLOGICAL SCIENCES
Volume 108, Issue 3, Pages 239-247Publisher
JAPANESE PHARMACOLOGICAL SOC
DOI: 10.1254/jphs.08096FP
Keywords
lipopolysaccharide; D-galactosamine; naltrexone; tumor necrosis factor-alpha; nitric oxide
Categories
Funding
- National Science Council [NSC 95-2320-B-016-030]
- Jenken Biosciences, Inc., Research Triangle Park, NC, USA.
Ask authors/readers for more resources
Naltrexone, an opiold receptor antagonist, has been claimed to have anti-in anti-inflammatory immunomodulatory effects both in vitro and in vivo. Thus, the aim of this Study was to evaluate the effects of naltrexone on acute hepatitis induced by intraperitoneal (i.p.) administration of lipopolysaccharide (LPS, 20 mu g/kg)/D-galactosamine (D-gal, 700 mg/kg) in conscious ICR mice. Results demonstrated that post-treatment with naltrexone (20 mg/kg, i.p.) significantly attenuated the deleterious liver function in mice treated with LPS/D-gal. It was also found that naltrexone significantly inhibited the elevation of plasma tumor necrosis Factor-alpha (TNF-alpha) caused by LPS/D-gal. The overproduction of nitric oxide (NO) and superoxide anions induced by LPS/D-gal were also significantly reduced by naltrexone. Moreover, infiltration of neutrophils into the liver of mice 12 h after treatment with LPS/D-gal was also decreased by naltrexone. In conclusion, the beneficial effects of naltrexone on LPS/D-gal-induced hepatitis result from its inhibition of pro-inflammatory factors and antioxidant effects. Thus, naltrexone is of therapeutic potential for treating liver injury.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available