Article
Psychiatry
Roberto Farina Almeida, Yasmine Nonose, Marcelo Ganzella, Samanta Oliveira Loureiro, Andreia Rocha, Daniele Guilhermano Machado, Bruna Bellaver, Fernanda Urruth Fontella, Douglas T. Leffa, Leticia Ferreira Pettenuzzo, Gianina Teribele Venturin, Samuel Greggio, Jaderson Costa da Costa, Eduardo R. Zimmer, Elaine Elisabetsky, Diogo O. Souza
Summary: This study aimed to investigate the long-term behavioral and neurochemical effects of GUO in a mouse model of depression induced by bilateral bulbectomy (OBX), showing beneficial neurochemical outcomes relevant to counteract depression.
FRONTIERS IN PSYCHIATRY
(2021)
Article
Biochemistry & Molecular Biology
Yamina El Hamdaoui, Fang Zheng, Nikolas Fritz, Lian Ye, Mai Anh Tran, Kevin Schwickert, Tanja Schirmeister, Albert Braeuning, Dajana Lichtenstein, Ute A. Hellmich, Dorothee Weikert, Markus Heinrich, Giulia Treccani, Michael K. E. Schaefer, Gabriel Nowak, Bernd Nuernberg, Christian Alzheimer, Christian P. Mueller, Kristina Friedland
Summary: This study identifies TRPC6 channel as a druggable target for controlling anxious and depressive behavior and demonstrates the antidepressant action of hyperforin through the activation of this channel. The researchers synthesized a hyperforin analog, Hyp13, which shows similar binding and anxiolytic and antidepressant effects without inducing drug-drug interactions.
MOLECULAR PSYCHIATRY
(2022)
Article
Neurosciences
Elena Carazo-Arias, Phi T. Nguyen, Marley Kass, Hyun Jung Jee, Katherine M. Nautiyal, Valerie Magalong, Lilian Coie, Valentine Andreu, Mark M. Gergues, Huzefa Khalil, Huda Akil, Danusa Mar Arcego, Michael Meaney, Christoph Anacker, Benjamin A. Samuels, John E. Pintar, Irina Morozova, Sergey Kalachikov, Rene Hen
Summary: The opioid system is involved in the antidepressant effects of fluoxetine, potentially mediated through the upregulation of proenkephalin in a specific subgroup of mature granule cells.
BIOLOGICAL PSYCHIATRY
(2022)
Article
Psychiatry
Chaoli Huang, Yuanyuan Wang, Zifeng Wu, Jiali Xu, Ling Zhou, Di Wang, Ling Yang, Bin Zhu, Guiquan Chen, Cunming Liu, Chun Yang
Summary: The study reveals that miR-98-5p plays an important role in the antidepressant mechanism of ketamine, as upregulation can alleviate depression-like behaviors and inhibition can block the antidepressant effect of ketamine. Targeting miR-98-5p may offer potential therapeutic strategies for depression treatment.
TRANSLATIONAL PSYCHIATRY
(2021)
Article
Psychology, Biological
David M. Coppola, R. Parrish Waters
Summary: The olfactory bulbectomized rodent model, long used in depression research, is found to exhibit hyperactivity, non-aggressiveness, and fearlessness, but not memory deficits. The immediate emergence of these behaviors after surgery challenges the common belief of compensatory reorganization in the brain, indicating that the loss of smell may be the key factor behind the behavioral changes observed. In conclusion, the model lacks validity as a representation of neuropsychiatric diseases due to its complexity and lack of simplicity.
PHYSIOLOGY & BEHAVIOR
(2021)
Article
Biochemistry & Molecular Biology
Wenjian Kang, Shan Liu, Jin Xu, Anna Abrimian, Ayma F. Malik, Raymond Chien, Adejuyigbe Adaralegbe, Akwasi Amponsah, Luca Cartegni, John Pintar, Ying-Xian Pan
Summary: The mu opioid receptor gene OPRM1 undergoes extensive alternative pre-mRNA splicing to generate multiple splice variants, which have distinct pharmacological functions. Gene-targeted mouse models have been used to study the functional importance of these splice variants in the actions of mu opioids.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Behavioral Sciences
Chang-Ming Chen, Huiping Ding, Kelsey M. Mabry, Mei-Chuan Ko
Summary: This study compared the antidepressant-like effects of a delta opioid receptor (DOR) agonist, SNC80, and a tricyclic antidepressant, amitriptyline, in rats under normal or inflammatory pain state. The results showed that the potency of SNC80-induced antidepressant-like effects, but not amitriptyline, was enhanced in rats under inflammatory pain. This suggests that DOR agonists may be more effective as potential antidepressants for patients experiencing both depression and pain.
PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR
(2022)
Article
Multidisciplinary Sciences
Kevin W. Zhu, Shawn D. Burton, Maira H. Nagai, Justin D. Silverman, Claire A. de March, Matt Wachowiak, Hiroaki Matsunami
Summary: This study utilized targeted spatial transcriptomics to map the distribution of olfactory receptors in the murine olfactory bulb and generated a 3D model. The findings revealed a relationship between receptors and odorants, providing significant insights into olfaction.
NATURE COMMUNICATIONS
(2022)
Article
Biology
Sho Kurihara, Masayoshi Tei, Junichi Hata, Eri Mori, Masato Fujioka, Yoshinori Matsuwaki, Nobuyoshi Otori, Hiromi Kojima, Hirotaka James Okano
Summary: Combined high-field MRI and DTI analyses allow visualization of olfactory sensory neurons and their projections, providing olfactory nerve maps in humans, marmosets, and mice. This technique has the potential to be used clinically for the diagnosis of olfactory dysfunction.
COMMUNICATIONS BIOLOGY
(2022)
Article
Immunology
Aurora Kraus, Mar Huertas, Laura Ellis, Pierre Boudinot, Jean-Pierre Levraud, Irene Salinas
Summary: Loss of smell is a prevalent symptom of SARS-CoV-2 infection. The SARS-CoV-2 spike protein can cause damage to the zebrafish olfactory system, leading to structural and functional impairment. Single cell RNA sequencing revealed loss of olfactory receptor expression and inflammatory responses.
BRAIN BEHAVIOR AND IMMUNITY
(2022)
Article
Chemistry, Medicinal
Daniel Zaienne, Sabine Willems, Simone Schierle, Jan Heering, Daniel Merk
Summary: The study found that indole-based inverse Nurr1 agonists can effectively regulate Nurr1 activity by inhibiting the monomer activity and reducing the receptor's transcriptional activity. These agonists disrupted Nurr1 activity in cell-free experiments and reduced the expression of Nurr1-regulated genes in cells, showing potential to investigate the role of Nurr1 in neuroinflammation, cancer, and beyond.
JOURNAL OF MEDICINAL CHEMISTRY
(2021)
Article
Pharmacology & Pharmacy
Keith M. Olson, Andrea L. Devereaux, Payal Chatterjee, Savanah L. Saldana-Shumaker, Amanda Shafer, Adam Plotkin, Ram Kandasamy, Alexander D. MacKerell, John R. Traynor, Christopher W. Cunningham
Summary: This study investigates the structure-activity relationships of benzylideneoxymorphone analogs in order to develop analgesics with reduced tolerance and side effects. One compound, nitro-BOM (NBOM), showed high-efficacy antinociception but also exhibited tolerance and toxicity upon repeated administration. Despite these issues, NBOM provides an important tool for understanding MOPr/DOPr pharmacology.
FRONTIERS IN PHARMACOLOGY
(2023)
Article
Clinical Neurology
Shannon C. Waye, O. Chandani Dinesh, S. M. Nageeb Hasan, Joshua D. Conway, Roger Raymond, Jose N. Nobrega, Jacqueline Blundell, Francis Rodriguez Bambico
Summary: The study explored the synergistic effects of prefrontal tDCS and paroxetine in adolescent rats with olfactory bulbectomy-induced depression. Treatment led to changes in various biomarkers and gene expressions, suggesting potential therapeutic mechanisms involving BDNF, 5-HT1A, SERT, and Zif268 in corticolimbic areas.
JOURNAL OF PSYCHOPHARMACOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Sadia Ashraf, O. Howard Frazier, Sylvia Carranza, David D. McPherson, Heinrich Taegtmeyer, Romain Harmancey
Summary: This study investigated the expression of OR genes in the human heart and found that certain ORs are dysregulated in heart failure caused by ischemic cardiomyopathy. Co-expression analysis suggested that these dysregulated ORs may play a role in the alteration of mitochondrial function, extracellular matrix remodeling, and inflammation in the pathogenesis of heart failure. This study provides a resource for studying the roles of ORs in the human heart and may aid in the identification of new therapeutic targets for the treatment of heart failure.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Psychiatry
Kohei Takahashi, Kazuhiro Kurokawa, Lihua Hong, Kazuya Miyagawa, Atsumi Mochida-Saito, Masahiro Iwasa, Hiroyuki Iwasa, Osamu Nakagawasai, Takeshi Tadano, Hiroshi Takeda, Minoru Tsuji
Summary: A therapeutic strategy through the gut-brain axis has been proven to be effective in the treatment of depression. This study investigated the effects of Enterococcus faecalis 2001 (EF-2001) on depressive-like behaviors in mice and found that it prevented depressive-like behaviors by regulating myelination in the prefrontal cortex (PFC) via the enhancement of CREB/BDNF and NFKB p65/LIF/STAT3 pathways. These findings provide strong support for the potential of gut microbiota-based therapeutic strategies as alternative treatments for depression.
JOURNAL OF PSYCHIATRIC RESEARCH
(2022)
Review
Psychiatry
Masatoshi Inagaki, Yoshitaka Kawashima, Naohiro Yonemoto, Mitsuhiko Yamada
Letter
Clinical Neurology
Tatsuo Akechi, Tadashi Kato, Noboru Fujise, Naohiro Yonemoto, Aran Tajika, Toshi A. Furukawa, Toshi A. Furukawa, Tatsuo Akechi, Shinji Shimodera, Mitsuhiko Yamada, Masatoshi Inagaki, Norio Watanabe, Naohiro Yonemoto, Kazuhira Miki, Yusuke Ogawa, Nozomi Takeshima, Aran Tajika, Teruhiko Higuchi, Yoshio Hirayasu, Akiko Kada, Tsukasa Koyama, Ichiro Kusumi, Takeshi Inoue, Yuki Kako, Kiyoto Kasai, Motomu Suga, Masafumi Mizuno, Naohisa Tsujino, Tatsuo Akechi, Masaki Kondo, Shigeto Yamawaki, Yasumasa Okamoto, Shinpei Inoue, Shigeru Morinobu, Shinji Shimodera, Naohisa Uchimura, Shingo Yasumoto, Keiichiro Mori, Manabu Ikeda, Noboru Fujise, Kahori Itoh, Kunihiko Kawamura, Takeshi Inoue, Masahito Tsukamoto, Miki Noda, Ikuko Nitta, Shin Nakagawa, Koichi Ito, Teruaki Tanaka, Yukie Usukubo, Tomoko Fujie, Ihoko Suzuki, Kazuyuki Sugishita, Naohiro Okada, Masaru Kinou, Kohei Marumo, Makoto Motoyama, Eisuke Sakakibara, Kazuki Taniguchi, Fumichika Nishimura, Mariko Tada, Shinjiro Dogan, Shuntaro Ando, Norichika Iwashiro, Bun Chino, Kazuhira Miki, Naohisa Tsujino, Yuki Kato, Sayaka Aikawa, Michiko Nakamura, Hiroko Hasuya, Tadashi Kato, Yoshio Ikeda, Yoshihiro Shinagawa, Masaki Kondo, Yoshiyuki Itakura, Ushio Isobe, Taku Sugiura, Toshiyuki Watanabe, Mino Kayukawa, Norio Watanabe, Tatsuo Akechi, Yumi Nakano, Akio Mantani, Ken'ichi Kurata, Ichiro Yanai, Kyoka Ozaki, Hiroaki Izumi, Yasuyuki Iwamoto, Yukitaka Morita, Ken Wada, Hajime Kubouchi, Hirotoshi Sato, Shinji Shimodera, Hirokazu Fujita, Takashi Itoh, Ryosuke Fujito, Sawako Kanno, Hiroshi Hashizume, Ippei Morokuma, Yosuke Suga, Mikako Fuji, Susumu Hirota, Ken Uematsu, Shigeto Yamada, Yuuki Hanada, Yuji Ito, Hiroshi Chikama, Hidetsugu Kodama, Keiichiro Mori, Takehiro Morita, Misari Oe, Shingo Yasumoto, Taro Oji, Hidefumi Kodama, Kimihiro Ogi, Yoshihisa Shoji, Noboru Fujise, Shigehiro Nakata, Masahiro Shono, Akinori Aizawa, Kosuke Nishiyama, Yasuhisa Abe, Midori Suematsu, Ken Ikegami, Kazuya Isoda, Kenshiro Miyamoto, Setsuko Yasugawa, Erika Mizutani, Ryuta Fukunaga, Yoshitomo Nishi
PSYCHIATRY AND CLINICAL NEUROSCIENCES
(2019)
Review
Psychiatry
Yoshitaka Kawashima, Naohiro Yonemoto, Masatoshi Inagaki, Keisuke Inoue, Chiaki Kawanishi, Mitsuhiko Yamada
GENERAL HOSPITAL PSYCHIATRY
(2019)
Letter
Psychiatry
Yoshitaka Kawashima, Naohiro Yonemoto, Masatoshi Inagaki, Keisuke Inoue, Chiaki Kawanishi, Mitsuhiko Yamada
GENERAL HOSPITAL PSYCHIATRY
(2020)
Article
Psychiatry
Chen He, Brooke Levis, Kira E. Riehm, Nazanin Saadat, Alexander W. Levis, Marleine Azar, Danielle B. Rice, Ankur Krishnan, Yin Wu, Ying Sun, Mahrukh Imran, Jill Boruff, Pim Cuijpers, Simon Gilbody, John P. A. Ioannidis, Lorie A. Kloda, Dean McMillan, Scott B. Patten, Ian Shrier, Roy C. Ziegelstein, Dickens H. Akena, Bruce Arroll, Liat Ayalon, Hamid R. Baradaran, Murray Baron, Anna Beraldi, Charles H. Bombardier, Peter Butterworth, Gregory Carter, Marcos Hortes Nisihara Chagas, Juliana C. N. Chan, Rushina Cholera, Kerrie Clover, Yeates Conwell, Janneke M. de Man-van Ginkel, Jesse R. Fann, Felix H. Fischer, Daniel Fung, Bizu Gelaye, Felicity Goodyear-Smith, Catherine G. Greeno, Brian J. Hall, Patricia A. Harrison, Martin Harter, Ulrich Hegerl, Leanne Hides, Stevan E. Hobfoll, Marie Hudson, Thomas N. Hyphantis, Masatoshi Inagaki, Khalida Ismail, Nathalie Jette, Mohammad E. Khamseh, Kim M. Kiely, Yunxin Kwan, Femke Lamers, Shen-Ing Liu, Manote Lotrakul, Sonia R. Loureiro, Bernd Loewe, Laura Marsh, Anthony McGuire, Sherina Mohd-Sidik, Tiago N. Munhoz, Kumiko Muramatsu, Flavia L. Osorio, Vikram Patel, Brian W. Pence, Philippe Persoons, Angelo Picardi, Katrin Reuter, Alasdair G. Rooney, Ina S. da Silva dos Santos, Juwita Shaaban, Abbey Sidebottom, Adam Simning, Lesley Stafford, Sharon Sung, Pei Lin Lynnette Tan, Alyna Turner, Henk C. P. M. van Weert, Jennifer White, Mary A. Whooley, Kirsty Winkley, Mitsuhiko Yamada, Brett D. Thombs, Andrea Benedetti
PSYCHOTHERAPY AND PSYCHOSOMATICS
(2020)
Article
Pharmacology & Pharmacy
Kusui Yuka, Daisuke Nishizawa, Junko Hasegawa, Kyosuke Uno, Hajime Miyanishi, Hiroshi Ujike, Norio Ozaki, Toshiya Inada, Nakao Iwata, Ichiro Sora, Masaomi Iyo, Mitsuhiko Yamada, Naoki Kondo, Moo-Jun Won, Nobuya Naruse, Kumi Uehara-Aoyama, Kazutaka Ikeda, Atsumi Nitta
CURRENT PHARMACEUTICAL DESIGN
(2020)
Article
Health Care Sciences & Services
Sean McGrath, XiaoFei Zhao, Russell Steele, Brett D. Thombs, Andrea Benedetti, Brooke Levis, Kira E. Riehm, Nazanin Saadat, Alexander W. Levis, Marleine Azar, Danielle B. Rice, Ying Sun, Ankur Krishnan, Chen He, Yin Wu, Parash Mani Bhandari, Dipika Neupane, Mahrukh Imran, Jill Boruff, Pim Cuijpers, Simon Gilbody, John P. A. Ioannidis, Lorie A. Kloda, Dean McMillan, Scott B. Patten, Ian Shrier, Roy C. Ziegelstein, Dickens H. Akena, Bruce Arroll, Liat Ayalon, Hamid R. Baradaran, Murray Baron, Anna Beraldi, Charles H. Bombardier, Peter Butterworth, Gregory Carter, Marcos H. Chagas, Juliana C. N. Chan, Rushina Cholera, Neerja Chowdhary, Kerrie Clover, Yeates Conwell, Janneke M. de Man-van Ginkel, Jaime Delgadillo, Jesse R. Fann, Felix H. Fischer, Benjamin Fischler, Daniel Fung, Bizu Gelaye, Felicity Goodyear-Smith, Catherine G. Greeno, Brian J. Hall, Patricia A. Harrison, Martin Harter, Ulrich Hegerl, Leanne Hides, Stevan E. Hobfoll, Marie Hudson, Thomas Hyphantis, Masatoshi Inagaki, Khalida Ismail, Nathalie Jette, Mohammad E. Khamseh, Kim M. Kiely, Yunxin Kwan, Femke Lamers, Shen-Ing Liu, Manote Lotrakul, Sonia R. Loureiro, Bernd Loewe, Laura Marsh, Anthony McGuire, Sherina Mohd Sidik, Tiago N. Munhoz, Kumiko Muramatsu, Flavia L. Osorio, Vikram Patel, Brian W. Pence, Philippe Persoons, Angelo Picardi, Katrin Reuter, Alasdair G. Rooney, Ina S. Santos, Juwita Shaaban, Abbey Sidebottom, Adam Simning, Lesley Stafford, Sharon C. Sung, Pei Lin Lynnette Tan, Alyna Turner, Christina M. van der Feltz-Cornelis, Henk C. van Weert, Paul A. Vohringer, Jennifer White, Mary A. Whooley, Kirsty Winkley, Mitsuhiko Yamada, Yuying Zhang
STATISTICAL METHODS IN MEDICAL RESEARCH
(2020)
Article
Multidisciplinary Sciences
Eri Takeuchi, Daisuke Yamada, Satoshi Suzuki, Akiyoshi Saitoh, Masayuki Itoh, Takashi Hayashi, Mitsuhiko Yamada, Keiji Wada, Masayuki Sekiguchi
Article
Clinical Neurology
Yoshitaka Kawashima, Naohiro Yonemoto, Chiaki Kawanishi, Kotaro Otsuka, Masaru Mimura, Yasushi Otaka, Kazuya Okamura, Toshihiko Kinoshita, Osamu Shirakawa, Reiji Yoshimura, Nobuaki Eto, Satoshi Hashimoto, Hirokazu Tachikawa, Taku Furuno, Tatsuya Sugimoto, Katsumi Ikeshita, Masatoshi Inagaki, Mitsuhiko Yamada
PSYCHIATRY AND CLINICAL NEUROSCIENCES
(2020)
Article
Psychiatry
Hiroshi Kuniishi, Daisuke Yamada, Keiji Wada, Mitsuhiko Yamada, Masayuki Sekiguchi
TRANSLATIONAL PSYCHIATRY
(2020)
Letter
Clinical Neurology
Kazuya Okamura, Takashi Komori, Mai Sugimoto, Yoshitaka Kawashima, Mitsuhiko Yamada, Toshifumi Kishimoto
PSYCHIATRY AND CLINICAL NEUROSCIENCES
(2021)
Article
Neurosciences
Hiroki Furuie, Mitsuhiko Yamada
Summary: During the postnatal period, NR2A-containing NMDA receptor plays a crucial role in proper brain development in rats, and disturbances in its functioning result in impaired spatial working memory in adulthood.
NEUROSCIENCE RESEARCH
(2022)
Review
Neurosciences
Yoshitaka Kawashima, Misa Yamada, Hiroki Furuie, Hiroshi Kuniishi, Kie Akagi, Tomoko Kawashima, Takamasa Noda, Mitsuhiko Yamada
Summary: This study aimed to evaluate the efficacy and tolerability of riluzole for patients with psychiatric disorders characterized by anxiety or fear. The findings indicate insufficient evidence to confirm the effects of riluzole for these patients.
NEUROPSYCHOPHARMACOLOGY REPORTS
(2023)
Article
Multidisciplinary Sciences
Leo Gotoh, Misa Yamada, Kotaro Hattori, Daimei Sasayama, Takamasa Noda, Sumiko Yoshida, Hiroshi Kunugi, Mitsuhiko Yamada
Review
Psychiatry
Naohiro Yonemoto, Yoshitaka Kawashima, Kaori Endo, Mitsuhiko Yamada
INTERNATIONAL JOURNAL OF MENTAL HEALTH SYSTEMS
(2019)
