Protective Efficacy of Candidate Vaccines Prior to Human Clinical Trials

Immunization of animals is one of the key standards for evaluation of vaccine efficacy prior to human clinical trials. However, vaccine organizations should not over-interpret these results as protective efficacy in animals may not be relevant in humans. Screening of vaccine candidates has recently been performed by several in vitro human models. A properly designed in vitro approach opens new venues for vaccine development. (c) 2018 American Pharmacists Association (R). Published by Elsevier Inc. All rights reserved.