Article
Polymer Science
Samahe Sadjadi, Abolfazl Heydari
Summary: In this study, a novel composite material was developed by combining β-cyclodextrin nanosponge and sodium alginate to immobilize palladium nanoparticles. The composite beads demonstrated excellent encapsulation capabilities and stability, making them suitable for hydrophobic substrates. The incorporation of cyclodextrin nanosponge within alginate beads improved the performance of the catalyst, allowing selective reduction of the nitro group in substrates with competing functionalities.
Article
Chemistry, Applied
Anna Vincze, Reka Facsko, Maria Budai-Szucs, Gabor Katona, Benjamin Gyarmati, Anita Csorba, Romana Zelko, Zoltan Zsolt Nagy, Lajos Szente, Gyorgy T. Balogh
Summary: In this study, eye drops containing nepafenac were prepared using hydroxypropyl-beta-cyclodextrin, sodium hyaluronate, and a preservative-free formula to improve patient compliance. Eleven formulations were tested in vitro and two promising formulations were further investigated on porcine eyes ex vivo. The results showed that one formulation had better bioavailability ex vivo compared to Nevanac (R) 0.1% suspension, while the other formulation had equivalent bioavailability with a reduced dose, opening the way to nepafenac-containing eye drops with better patient compliance in the future.
CARBOHYDRATE POLYMERS
(2023)
Article
Pharmacology & Pharmacy
Safaa Omer, Nandor Nagy, Emoke Szocs, Szabina Kadar, Gergely Volgyi, Balazs Pinke, Laszlo Meszaros, Gabor Katona, Anna Vincze, Peter Dorman, Zoltan Zs. Nagy, Gyorgy T. Balogh, Adrienn Kazsoki, Romana Zelko
Summary: Electrospun nanofibers loaded with nepafenac have been developed as a potential candidate for ocular drug delivery. The nanofibers showed good solubility, stability, drug release, and permeability, making them a promising option for ophthalmic formulations.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2023)
Article
Chemistry, Multidisciplinary
Ying Huang, Jialun Wang, Chunyan Yue, Ran Wang, Qiyuan Guo, Tingyu Wang, Daojuan Wang, Hong Dong, Yiqiao Hu, Gaojian Tao, Xihan Li
Summary: An in situ assembled trapping gel (PF-SA-GAD) has been developed to sweep glutamate and free Ca2+ from spinal cord injuries, promoting functional repair. This gel effectively reduces secondary neuron injury, inflammation, and restores motor function in rat models of SCI.
Article
Chemistry, Multidisciplinary
Chenglong Cai, Ting Wang, Xu Han, Shaoqiang Yang, Chengteng Lai, Tao Yuan, Zhangqi Feng, Nongyue He
Summary: A gel-like wound adhesive patch has been developed in this study, which can adapt to the wound area and form a gel-film quickly. It possesses the properties of hemostats, anti-inflammation, and promoting wound healing.
CHINESE CHEMICAL LETTERS
(2022)
Article
Food Science & Technology
Chenxi Wang, Xiaojing Li, Shangyuan Sang, David Julian McClements, Long Chen, Jie Long, Aiquan Jiao, Jinpeng Wang, Zhengyu Jin, Chao Qiu
Summary: This study successfully prepared stable nano-scale emulsions using gamma-cyclodextrin, sodium caseinate, and alginate as emulsifiers. The emulsions remained stable under high-acidic, high-alkaline, and high temperature conditions, and exhibited elastic gel networks in rheological measurements.
FOOD RESEARCH INTERNATIONAL
(2022)
Article
Biochemistry & Molecular Biology
Minrui Ou, Wanying Li, Zihui Zhang, Xiaoping Xu
Summary: This study developed a novel biosorbent using sodium alginate, beta-cyclodextrin, and diatomite, which demonstrated low cost, easy availability, simple preparation process, and environmental friendliness. The biosorbent showed significant selectivity for uranium(VI) adsorption, with high adsorption capacity and excellent reusability.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2022)
Article
Chemistry, Applied
Furui He, Longzheng Wang, Shujuan Yang, Wenqi Qin, Yuhong Feng, Yuanyuan Liu, Yang Zhou, Gaobo Yu, Jiacheng Li
Summary: In this study, a highly stretchable and tough interpenetrating composite hydrogel with self-repairing behavior under light irradiation was successfully fabricated. The self-healing behavior of the gel is achieved through the host-guest interaction between cyclodextrin and azobenzene, enabling significant recovery of gel elongation within 48 hours under dark conditions. This gel demonstrates the ability to achieve self-healing while maintaining highly stretchable and tough performance.
CARBOHYDRATE POLYMERS
(2021)
Article
Biochemistry & Molecular Biology
Kaiqiang Dong, Yanling Jiang, Yidan Zhang, Zhiyong Qin, Liuting Mo
Summary: In this study, a sustainable and antibacterial gel bead adsorbent was developed for efficient removal of Cr(VI) and dyes. The gel bead exhibited honeycomb cellular architecture, abundant functional groups, and active adsorption sites, resulting in outstanding antibacterial activity and broad-spectrum adsorption performance.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Polymer Science
Mohammed F. Aldawsari, Ehssan H. Moglad, Hadil Faris Alotaibi, Hamad M. Alkahtani, El-Sayed Khafagy
Summary: This study aimed to develop a niosomal in situ gel formulation of the antiglaucoma agent Bimatoprost for ocular delivery. The optimized BMT-loaded niosomes showed high entrapment efficiency and small particle size, and were successfully incorporated into in situ gelling systems. In vivo experiments demonstrated that the optimized BMT-ISG formulation effectively lowered intraocular pressure without causing irritation to the rabbit's eye.
Article
Biochemistry & Molecular Biology
Chen Chen, Enhui He, Weina Jia, Shuwei Xia, Liangmin Yu
Summary: In this study, a novel magnetic adsorbent material Fe3O4@SA/CMC-Fe was successfully synthesized for efficient adsorption of dye wastewater. The Fe3O4@SA/CMC-Fe exhibited high adsorption efficiency for dye wastewater, and the adsorption mechanism involved hydrogen bonding, complexation, and electrostatic adsorption.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Pharmacology & Pharmacy
Victoria Diaz-Tome, Xurxo Garcia-Otero, Ruben Varela-Fernandez, Manuel Martin-Pastor, Andrea Conde-Penedo, Pablo Aguiar, Miguel Gonzalez-Barcia, Anxo Fernandez-Ferreiro, Francisco J. Otero-Espinar
Summary: The study developed two hydrogels to improve voriconazole's ophthalmic solubility, permanence, and safety. Voriconazole-cyclodextrin inclusion complexes significantly increased water solubility and both hydrogels showed good corneal permeability. In vivo ocular permanence study showed longer permanence time compared to the voriconazole control formulation, suggesting these formulations are a good alternative for the treatment of fungal keratitis.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2021)
Article
Materials Science, Paper & Wood
Yijun Yao, Yanqin Shen, Chengmeng Hu, Hailiang Wu
Summary: A comfortable microenvironment can be achieved by using superabsorbent fabrics in personal protective equipment. A superabsorbent and high-water-retention fabric was prepared by in situ polymerization of Starch-Sodium Alginate-Polyacrylate (St-SA-PAA) hydrogel on polyester fabric. The water-absorption rate of the fabric increased from 2.8 to 10 g/min with the deposition of St-SA-PAA gel on the fabric, and the water absorption capacity reached 343 g/g. The mechanical properties of the gel improved after water absorption due to the supporting effect of the polyester fiber. The superabsorbent fabric exhibited isotropic characteristics and its water absorption capacity and softness could be adjusted by controlling the amount of deposited gel.
Article
Chemistry, Multidisciplinary
Elena Irina Popescu, Ludmila Aricov, Sorin Mocanu, Iulia Matei, Elena Hristea, Rodica Baratoiu, Anca Leonties, Cristian Petcu, Elvira Alexandrescu, Gabriela Ionita
Summary: Alginates gels have been explored for applications in different fields such as pharmaceuticals and environmental remediation. The addition of cyclodextrin and adamantane units to alginate chains induces morphological changes in the gel network and affects rheological properties. Host-guest interactions may not be the driving force for alginate gel generation, but they can influence and modulate gel properties.
NEW JOURNAL OF CHEMISTRY
(2021)
Article
Biochemistry & Molecular Biology
Kinga Koziel-Trabska, Sandra Zarska, Tomasz Girek, Wojciech Ciesielski
Summary: The beta-cyclodextrin polymer cross-linked with pyromellitic dianhydride and functionalized with an amino group was successfully introduced into a sodium alginate matrix. SEM images showed a homogeneous surface of the composite material. FTIR testing confirmed the formation of the polymer. The tested polymer exhibited increased solubility compared to the polymer without the amino group. TGA confirmed the stability of the system, and DSC showed the chemical binding of the polymer and sodium alginate. GPC-SEC demonstrated high cross-linking and accurate determination of the polymer's weight. The formation of this composite material has potential environmental implications, including the use of sustainable materials, reduced waste generation, reduced toxicity, and improved solubility.
Article
Veterinary Sciences
Stacey LaFrentz, Eva Abarca, Haitham H. Mohammed, Rosemary Cuming, Covadonga R. Arias
VETERINARY OPHTHALMOLOGY
(2020)
Article
Pharmacology & Pharmacy
Hamad Alrbyawi, Ishwor Poudel, Manjusha Annaji, Sai H. S. Boddu, Robert D. Arnold, Amit K. Tiwari, R. Jayachandra Babu
Summary: In this study, a pH-sensitive liposomal system was used to deliver daunorubicin to melanoma cells, resulting in enhanced cytotoxic effects. The liposomes exhibited high drug encapsulation efficiency and rapid release at acidic pH, leading to significantly higher cytotoxicity compared to conventional daunorubicin or liposomes.
Article
Agriculture, Dairy & Animal Science
Jose F. Fernandez-Garayzabal, Stacey LaFrentz, Almudena Casamayor, Eva Abarca, Haitham H. Mohammed, Rosemary S. Cuming, Cova R. Arias, Lucas Dominguez, Ana Vela
Summary: This study identified and characterized a new commensal species, Corynebacterium conjunctivae, recovered from the conjunctival sac of healthy adult horses. The bacterial isolates displayed specific cellular morphology, biochemical properties, and gene sequences. This research provides important insights into the diversity of commensal bacteria in horse eyes.
Article
Biochemistry & Molecular Biology
Hamad Alrbyawi, Sai H. S. Boddu, Ishwor Poudel, Manjusha Annaji, Nur Mita, Robert D. Arnold, Amit K. Tiwari, R. Jayachandra Babu
Summary: This study developed a co-delivery system of daunorubicin and cardiolipin encapsulated in thermosensitive liposomes for the treatment of breast cancer. The liposomes exhibited high drug encapsulation efficiency, small size, and rapid release under mild hyperthermia, resulting in significantly higher cytotoxicity against breast cancer cells compared to daunorubicin or conventional liposomes. This research lays the foundation for future development of liposomal co-delivery systems for breast cancer therapy.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Chanchal Kiran Thakur, Rabin Neupane, Chandrabose Karthikeyan, Charles R. Ashby, R. Jayachandra Babu, Sai H. S. Boddu, Amit K. Tiwari, Narayana Subbiah Hari Narayana Moorthy
Summary: A simple and cost-effective method was reported to functionalize MWCNTs with carbohydrate ligands using lysine as a linker. The results showed that carbohydrate-modified MWCNTs had higher drug loading capacity and improved anticancer efficacy.
Article
Pharmacology & Pharmacy
Manjusha Annaji, Nur Mita, Shivani Rangari, Mohammed F. Aldawsari, Ahmed Alsaqr, Ishwor Poudel, Oladiran Fasina, R. Jayachandra Babu
Summary: In this study, a topical gel formulation containing acyclovir and lidocaine was tested for its skin permeation properties. The results showed that the gel had significantly higher transdermal flux and skin retention compared to commercial formulations. It also showed increased permeation across microporated skin.
Article
Biochemistry & Molecular Biology
Ishwor Poudel, Manjusha Annaji, Fajar Setyo Wibowo, Robert D. Arnold, Oladiran Fasina, Brian Via, Vijaya Rangari, Maria Soledad Peresin, Forrest Smith, Muralikrishnan Dhanasekaran, Amit K. Tiwari, R. Jayachandra Babu
Summary: This study investigates the preparation of an inclusion complex of Hispolon with Sulfobutylether-beta-cyclodextrin (SBE beta CD) and the formulation of Hispolon-SBE beta CD trapped within sterically stabilized liposomes (HSC-SL). The results show that HSC-SL exhibits enhanced anticancer activity against melanoma cell lines and sustained drug release compared to Hispolon liposomes and Hispolon-SBE beta CD liposomes.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Pharmacology & Pharmacy
Chanchal Kiran Thakur, Chandrabose Karthikeyan, Mariam Sami Abou-Dahech, Moawia Mohd A. M. Altabakha, Moayad Jamal Saeed Al Shahwan, Charles R. R. Ashby Jr, Amit K. Tiwari, R. Jayachandra Babu, Narayana Subbiah Hari Narayana Moorthy
Summary: Microwave-assisted synthetic methods are commonly used for the surface modification and functionalization of multi-walled carbon nanotubes (MWCNTs) in diverse drug delivery applications. Microwave-induced functionalization of MWCNTs offers high efficiency and shorter reaction time compared to conventional techniques. Microwave methods are simple, fast, and effective for the covalent and noncovalent conjugation of MWCNTs with various biomolecules and polymers. This review focuses on the synthesis and drug delivery applications of microwave irradiation techniques (MITs) for the functionalization of MWCNTs using amino acids, vitamins, proteins, epoxy moieties, metal nanoparticles, and polymers.
Article
Pharmacology & Pharmacy
Ahmed Al Saqr, Manjusha Annaji, Ishwor Poudel, Mohammed F. Aldawsari, Hamad Alrbyawi, Nur Mita, Muralikrishnan Dhanasekaran, Sai H. S. Boddu, Rabin Neupane, Amit K. Tiwari, R. Jayachandra Babu
Summary: This study aimed to develop a microemulsion formulation for topical delivery of Diacetyl Boldine (DAB) and evaluate its cytotoxicity against melanoma cell line (B16BL6) in vitro. The results showed that the microemulsion formulation exhibited significantly higher skin retention levels than the DAB solution in MCT oil. Additionally, the microemulsion formulations showed substantially higher cytotoxicity toward B16BL6 cell lines than the control formulation.
Review
Pharmacology & Pharmacy
Xuejia Kang, Sanika Jadhav, Manjusha Annaji, Chung-Hui Huang, Rajesh Amin, Jianzhong Shen, Charles R. R. Ashby Jr, Amit K. K. Tiwari, R. Jayachandra Babu, Pengyu Chen
Summary: Disulfiram (DSF) is an approved drug for alcoholism treatment and has shown anticancer efficacy in preclinical studies. Supplementing DSF with copper (CuII) enhances its efficacy. However, clinical trials have not yielded promising results. Understanding the anticancer mechanisms of DSF/Cu (II) may lead to repurposing DSF as a new cancer treatment.
Article
Biochemistry & Molecular Biology
Xuejia Kang, Qi Wang, Siqi Wu, Chuanyu Wang, Manjusha Annaji, Chung-Hui Huang, Jianzhong Shen, Pengyu Chen, R. Jayachandra Babu
Summary: Therapeutic strategies for ARID1A-mutant ovarian cancers are limited. Higher basal ROS and lower basal GSH enhance the aggressive proliferation ability and metastatic property of OCCCs through EMT induction and immunosuppressive microenvironment. However, the aberrant redox homeostasis also increases the sensitivity of DQ-Lipo/Cu in mutant cells. DQ generates DDC in response to ROS, which together with Cu generates ROS cascade and targets GSH vulnerability, disrupting redox homeostasis and causing cancer cell death. The formed Cu(DDC)2 acts as a potent cytotoxic anti-cancer drug inducing immunogenic cell death, providing a promising strategy for managing cancer metastasis and drug resistance.
Review
Chemistry, Medicinal
Qi Wang, Keerthi Atluri, Amit K. Tiwari, R. Jayachandra Babu
Summary: Various formulations of polymeric micelles are being investigated as potential nanomedicines for cancer treatment. They target specific tissues and have prolonged circulation in the body. This review focuses on the different polymeric materials available for micelle synthesis and the ways they can be tailored to be responsive to different stimuli. It also discusses clinical trends, drug delivery applications, and challenges in this field.
Review
Oncology
Suhrud Pathak, Kelsee K. Zajac, Manjusha Annaji, Manoj Govindarajulu, Rishi M. Nadar, Dylan Bowen, R. Jayachandra Babu, Muralikrishnan Dhanasekaran
Summary: Choosing the most effective and least toxic chemotherapy drug is a challenge in cancer treatment. The individual's genetic makeup plays a significant role in drug response, and personalized medication regimens based on pharmacogenomics can optimize treatment outcomes. However, current standardized chemotherapy protocols rarely consider these individual differences. Therefore, integrating personalized medicine with clinical data of different ethnicities can improve treatment outcomes for patients of different ethnic backgrounds.
Article
Medicine, Research & Experimental
Ishwor Poudel, Manjusha Annaji, Chu Zhang, Peter R. Panizzi, Robert D. Arnold, Amal Kaddoumi, Rajesh H. Amin, Seungjong Lee, Nima Shamsaei, R. Jayachandra Babu
Summary: A surgically implantable device is a necessary treatment option for millions worldwide with orthopedic injuries. The use of additive manufacturing has enabled the customized fabrication of orthopedic implants with surface modifications. This study investigates the application of laser powder bed fusion to create 3D-printed implants functionalized with antimicrobial coatings to treat postsurgical infections.
MOLECULAR PHARMACEUTICS
(2023)
Article
Veterinary Sciences
Ana Ripolles-Garcia, Alba Sanz, Josep Pastor, Eva M. Abarca
Summary: The study compared the quality of conjunctival samples obtained with two different brushes for cytologic examination in healthy dogs. Results showed that samples collected with a standard cytology brush had better cellularity, less background debris, and more uniform distribution of cells, while samples collected with a mini cytology brush had less cellular overlapping and mucus in the background.
JAVMA-JOURNAL OF THE AMERICAN VETERINARY MEDICAL ASSOCIATION
(2021)