Review
Chemistry, Multidisciplinary
Sobia Noreen, Andreas Bernkop-Schnuerch
Summary: Thiolation of poly- and oligosaccharides introduces various favorable properties for tissue engineering and wound healing, including stable 3D networks, enhanced cell adhesion and signaling, and controlled release of active ingredients.
ADVANCED FUNCTIONAL MATERIALS
(2023)
Review
Chemistry, Multidisciplinary
Simona Summonte, Giuseppe Francesco Racaniello, Angela Lopedota, Nunzio Denora, Andreas Bernkop-Schnuerch
Summary: Thiomers, such as thiolated hyaluronic acid and chitosan, are widely studied for their high reactivity in hydrogel synthesis. They exhibit in situ gelling properties and can undergo various click reactions, making them versatile materials for tissue engineering, regenerative medicine, and drug delivery.
JOURNAL OF CONTROLLED RELEASE
(2021)
Review
Engineering, Biomedical
Shreya S. Soni, Christopher B. Rodell
Summary: Biomaterials serve as complex engineered tools for interacting with biological systems and aiding in the treatment of diseases. The immune response to polymeric materials is crucial in governing how the body reacts to biomaterial implants and drug delivery systems. Understanding molecular interactions and bulk biophysical properties is key in designing biomaterials that drive immune responses.
ACTA BIOMATERIALIA
(2021)
Article
Chemistry, Multidisciplinary
Rajesh Kumar, Julia Garcia Mancebo, Ryan Patenaude, Kristen Sack, Maksymilian Prondzynski, Alan B. Packard, Jason L. J. Dearling, Ruihan Li, Michelle Balcarcel-Monzon, Saffron Dominguez, Sirisha Emani, John N. Kheir, Brian Polizzotti, Yifeng Peng
Summary: This study proposes a low-fouling zwitterionic polymer as an alternative volume expander for hypovolemic shock. The polymer shows improved biocompatibility and efficacy, with resistance to cell interaction and deposition in major organs. It is rapidly cleared from the body, reducing the risk of long-term side effects. In comparison to existing colloids and plasma, the polymer serves as a more potent oncotic agent for restoring intravascular volume.
ADVANCED MATERIALS
(2022)
Review
Polymer Science
Weslen Vedakumari Sathyaraj, Lokesh Prabakaran, Jayavardhini Bhoopathy, Sankari Dharmalingam, Ramadoss Karthikeyan, Raji Atchudan
Summary: Diabetic wounds pose a serious health issue for individuals with diabetes, as they have a slow and improper healing process. Current diabetic wound dressings vary in their ability to absorb wound exudates and may cause maceration to surrounding tissues. This review focuses on the recent advances in polymeric biomaterial-based wound dressings and novel therapeutic regimes for diabetic wound treatment, highlighting the importance of developing dressings that can absorb exudates, promote gas exchange, protect against infections, and support the synthesis of crucial biochemical factors for faster wound healing. The use of polymeric wound dressings loaded with bioactive compounds and their in vitro and in vivo performance in treating diabetic wounds are also discussed.
Article
Materials Science, Multidisciplinary
Mayank Goswami, Rajkumar Sadasivam, Gopinath Packirisamy
Summary: This study presents an Avastin loaded PHEMA hydrogel lens as a topical implant for the therapy of diabetic retinopathy (DR). The lens is designed using a novel and cost-effective 3D printed platform, with contours similar to a commercial contact lens for patient comfort and drug delivery capabilities. The release kinetics of the lens follows the Korsmeyer-Pappas (KP) release model, resulting in 40-60% anti-VEGF effects.
Review
Engineering, Biomedical
Sathishkumar Gnanasekar, Gopinath Kasi, Xiaodong He, Kai Zhang, Liqun Xu, En-Tang Kang
Summary: This review assesses recent advancements in polymer-photosensitizer hybrid materials developed for antibacterial photodynamic therapy (APDT) applications. The review discusses the integration and functionalization of photosensitizers with polymers, the use of photosensitizer coatings to eliminate healthcare-associated infections, and the application of photosensitizers in films, scaffolds, and hydrogels for regenerative medicine.
BIOACTIVE MATERIALS
(2023)
Review
Polymer Science
Cheirmadurai Kalirajan, Amey Dukle, Arputharaj Joseph Nathanael, Tae-Hwan Oh, Geetha Manivasagam
Summary: This review summarizes recent advancements in the preparation of smart polymeric biomaterials with self-healing and shape memory properties. It also discusses novel approaches for developing various forms of polymeric biomaterials and highlights their applications in soft and hard tissue engineering. It underlines the future directions of polymeric biomaterials for successful clinical implications.
Article
Polymer Science
Hamouda M. Mousa, Mustafa Ghazali Ali, Abdelrahman I. Rezk, Emad Abouel Nasr, Kamal Hany Hussein
Summary: Electrically conductive patches made of biocompatible polymeric nanofibers have shown beneficial effects on electroresponsive tissues and have been widely studied as a promising technology in tissue engineering. In this study, conductive nanofibrous patches mimicking the properties of native myocardial extracellular matrix were developed and evaluated for their physical, mechanical, and biocompatible properties. The results showed that the developed patches had appropriate surface wettability, mechanical stability, and enhanced conductivity, leading to better cell proliferation and attachment.
JOURNAL OF APPLIED POLYMER SCIENCE
(2022)
Article
Materials Science, Multidisciplinary
Yuanxin Deng, Qi Zhang, Da-Hui Qu
Summary: Hydrogen bond is a simple and versatile noncovalent interaction that is crucial for dynamic functions in living systems. In recent years, the interest in dynamic polymeric materials has led to emerging applications of hydrogen bond chemistry in material design. This Perspective discusses the design principles of hydrogen bond-based dynamic materials by summarizing the state of the art of hydrogen bond chemistry and materials. It also provides an overview of this research topic, possible future directions, and potential material applications.
ACS MATERIALS LETTERS
(2023)
Review
Pharmacology & Pharmacy
Paula de Freitas Rosa Remiro, Mariana Harue Taniguchi Nagahara, Rafael Abboud Azoubel, Michelle Franz-Montan, Marcos Akira d'avila, Angela Maria Moraes
Summary: There are various routes of drug administration, each with its own advantages and limitations. Topical application in the oral cavity offers benefits such as painlessness, non-invasiveness, easy application, and the ability to bypass drug swallowing. The oral mucosa has high permeability, allowing rapid delivery of medication to the bloodstream without harming the stomach. This drug delivery route is gaining significant interest in the pharmaceutical industry. This review provides a condensed overview of biomaterials, polymers, production methods, and market perspectives for topical drug delivery in the oral cavity.
Article
Emergency Medicine
Pratik Das, Suvendu Manna, Shivam Roy, Samit K. Nandi, Piyali Basak
Summary: This review examines the use of biomaterials for wound healing, focusing on natural and synthetic polymer composites and their mechanisms of action. It highlights the advancements in the field and the challenges posed by the availability and suitability of biomaterials for clinical use.
Review
Engineering, Biomedical
Jacob G. Hodge, David S. Zamierowski, Jennifer L. Robinson, Adam J. Mellott
Summary: In this review, the key principles of polymeric biomaterials in wound healing are discussed, along with how they affect wound dressing design. The importance of collaboration between the clinical and material science realms in developing novel wound care therapies is emphasized.
BIOMATERIALS RESEARCH
(2022)
Article
Chemistry, Multidisciplinary
Ruiyi Zhou, Yueming Wu, Kang Chen, Deteng Zhang, Qi Chen, Donghui Zhang, Yunrui She, Wenjing Zhang, Longqiang Liu, Yueqi Zhu, Changyou Gao, Runhui Liu
Summary: This study reports a polymeric strategy for designing and finding endothelial cell (EC)-selective biomaterials by tuning serum protein adsorption. The optimal beta-peptide polymer shows superior EC versus smooth muscle cell (SMC) selectivity compared to the commonly used EC-selective peptides. Surface adsorption of bovine serum albumin plays a critical role in the selectivity of the beta-peptide polymer. Surface modification of the optimal polymer promotes the endothelialization of vascular implants and inhibits intimal hyperplasia.
ADVANCED MATERIALS
(2022)
Article
Materials Science, Multidisciplinary
Eryun Yan, Jinyu Jiang, Xihua Ren, Jianwei Gao, Xunhai Zhang, Shuhua Li, Shengnan Chen, Yuxin Li
Summary: Polymer nanofibers with pH-responsive properties were successfully prepared by coaxial electrospinning, which can be used as carriers for anticancer drug paclitaxel (PTX) and effectively degrade under acidic or neutral condition, showing good inhibitory effects on colon cancer cells.
Article
Chemistry, Medicinal
Arshad Mahmood, Sonja Bonengel, Flavia Laffleur, Muhammad Ijaz, Muneeb Ahmad Idrees, Shah Hussain, Christian W. Huck, Barbara Matuszczak, Andreas Bernkop-Schnuerch
DRUG DEVELOPMENT AND INDUSTRIAL PHARMACY
(2016)
Article
Chemistry, Applied
Gintare Leonaviciute, Sonja Bonengel, Arshad Mahmood, Muneeb Ahmad Idrees, Andreas Bernkop-Schnuerch
CARBOHYDRATE POLYMERS
(2016)
Article
Pharmacology & Pharmacy
Sabeeh Mohsin, Nisar-Ur-Rahman, Muneeb Ahmad Idrees, Mohammad Khan Sarfraz, Muhammad Khalid Khan, Ghulam Mustafa
PAKISTAN JOURNAL OF PHARMACEUTICAL SCIENCES
(2012)
Article
Pharmacology & Pharmacy
M. A. Idrees, N. U. Rahman, S. Ahmad, M. Y. Ali, I Ahmad
DARU-JOURNAL OF PHARMACEUTICAL SCIENCES
(2011)