Journal
JOURNAL OF PHARMACEUTICAL SCIENCES
Volume 100, Issue 7, Pages 2658-2664Publisher
ELSEVIER SCIENCE INC
DOI: 10.1002/jps.22482
Keywords
X-ray powder diffractometry; polymorphism; crystallography; crystal structure; solid-state stability; quantitative phase analysis; synchrotron; carbamazepine; Rietveld method
Funding
- FAPESP
- CAPES
- CNPq
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The present work shows that the heated carbamazepine (CBZ) powder form III can be described as purely triclinic form I or a mixture of triclinic form I and monoclinic form III, depending on the resolution of the X-ray diffraction equipment used. Visual identification of the minor phase is possible when high-resolution synchrotron light is used. Quantitative phase analyses of CBZ forms I and III, after thermal treatment, were performed by using both synchrotron and conventional copper rotating anode X-ray powder diffraction data and the Rietveld method. Also, the Rietveld method could be adequately applied to determine the phase percentage in the heated material, even when usual resolution data are acquired. (C) 2011 Wiley-Liss, Inc. and the American Pharmacists Association J Pharm Sci 100: 2658-2664, 2011
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