Article
Food Science & Technology
Jose Marcelino S. Netto, Fernanda A. Honorato, Patricia M. Azoubel, Louise E. Kurozawa, Douglas F. Barbin
Summary: This study presented a quick and non-destructive means to evaluate the melon drying process under different pretreatments using hyperspectral images in near infrared. The results showed that the use of vacuum and the combination of vacuum and ultrasound resulted in uniform drying, facilitating water diffusion in the samples.
LWT-FOOD SCIENCE AND TECHNOLOGY
(2021)
Article
Food Science & Technology
Eva M. Achata, Carlos Esquerre, K. Shikha Ojha, Brijesh K. Tiwari, Colm P. O'Donnell
Summary: In this study, beef jerky samples were dried under different conditions with and without ultrasound treatment, and their moisture content was predicted using near infrared hyperspectral imaging and chemometrics. The developed moisture content prediction models show potential for process control applications, with different optimal models for ultrasound treated and non-treated samples.
INNOVATIVE FOOD SCIENCE & EMERGING TECHNOLOGIES
(2021)
Article
Pharmacology & Pharmacy
Tim D. Lillotte, Maike Joester, Benjamin Frindt, Andreas Berghaus, Robert F. Lammens, Karl G. Wagner
Summary: A novel approach using ultraviolet-visible spectrophotometry was developed to determine the density of compressed materials, showing a direct and efficient correlation between color information and density. Compared to partial least square regression, the color information obtained from visible spectra is directly proportional to density and does not require excessive data pre-processing. Therefore, this new method has the potential to be a process analytical technology tool for compression processes such as tableting or roller compaction.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2021)
Article
Chemistry, Analytical
Cristina Manis, Cristina Malegori, Eugenio Alladio, Marco Vincenti, Paolo Garofano, Filippo Barni, Andrea Berti, Paolo Oliveri
Summary: This study introduces a novel nondestructive analytical strategy using hyperspectral imaging and multivariate regression methods to accurately determine the date of biological fluids such as semen and urine, as well as blood traces. The results have significant implications for limiting the number of suspects and clarifying the sequence of events in a crime.
Article
Chemistry, Medicinal
Maja Preskar, Klemen Korasa, Tomislav Vrbanec, Dejan Klement, Franc Vrecer, Mirjana Gasperlin
Summary: The study demonstrates the feasibility of using NIR and Raman spectroscopy for monitoring the freeze-drying process, with NIR being a useful tool for predicting residual moisture content and IBP values. Despite some challenges with overlapping absorption bands in a multi-component system, NIR spectra were consistent with HPLC measurements.
DRUG DEVELOPMENT AND INDUSTRIAL PHARMACY
(2021)
Article
Chemistry, Analytical
Bo Zhou, Yan-Mei Liang, Jun Bin, Meng-Jiao Ding, Min Yang, Chao Kang
Summary: This study investigates the feasibility of using portable near-infrared spectroscopy (NIR) and infrared spectroscopy (IR) combined with multivariate calibration to determine phosphogypsum (PG) in soil. The predictive determination coefficients and root mean square error of prediction (RMSEP) for the IR and NIR partial least squares (PLS) models are 0.9933 and 1.88% and 0.8830 and 6.55%, respectively. The limits of detection (LOD) for the models are 4.0006% and 14.225%. The results obtained by extreme learning machine (ELM) and support vector machine (SVM) algorithms are similar to those obtained by PLS. The methods reported in this study have the advantages of on-site analysis, speed, and convenience for the determination of phosphogypsum in soil.
ANALYTICAL LETTERS
(2023)
Article
Energy & Fuels
Slobodan Sasic, Tincuta Veriotti, Todd Kotecki, Stacy Austin
Summary: This study conducts a detailed analysis on commercial crude oil partial least square (PLS) predictions of Sulfur based on near-infrared (NIR) spectra over a six-month period. The accuracy of Sulfur predictions shows a significant trend when the data set is split into monthly subsets. Principal component analysis (PCA) is used to analyze the spectra of selected individual crudes, and it is found that the trends in the spectra largely overlap with the observed trends in the Sulfur predictions for the heavy crudes. The trends in PC scores are clearly illustrated in the spectral differences among the pre-treated spectra, and these spectral trends partially translate into the trends in predictions of distillation fractions.
Article
Chemistry, Analytical
Yiming Bi, Xianwei Hao, Lu Dai, Yuhan Peng, Jinxin Tie, Yunong Tian, Fu Liao, Yongsheng Li, Wenmiao He, Shitou Li, Lili Zhang, Zhenjie Zhao, Jizhong Wu, Hui Wang
Summary: The study introduces a novel variable selection method that requires no reference information, utilizing replicate spectra and an index to evaluate variable importance. It outperforms the original partial least squares model with limited calibration samples, and shows comparable results to state-of-the-art methods with a large number of calibration samples while reducing the risk of overfitting.
ANALYTICAL LETTERS
(2022)
Article
Agricultural Engineering
M. I. S. Verissimo, C. Soares, C. F. Moreirinha, M. T. S. R. Gomes
Summary: In this study, a method based on NIR spectroscopy was used to predict the pour point and ethanol content of biodiesel mixtures. The results showed that this method has good prediction capability and is faster and more convenient compared to the traditional ASTM D97-08 procedure.
BIOMASS & BIOENERGY
(2023)
Article
Chemistry, Applied
Muhammad Zareef, Muhammad Arslan, Md Mehedi Hassan, Shujat Ali, Qin Ouyang, Huanhuan Li, Xiangyang Wu, Malik Muhammad Hashim, Sadaf Javaria, Quansheng Chen
Summary: Benchtop near-infrared (NIR) spectroscopy combined with multivariate analysis was employed for the classification and prediction of antioxidant properties of walnut. The study revealed that decent discrimination was achieved using principal component analysis (PCA), and Si-CARS-PLS showed optimal performance for predicting various antioxidant properties. The findings suggest that NIR integrated with Si-CARS-PLS could be a useful tool for predicting the antioxidant properties of walnut.
Article
Agronomy
Achiraya Tantinantrakun, Supawan Sukwanit, Anthony Keith Thompson, Sontisuk Teerachaichayut
Summary: This study tested two nondestructive techniques, SW-NIRS and NIR-HSI, for predicting the maturity index of intact pineapple fruit. Both techniques showed reliable performance in predicting the maturity index of individual fruit.
POSTHARVEST BIOLOGY AND TECHNOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Claudia Scappaticci, Stella Spera, Alessandra Biancolillo, Federico Marini
Summary: In this study, a fast and environmentally friendly analytical strategy using near-infrared spectroscopy and chemometrics was developed to identify and quantify the addition of a drug in alcoholic drinks. The approach showed high accuracy in detecting the presence of the drug and quantifying its concentration.
Article
Chemistry, Applied
Hong-Ju He, Yangyang Wang, Mian Zhang, Yuling Wang, Xingqi Ou, Jingli Guo
Summary: This study aimed to predict the reducing sugar content of sweet potatoes using near-infrared reflectance and absorbance spectra. The results showed that the model built with optimal wavelengths had good performance in predicting the reducing sugar content.
JOURNAL OF FOOD COMPOSITION AND ANALYSIS
(2022)
Article
Chemistry, Medicinal
Serena Bobba, Nunzio Zinfollino, Davide Fissore
Summary: This paper presents an accurate model for measuring residual moisture in freeze-dried pharmaceutical products using near-infrared spectroscopy. The model is robust and provides accurate estimates even for products with different concentrations, compositions, and those not involved in the calibration step.
JOURNAL OF PHARMACEUTICAL SCIENCES
(2022)
Article
Chemistry, Multidisciplinary
Karla R. Borba, Didem P. Aykas, Maria I. Milani, Luiz A. Colnago, Marcos D. Ferreira, Luis E. Rodriguez-Saona
Summary: Portable spectrometers show potential in quickly and accurately assessing various quality attributes of different types of tomatoes, demonstrating a practical and efficient method for food quality analysis.
APPLIED SCIENCES-BASEL
(2021)
Article
Chemistry, Analytical
Bingbing Liu, Jie Cao, Lu Liu, Min Zeng, Hongli Yu, Hao Wu
Summary: This study investigated the effect of processing with Chebulae Fructus on the chemical composition of Euphorbia pekinensis (EP) and found that it could alter the composition and reduce toxicity, providing a scientific basis for optimizing processing technology and handling other ethnomedicines with toxic properties.
JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS
(2024)
Article
Chemistry, Analytical
Renuka P. Rathnasekara, Abu M. Rustum
Summary: A simple and robust HPLC method was developed for simultaneous determination of four active pharmaceutical ingredients and their degradation products. The method successfully separated the peaks of interest and demonstrated stability-indicating capability by separating the degradation products in stressed samples.
JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS
(2024)
Article
Chemistry, Analytical
Bryan Lee, Gita Kharal, Benjamin Sreenan, Claire Lin, Ruosheng Zeng, Colin A. Fox, Patricia Ellison, Robert O. Ryan, Paul J. Brett, David Aucoin, Xiaoshan Zhu
Summary: In this study, a new type of Mn-doped nanocrystals was developed for detecting a biomarker of a fatal disease. The sensitivity of the detection was enhanced by surface treatment and time-resolved reading, achieving a detection limit comparable to enzyme-based immunoassay.
JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS
(2024)
Article
Chemistry, Analytical
Xiaoling Liu, Ting Yang, Lu Chen, Lili Lan, Guoxiang Sun, Ping Guo
Summary: In this study, the quality of Yiqing tablet was comprehensively evaluated using multi-component quantification, multi-dimensional fingerprint construction, and antioxidant activity analysis. The results showed that the sample had 25 components with antioxidant activity according to the HPLC fingerprint and most bands of FTIR also showed antioxidant activity. Based on the evaluation results of HPLC and FTIR fingerprint, all samples were classified as first level, demonstrating the consistency of sample quality. This study provides a new idea for achieving comprehensive quality evaluation of traditional Chinese medicines.
JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS
(2024)
Article
Chemistry, Analytical
Siqi Li, Hao Guo, Yan Gao, Wen Tian, Shan Wang, Chen Shen, Lili Xu, Hailong Liu, Jinliang Zhang, Yingwu Wang
Summary: Using competitive ELISA to detect free cytokines is limited in accurately determining their real state and quantity. In this study, a novel cytokine immunoassay was developed using Rosetta molecular docking prediction technique to establish a method that can detect the true concentration of free cytokines without disrupting the dynamic equilibrium.
JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS
(2024)
Article
Chemistry, Analytical
Changqing Yu, Tiantian Xie, Haiyan Liu, Ligai Bai
Summary: A phenyl-hybrid monolithic adsorbent with porous structure and multiple functional groups was prepared. It was used for the online extraction and quantification of coumarins in mouse plasma, showing good removal ability and selectivity.
JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS
(2024)
Article
Chemistry, Analytical
Joao B. Pereira Jr, Vanessa S. Carvalho, William Q. Ferreira, Rennan G. O. Araujo, Sergio L. C. Ferreira
Summary: This work presents a simple, cost-effective, and environmentally friendly method for determining the content of multiple elements in medicinal herbs using ICP OES. The optimized experimental parameters result in low dissolved organic carbon content and residual acidity concentration. The accuracy of the method is confirmed through the analysis of certified reference materials, and its environmental friendliness is validated using the AGREE metric. Principal component analysis is used to classify the medicinal herbs based on their inorganic constituent concentrations.
JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS
(2024)
Article
Chemistry, Analytical
Orwa Siddig, Chenxi Liu, Mohamed Abdulbagi, Min Song, Yu-ting Lu, Tai-jun Hang
Summary: In this study, a reliable LC-QTOF-MS method was developed to separate and characterize process-related substances and degradation products of Lurasidone hydrochloride. The results showed that Lurasidone hydrochloride exhibited instability under certain stress conditions, and several previously unidentified compounds were discovered. The study emphasizes the importance of monitoring and controlling related substances in the manufacturing processes to optimize the process and ensure quality control.
JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS
(2024)
Article
Chemistry, Analytical
Jiaxi Fang, Luping Wang, Di Zhang, Yan Liang, Shouxin Li, Jingkui Tian, Qiang He, Juan Jin, Wei Zhu
Summary: This study reports that a novel compound called CPS-A exhibits therapeutic effects on cisplatin-induced acute kidney injury (AKI) and explores its potential mechanisms through transcriptomics and metabolomics. CPS-A improves cell viability, reduces inflammatory markers, and attenuates cisplatin-induced kidney injury. The study also identifies potential targets related to amino acid metabolism.
JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS
(2024)
Article
Chemistry, Analytical
Ricardo Conde, Nadia Oliveira, Elisabete Morais, Ana Paula Amaral, Adriana Sousa, Goncalo Graca, Ignacio Verde
Summary: Decreased levels of tyrosine, glutamate, valine, leucine, and isoleucine are associated with worsening pathological cognitive decline. Decreased levels of isobutyrate, histidine, acetone, and unknown-1 metabolite are potential biomarkers with neuroprotective and antioxidant actions for cognitive decline.
JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS
(2024)
Article
Chemistry, Analytical
A. L. Santunione, F. Palazzoli, P. Verri, D. Vandelli, V. Castagnetti, C. Profeta, E. Silingardi
Summary: This study describes two fatal suicide cases involving four cardiovascular drugs, and presents the concentrations and distribution of these drugs in different post-mortem specimens. The study developed a fast, sensitive, and simple method for drug detection suitable for forensic purposes.
JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS
(2024)
Article
Chemistry, Analytical
Meiyun Shi, Xinyue Zheng, Yuncheng Ge, Ning Zhang, Luyao Yu, Xujian Duan, Yajun Liu, Hongyu Xue, Jiansong You, Lei Yin
Summary: This study investigated the cellular uptake of low, medium and high molecular weight polyethylene glycol (PEG) in MCF-7 cells using UPLC-MS/MS and CID techniques. The results showed that PEG600, PEG2K, PEG4K and PEG10K exhibited low toxicity and had limited cellular entry at concentrations of 5-1200 μg/mL. Additionally, the environmental friendliness of the developed analytical methods was evaluated.
JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS
(2024)
Article
Chemistry, Analytical
Ruijin Geng, Mengjie Yu, Jinbiao Xu, Yuanwang Wei, Qiong Wang, Junguo Chen, Fei Sun, Kun Xu, Han Xu, Xiaohui Liu, Juhua Xiao, Xianchao Zhang, Baogang Xie
Summary: This study validated serum methionine as a potential biomarker for Kawasaki disease (KD), and found that its alteration is associated with the activation of DNMT1 in KD patients.
JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS
(2024)
Article
Chemistry, Analytical
Eman Shawky, Rasha A. Nassra, Aliaa M. T. El-Alkamy, Shaimaa M. Sallam, Samah M. El Sohafy
Summary: This study employed network pharmacology-based analysis and reverse molecular docking to investigate the molecular targets and pathways associated with gynecological disorders and the potential therapeutic effects of fenugreek constituents. The results highlighted the potential of steroidal saponins, isoflavones, and flavones as active constituents of fenugreek with implications for lactation, reproductive processes, and estrogenic activity. Animal model study further supported the presence of these bioactive compounds and their effects on body weight, serum prolactin levels, serum estradiol levels, and ovarian histological structure.
JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS
(2024)
Article
Chemistry, Analytical
Xuelong Zhao, Ruixue Dai, Jing Wang, Liangliang Cao, Peidong Chen, Weifeng Yao, Fangfang Cheng, Beihua Bao, Li Zhang
Summary: This study identified the skin-permeable and skin-retainable components of Cayratia japonica ointment and found that flavonoids are the main active components that play a crucial role in the inflammatory and proliferative phases of wound healing.
JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS
(2024)