Article
Biochemistry & Molecular Biology
Binh Thuc Tran, Tuyen Ngoc Tran, Ai My Thi Tran, Giang Chau Dang Nguyen, Quynh Trang Thi Nguyen
Summary: This paper simultaneously determined the concentrations of PAR, IBU, and CAF in tablets using the classical least-squares method and molecular absorption spectrophotometric measurement. A simple and cost-effective analytical procedure was developed.
Article
Chemistry, Medicinal
Ayman Ismail, Moataz Gamal, Maha Nasr
Summary: A combination of acetaminophen, caffeine, and aspirin in tablets is present in the US Pharmacopoeia. An optimized method of analysis for the simultaneous assay of the three analytes by HPLC without using the internal standard was developed, resulting in a shortened chromatogram runtime. The method is specific, linear, and accurate, allowing for the reduction of analysis time and resources.
PHARMACEUTICAL CHEMISTRY JOURNAL
(2023)
Article
Agronomy
Dapeng Li, Jiang Long, Ziye Tang, Longbo Han, Zhongliang Gong, Liang Wen, Hailong Peng, Tao Wen
Summary: A multi-path Vis/NIR spectroscopy system was developed to detect Bactrocera dorsalis infestations in citrus fruits. Spectra were acquired for 252 citrus fruits in three stages of infestation, with different fruit orientations. Classification models based on joint X-Y distance and various algorithms were developed, and the average spectra of different fruit orientations consistently gave better classification results. Therefore, the multi-path Vis/NIR spectroscopy system is conducive to the detection of B. dorsalis infestation in citrus fruits.
Article
Automation & Control Systems
Abbas Saadatmandi, Mahmoud Reza Sohrabi, Hasan Kabiri Fard
Summary: In this study, a fast, easy, inexpensive, and precise method combining UV-Vis spectrophotometry, continuous wavelet transform, and partial least squares multivariate calibration was developed for the simultaneous determination of paracetamol, diphenhydramine, and phenylephrine in tablet dosage form without extraction. The method was validated using synthetic mixtures and showed good performance.
CHEMOMETRICS AND INTELLIGENT LABORATORY SYSTEMS
(2023)
Article
Pharmacology & Pharmacy
Yoshihiro Hayashi, Miho Noguchi, Takuya Oishi, Takashi Ono, Kotaro Okada, Yoshinori Onuki
Summary: The study demonstrates the usefulness of machine learning (ML) in analyzing a material attribute database from tablets produced at different granulation scales. Unsupervised learning is used to visualize the regions of tablets produced at each scale, while supervised learning with feature selection is applied to construct predictive models for critical quality attributes. The models can accurately predict the tensile strength (TS) and dissolution rate after 10 min (DS10) independent of scale, and identify important factors. Machine learning can be used to better understand similarity/dissimilarity between scales and determine critical factors.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2023)
Article
Spectroscopy
L. L. M. Guio, L. O. Coutinho, V. Cavalcante, A. Ferreira, Z. B. Amorim, J. S. Ribeiro
Summary: Two chemometric models were proposed to predict caffeine content in tablets using diffuse reflectance near-infrared spectroscopy and Raman scattering. The construction of robust calibration models requires simultaneous use of both analytical methods, which limits the widespread use of spectroscopy. The prediction models for caffeine presented high correlation coefficients and low root-mean-square errors.
JOURNAL OF APPLIED SPECTROSCOPY
(2021)
Article
Neurosciences
Zhongmin Lin, Fred Tam, Nathan W. Churchill, Fa-Hsuan Lin, Bradley J. MacIntosh, Tom A. Schweizer, Simon J. Graham
Summary: The study examined the Trail Making Test (TMT) performance using a touch-sensitive tablet and EEG recordings in healthy young adults. The results showed significant effects of TMT Parts A and B on the time spent per link, as well as robust EEG effects in various frequency bands during linking and non-linking periods.
FRONTIERS IN HUMAN NEUROSCIENCE
(2021)
Article
Psychiatry
Gabriella Buck, Carolina Makowski, M. Mallar Chakravarty, Bratislav Misic, Ridha Joober, Ashok Malla, Martin Lepage, Katie M. Lavigne
Summary: This study found significant differences in verbal memory, symptoms, and brain structure between different sexes in FEP patients. Verbal memory deficits and core psychotic symptoms in male patients were associated with changes in frontal and temporal cortical thickness, as well as reductions in CA2/3 hippocampal subfield and fornix volumes. In female patients, fewer negative/depressive symptoms were related to a less pronounced cortical thickness pattern and more diffuse reductions in hippocampal white matter regions.
JOURNAL OF PSYCHIATRIC RESEARCH
(2022)
Article
Automation & Control Systems
Nicole M. Ralbovsky, Joseph P. Smith
Summary: The utilization of Raman spectroscopy with chemometrics is crucial for accurately identifying and classifying active ingredients in different tablets, impacting the safety and effectiveness of drug delivery.
JOURNAL OF CHEMOMETRICS
(2023)
Article
Engineering, Chemical
Yusuke Hayashi, Saho Okazaki, Kensaku Matsunami, Kazuya Tanabe, Takuya Nagato, Hirokazu Sugiyama
Summary: This study developed concentration prediction models for personalized tablet manufacturing using near-infrared spectroscopy. The accuracy of two modeling methods, partial least squares regression and extreme gradient boosting, were compared, and the results showed that the model accuracy was higher with partial least squares regression. Additionally, this modeling method could be useful in predicting ion-binding inorganic compounds and indicating the presence of metallic foreign matter in tablets.
CHEMICAL ENGINEERING RESEARCH & DESIGN
(2023)
Article
Biochemical Research Methods
Parvateesam Yenda, Naresh Kumar Katari, Santhosh Kumar Ettaboina, Balasubramanian Satheesh, Siva Krishna Muchakayala, Rambabu Gundla
Summary: This article discusses a quality-by-design-based HPLC method for evaluating acetaminophen, caffeine, and aspirin in tablet dosage form. The method can separate degradation products and is considered stability indicating.
BIOMEDICAL CHROMATOGRAPHY
(2023)
Article
Automation & Control Systems
Valeh Arabzadeh, Mahmoud Reza Sohrabi
Summary: In this paper, chemometrics and spectrophotometry methods were used to simultaneously measure MET and PIO in Actoplus MET, without the need for separation steps. The results showed that the artificial neural network and partial least squares regression methods performed well in the measurement.
CHEMOMETRICS AND INTELLIGENT LABORATORY SYSTEMS
(2022)
Article
Engineering, Environmental
Xingren Jiang, Zundong Xiao, Junan Jiang, Xiaoxia Yang, Rijie Wang
Summary: This study focuses on the impact of element thickness on pressure drop in static mixers, proposing a new pressure drop correlation using PLSR method and LHS sampling. Experimental validation shows good prediction accuracy of the proposed correlation.
CHEMICAL ENGINEERING JOURNAL
(2021)
Article
Pharmacology & Pharmacy
Rusha Sardhara, Kaushalendra Chaturvedi, Harsh S. Shah, Bhavani Prasad Vinjamuri, Antoine Al-Achi, Kenneth R. Morris, Rahul Haware
Summary: The study used multivariate modeling to address inaccuracy in dissolution testing caused by high absorbance in in-situ UV fiber optics dissolution systems. Linear PLS and PCR models showed accurate predictions, while quadratic models did not. Overall, the linear models demonstrated flexibility and accuracy in predicting dissolution profiles.
EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES
(2021)
Article
Chemistry, Analytical
Marina Antonio, Mariano Raffaghelli, Ruben M. Maggio
Summary: This study developed a comprehensive strategy using near infrared spectroscopy (NIR) coupled with partial least squares regression (PLS) to quantify Form a of PZA in both drug substance and PZA/RIF/ISH-FDC tablets. The NIR-PLS models were optimized using radial optimization and showed satisfactory results in validation.
JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS
(2021)
Article
Chemistry, Medicinal
Kousuke Tamura, Makoto Ono, Takefumi Kawabe, Motomu Ohara, Etsuo Yonemochi
CHEMICAL & PHARMACEUTICAL BULLETIN
(2020)
Article
Pharmacology & Pharmacy
Tetsuo Ono, Etsuo Yonemochi
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2020)
Article
Pharmacology & Pharmacy
Hirotaka Ando, Yusuke Nozaki, Kazunari Sato, Masafumi Dohi, Tadashi Hakomori, Etsuo Yonemochi
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2020)
Article
Chemistry, Multidisciplinary
Hiroki Tanaka, Tatsunari Takahashi, Manami Konishi, Nae Takata, Masaki Gomi, Daiki Shirane, Ryo Miyama, Shinya Hagiwara, Yuki Yamasaki, Yu Sakurai, Keisuke Ueda, Kenjirou Higashi, Kunikazu Moribe, Eiji Shinsho, Ruka Nishida, Kaori Fukuzawa, Etsuo Yonemochi, Koji Okuwaki, Yuji Mochizuki, Yuta Nakai, Kota Tange, Hiroki Yoshioka, Shinya Tamagawa, Hidetaka Akita
ADVANCED FUNCTIONAL MATERIALS
(2020)
Article
Pharmacology & Pharmacy
Hiroaki Arai, Takuya Nagato, Tatsuo Koide, Etsuo Yonemochi, Hiromitsu Yamamoto, Hirokazu Sugiyama
Summary: The study aimed to develop a model to predict the critical quality attribute (CQA) of tablets during continuous and batch manufacturing using only critical material attributes (CMAs). By investigating the influence of granulation conditions on particle-size distribution and constructing a CQA estimation model, it was found that the CQA was strongly influenced by the particle-size distribution and that the CMA-CQA correlations were similar for both processes. A model based on partial least-squares regression could reasonably estimate the CQA using CMAs without involving any process parameters.
JOURNAL OF PHARMACEUTICAL INNOVATION
(2021)
Article
Chemistry, Multidisciplinary
Shinji Katsura, Takayuki Furuishi, Haruhisa Ueda, Etsuo Yonemochi
Summary: The study synthesized cholesteryl-conjugated ribonuclease A (CHRNase A) and found that it exhibited differences in secondary and tertiary structure compared to RNase A, with cholesterol conjugated to a tyrosine residue on the protein surface. CHRNase A showed slightly decreased activity relative to RNase A, but this activity could be increased by adding beta-cyclodextrin.
Article
Pharmacology & Pharmacy
Kazuya Sugita, Noriyuki Takata, Etsuo Yonemochi
Summary: The study found that using solubilizer additive SLS under non-sink conditions can increase the total permeated amount of high-permeable drugs, while not significantly affecting the permeation rate of low-permeable drugs. Even exceeding solubility, the total permeated amount of high-permeable drugs would increase, while that of low-permeable drugs remains almost constant.
Article
Pharmacology & Pharmacy
Yada Vattanagijyingyong, Etsuo Yonemochi, Jittima Chatchawalsaisin
Summary: Composite films composed of zein and methacrylic acid copolymer were studied to understand their miscibility and the effects of composition and plasticizers. Techniques such as DSC, FTIR, and Raman spectroscopy were used to analyze the molecular level miscibility and phase behavior of the polymer blends. The results showed that polyethylene glycol 1000 had a more significant plasticization effect, increasing the beta-sheets content in the film.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2021)
Article
Crystallography
Majid Ismail Tamboli, Yohei Utusmi, Takayuki Furuishi, Kaori Fukuzawa, Etsuo Yonemochi
Summary: The salt of Disopyramide with Terephthalic acid was obtained by slow solvent evaporation and slurry crystallization methods. X-ray single crystal diffraction confirmed the mechanism of salt formation, while the salt crystals showed strong binding through hydrogen bonds.
Article
Crystallography
Majid Ismail Tamboli, Yushi Okamoto, Yohei Utsumi, Takayuki Furuishi, Siran Wang, Daiki Umeda, Okky Dwichandra Putra, Kaori Fukuzawa, Hidehiro Uekusa, Etsuo Yonemochi
Summary: Disopyramide (DPA) is a class IA antiarrhythmic drug, and its crystallization with phthalic acid (PA) forms a salt with specific hydrogen bonding structure; pure DPA and DPA_PA salt were further characterized by various experimental methods.
Article
Pharmacology & Pharmacy
Kazuya Sugita, Noriyuki Takata, Etsuo Yonemochi
Summary: This passage mainly discusses the evaluation of the in vitro permeability of high and low lipophilic compound nanoparticle formulations under non-sink conditions. The results show that nanonization can improve the permeability of highly lipophilic compounds, but it does not improve the permeability of low lipophilic compounds. Nanonization improves the overall permeability of highly lipophilic compounds by improving the permeability of the unstirred water layer, while for low lipophilic compounds, nanonization does not improve overall permeability because the rate-limiting step is diffusion in the membrane. Therefore, when predicting the absorption of nanoparticle formulations, it is necessary to consider their permeability under non-sink conditions.
Article
Chemistry, Medicinal
Mizuki Yamada, Agata Ishikawa, Shun Muramatsu, Takayuki Furuishi, Yoshinori Onuki, Kaori Fukuzawa, Etsuo Yonemochi
Summary: Moisture-activated dry granulation (MADG) is an eco-friendly granulation method that can improve tabletability and manufacturing efficiency. In this study, MADG was used to optimize the manufacturing conditions of orally disintegrating tablets (ODTs) containing erythritol. The results showed that MADG significantly reduced disintegration time and increased tablet hardness. The amount of water used in MADG had a direct impact on the disintegration time and tablet hardness, with excessive water leading to decreased hardness due to granule aggregation.
Article
Crystallography
Yuto Kawano, Yoshiharu Tanaka, Nanami Hata, Yuki Yoshiike, Masato Nakajima, Etsuo Yonemochi, Nobuhiro Ishihara
Summary: This study investigated the mechanism of swelling in Ibuprofen (IBP) and Tranexamic acid (TXA) tablets during high-temperature storage. The results showed the formation of a new complex in the swollen tablets, which was closely related to the crystal structures of IBP and TXA.
Article
Pharmacology & Pharmacy
Qihui Xu, Takayuki Furuishi, Kaori Fukuzawa, Etsuo Yonemochi
Summary: This study aimed to develop a transdermal system containing an amorphous complex of the nonsteroidal anti-inflammatory drug (NSAID) flurbiprofen (FLU) and lidocaine (LDC) for alleviating chronic pain. The complex between FLU and LDC was obtained by heating in ethanol, and various spectroscopic methods confirmed the interaction between the two drugs. The addition of LDC significantly increased the solubility and skin permeation of FLU, suggesting that this formulation could be useful for treating chronic pain and inflammatory diseases.
Article
Pharmacology & Pharmacy
Takayuki Furuishi, Nanami Sato-Hata, Kaori Fukuzawa, Etsuo Yonemochi
Summary: The aim of this study was to enhance the solubility and stability of the water-insoluble drug carvedilol (CAR) with maleic acid (MLE) to create a co-amorphous system. The optimal molar ratio of CAR to MLE was found to be 2:1. The co-amorphous system showed improved solubility of CAR and maintained stability in an amorphous form.
PHARMACEUTICAL DEVELOPMENT AND TECHNOLOGY
(2023)
Article
Chemistry, Analytical
Bingbing Liu, Jie Cao, Lu Liu, Min Zeng, Hongli Yu, Hao Wu
Summary: This study investigated the effect of processing with Chebulae Fructus on the chemical composition of Euphorbia pekinensis (EP) and found that it could alter the composition and reduce toxicity, providing a scientific basis for optimizing processing technology and handling other ethnomedicines with toxic properties.
JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS
(2024)
Article
Chemistry, Analytical
Renuka P. Rathnasekara, Abu M. Rustum
Summary: A simple and robust HPLC method was developed for simultaneous determination of four active pharmaceutical ingredients and their degradation products. The method successfully separated the peaks of interest and demonstrated stability-indicating capability by separating the degradation products in stressed samples.
JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS
(2024)
Article
Chemistry, Analytical
Bryan Lee, Gita Kharal, Benjamin Sreenan, Claire Lin, Ruosheng Zeng, Colin A. Fox, Patricia Ellison, Robert O. Ryan, Paul J. Brett, David Aucoin, Xiaoshan Zhu
Summary: In this study, a new type of Mn-doped nanocrystals was developed for detecting a biomarker of a fatal disease. The sensitivity of the detection was enhanced by surface treatment and time-resolved reading, achieving a detection limit comparable to enzyme-based immunoassay.
JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS
(2024)
Article
Chemistry, Analytical
Xiaoling Liu, Ting Yang, Lu Chen, Lili Lan, Guoxiang Sun, Ping Guo
Summary: In this study, the quality of Yiqing tablet was comprehensively evaluated using multi-component quantification, multi-dimensional fingerprint construction, and antioxidant activity analysis. The results showed that the sample had 25 components with antioxidant activity according to the HPLC fingerprint and most bands of FTIR also showed antioxidant activity. Based on the evaluation results of HPLC and FTIR fingerprint, all samples were classified as first level, demonstrating the consistency of sample quality. This study provides a new idea for achieving comprehensive quality evaluation of traditional Chinese medicines.
JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS
(2024)
Article
Chemistry, Analytical
Siqi Li, Hao Guo, Yan Gao, Wen Tian, Shan Wang, Chen Shen, Lili Xu, Hailong Liu, Jinliang Zhang, Yingwu Wang
Summary: Using competitive ELISA to detect free cytokines is limited in accurately determining their real state and quantity. In this study, a novel cytokine immunoassay was developed using Rosetta molecular docking prediction technique to establish a method that can detect the true concentration of free cytokines without disrupting the dynamic equilibrium.
JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS
(2024)
Article
Chemistry, Analytical
Changqing Yu, Tiantian Xie, Haiyan Liu, Ligai Bai
Summary: A phenyl-hybrid monolithic adsorbent with porous structure and multiple functional groups was prepared. It was used for the online extraction and quantification of coumarins in mouse plasma, showing good removal ability and selectivity.
JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS
(2024)
Article
Chemistry, Analytical
Joao B. Pereira Jr, Vanessa S. Carvalho, William Q. Ferreira, Rennan G. O. Araujo, Sergio L. C. Ferreira
Summary: This work presents a simple, cost-effective, and environmentally friendly method for determining the content of multiple elements in medicinal herbs using ICP OES. The optimized experimental parameters result in low dissolved organic carbon content and residual acidity concentration. The accuracy of the method is confirmed through the analysis of certified reference materials, and its environmental friendliness is validated using the AGREE metric. Principal component analysis is used to classify the medicinal herbs based on their inorganic constituent concentrations.
JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS
(2024)
Article
Chemistry, Analytical
Orwa Siddig, Chenxi Liu, Mohamed Abdulbagi, Min Song, Yu-ting Lu, Tai-jun Hang
Summary: In this study, a reliable LC-QTOF-MS method was developed to separate and characterize process-related substances and degradation products of Lurasidone hydrochloride. The results showed that Lurasidone hydrochloride exhibited instability under certain stress conditions, and several previously unidentified compounds were discovered. The study emphasizes the importance of monitoring and controlling related substances in the manufacturing processes to optimize the process and ensure quality control.
JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS
(2024)
Article
Chemistry, Analytical
Jiaxi Fang, Luping Wang, Di Zhang, Yan Liang, Shouxin Li, Jingkui Tian, Qiang He, Juan Jin, Wei Zhu
Summary: This study reports that a novel compound called CPS-A exhibits therapeutic effects on cisplatin-induced acute kidney injury (AKI) and explores its potential mechanisms through transcriptomics and metabolomics. CPS-A improves cell viability, reduces inflammatory markers, and attenuates cisplatin-induced kidney injury. The study also identifies potential targets related to amino acid metabolism.
JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS
(2024)
Article
Chemistry, Analytical
Ricardo Conde, Nadia Oliveira, Elisabete Morais, Ana Paula Amaral, Adriana Sousa, Goncalo Graca, Ignacio Verde
Summary: Decreased levels of tyrosine, glutamate, valine, leucine, and isoleucine are associated with worsening pathological cognitive decline. Decreased levels of isobutyrate, histidine, acetone, and unknown-1 metabolite are potential biomarkers with neuroprotective and antioxidant actions for cognitive decline.
JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS
(2024)
Article
Chemistry, Analytical
A. L. Santunione, F. Palazzoli, P. Verri, D. Vandelli, V. Castagnetti, C. Profeta, E. Silingardi
Summary: This study describes two fatal suicide cases involving four cardiovascular drugs, and presents the concentrations and distribution of these drugs in different post-mortem specimens. The study developed a fast, sensitive, and simple method for drug detection suitable for forensic purposes.
JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS
(2024)
Article
Chemistry, Analytical
Meiyun Shi, Xinyue Zheng, Yuncheng Ge, Ning Zhang, Luyao Yu, Xujian Duan, Yajun Liu, Hongyu Xue, Jiansong You, Lei Yin
Summary: This study investigated the cellular uptake of low, medium and high molecular weight polyethylene glycol (PEG) in MCF-7 cells using UPLC-MS/MS and CID techniques. The results showed that PEG600, PEG2K, PEG4K and PEG10K exhibited low toxicity and had limited cellular entry at concentrations of 5-1200 μg/mL. Additionally, the environmental friendliness of the developed analytical methods was evaluated.
JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS
(2024)
Article
Chemistry, Analytical
Ruijin Geng, Mengjie Yu, Jinbiao Xu, Yuanwang Wei, Qiong Wang, Junguo Chen, Fei Sun, Kun Xu, Han Xu, Xiaohui Liu, Juhua Xiao, Xianchao Zhang, Baogang Xie
Summary: This study validated serum methionine as a potential biomarker for Kawasaki disease (KD), and found that its alteration is associated with the activation of DNMT1 in KD patients.
JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS
(2024)
Article
Chemistry, Analytical
Eman Shawky, Rasha A. Nassra, Aliaa M. T. El-Alkamy, Shaimaa M. Sallam, Samah M. El Sohafy
Summary: This study employed network pharmacology-based analysis and reverse molecular docking to investigate the molecular targets and pathways associated with gynecological disorders and the potential therapeutic effects of fenugreek constituents. The results highlighted the potential of steroidal saponins, isoflavones, and flavones as active constituents of fenugreek with implications for lactation, reproductive processes, and estrogenic activity. Animal model study further supported the presence of these bioactive compounds and their effects on body weight, serum prolactin levels, serum estradiol levels, and ovarian histological structure.
JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS
(2024)
Article
Chemistry, Analytical
Xuelong Zhao, Ruixue Dai, Jing Wang, Liangliang Cao, Peidong Chen, Weifeng Yao, Fangfang Cheng, Beihua Bao, Li Zhang
Summary: This study identified the skin-permeable and skin-retainable components of Cayratia japonica ointment and found that flavonoids are the main active components that play a crucial role in the inflammatory and proliferative phases of wound healing.
JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS
(2024)