Article
Integrative & Complementary Medicine
Jiahao Wang, Jiamiao Shi, Ning Jia, Qinru Sun
Summary: This study identified active compounds and targets of GpM in the treatment of AD through database analysis. The neuroprotective mechanism of GpM involves multiple pathways, providing new treatment options for AD. The findings shed light on the potential anti-AD effects of GpM.
BMC COMPLEMENTARY MEDICINE AND THERAPIES
(2022)
Article
Integrative & Complementary Medicine
Ying Li, Qiong Ouyang, Xu Li, Raphael N. N. Alolgal, Yuanming Fan, Yangyang Sun, Hang Gong, Pingxi Xiao, Gaoxiang Ma
Summary: In this study, the lipid-lowering effects of Gynostemma pentaphyllum (GP) were investigated using a meta-analysis, animal experiments, and metabolomic analysis. The results showed that GP can effectively reduce triglyceride levels and improve blood lipid metabolism by regulating the intestinal microbiota and tryptophan metabolism.
AMERICAN JOURNAL OF CHINESE MEDICINE
(2023)
Article
Medicine, General & Internal
Wen-Xiang Wang, Xiao-Yan He, Dong-Yang Yi, Xiao-Yan Tan, Li-Juan Wu, Ning Li, Bin-Bin Feng
Summary: This study employed network pharmacology and molecular docking to investigate the mechanistic details of Gynostemma pentaphyllum (GP) in treating breast cancer (BC). The findings suggest that GP may potentially target ALB, EGFR, ESR1, AR, PGR, and HSP90AA1 to exert its therapeutic effects against BC.
Article
Biochemistry & Molecular Biology
Xin-Can Li, Fang-Fang Li, Wen-Jing Pei, Jing Yang, Yu-Long Gu, Xiang-Lan Piao
Summary: Rare ginsenosides Rg3, Rk1, and Rg5 can be obtained from Panax ginseng through heat treatment of Gynostemma pentaphyllum. The study used scanning electron microscopy (SEM) and thermal gravity-differential thermal gravity (TG-DTG) to investigate the process, and liquid chromatography-mass spectrometry (LC-MS) to analyze the content change of ginsenosides. The results showed that the formation of new saponins before and after heat treatment was due to the breakage or rearrangement of chemical bonds. Additionally, the content of ginsenoside Rb3 decreased while the contents of ginsenoside Rk1 and Rg5 increased after heat treatment. The rare ginsenosides Rg3(S), Rg3(R), Rk1, and Rg5 can be obtained from G. pentaphyllum through heat treatment.
Article
Dermatology
Xiaojin Liu, Xiaobing Lv, Tiancheng Ji, Haoya Hu, Lei Chang
Summary: This study provides preclinical evidence for the potential of Gynostemma pentaphyllum Makino leaf extract as a promising agent for hair growth and anti-graying.
JOURNAL OF COSMETIC DERMATOLOGY
(2023)
Review
Pharmacology & Pharmacy
Ning Dai, Fang-fang Zhao, Min Fang, Feng-lan Pu, Ling-yao Kong, Jian-ping Liu
Summary: This study evaluated the lipid-lowering effect and safety of Gynostemma pentaphyllum (GP) used alone or as adjunctive therapy for dyslipidemia. The findings suggest that GP has a similar effect as lipid-lowering agents in regulating serum lipids, but is inferior to red yeast rice.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Xin Weng, Yun-Yun Lou, Yun-Shan Wang, Ya-Ping Huang, Jian Zhang, Zhi-Qi Yin, Ke Pan
Summary: Gynostemma pentaphyllum has a long history as a food and dietary supplement in China. Research has found that compounds from G. pentaphyllum can serve as PCSK9 inhibitors and play a role in the treatment of hyperlipidemia.
BIOORGANIC CHEMISTRY
(2021)
Article
Gastroenterology & Hepatology
Weilin Liao, Imran Khan, Guoxin Huang, Shengshuang Chen, Liang Liu, Wai Kit Leong, Xiao Ang Li, Jianlin Wu, W. L. Wendy Hsiao
Summary: Colorectal cancer ranks the third most common cancer type in both men and women, with disturbed gut microbes potentially contributing to its onset and progression. Maintaining a balanced gut microbiota has become a novel pursuit in the medical field, particularly in gastrointestinal disorders. Gynostemma pentaphyllum saponins have shown prebiotic and cancer-preventive properties through modulation of gut microbiota, with the specific bacteria Bifidobacterium animalis demonstrating anticancer and cancer-preventive activities.
Article
Biochemistry & Molecular Biology
Duc Duy Le, Woohyun Kim, Soohwan Lim, Sun Chang Kim, Giltsu Choi
Summary: Ginsenosides, glycosylated dammarene-type triterpenes found in Panax ginseng and Gynostemma pentaphyllum, share common UGT families for biosynthesis despite belonging to different subfamilies, indicating independent evolutionary selection for their synthesis.
Article
Plant Sciences
Yunyi Zhou, Lixiang Yao, Xueyan Huang, Ying Li, Chunli Wang, Qinfen Huang, Liying Yu, Chunliu Pan
Summary: Through physiological response analysis, transcriptomics, and metabolomics, this study reveals the stress response mechanisms and metabolic changes in Gynostemma pentaphyllum under cadmium stress. It is found that G. pentaphyllum enhances antioxidant enzyme activity and accumulation of proline and polysaccharides under cadmium stress. Transcriptomics and metabolomics analysis identify genes and metabolic pathways associated with cadmium stress.
FRONTIERS IN PLANT SCIENCE
(2023)
Article
Chemistry, Multidisciplinary
Houran Cao, Dongmei Li, Guangying Wu, Peihong Chen, Guanlin Xiao, Xiaoli Bi, Zhao Chen
Summary: This study established the metabolomic profile of Gynostemma pentaphyllum's therapeutic effect and found that 24 metabolites are related to the PXR-IL-6SERCA1a pathway, providing a scientific explanation for its role in traditional Chinese medicine theory.
ARABIAN JOURNAL OF CHEMISTRY
(2023)
Article
Biochemistry & Molecular Biology
Yun-Yun Lou, Xian Zheng, Ya-Ping Huang, Long Mu, Xiao-Gai Zhang, Zhi-Wei Zhao, Zhe Song, Jian Zhang, Zhi-Qi Yin, Ke Pan
Summary: This study isolated and structurally characterized novel, minor gypenosides from Gynostemma pentaphyllum, and evaluated their Sirt1 agonist activity. Results showed satisfactory Sirt1 agonist activity in four saponins, indicating the potential for further research on G. pentaphyllum as a source of Sirt1 agonists.
BIOORGANIC CHEMISTRY
(2021)
Article
Chemistry, Analytical
Xuan Sun, Li Xu, Huijiao Yan, Peng Li, Hidayat Hussain, Jiguo Liu, Jinjie Zhang, Daijie Wang
Summary: This study utilized linear gradient counter-current chromatography to rapidly and efficiently separate highly polar glycosides from the aboveground parts of G. pentaphyllum. By adjusting the proportions of ethyl acetate and n-butanol, a binary mobile phase was achieved. Six glycosides were successfully isolated with purities greater than 98%. Structural identification was performed using electrospray ionization mass spectrometry and nuclear magnetic resonance tandem mass spectrometry. This study provides an efficient strategy for the separation of active compounds from complex natural products.
JOURNAL OF SEPARATION SCIENCE
(2023)
Article
Chemistry, Applied
Wei-Ye Cui, Yulian Jin, Hui Liu, Ma-Li Zu, Xin-Fang Zhai, Ce Yang, Yu-Long Gu, Yong Cheng, Xiang-Lan Piao
Summary: Two dammarane-type saponins were isolated from the heat-processed Gynostemma pentaphyllum, showing moderate activity against human lung carcinoma A549 cells. In vitro assays revealed that damulin E and damulin F exhibited moderate activity against various cell lines.
NATURAL PRODUCT RESEARCH
(2021)
Review
Biochemistry & Molecular Biology
Chao Su, Nan Li, Ruru Ren, Yingli Wang, Xiaojuan Su, Fangfang Lu, Rong Zong, Lingling Yang, Xueqin Ma
Summary: Gynostemma pentaphyllum, also known as Jiaogulan, is a tea traditionally consumed for its taste and weight loss benefits, but is now recognized for its various bioactive compounds with medicinal properties. Studies have shown that it possesses anti-cancer, anti-atherogenic, anti-dementia, and anti-Parkinson's disease effects, as well as lipid-regulating, neuroprotective, hepatoprotective, and hypoglycemic properties. Ongoing research on its chemical constituents and pharmacological activities has shown promising potential for treating various human diseases.
Article
Biochemistry & Molecular Biology
Po-Hsuan Lu, Jen-Yu Wang, Ling-Ya Chiu, Yi-Ting Huang, Chi-Feng Hung, Nan-Lin Wu
Summary: Syk is involved in UVB-induced skin inflammation, and inhibiting Syk may have potential photoprotective effects against UVB-induced skin inflammation.
FREE RADICAL BIOLOGY AND MEDICINE
(2022)
Article
Biochemistry & Molecular Biology
Chi-Cheng Huang, Chih-Yi Liu, Chi-Jung Huang, Yao-Chun Hsu, Heng-Hui Lien, Jia-Uei Wong, Feng-Chuan Tai, Wen-Hui Ku, Chi-Feng Hung, Jaw-Town Lin, Ching-Shui Huang, Han-Sun Chiang
Summary: Pancreatic adenocarcinoma (PAC) is the 8th leading cause of cancer-related deaths in Taiwan, and its incidence is increasing. Targeted next-generation sequencing can identify somatic mutations in PAC patients, providing insights into the molecular changes and potential therapeutic options.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Neurosciences
Kun-Chieh Yeh, Chi-Feng Hung, Hui-Ling Lee, Ting-Yang Hsieh, Su-Jane Wang
Summary: Soybean meal extract can improve memory function and increase the expression of presynaptic proteins and protein kinases, while also impacting the gut microbiota.
MOLECULAR NEUROBIOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Tzu-Kang Lin, Chi-Feng Hung, Jing-Ru Weng, Ting-Yang Hsieh, Su-Jane Wang
Summary: This study found that Kaempferol 3-rhamnoside (KR) can inhibit 4-aminopyridine (4-AP)-evoked glutamate release. The inhibitory effect of KR is linked to the omission of external Ca2+ or the depletion of glutamate in synaptic vesicles, as well as the suppression of P/Q-type Ca2+ channel activity. Additionally, KR reduces the increase in Ca2+ concentration and the phosphorylation of CaMKII and its substrate synapsin I.
Article
Biochemistry & Molecular Biology
Pa-Fan Hsiao, Yi-Ting Huang, Po-Hsuan Lu, Ling-Ya Chiu, Tzu-Han Weng, Chi-Feng Hung, Nan-Lin Wu
Summary: This study investigates the expression and regulation of TXNIP in psoriasis, as well as its role in skin keratinocyte differentiation and EGFR signaling.
Article
Chemistry, Applied
Y. W. Lai, Y. T. Lee, H. Cao, H. L. Zhang, B. H. Chen
Summary: This study simultaneously extracted PAHs and HAs from pork jerky using QuEChERS and analyzed them using GC-MS/MS and UPLC-MS/MS. The study found that acetonitrile containing 1% acetic acid had the highest extraction efficiency, and processing temperature and flavoring materials had effects on the formation of PAHs and HAs.
Article
Biochemistry & Molecular Biology
Rui Li, Baskaran Stephen Inbaraj, Bing-Huei Chen
Summary: Mangosteen peel was found to contain seven xanthones and two anthocyanins, and the methanol extract showed inhibitory effects on liver cancer cells. Xanthone nanoemulsion was more effective than xanthone extract in inhibiting the growth of HepG2 cells.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Wen-Xuan Tsao, Bing-Huei Chen, Pinpin Lin, Shu-Han You, Tsai-Hua Kao
Summary: The objective of this study was to develop a method for simultaneous analysis of furan and its 10 derivatives in various food commodities. The study successfully separated furan and its derivatives using a HP-5MS column and GC-MS/MS within 9.5 minutes. The method could also distinguish different furan isomers. The method validation demonstrated that the developed method was reliable for the analysis of furan and its derivatives in commercial foods.
Article
Oncology
Cheng-Kuang Yang, Chi-Rei Yang, Yen-Chuan Ou, Chen-Li Cheng, Hao-Chung Ho, Kun-Yuan Chiu, Shian-Shiang Wang, Jian-Ri Li, Chuan-Shu Chen, Chi-Feng Hung, Cheng-Che Chen, Shu-Chi Wang, Chia-Yen Lin, Sheng-Chun Hung
Summary: Patients with high-risk and very high-risk prostate cancer who undergo prostatectomy have a high risk of biochemical recurrence (BCR). This retrospective observational study aimed to identify the risk factors for BCR after radical prostatectomy in these patients. The study found that patients in the very high-risk group had a lower BCR-free survival rate and even if their PSA levels were undetectable initially after surgery, they still had a high risk of BCR. Preoperative MRI imaging stage and PSA density were found to be predictors of short-term BCR after prostatectomy.
Article
Chemistry, Medicinal
Chieh-Chen Huang, Yuan-Hsin Lo, Yu-Jou Hsu, Yuan-Bin Cheng, Chia-Chi Kung, Cher-Wei Liang, Der-Chen Chang, Kang-Ling Wang, Chi-Feng Hung
Summary: Atopic dermatitis (AD, eczema) is a common skin condition that primarily affects children and adults, but current treatments have limited effectiveness and side effects. This study investigated the potential use of epi-oxyzoanthamine, a bioactive compound derived from Formosan zoanthid, for treating AD. In vitro and in vivo experiments showed that epi-oxyzoanthamine inhibited cytokine expression and reduced skin inflammation, indicating its potential as an alternative treatment for AD. Overall, the study highlights the importance of exploring new therapies for atopic dermatitis.
Article
Food Science & Technology
Yu-Wen Lai, Baskaran Stephen Inbaraj, Bing-Huei Chen
Summary: This study aimed to monitor the formation of toxic compounds HAs and PAHs in fried pork fiber, a common meat product in Taiwan. The results showed that frying in sesame oil or lard produced more HAs in pork fiber processed at 160°C for 15 min compared to 200°C for 6 min. Sesame oil frying also resulted in higher levels of HAs than lard frying under the same heating conditions. Among the various HAs, Harman and Norharman were the most abundant. Precursors such as reducing sugar, amino acid, and creatine/creatinine played a vital role in HAs formation. For total PAHs, the highest level was observed in pork fiber fried in lard at 200°C for 6 min. Frying in sesame oil also resulted in higher levels of total PAHs compared to lard frying. Notably, the highly toxic benzo[a]pyrene was undetected in fried pork fiber. The precursor benzaldehyde played a more important role in PAH formation. Principal component analysis revealed that the formation mechanisms of HAs and PAHs in fried pork fiber were different.
Article
Food Science & Technology
Wen-Xuan Tsao, Bing-Huei Chen, Tsai-Hua Kao
Summary: The study revealed that sterilization conditions have a significant impact on the formation of furan in canned foods, with lower furan content under high-temperature-short-time conditions and higher oxygenated furan content.
JOURNAL OF FOOD AND DRUG ANALYSIS
(2022)
Review
Food Science & Technology
Bing-Huei Chen, Baskaran Stephen Inbaraj, Kuo-Chiang Hsu
Summary: This article provides an overview of recent advances in chromatographic and sensor-based analytical methods for the analysis of PAHs in food and water. It covers conventional sample preparation methods, advanced extraction techniques, gas chromatography coupled with various detection techniques, high performance liquid chromatography coupled with fluorescence, diode array or mass/tandem mass detection, and emerging supercritical fluid chromatographic techniques. It also discusses the development of electrochemical sensors and SERS-based optical sensors for onsite detection of PAHs. The review article serves as a research update and identifies research gaps for future studies.
JOURNAL OF FOOD AND DRUG ANALYSIS
(2022)
Article
Surgery
Chi-Feng Hung, Tsung-Wei Wang, Cheng-Kuang Yang, Yung-Cheng Yang, Yeong-Chin Jou, Yen-Chuan Ou
Summary: This study aimed to determine the 10-year survival rate and clinical prognostic factors of men with newly diagnosed bone metastatic prostate cancer treated with hormone therapy. The results showed that the posttreatment nadir serum PSA level significantly influenced patient survival.
FORMOSAN JOURNAL OF SURGERY
(2022)
Article
Biochemistry & Molecular Biology
Chih-Cheng Lin, Hsiu-Hua Lin, Hsiang Chang, Lu-Te Chuang, Chih-Yu Hsieh, Shing-Hwa Lu, Chi-Feng Hung, Jia-Feng Chang
Summary: This study compared the effects of different tea processes on immune modulation and oxidative stress in macrophages. The results showed that purple shoot tea has potential prophylactic benefits for reducing inflammation and regulating cytokine expression. Purple shoot green tea, in particular, exhibited strong antioxidant properties. Tea extracts were able to reduce inflammation and modulate immune cell responses by regulating cytokine expression.
CURRENT ISSUES IN MOLECULAR BIOLOGY
(2022)
Article
Chemistry, Analytical
Bingbing Liu, Jie Cao, Lu Liu, Min Zeng, Hongli Yu, Hao Wu
Summary: This study investigated the effect of processing with Chebulae Fructus on the chemical composition of Euphorbia pekinensis (EP) and found that it could alter the composition and reduce toxicity, providing a scientific basis for optimizing processing technology and handling other ethnomedicines with toxic properties.
JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS
(2024)
Article
Chemistry, Analytical
Renuka P. Rathnasekara, Abu M. Rustum
Summary: A simple and robust HPLC method was developed for simultaneous determination of four active pharmaceutical ingredients and their degradation products. The method successfully separated the peaks of interest and demonstrated stability-indicating capability by separating the degradation products in stressed samples.
JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS
(2024)
Article
Chemistry, Analytical
Bryan Lee, Gita Kharal, Benjamin Sreenan, Claire Lin, Ruosheng Zeng, Colin A. Fox, Patricia Ellison, Robert O. Ryan, Paul J. Brett, David Aucoin, Xiaoshan Zhu
Summary: In this study, a new type of Mn-doped nanocrystals was developed for detecting a biomarker of a fatal disease. The sensitivity of the detection was enhanced by surface treatment and time-resolved reading, achieving a detection limit comparable to enzyme-based immunoassay.
JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS
(2024)
Article
Chemistry, Analytical
Xiaoling Liu, Ting Yang, Lu Chen, Lili Lan, Guoxiang Sun, Ping Guo
Summary: In this study, the quality of Yiqing tablet was comprehensively evaluated using multi-component quantification, multi-dimensional fingerprint construction, and antioxidant activity analysis. The results showed that the sample had 25 components with antioxidant activity according to the HPLC fingerprint and most bands of FTIR also showed antioxidant activity. Based on the evaluation results of HPLC and FTIR fingerprint, all samples were classified as first level, demonstrating the consistency of sample quality. This study provides a new idea for achieving comprehensive quality evaluation of traditional Chinese medicines.
JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS
(2024)
Article
Chemistry, Analytical
Siqi Li, Hao Guo, Yan Gao, Wen Tian, Shan Wang, Chen Shen, Lili Xu, Hailong Liu, Jinliang Zhang, Yingwu Wang
Summary: Using competitive ELISA to detect free cytokines is limited in accurately determining their real state and quantity. In this study, a novel cytokine immunoassay was developed using Rosetta molecular docking prediction technique to establish a method that can detect the true concentration of free cytokines without disrupting the dynamic equilibrium.
JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS
(2024)
Article
Chemistry, Analytical
Changqing Yu, Tiantian Xie, Haiyan Liu, Ligai Bai
Summary: A phenyl-hybrid monolithic adsorbent with porous structure and multiple functional groups was prepared. It was used for the online extraction and quantification of coumarins in mouse plasma, showing good removal ability and selectivity.
JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS
(2024)
Article
Chemistry, Analytical
Joao B. Pereira Jr, Vanessa S. Carvalho, William Q. Ferreira, Rennan G. O. Araujo, Sergio L. C. Ferreira
Summary: This work presents a simple, cost-effective, and environmentally friendly method for determining the content of multiple elements in medicinal herbs using ICP OES. The optimized experimental parameters result in low dissolved organic carbon content and residual acidity concentration. The accuracy of the method is confirmed through the analysis of certified reference materials, and its environmental friendliness is validated using the AGREE metric. Principal component analysis is used to classify the medicinal herbs based on their inorganic constituent concentrations.
JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS
(2024)
Article
Chemistry, Analytical
Orwa Siddig, Chenxi Liu, Mohamed Abdulbagi, Min Song, Yu-ting Lu, Tai-jun Hang
Summary: In this study, a reliable LC-QTOF-MS method was developed to separate and characterize process-related substances and degradation products of Lurasidone hydrochloride. The results showed that Lurasidone hydrochloride exhibited instability under certain stress conditions, and several previously unidentified compounds were discovered. The study emphasizes the importance of monitoring and controlling related substances in the manufacturing processes to optimize the process and ensure quality control.
JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS
(2024)
Article
Chemistry, Analytical
Jiaxi Fang, Luping Wang, Di Zhang, Yan Liang, Shouxin Li, Jingkui Tian, Qiang He, Juan Jin, Wei Zhu
Summary: This study reports that a novel compound called CPS-A exhibits therapeutic effects on cisplatin-induced acute kidney injury (AKI) and explores its potential mechanisms through transcriptomics and metabolomics. CPS-A improves cell viability, reduces inflammatory markers, and attenuates cisplatin-induced kidney injury. The study also identifies potential targets related to amino acid metabolism.
JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS
(2024)
Article
Chemistry, Analytical
Ricardo Conde, Nadia Oliveira, Elisabete Morais, Ana Paula Amaral, Adriana Sousa, Goncalo Graca, Ignacio Verde
Summary: Decreased levels of tyrosine, glutamate, valine, leucine, and isoleucine are associated with worsening pathological cognitive decline. Decreased levels of isobutyrate, histidine, acetone, and unknown-1 metabolite are potential biomarkers with neuroprotective and antioxidant actions for cognitive decline.
JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS
(2024)
Article
Chemistry, Analytical
A. L. Santunione, F. Palazzoli, P. Verri, D. Vandelli, V. Castagnetti, C. Profeta, E. Silingardi
Summary: This study describes two fatal suicide cases involving four cardiovascular drugs, and presents the concentrations and distribution of these drugs in different post-mortem specimens. The study developed a fast, sensitive, and simple method for drug detection suitable for forensic purposes.
JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS
(2024)
Article
Chemistry, Analytical
Meiyun Shi, Xinyue Zheng, Yuncheng Ge, Ning Zhang, Luyao Yu, Xujian Duan, Yajun Liu, Hongyu Xue, Jiansong You, Lei Yin
Summary: This study investigated the cellular uptake of low, medium and high molecular weight polyethylene glycol (PEG) in MCF-7 cells using UPLC-MS/MS and CID techniques. The results showed that PEG600, PEG2K, PEG4K and PEG10K exhibited low toxicity and had limited cellular entry at concentrations of 5-1200 μg/mL. Additionally, the environmental friendliness of the developed analytical methods was evaluated.
JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS
(2024)
Article
Chemistry, Analytical
Ruijin Geng, Mengjie Yu, Jinbiao Xu, Yuanwang Wei, Qiong Wang, Junguo Chen, Fei Sun, Kun Xu, Han Xu, Xiaohui Liu, Juhua Xiao, Xianchao Zhang, Baogang Xie
Summary: This study validated serum methionine as a potential biomarker for Kawasaki disease (KD), and found that its alteration is associated with the activation of DNMT1 in KD patients.
JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS
(2024)
Article
Chemistry, Analytical
Eman Shawky, Rasha A. Nassra, Aliaa M. T. El-Alkamy, Shaimaa M. Sallam, Samah M. El Sohafy
Summary: This study employed network pharmacology-based analysis and reverse molecular docking to investigate the molecular targets and pathways associated with gynecological disorders and the potential therapeutic effects of fenugreek constituents. The results highlighted the potential of steroidal saponins, isoflavones, and flavones as active constituents of fenugreek with implications for lactation, reproductive processes, and estrogenic activity. Animal model study further supported the presence of these bioactive compounds and their effects on body weight, serum prolactin levels, serum estradiol levels, and ovarian histological structure.
JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS
(2024)
Article
Chemistry, Analytical
Xuelong Zhao, Ruixue Dai, Jing Wang, Liangliang Cao, Peidong Chen, Weifeng Yao, Fangfang Cheng, Beihua Bao, Li Zhang
Summary: This study identified the skin-permeable and skin-retainable components of Cayratia japonica ointment and found that flavonoids are the main active components that play a crucial role in the inflammatory and proliferative phases of wound healing.
JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS
(2024)