Article
Medical Laboratory Technology
Pasindu Wickramarachchi, Jessica M. Boyd, Dennis J. Orton
Summary: The study defined the biological variability of clozapine metabolism and found a significant relationship between kidney function and levels of CLO and NCLO.
CLINICA CHIMICA ACTA
(2022)
Article
Chemistry, Analytical
Yanni Bi, Mimi Sun, Jingjuan Wang, Ziyu Zhu, Jing Bai, Mohammed Y. Emran, Ahmed Kotb, Xiangjie Bo, Ming Zhou
Summary: Fully integrated wearable sensors can directly and independently track biomarkers in raw noninvasive biofluids without any other equipment or accessories. We propose the first single universal FIWSAs for wirelessly and noninvasively measuring metabolites and electrolytes in sweat, saliva, or urine. This technology has the potential to enhance the understanding of biomarker levels in the body and facilitate self-health management.
ANALYTICAL CHEMISTRY
(2023)
Article
Public, Environmental & Occupational Health
Jun Ueyama, Yuki Ito, Risa Hamada, Naoko Oya, Sayaka Kato, Taro Matsuki, Hazuki Tamada, Kayo Kaneko, Shinji Saitoh, Mayumi Sugiura-Ogasawara, Takeshi Ebara, Michihiro Kamijima
Summary: This study conducted biomonitoring of urinary pyrethroid metabolites in 1.5-year-old Japanese children throughout the year and found widespread and seasonally specific exposure to multiple hygiene- and agriculture-PYRs.
ENVIRONMENTAL HEALTH AND PREVENTIVE MEDICINE
(2022)
Article
Chemistry, Analytical
Farah C. Alimagham, Dan Hutter, Nuria Marco-Garcia, Emma Gould, Victoria H. Highland, Anna Huefner, Susan Giorgi-Coll, Monica J. Killen, Agnieszka P. Zakrzewska, Stephen R. Elliott, Keri L. H. Carpenter, Peter J. Hutchinson, Tanya Hutter
Summary: Continuous monitoring of dynamic chemical changes in traumatic brain injury (TBI) patients is crucial for improved outcomes. Traditional offline hourly monitoring may miss subhourly neurochemical changes, while mid-infrared spectroscopy offers the potential for continuous, automated, reagent-free, and online monitoring of these changes.
ANALYTICAL CHEMISTRY
(2021)
Review
Chemistry, Multidisciplinary
Chun-Yip Hon, Naqiyah Motiwala
Summary: Although urine sampling for healthcare workers exposed to hazardous drugs is not routine, it is meaningful for biological monitoring. A scoping review identified knowledge gaps including a lack of exposure limit, standardized sampling method, and correlation between health effects and urinary contamination levels. Most studies reported positive urine samples and statistically significant findings in case-control studies.
APPLIED SCIENCES-BASEL
(2022)
Article
Public, Environmental & Occupational Health
Sangho Choi, Do-Hwan Ahn, Min-Gyu Yoo, Hye-Ja Lee, Seong Beom Cho, Hee-Bin Park, Sung Soon Kim, Hyuk Chu
Summary: In this study, a targeted urine metabolomics approach was used to evaluate the host response to scrub typhus infection. The researchers identified 65 differential metabolites in the urine, including acylcarnitines, glycerophospholipids, biogenic amines, and amino acids. This study provides the first report of urinary metabolite biomarkers of scrub typhus infection and sheds light on the involved metabolic pathways.
AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE
(2023)
Article
Multidisciplinary Sciences
Yurui Sheng, Di Yin, Qingshi Zeng
Summary: This study used the CRISPR/Cas9 technique to construct AEG-1 knockout U251 cell lines and evaluated their impact on cell behavior and metabolite ratios. The results showed that decreased expression of AEG-1 led to increased apoptosis rate, decreased metastatic capacity, and reduced levels of total choline and lactate. The study suggests that the metabolite ratios monitored by 1H MRS can reflect AEG-1 expression level, providing potential biomarkers for accurate preoperative diagnosis and treatment evaluation of gliomas.
Article
Agriculture, Multidisciplinary
Shuyun Zhang, Lei Wang, Hang Liu, Na Yang, Shujing Yu, Baolei Wang
Summary: This study synthesized and identified a series of novel xanthine derivatives. The compounds exhibited promising insecticidal and fungicidal activities, indicating their potential as lead structures for further investigation.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2022)
Article
Nanoscience & Nanotechnology
Chenlei Cai, Yujie Liu, Zheng Zhang, Tongtong Tian, Yuning Wang, Lei Wang, Kun Zhang, Baohong Liu
Summary: We develop an abSLIPSERS sensor for facile quantification of metabolites, which simplifies the detection workflow and improves the reproducibility.
ACS APPLIED MATERIALS & INTERFACES
(2023)
Article
Multidisciplinary Sciences
Yurong Cheng, Pascal Schlosser, Johannes Hertel, Peggy Sekula, Peter J. Oefner, Ute Spiekerkoetter, Johanna Mielke, Daniel F. Freitag, Miriam Schmidts, Florian Kronenberg, Kai-Uwe Eckardt, Ines Thiele, Yong Li, Anna Koettgen
Summary: This study explores the cumulative contribution of rare, exonic genetic variants on urine metabolite levels and identifies 30 genes related to inborn errors of metabolism, with shared expression in liver and kidney. By using in silico constraint-based modeling, the study correctly predicts the direction of metabolite changes, emphasizing the potential of linking population genetics to modeling.
NATURE COMMUNICATIONS
(2021)
Article
Endocrinology & Metabolism
Zaifang Li, Yanhui Zhang, Miriam Hoene, Louise Fritsche, Sijia Zheng, Andreas Birkenfeld, Andreas Fritsche, Andreas Peter, Xinyu Liu, Xinjie Zhao, Lina Zhou, Ping Luo, Cora Weigert, Xiaohui Lin, Guowang Xu, Rainer Lehmann
Summary: In this study, a metabolomics-based strategy using urine samples was developed to identify sex-specific biomarkers for the diagnosis of impaired glucose tolerance. The diagnostic performance of this approach was found to be superior to conventional blood parameters.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Engineering, Environmental
Xiaowu Huang, Yingyu Li, Michael Tsang-ming Choi, Xiao-yan Li
Summary: This study investigated the impact of high-strength pyrethroids on the biological treatment process of wastewater. The results showed that even at extremely high concentrations, pyrethroids did not affect the efficiency of the treatment process. Moreover, the microbial community in the sludge could adapt and enable the biodegradation of pyrethroids.
CHEMICAL ENGINEERING JOURNAL
(2022)
Article
Chemistry, Analytical
Lilian de Lima Feltraco Lizot, Marcos Frank Bastiani, Roberta Zilles Hahn, Yasmin Fazenda Meireles, Mariana Freitas, Carlos Augusto do Nascimento, Rafael Linden
Summary: Wastewater-based epidemiology (WBE) is a method that obtains epidemiological information by analyzing wastewater. This study developed a method to estimate the concentration of a pyrethroid insecticide metabolite using POCIS sampling and LC-MS/MS analysis. The concentration of the metabolite in POCIS sorbents was 208.6-2456.9 ng g-1, with an estimated concentration in wastewater of 24.3 to 335.2 ng/L.
MICROCHEMICAL JOURNAL
(2023)
Article
Chemistry, Multidisciplinary
Ewa K. Nawrocka, Mateusz Urbanczyk, Kamil Kozinski, Krzysztof Kazimierczuk
Summary: Nuclear magnetic resonance is a commonly used technique in metabolomics, but current methods are not sensitive enough for fast medical screening. This study identifies overlooked parameters in H-1 NMR spectra that could be helpful in metabolite identification.
Article
Multidisciplinary Sciences
Sandra Burgstaller, Teresa R. Wagner, Helmut Bischof, Sarah Bueckle, Aman Padamsey, Desiree Frecot, Philipp D. Kaiser, David Skrabak, Roland Malli, Robert Lukowski, Ulrich Rothbauer
Summary: In this study, the researchers combined FRET-based biosensors with nanobodies to specifically visualize and monitor extracellular changes in K+, pH, and glucose on cell surfaces. They successfully demonstrated quantitative visualization of K+ alterations on different cell lines and generated functional K+ and pH sensors that specifically stained breast cancer cells. This approach can be extended to other biosensors and provides new opportunities for studying extracellular analytes in advanced experimental settings.
Article
Nutrition & Dietetics
Hazuki Tamada, Takeshi Ebara, Taro Matsuki, Sayaka Kato, Hirotaka Sato, Yuki Ito, Shinji Saitoh, Michihiro Kamijima, Mayumi Sugiura-Ogasawara
Summary: The consumption of processed food during pregnancy is associated with pregnancy outcomes, and frequent consumption of ready-meals and frozen meals may increase the risk of stillbirth.
Article
Environmental Sciences
Shota Yamada, Takeshi Ebara, Toru Uehara, Taro Matsuki, Shingo Kimura, Yuya Satsukawa, Akira Yoshihara, Kazuji Aoki, Atsushi Inada, Michihiro Kamijima
Summary: This study aimed to identify effective measurement angles for pelvic incidence (PI) classification and develop a quick, noninvasive assessment tool. The results revealed that the HKL angle can accurately distinguish the size of PI and a reliable tool was designed for practical application.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
(2022)
Article
Public, Environmental & Occupational Health
Hiroshi Nomura, Risa Hamada, Keiko Wada, Isao Saito, Nanami Nishihara, Yugo Kitahara, Satoru Watanabe, Kunihiko Nakane, Chisato Nagata, Takaaki Kondo, Michihiro Kamijima, Jun Ueyama
Summary: This study revealed an increasing trend of Gly exposure in Japanese children's urine samples between 2006 and 2015, with no significant seasonal or gender differences. Overall, the urinary concentrations of Gly were comparable to studies conducted in other countries.
INTERNATIONAL JOURNAL OF HYGIENE AND ENVIRONMENTAL HEALTH
(2022)
Article
Public, Environmental & Occupational Health
Toshio Masumoto, Hiroki Amano, Shinji Otani, Michihiro Kamijima, Shin Yamazaki, Yayoi Kobayashi, Youichi Kurozawa
Summary: Cadmium, a heavy metal, has toxic effects on the human body. This study found that prenatal exposure to cadmium affects the mental development of children, but the effect decreases with age.
INTERNATIONAL JOURNAL OF HYGIENE AND ENVIRONMENTAL HEALTH
(2022)
Article
Biochemistry & Molecular Biology
Shogo Tamura, Masato Mukaide, Yumi Katsuragi, Wataru Fujii, Koya Odaira, Nobuaki Suzuki, Nagaharu Tsukiji, Shuichi Okamoto, Atsuo Suzuki, Takeshi Kanematsu, Akira Katsumi, Akira Takagi, Katsuhide Ikeda, Jun Ueyama, Masaaki Hirayama, Katsue Suzuki-Inoue, Tadashi Matsushita, Tetsuhito Kojima, Fumihiko Hayakawa
Summary: This study found that PDPN-expressing stromal cells are involved in postnatal bone marrow generation and regulate the integrity of primitive vasculatures in the marrow. This is the first comprehensive study on how PDPN-expressing stromal cells contribute to marrow development and homeostasis.
JOURNAL OF BIOLOGICAL CHEMISTRY
(2022)
Article
Cardiac & Cardiovascular Systems
Yo Ishimaru, Takuji Adachi, Hironobu Ashikawa, Masaya Hori, Takashi Shimozato, Hiroshi Ohtake, Shinya Shimizu, Jun Ueyama, Sumio Yamada
Summary: This study investigated the relationship between the redox state of human serum albumin (HSA) and exercise capacity in patients with cardiovascular disease. The findings revealed a positive association between the redox state of HSA and exercise capacity, suggesting that it could serve as a novel biomarker for cardiac disease.
AMERICAN JOURNAL OF CARDIOLOGY
(2023)
Article
Public, Environmental & Occupational Health
Shoji F. Nakayama, Annie St-Amand, Tyler Pollock, Petra Apel, Yu Ait Bamai, Dana Boyd Barr, Jos Bessems, Antonia M. Calafat, Argelia Castano, Adrian Covaci, Radu Corneliu Duca, Sarah Faure, Karen S. Galea, Sean Hays, Nancy B. Hopf, Yuki Ito, Maryam Zare Jeddi, Marike Kolossa-Gehring, Eva Kumar, Judy S. LaKind, Marta Esteban Lopez, Henriqueta Louro, Kristin Macey, Konstantinos C. Makris, Lisa Melnyk, Aline Murawski, Josh Naiman, Julianne Nassif, Nolwenn Noisel, Devika Poddalgoda, Lesliam Quiros-Alcala, Ata Rafiee, Loic Rambaud, Maria Joao Silva, Jun Ueyama, Marc-Andre Verner, Maisarah Nasution Waras, Kate Werry
Summary: Human biomonitoring (HBM) data can be used to compare population exposures, but finding the relevant health-based biomonitoring guidance values can be time-consuming. To address this issue, an online repository called the Human Biomonitoring Health-Based Guidance Value (HB2GV) Dashboard has been created. This database provides a centralized location for researchers and decision makers to access and interpret HBM data.
INTERNATIONAL JOURNAL OF HYGIENE AND ENVIRONMENTAL HEALTH
(2023)
Article
Environmental Sciences
Jun Ueyama, Mai Hayashi, Masaaki Hirayama, Hiroshi Nishiwaki, Mikako Ito, Isao Saito, Yoshio Tsuboi, Tomohiko Isobe, Kinji Ohno
Summary: Animal experiments suggest that pesticides may impact gut microbiota and the production of SCFAs and polyamines. This study investigated the relationship between pesticide exposure and fecal SCFAs and polyamines in Japanese adults. The findings indicate that OP exposure is independently associated with lower fecal acetate levels, possibly affecting the health of middle-aged and older adults. Further studies on a wider age range, including children, are needed to fully understand the long-term effects of pesticide exposure on gut health.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
(2023)
Article
Pediatrics
Aya Yoshida, Kayo Kaneko, Kohei Aoyama, Naoya Yamaguchi, Atsushi Suzuki, Sayaka Kato, Takeshi Ebara, Mayumi Sugiura-Ogasawara, Michihiro Kamijima, Shinji Saitoh
Summary: Later-borns tend to be shorter than first-borns in childhood and adulthood, and this study aimed to investigate the relationship between birth order and growth during the first 4 years of life. The study found that birth order was significantly associated with postnatal growth, with later-borns having lower length Z-scores and higher odds of short stature compared to first-borns having no sibling. This suggests that birth order may be a predisposing factor for short stature in early childhood.
Article
Environmental Sciences
Yukiko Nishihama, Shoji F. Nakayama, Tomohiko Isobe, Michihiro Kamijima
Summary: This study aimed to examine the association between NEO exposure and child development. The results showed no statistically significant association between maternal urinary NEO concentrations during pregnancy and child development delays. Objective assessment of child development in different populations may be warranted to confirm these findings.
ENVIRONMENT INTERNATIONAL
(2023)
Article
Environmental Sciences
Junji Miyazaki, Satoyo Ikehara, Kanami Tanigawa, Takashi Kimura, Kimiko Ueda, Keiichi Ozono, Tadashi Kimura, Yayoi Kobayashi, Shin Yamazaki, Michihiro Kamijima, Tomotaka Sobue, H. Iso
Summary: This study examined the associations between prenatal exposure to metallic elements (mercury, selenium, and manganese) and the risk of allergic diseases in early childhood. The findings suggest that prenatal selenium exposure may be beneficial in reducing the risk of atopic dermatitis, food allergies, allergic rhinitis, and any allergic diseases, particularly with lower prenatal mercury exposure.
ENVIRONMENT INTERNATIONAL
(2023)
Article
Environmental Sciences
Tomoyuki Tsuchiyama, Yuki Ito, Masaru Taniguchi, Miki Katsuhara, Hitoshi Miyazaki, Michihiro Kamijima
Summary: High urinary levels of dialkylphosphates (DAPs) have been associated with adverse health outcomes. This study analyzed the levels of organophosphate pesticides (OPs) and DAPs in different food items. Certain fruits had high levels of DAPs, while vegetables showed positive associations with OPs and DAPs. This suggests that dietary habits and intake of preformed DAPs should be considered when interpreting urinary DAP biomonitoring data.
ENVIRONMENTAL RESEARCH
(2023)
Article
Environmental Sciences
Neeranuch Suwannarin, Tomohiko Isobe, Yukiko Nishihama, Yuki Ito, Michihiro Kamijima, Takeshi Ebara, Mayumi Sugiura-Ogasawara, Naomi Nishikawa, Kunihiko Nakai, Yumina Minamikawa, Shoji F. Nakayama
Summary: The study aimed to evaluate the utility of urinary biomarkers for the exposure to low doses of neonicotinoid insecticides during pregnancy. The results showed that a single measurement of urinary NEO concentrations may not be an appropriate method of characterizing overall exposure, except for N-dm-ACE.
ENVIRONMENTAL RESEARCH
(2024)
Article
Food Science & Technology
Yugo Kitahara, Hiroshi Nomura, Nanami Nishihara, Takuya Ueda, Satoru Watanabe, Isao Saito, Jun Ueyama
Summary: This study investigated the presence of arsenic, heavy metals, and pesticide residues in 14 edible insects. The results showed that the levels of these elements exceeded the safety standards. Further research on these contaminants may help ensure the safety of consuming edible insects.
FOOD HYGIENE AND SAFETY SCIENCE
(2022)
Article
Public, Environmental & Occupational Health
Jun Ueyama, Yuki Ito, Risa Hamada, Naoko Oya, Sayaka Kato, Taro Matsuki, Hazuki Tamada, Kayo Kaneko, Shinji Saitoh, Mayumi Sugiura-Ogasawara, Takeshi Ebara, Michihiro Kamijima
Summary: This study conducted biomonitoring of urinary pyrethroid metabolites in 1.5-year-old Japanese children throughout the year and found widespread and seasonally specific exposure to multiple hygiene- and agriculture-PYRs.
ENVIRONMENTAL HEALTH AND PREVENTIVE MEDICINE
(2022)
