Article
Dentistry, Oral Surgery & Medicine
Hiroshi Ito, Yukihiro Numabe, Shuichi Hashimoto, Sunao Uehara, Ya-Hsin Wu, Tomohisa Ogawa
Summary: The study suggests that the presence of hemoglobin in gingival crevicular fluid may indicate slight tissue damage in pre-symptomatic periodontal disease, even in healthy sites without bleeding on probing. Therefore, hemoglobin examination could be a promising candidate marker for early detection of periodontal disease.
CLINICAL ORAL INVESTIGATIONS
(2021)
Article
Dentistry, Oral Surgery & Medicine
Luigi Nibali, Abish Stephen, Eleni Hagi-Pavli, Robert Allaker, Antonino Di Pino, Valentina Terranova, Marcella Pisano, Salvatore Di Marca, Viviana Ferrara, Roberto Scicali, Mauro Giordano, Francesco Purrello, Nikolaos Donos, Lorenzo Malatino
Summary: The study suggests that GCF markers in patients with metabolic syndrome may be associated with concomitant periodontitis, particularly the levels of markers such as Aggrecan, IL-6, and IL-8 are correlated with the severity of the disease.
JOURNAL OF DENTISTRY
(2022)
Article
Dentistry, Oral Surgery & Medicine
Bardia Vadiati Saberi, Farouq Yousefi, Tooba Yousefi, Durdi Qujeq
Summary: This study determined the correlation between mucin and alpha-amylase protein levels in gingival crevicular fluid (GCF) with chronic periodontitis. The results showed that the levels of both markers were higher in patients with chronic periodontitis compared to successfully recovered patients, suggesting that they could be used to determine the activity of periodontal disease.
Article
Health Care Sciences & Services
Hammam Ibrahim Fageeh, Hytham N. Fageeh, Shankargouda Patil
Summary: Periodontitis is an inflammatory condition caused by pathogenic bacteria in dental plaque. Macrophages derived from monocytes play a dual role in periodontitis, presenting antigens to lymphocytes while also contributing to periodontal destruction. The study found that GCF samples from periodontitis patients have higher levels of specific cytokines, and that treatment with these samples can induce monocytes to differentiate into destructive macrophages, affecting the phenotype and function of resident cells in the periodontium.
JOURNAL OF PERSONALIZED MEDICINE
(2021)
Article
Dentistry, Oral Surgery & Medicine
Alfredo Torres, M. Angelica Michea, Akos Vegvari, Marion Arce, Alicia Morales, Elias Lanyon, Marcela Alcota, Camila Fuentes, Rolando Vernal, Mauricio Budini, Roman A. Zubarev, Fermin E. Gonzalez
Summary: The study aimed to explore the qualitative and quantitative differences in gingival crevicular fluid (GCF) proteome of periodontitis patients during disease progression. It was found that the GCF proteome of progressive periodontitis was associated with metabolic processes, immune response, and cellular stress, while the proteome of stable periodontitis was mainly related to wound repair, cell death regulation, and autophagy.
JOURNAL OF PERIODONTAL RESEARCH
(2023)
Article
Chemistry, Multidisciplinary
Alina-Ramona Dimofte, Dorin Nicolae Gheorghe, Dora Maria Popescu, Ioana Mitrut, Petre Costin Marasescu, Horia Octavian Manolea, Mihail Virgil Boldeanu, Petra Surlin
Summary: This study evaluated the influence of metal-ceramic crowns on periodontal parameters and inflammatory marker levels. The results showed that metal-ceramic crowns can cause changes in periodontal clinical parameters and are associated with inflammatory marker levels.
APPLIED SCIENCES-BASEL
(2023)
Article
Microbiology
Simran Preet Bhalla, Ann Maria Shaju, Carlos Marcelo da Silva Figueredo, Leticia Algarves Miranda
Summary: C5a levels were significantly increased in both gingival crevicular fluid and saliva of patients with periodontal disease, indicating a potential role of this molecule in the pathogenesis of the disease.
Article
Dentistry, Oral Surgery & Medicine
Zeliha Guney, Sivge Kurgan, Canan Onder, Cavid Mammadov, Muhittin A. Serdar, Meral Gunhan
Summary: This study aimed to evaluate the levels of ADMA, SDMA, and IL-1 beta in GCF from periodontitis patients. The results showed that the levels of IL-1 beta, ADMA, and SDMA in GCF were significantly higher in periodontitis patients compared to the control group, and they were positively correlated with clinical periodontal parameters. It suggests that ADMA and SDMA may be involved in the pathogenesis of periodontal disease.
JOURNAL OF PERIODONTAL RESEARCH
(2023)
Article
Biology
Hytham N. Fageeh, Hammam Ibrahim Fageeh, Samar Saeed Khan, Prabhadevi C. Maganur, Nishant Vyas, Vikrant R. Patil, A. Thirumal Raj, Hosam Ali Baeshen, Shankargouda Patil
Summary: This study aimed to characterize monocytes isolated from the gingival crevicular fluid (GCF) in patients with periodontitis, evaluating cytokine levels, gene expression, and secreted cytokines and chemokines. CD14+ monocytes from GCF secreted higher levels of CCL2 and expressed genes responsible for monocyte migration, indicating their role in the inflammatory microenvironment of periodontitis.
SAUDI JOURNAL OF BIOLOGICAL SCIENCES
(2021)
Article
Dentistry, Oral Surgery & Medicine
Hyun-Duck Kim, Sandeep Karna, YooJin Shin, Huong Vu, Hyun-Jae Cho, Sungtae Kim
Summary: This study compared the association and screening ability of S100A8 and S100A9 in saliva, blood, and gingival crevicular fluid for periodontitis status. Salivary S100A8 was significantly higher in established periodontitis, while GCF S100A8 and S100A9 were higher in no or initial periodontitis. Salivary S100A8 could be a potential diagnostic marker for established periodontitis.
Article
Dentistry, Oral Surgery & Medicine
Beral Afacan, Harika Atmaca Ilhan, Timur Kose, Gulnur Emingil
Summary: This study aims to evaluate the levels of GCF Galectin-3 and IL-1 beta in different grades of stage 3 periodontitis and investigate their efficiency in discriminating periodontal diseases. ELISA was used to measure the total amounts of GCF Galectin-3 and IL-1 beta in 80 individuals. The results showed that GCF Galectin-3 is associated with the pathogenesis of periodontal diseases and has high diagnostic performance.
CLINICAL ORAL INVESTIGATIONS
(2023)
Article
Biochemistry & Molecular Biology
Federica Romano, Giovanni Iaderosa, Matteo Corana, Stefano Perotto, Giacomo Baima, Federica Di Scipio, Giuliana Abbadessa, Giulia Maria Mariani, Mario Aimetti, Giovanni Nicolao Berta
Summary: This study analyzed the elemental composition of gingival crevicular fluid (GCF) and saliva and found differences in their content that could be used to diagnose periodontitis and periodontal health. GCF showed higher clustering potential than saliva.
Article
Dentistry, Oral Surgery & Medicine
Jie Zhang, Wenjing Li, Hongye Lu, Ruifang Lu, Yalin Zhan, Huanxin Meng
Summary: The level of platelets in the GCF of patients with periodontitis is higher than that of healthy individuals. Platelets can interact with periodontal pathogens and neutrophils, and promote the formation of NETs.
JOURNAL OF CLINICAL PERIODONTOLOGY
(2022)
Article
Biology
Ashley L. L. Gard, Rebeccah J. J. Luu, Ryan Maloney, Madeline H. H. Cooper, Brian P. P. Cain, Hesham Azizgolshani, Brett C. C. Isenberg, Jeffrey T. T. Borenstein, Jane Ong, Joseph L. L. Charest, Else M. M. Vedula
Summary: A microfluidic model of human gingival tissue allows for the study of disease progression and evaluation of therapeutic agents for gum disease. This model demonstrates physiological tissue structure and response to inflammatory triggers, providing a platform for identification of new therapeutic targets.
COMMUNICATIONS BIOLOGY
(2023)
Article
Dentistry, Oral Surgery & Medicine
Pasquale Santamaria, Aysegul Sari, Luigi Nibali
Summary: The aim of this study was to assess the differential molecular profiling of gingival crevicular fluid (GCF) from infrabony and suprabony periodontal defects compared with healthy sites. The results showed that 14 biomarkers levels were elevated in GCF from infrabony and suprabony defects compared with healthy sites, while the difference between infrabony and suprabony defects was not significant in biomarker changes.
JOURNAL OF CLINICAL PERIODONTOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Vikram Haridas, Praveenkumar Shetty, E. Sarathkumar, Anil Bargale, Jamboor K. Vishwanatha, Vidya Patil, U. S. Dinesh
MOLECULAR BIOLOGY REPORTS
(2019)
Article
Dentistry, Oral Surgery & Medicine
S. Pourshahidi, H. Ebrahimi, A. Mansourian, Y. Mousavi, M. Kharazifard
CLINICAL ORAL INVESTIGATIONS
(2019)
Review
Dentistry, Oral Surgery & Medicine
Carlos Miguel Marto, Anabela Baptista Paula, Tiago Nunes, Miguel Pimenta, Ana Margarida Abrantes, Ana Salome Pires, Mafalda Laranjo, Ana Coelho, Helena Donato, Maria Filomena Botelho, Manuel Marques Ferreira, Eunice Carrilho
JOURNAL OF ORAL REHABILITATION
(2019)
Article
Dentistry, Oral Surgery & Medicine
Vivek Rajiv Patel, Leena Shettar, Srinath Thakur, David Gillam, Daripineni Narayana Kamala
JOURNAL OF ORAL REHABILITATION
(2019)
Article
Oncology
Shankargouda Patil, Clinton D'Souza, Prakash Patil, Vidya Patil, Mridula Prabhu, Anil Bargale, Vishwas Kaveeshwar, Sarath Kumar, Praveenkumar Shetty
MOLECULAR MEDICINE REPORTS
(2019)
Article
Chemistry, Multidisciplinary
Felice Femiano, Rossella Femiano, Luigi Femiano, Ludovica Nucci, Giuseppe Minervini, Alessandro Antonelli, Francesco Bennardo, Selene Barone, Nicola Scotti, Vittoria Sorice, Rossella Sorice
Summary: The goal of this research was to evaluate the desensitizing effect of a diode laser on dentin hypersensitivity caused by non-carious cervical lesions through different output forces and combination modalities. The study found that the treatment approach combining two separate output forces of the diode laser yielded the best improvement in symptoms.
APPLIED SCIENCES-BASEL
(2021)
Article
Medicine, General & Internal
Alagilawada S. Shilpasree, Vidya S. Patil, Manjunath Revanasiddappa, Vijayetha P. Patil, Deepti S. Ireshnavar
Summary: The study found that the prevalence of hyperfiltration was higher in prediabetes and diabetes patients compared to normal controls, and increased with higher levels of hemoglobin A1c. Urine albumin excretion was higher in prediabetes and diabetes groups compared to normal controls, but was significantly different only in the diabetes group.
JOURNAL OF LABORATORY PHYSICIANS
(2021)
Article
Dentistry, Oral Surgery & Medicine
Hawra'a Wisam Al-Ameri, Sunaina Shetty, Betul Rahman, Aghila Rani Koippallil Gopalakrishnan, Asmaa Anwer Ismail, Anirudh B. Acharya
Summary: This study aimed to investigate the salivary levels of Thy-1 in health, periodontitis, obesity, and any potential association. The levels of Thy-1 were measured in the saliva of participants from different groups, and significant differences were observed among the groups. Periodontitis patients had the highest Thy-1 levels, while obese individuals had the lowest. Overall, Thy-1 levels showed correlations with periodontal parameters, particularly in the group with obesity and periodontitis.
Article
Dentistry, Oral Surgery & Medicine
Swetha Acharya, Prashant Prabhu, Vidya S. Patil, Anirudh B. Acharya, Krithi Nikhil
JOURNAL OF INVESTIGATIVE AND CLINICAL DENTISTRY
(2019)
Article
Endocrinology & Metabolism
Anirudh B. Acharya, Apoorva Chandrashekar, Swetha Acharya, Leena Shettar, Srinath Thakur
DIABETES & METABOLIC SYNDROME-CLINICAL RESEARCH & REVIEWS
(2019)
Article
Medicine, General & Internal
Vijayetha P. Patil, Alagilwada S. Shilpasree, Vidya S. Patil, Kangokar R. Pravinchandra, Deepti G. Ingleshwar, Axita C. Vani
JOURNAL OF LABORATORY PHYSICIANS
(2018)
Article
Endocrinology & Metabolism
Anirudh B. Acharya, Srinath Thakur, M. V. Muddapur, Raghavendra D. Kulkarni
DIABETES & METABOLIC SYNDROME-CLINICAL RESEARCH & REVIEWS
(2017)
Article
Endocrinology & Metabolism
Anirudh B. Acharya, Srinath Thakur, M. V. Muddapur, Raghavendra D. Kulkarni
CURRENT DIABETES REVIEWS
(2018)