Review
Pharmacology & Pharmacy
Most Afia Akhtar
Summary: This article reviews the use of traditional medicinal plants in Bangladesh for the treatment of inflammatory disorders and discusses their anti-inflammatory potential and future research directions. A total of 48 plant species have been reviewed, and the mechanisms, habitats, and anti-inflammatory studies conducted outside of Bangladesh are also discussed.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Oncology
Vivian Cristina Noronha Novaes, Edilson Ervolino, Giovani Lopes Fernandes, Clara Possarle Cunha, Leticia Helena Theodoro, Valdir Gouveia Garcia, Juliano Milanezi de Almeida
Summary: Chemotherapy with antineoplastic agents 5-FU and CIS increased the intensity and duration of inflammation and compromised tissue repair by reducing cellular and vascular turnover. The more severe periodontal breakdown was caused by 5-FU.
SUPPORTIVE CARE IN CANCER
(2022)
Article
Plant Sciences
Windmi Kagambega, Hadidjatou Belem, Roland Nag-Tiero Meda, Benjamin Kouliga Koama, Anne-Flora Drabo, Jacques Kabore, Amadou Traore, Georges Anicet Ouedraogo, Daniela Benedec, Daniela Hanganu, Laurian Vlase, Ana-Maria Vlase, Oliviu Vostinaru, Cristina Mogosan, Ilioara Oniga
Summary: The present study aimed to investigate the polyphenolic profile and anti-inflammatory and anti-nociceptive activities of four traditionally used medicinal plants from Burkina Faso. The results showed that these plants contained high levels of phenolic compounds and demonstrated significant inhibitory effects on inflammation and pain.
Article
Biochemistry & Molecular Biology
Myung Jin Lee, Hyang Hwa Ryu, Jae Won Hwang, Jung Ryul Kim, Eui-Sic Cho, Jin Kyeong Choi, Young Jae Moon
Summary: Periodontitis is an inflammatory disease that causes destruction of periodontal tissue. Sirt6, a protein, has been found to suppress inflammation and bone resorption, but its role in periodontitis was unclear. By studying mice with Sirt6 overexpression and using a Sirt6 activator called MDL801, the researchers found that Sirt6 activation prevented bone loss in periodontitis. This suggests that a Sirt6 activator could be a potential therapeutic approach for treating periodontitis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Dentistry, Oral Surgery & Medicine
Mark Lindholm, Rolf Claesson, Hanna Lof, Huei-Min Chiang, Jan Oscarsson, Anders Johansson, Carola Hoglund Aberg
Summary: Periodontitis is becoming more prevalent among adolescents in Sweden due to changing demographics, and early detection of this disease is important. This study examined the presence of radiographic bone loss and compared periodontal and microbial parameters between cases with bone loss and controls without. The results showed higher concentrations and prevalence of specific bacteria in the cases with bone loss, indicating the importance of radiographs for early detection.
JOURNAL OF PERIODONTOLOGY
(2023)
Article
Dentistry, Oral Surgery & Medicine
Turan Emre Kuzu, Kuebra Ozturk, Cem A. Gurgan, Arzu Yay, Ozge Goktepe, Alpdogan Kantarci
Summary: Objective: This study aimed to investigate the potential anti-inflammatory effect of paeoniflorin (Pae) on diabetic periodontitis and its impact on bone loss.
JOURNAL OF PERIODONTAL RESEARCH
(2023)
Article
Dentistry, Oral Surgery & Medicine
Xiaoyue Guan, Chen Shi, Yuting Wang, Yani He, Yingxue Li, Yao Yang, Wenli Mu, Wenlan Li, Tiezhou Hou
Summary: The study revealed that Gremlin1 expression levels are significantly increased in periapical lesions and may be positively correlated with IL-18 levels. Blocking Gremlin1 can significantly suppress bone resorption loss and restrain inflammatory status by affecting the activation levels of phosphorylated-CREB, ICAM-1, VCAM-1, IL-18.
ARCHIVES OF ORAL BIOLOGY
(2024)
Article
Dentistry, Oral Surgery & Medicine
Wenrui Han, Yao Jiao, Sicong Mi, Shu Han, Junji Xu, Song Li, Yi Liu, Lijia Guo
Summary: This study explored the effect of stevioside on periodontitis in mice. The results showed that 0.1% stevioside intake can reduce alveolar bone resorption and inflammation in periodontal tissues, and improve the bacterial composition. In vitro experiments also demonstrated that stevioside can reduce the activity and toxicity of periodontal bacteria. Therefore, stevioside is a potential alternative to glucose for patients with periodontitis.
Review
Biochemistry & Molecular Biology
Asmatullah Khan, Muhammad Akram, Muthu Thiruvengadam, Muhammad Daniyal, Shahbaz Ahmad Zakki, Naveed Munir, Rida Zainab, Mojtaba Heydari, Seyed Hamdollah Mosavat, Maksim Rebezov, Mohammad Ali Shariati
Summary: Exploration of medicinal plants as a potential source of new drugs for anxiety treatment is discussed in this review. Promising effects of certain plants are observed in animal models and clinical studies, but further research is needed.
CURRENT PHARMACEUTICAL BIOTECHNOLOGY
(2022)
Article
Medicine, General & Internal
Ting-Yen Kuo, Ming-Chieh Hsieh, Chia-Dan Cheng, Ren-Yeong Huang, Thomas E. Van Dyke, Cheng-En Sung, Chen-Ying Wang, Yi-Shing Hsieh, Wan-Chien Cheng
Summary: This study aimed to evaluate the impact of chlorhexidine (CHX) gel on inflammation-induced periodontal tissue destruction, osteoclastogenesis, subgingival microbiota, and on the modulation of the RANKL/OPG as well as inflammatory mediators during bone remodeling in vivo. The results showed that CHX gel significantly reduced alveolar bone destruction, osteoclast number, and RANKL protein level. It also decreased inflammatory cell infiltration and the expression of inflammatory mediators COX-2 and iNOS. Evaluation of the subgingival microbiota revealed changes in rats with CHX gel treatment.
JOURNAL OF THE FORMOSAN MEDICAL ASSOCIATION
(2023)
Article
Dentistry, Oral Surgery & Medicine
Thayana S. S. Lea, Gustavo H. Tomasi, Lucas P. Conzatti, Luiz C. P. Marrone, Mark A. Reynolds, Maximiliano S. Gomes
Summary: This study found that a higher oral inflammatory burden (sum of endodontic and periodontal diseases) was independently associated with higher levels of carotid atherosclerotic burden among hospital patients with ischemic stroke. Oral inflammatory diseases may boost the vascular risk in this specific population.
JOURNAL OF ENDODONTICS
(2022)
Article
Medicine, General & Internal
Qiang Zhang, Shuhan Xu, Wenxiu Xu, Yang Zhou, Hairong Luan, Deli Wang
Summary: The study found that resveratrol has an inhibitory effect on inflammation in patients with periodontitis, improving their periodontal condition and reducing systemic inflammation. The ideal dosage for patients with periodontitis is 500mg/d.
Review
Biochemistry & Molecular Biology
Karma Yeshi, Gerry Turpin, Tenzin Jamtsho, Phurpa Wangchuk
Summary: Australian tropical plants have been a valuable resource of food and medicine for Aboriginal people, with over 900 medicinal plants recorded. Many of these plants are used traditionally to treat inflammation and related conditions. Research has identified several compounds from these plants with anti-inflammatory properties, showing potential for the development of novel therapeutics.
Review
Plant Sciences
Dereje Nigussie, Eyasu Makonnen, Takele Beyene Tufa, Malcolm Brewster, Belete Adefris Legesse, Abebaw Fekadu, Gail Davey
Summary: The study aimed to assess Ethiopian medicinal plants with anti-inflammatory or wound healing activities to gather information for further investigation of their potential role in managing lymphoedema.
JOURNAL OF ETHNOPHARMACOLOGY
(2021)
Article
Plant Sciences
Marziyeh Esmaeilzadeh Kashi, Vahid Soheili, Javad Asili, Javid Davoodi, Saman Soleimanpour, Gholamreza Karimi, Seyedeh Faezeh Taghizadeh, Ramin Rezaee, Abolfazl Shakeri
Summary: The methanol-dichloromethane extracts of nine medicinal plants were screened for their antibacterial, anti-tuberculosis, and cytotoxic activities. Among them, Hypericum scabrum extract showed significant activity against several bacteria and moderate cytotoxicity against certain cancer cell lines. It also exhibited moderate inhibition against Mycobacterium tuberculosis. The extract of Hypericum scabrum holds promise for the development of novel agents against bacteria and tuberculosis.
SOUTH AFRICAN JOURNAL OF BOTANY
(2023)
Article
Dentistry, Oral Surgery & Medicine
Mabelle Freitas Monteiro, Marcio Zaffalon Casati, Enilson Antonio Sallum, Karina Gonzales Silverio, Francisco Humberto Nociti-Jr, Renato Correa Viana Casarin
Summary: This study found that aggressive periodontitis (GAgP) patients and their children have a different local inflammatory response compared to healthy controls, and there is a familial aggregation. The cytokine profile and subgingival response imbalance characterized by decreased IFN-gamma/IL-4 and IL-10/IL-1 beta ratios were observed in both GAgP patients and their children.
Article
Dentistry, Oral Surgery & Medicine
Giselle A. Silva, Andre L. G. Moreira, Pedro H. F. Silva, Sergio L. Salvador, Renato C. Casarin, Raphael M. Vicente, Graziele C. Ferreira, Jose E. Tanus-Santos, Flavia A. C. Furlaneto, Michel R. Messora
Summary: The study found that the use of B. lactis HN019 in rats can reduce the severity of periodontitis while regulating systemic metabolic and immunoinflammatory parameters. The use of probiotics has a beneficial effect on dyslipidemia parameters in rats with or without metabolic syndrome.
JOURNAL OF PERIODONTOLOGY
(2022)
Article
Dentistry, Oral Surgery & Medicine
Camila S. Stolf, Catharina M. Sacramento, Helvis E. S. Paz, Renato A. Machado, Lucas P. Ramos, Luciane D. de Oliveira, Karina Cogo-Muller, Mauro P. Santamaria, Karina G. S. Ruiz, Renato C. V. Casarin
Summary: This study demonstrated the association between the IL10 promoter rs6667202 SNP and IL10 expression and production. In patients with periodontal health, the AA and AC genotypes were associated with lower levels of IL10, while in patients with Perio4C, other factors may be affecting the IL-10 response despite the genetic variation.
JOURNAL OF PERIODONTAL RESEARCH
(2022)
Article
Dentistry, Oral Surgery & Medicine
Helvis E. S. Paz, Mabelle F. Monteiro, Camila S. Stolf, Khaled Altabtbaei, Marcio Z. Casati, Renato C. Casarin, Purnima S. Kumar
Summary: This study evaluated the taxonomic and predicted functional content of the subgingival microbiome of young patients with Grade C periodontitis under supportive periodontal therapy. The results showed that despite clinical improvements, the microbiome of these patients remained different from individuals without a history of disease.
JOURNAL OF PERIODONTOLOGY
(2022)
Article
Dentistry, Oral Surgery & Medicine
Sandro Santana, Pedro H. F. Silva, Sergio L. Salvador, Renato C. Casarin, Flavia A. C. Furlaneto, Michel R. Messora
Summary: This clinical trial evaluated the effects of a multispecies probiotic as an adjunct to mechanical debridement on changes in bleeding on probing in edentulous patients with peri-implant mucositis. The results showed that the probiotic group had a higher prevalence of restored peri-implant health and lower bleeding on probing at 24 weeks compared to the placebo group.
JOURNAL OF CLINICAL PERIODONTOLOGY
(2022)
Article
Chemistry, Physical
Hugo Robertson Sant'Anna, Marcio Zaffalon Casati, Mounir Colares Mussi, Fabiano Ribeiro Cirano, Suzana Peres Pimentel, Fernanda Vieira Ribeiro, Monica Grazieli Correa
Summary: This study found that the use of implants with modified macrogeometry can improve biomechanical retention and positively modulate important bone markers in the peri-implant bone tissue under diabetic conditions.
Article
Dentistry, Oral Surgery & Medicine
Luiz Fernando Ferreira de Oliveira, Pedro Henrique Felix Silva, Sergio Luiz Salvador, Edilson Ervolino, Renato Casarin, Luciene Figueiredo, Milla Tavares Ricoldi, Sergio Luis Scombatti de Souza, Flavia Furlaneto, Michel Reis Messora
Summary: This study evaluated the effects of administering Bifidobacterium animalis subsp. lactis HN019 on rats with experimental periodontitis. The results showed that the rats treated with HN019 had less alveolar bone loss, lower proinflammatory/anti-inflammatory cytokine ratios, and a different composition of oral biofilm compared to the control group. The consumption of HN019 promoted a protective effect against alveolar bone loss by modifying local and systemic microbiological and immunoinflammatory parameters.
JOURNAL OF PERIODONTOLOGY
(2023)
Article
Dentistry, Oral Surgery & Medicine
Rodrigo Soler Zamai, Monica Grazieli Correa, Fernanda Vieira Ribeiro, Fabiano Ribeiro Cirano, Marcio Zaffalon Casati, Michel Reis Messora, Suzana Peres Pimentel
Summary: This study investigated the effects of resveratrol on peri-implant repair and bone-related markers in osteoporosis induced by ovariectomy in rats. The results showed that resveratrol did not improve peri-implant bone repair.
BRAZILIAN ORAL RESEARCH
(2023)
Article
Dentistry, Oral Surgery & Medicine
Renato C. V. Casarin, Cristiane R. Salmon, Camila S. Stolf, Helvis E. S. Paz, Thiago P. Rangel, Romenia R. Domingues, Bianca A. Pauletti, Adriana F. Paes-Leme, Cassia Araujo, Mauro P. Santamaria, Karina S. Ruiz, Mabelle F. Monteiro
Summary: The aim of this study was to compare the salivary proteomic profile of periodontitis-affected parents and their offspring to periodontally healthy dyads in order to find potential biomarkers for early diagnosis of this disease. The results showed that ANXA1, KRT4, GSTP1, HPX, A2M, and KRT13 were lower in periodontitis-affected parents and their children, while IGHG1, CSTB, KRT9, SMR3B, IGHG4, and SERPINA1 were higher. ANXA1 had the lowest abundance and was selected as a potential biomarker for periodontitis. The in vitro assay also confirmed lower ANXA1 production in cells of periodontitis patients.
JOURNAL OF CLINICAL PERIODONTOLOGY
(2023)
Article
Dentistry, Oral Surgery & Medicine
Aurelio Amorim Reis, Mabelle Freitas Monteiro, Gabriela Martin Bonilha, Luciana Saraiva, Cassia Araujo, Mauro Pedrine Santamaria, Marcio Zaffalon Casati, Purnima Kumar, Renato Correa Viana Casarin
Summary: The aim of this study was to evaluate microbial colonization in different dentition phases among individuals from 0 to 18 years old with a family history of periodontitis compared to descendants of periodontally healthy parents. The results showed that the parents' periodontal status significantly affected the microbiome composition of their offspring, and descendants with a family history of periodontitis exhibited different microbial diversity and a higher prevalence of periodontitis-associated species in the mixed and permanent dentition phases.
JOURNAL OF CLINICAL PERIODONTOLOGY
(2023)
Article
Dentistry, Oral Surgery & Medicine
Marcelo Vitale, Monica Grazieli Correa, Edilson Ervolino, Fabiano Ribeiro Cirano, Fernanda Vieira Ribeiro, Mabelle Freitas Monteiro, Marcio Zaffalon Casati, Suzana Peres Pimentel
Summary: This study evaluated the effect of resveratrol (RES) on the prevention of medication-related osteonecrosis of the jaws (MRONJ) in ovariectomized (OVX) rats treated with zoledronate (ZOL). The results showed that RES reduced tissue impairment caused by ZOL, but it could not prevent the occurrence of MRONJ.
Article
Dentistry, Oral Surgery & Medicine
Mounir Colares Mussi, Fernanda Vieira Ribeiro, Monica Grazieli Correa, Cristiane Ribeiro Salmon, Suzana Peres Pimentel, Fabiano Ribeiro Cirano, Marcio Zaffalon Casati
Summary: This study examined the effect of a modified implant macrogeometry on peri-implant healing and bone-related molecules in rats. The test group, which received implants with modified macrogeometry, exhibited higher counter-torque values and upregulation of OPN expression compared to the control group. These findings suggest that the modified macrogeometry optimized peri-implant healing by modulating OPN expression in the surrounding bone tissue.
BRAZILIAN ORAL RESEARCH
(2023)
Article
Dentistry, Oral Surgery & Medicine
Tamires Pereira Dutra, Mabelle Freitas Monteiro, Isabela Lima Franca-Grohmann, Renato Correa Viana Casarin, Marcio Zaffalon Casati, Karina Gonzalez Silverio Ruiz, Purnima S. Kumar, Enilson Antonio Sallum
Summary: This study compared individuals with a history of periodontitis to periodontally healthy subjects in terms of immunological and microbiological changes during experimental peri-implant mucositis and gingivitis. The results showed that different microbial shifts contribute to the onset and progression of inflammatory responses around teeth and implants, while the history of periodontal disease plays a role in modulating the immune response.
JOURNAL OF CLINICAL PERIODONTOLOGY
(2023)