Article
Dentistry, Oral Surgery & Medicine
Nur Atalay, Nur Balci, Hilal Uslu Toygar, Gurkan Yardimci, Ulvi Kahraman Gursoy
Summary: The study analyzed the effect of systemic retinoic acid use on the levels of human beta-defensin (hBD-1, hBD-2, and hBD-3) in serum, saliva, and gingival tissue. The results showed reduced levels of hBD-2 in saliva of retinoic acid users, but no difference in serum or tissue levels of hBD-1, hBD-2, or hBD-3.
JOURNAL OF PERIODONTOLOGY
(2023)
Article
Rheumatology
Clio P. Mavragani, Kyriakos A. Kirou, Surya Seshan, Mary K. Crow
Summary: The study found that there is overexpression of IFN-I in the kidney tissue of patients with proliferative LN, which is associated with impaired renal function. The elevated expression of defensin-alpha 3 transcripts may be a driver of local IFN-I expression. These findings are important for understanding the mechanisms of proliferative LN and guiding therapeutic decisions.
Article
Medicine, General & Internal
Ulvi Kahraman Gursoy, Mervi Gursoy, Anna Liukkonen, Anna Liisa Suominen, Eija Kononen
Summary: The aim of this study was to examine the levels of human beta-defensin 1-3 and human neutrophil peptide 1 (HNP-1) in the saliva of elderly individuals, in order to establish the extent of periodontal disease and tooth loss. The results showed that salivary HNP-1 levels were significantly higher in individuals with periodontal disease. The association between salivary HNP-1 levels and the number of pocket teeth remained significant after adjusting for various factors.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Dentistry, Oral Surgery & Medicine
Xue Yuan, Xibo Pei, Jinlong Chen, Yuan Zhao, John B. Brunski, Jill A. Helms
Summary: The study evaluated the barrier function of PIE compared with a native JE in a mouse model. The PIE lacked a Wnt-responsive stem cell niche and exhibited characteristics of chronically inflamed tissue, which contributed to its suboptimal barrier function compared with a native JE.
JOURNAL OF CLINICAL PERIODONTOLOGY
(2021)
Article
Immunology
Chandradeo Narayan, Vishal Kant, Jai Kumar Mahajan, Balvinder Mohan, Neelam Taneja
Summary: This study investigated the invasiveness and antimicrobial peptide (AMP) production induced by different serotypes of Shigella using an in vitro organ culture (IVOC) model. The results showed differences in invasiveness and AMP production among different serotypes. The IVOC model represents a system for studying the early interaction between pathogenic bacteria and the human gut.
INDIAN JOURNAL OF MEDICAL RESEARCH
(2023)
Article
Cell Biology
Jack A. Bibby, Divyansh Agarwal, Tilo Freiwald, Natalia Kunz, Nicolas S. Merle, Erin E. West, Parul Singh, Andre Larochelle, Fariba Chinian, Somabha Mukherjee, Behdad Afzali, Claudia Kemper, Nancy R. Zhang
Summary: This study developed a statistical framework for single-cell pathway analysis, demonstrated its effectiveness compared to commonly used methods, and identified regulatory mechanisms and pathway activity in T cells.
Article
Cell Biology
Zhun Sun, Anning Chen, Hongwei Fang, Donglin Sun, Meiying Huang, Erdeng Cheng, Mengyuan Luo, Xiaoren Zhang, Hao Fang, Guojun Qian
Summary: This study reveals that IL-10 derived from B cells plays a critical role in the resolution of acute lung injury (ALI). IL-10 inhibits inflammation and reduces leukocyte infiltration and prolonged damage. This finding has potential implications for the development of new therapeutic approaches.
CELL DEATH & DISEASE
(2023)
Article
Biochemistry & Molecular Biology
Andrea Olmos-Ortiz, Mayra Hernandez-Perez, Pilar Flores-Espinosa, Gabriela Sedano, Addy Cecilia Helguera-Repetto, Oscar Villavicencio-Carrisoza, Maria Yolotzin Valdespino-Vazquez, Arturo Flores-Pliego, Claudine Irles, Bruno Rivas-Santiago, Elsa Romelia Moreno-Verduzco, Lorenza Diaz, Veronica Zaga-Clavellina
Summary: Infectious processes in the uterine cavity can compromise the maternal-fetal unit and increase the risk of preterm birth and premature rupture of membranes. This study aimed to characterize the synthesis, activity, and distribution of antimicrobial peptides (AMPs) produced by fetal membranes in response to a choriodecidual Escherichia coli infection. The results showed a temporal- and tissue-specific pattern of AMP synthesis, but the membranes were unable to contain bacterial growth and migration despite the production of AMPs, increasing the risk of preterm birth and premature rupture of membranes.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Hematology
Suhair Abdeen, Khalil Bdeir, Rami Abu-Fanne, Emad Maraga, Mohamed Higazi, Nigar Khurram, Michael Feldman, Charuhas Deshpande, Leslie A. Litzky, Samuel N. Heyman, Kathleen T. Montone, Douglas B. Cines, Abd Al-Roof Higazi
Summary: The study found elevated plasma levels of alpha-defensins in COVID-19 patients, which correlated with disease progression, mortality or resolution, as well as plasma levels of interleukin-6 (IL-6) and D-dimers. This indicates a link between inflammation and the risk of thromboembolism.
BRITISH JOURNAL OF HAEMATOLOGY
(2021)
Article
Immunology
Amelie Bos, Esil Aleyd, Lydia P. E. van der Steen, P. J. Winter, Niels Heemskerk, Stephan M. Pouw, Louis Boon, Rene J. P. Musters, Jantine E. Bakema, Cassian Sitaru, Michel Cogne, Marjolein van Egmond
Summary: IgA autoantibodies may play a role in autoimmune or chronic inflammatory diseases. A novel IgA autoimmune blistering model using genetically modified mice showed that IgA anti-collagen XVII could activate neutrophils and cause tissue damage, while treatment with anti-Fc alpha RI monoclonal antibodies prevented and resolved the disease.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Dentistry, Oral Surgery & Medicine
Ana M. Chang, Nutthapong Kantrong, Richard P. Darveau
Summary: The coordination between oral commensal bacteria and the host innate immune response is crucial for maintaining oral homeostasis. Commensal bacteria are speculated to play a host protective role in maintaining health, although little is known about their specific contributions to oral health.
PERIODONTOLOGY 2000
(2021)
Article
Cell Biology
Kinga Skieresz-Szewczyk, Hanna Jackowiak, Marek Skrzypski
Summary: This study investigates the expression of alpha-keratin, keratin-associated proteins (KAPs), and transglutaminase 1 in the para- and orthokeratinized epithelium of the tongue in domestic ducks, geese, and turkeys. The results show the presence of alpha-keratin and KAPs in both epithelia, with a stronger expression in the orthokeratinized epithelium. This suggests a more efficient protective mechanical barrier in this type of epithelium.
Article
Medicine, General & Internal
Hyun-Chang Lim, Jaemin Lee, Dae-Young Kang, In-Woo Cho, Hyun-Seung Shin, Jung-Chul Park
Summary: This study aimed to measure gingival dimensions in a healthy Korean population using digital scanning, highlighting similar distribution patterns but with significantly greater values in the maxilla compared to the mandible. Variations in the heights and areas of keratinized gingiva and attached gingiva were observed among different teeth, with the largest area of keratinized gingiva found in the canine and first molar in each jaw. Certain teeth showed higher value of area under the receiver operation characteristics curve for differentiating between males and females.
JOURNAL OF CLINICAL MEDICINE
(2021)
Letter
Reproductive Biology
Jonathan Matthew Hancock, Yuehuan Li, Taylor Elijah Martin, Christian Lee Andersen, Xiaoqin Ye
Summary: FOXA2 is an important pioneer transcription factor for epithelial budding and morphogenesis in different organs. It is used as a specific marker for uterine glandular epithelial cells (GE) and has close interactions with estrogen receptor alpha (ER alpha). This study investigates the expression of FOXA2 in the female reproductive tract of pre-implantation epiER alpha(-/-) mice. The loss of ER alpha in luminal epithelial cells and vaginal basal layer upregulates FOXA2 expression during early pregnancy.
BIOLOGY OF REPRODUCTION
(2023)
Article
Immunology
Ben A. A. Calvert, Erik J. J. Quiroz, Zareeb Lorenzana, Ngan Doan, Seongjae Kim, Christiana N. N. Senger, Jeffrey J. J. Anders, Wiliam D. D. Wallace, Matthew P. P. Salomon, Jill Henley, Amy L. L. Ryan
Summary: Neutrophils play a crucial role in the innate immune response against viral infection. Chronic airway neutrophilia is associated with severe COVID-19 cases. COVID-19 infection leads to epithelial pathologies and the activation of neutrophils.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Dentistry, Oral Surgery & Medicine
Yigit Firatli, Erhan Firatli, Vuokko Loimaranta, Samira Elmanfi, Ulvi K. Gursoy
Summary: This study evaluated the effects of periodontitis-associated bacteria and inflammatory mediators on oral cells, and found that the expression of MCPIP-1 and MALT-1 proteins and mRNA in oral cells is regulated by these factors.
JOURNAL OF PERIODONTOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Mervi Gursoy, Jaana Rautava, Pirkko Pussinen, Anna Karin Kristoffersen, Morten Enersen, Vuokko Loimaranta, Ulvi Kahraman Gursoy
Summary: This study evaluated the levels of IgA and IgG antibodies against Porphyromonas gingivalis, Tannerella forsythia, Aggregatibacter actinomycetemcomitans, and Prevotella intermedia in the saliva of Crohn's disease patients. Higher levels of salivary IgG2 and IgG3 antibodies, as well as IgG antibodies against P. gingivalis, A. actinomycetemcomitans, and P. intermedia, were detected in Crohn's disease patients. The carriage of P. gingivalis in the saliva was lower in Crohn's disease patients.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Dentistry, Oral Surgery & Medicine
Mustafa Yilmaz, Timo Sorsa, Esra Demir, Mervi Gursoy, Auli Suominen, Taina Tervahartiala, Ismo T. Raisanen, Ulvi K. Gursoy
Summary: This study aimed to analyze the correspondence between the aMMP-8 PoC test results and the clinical endpoints of non-surgical periodontal treatment. The results demonstrated that the accuracy of the aMMP-8 PoC test in identifying clinical endpoints after non-surgical periodontal treatment is reduced.
JOURNAL OF PERIODONTAL RESEARCH
(2023)
Article
Dentistry, Oral Surgery & Medicine
Neslihan Yilmaz, Recep Polat, Mervi Gursoy, Wendy Kaman, Elif Gul Aydin, Dareen Fteita, Dogukan Yilmaz, Floris Bikker, Ulvi Kahraman Gursoy
Summary: This study evaluated the salivary concentrations of macrophage activation-related chemokines and proteolytic activity of MAPKK in children and adolescents with and without T1DM. The results showed that T1DM disrupted the salivary chemokine profile and dysregulated proteolytic MAPKK cleavage.
JOURNAL OF PERIODONTOLOGY
(2023)
Article
Dentistry, Oral Surgery & Medicine
Nur Atalay, Nur Balci, Hilal Uslu Toygar, Gurkan Yardimci, Ulvi Kahraman Gursoy
Summary: The study analyzed the effect of systemic retinoic acid use on the levels of human beta-defensin (hBD-1, hBD-2, and hBD-3) in serum, saliva, and gingival tissue. The results showed reduced levels of hBD-2 in saliva of retinoic acid users, but no difference in serum or tissue levels of hBD-1, hBD-2, or hBD-3.
JOURNAL OF PERIODONTOLOGY
(2023)
Review
Dentistry, Oral Surgery & Medicine
Georgios N. Belibasakis, Daniel Belstrom, Sigrun Eick, Ulvi K. Gursoy, Anders Johansson, Eija Koenoenen
Summary: This narrative review provides an overview of the collective knowledge on periodontal microbiology, with a focus on the European contribution in the global field. It discusses the etiological concepts of periodontal disease, particularly the ecological plaque hypothesis and its interpretation. The review also explores anaerobic microbiology, the discovery of periodontal pathogens and their virulence factors, as well as biofilms. Additionally, it highlights the evolution of molecular methods and high-throughput platforms in understanding the periodontal microbiome. Finally, the review examines the role of different microbial species in periodontal diagnosis, the use of microbial and host biomarkers, and the application of antimicrobials in treatment.
PERIODONTOLOGY 2000
(2023)
Article
Chemistry, Multidisciplinary
Mutlu Keskin, Emma Suomi, Ilknur Harmankaya, Didem Karacetin, Timo Sorsa, Ulvi Kahraman Gursoy
Summary: This study aimed to investigate the levels of hBD 1-3 in the oral cavity of head and neck cancer patients and its relation to radiotherapy treatment. The results showed that hBD-1 levels increased during radiotherapy but returned to pretreatment levels after the end of radiotherapy. No significant change was detected for hBD-2 or hBD-3 levels during or after radiotherapy.
APPLIED SCIENCES-BASEL
(2023)
Article
Medicine, General & Internal
Ulvi Kahraman Gursoy, Mervi Gursoy, Anna Liukkonen, Anna Liisa Suominen, Eija Kononen
Summary: The aim of this study was to examine the levels of human beta-defensin 1-3 and human neutrophil peptide 1 (HNP-1) in the saliva of elderly individuals, in order to establish the extent of periodontal disease and tooth loss. The results showed that salivary HNP-1 levels were significantly higher in individuals with periodontal disease. The association between salivary HNP-1 levels and the number of pocket teeth remained significant after adjusting for various factors.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Oncology
Ella Brandt, Mutlu Keskin, Taina Tervahartiala, Mustafa Yilmaz, Ilknur Harmankaya, Didem Karacetin, Turgut Ipek, Ulvi Kahraman Gursoy, Jaana Rautava, Shipra Gupta, Jaana Hagstrom, Ismo T. Raisanen, Timo Sorsa
Summary: This study investigated the levels of aMMP-8, molecular forms of MMP-8, blood neutrophil counts and neutrophil/lymphocyte ratios before and after radiotherapy for HNC. The results showed significant increases in aMMP-8 levels and neutrophil/lymphocyte ratios after 3 weeks of radiotherapy. Western immunoblot analysis confirmed elevated levels of activated and fragmented MMP-8 after HNC radiotherapy. These findings suggest an increased risk for periodontitis due to local and systemic inflammation caused by HNC radiotherapy.
Article
Dentistry, Oral Surgery & Medicine
Lili Yu, Yigit Firatli, Samira Elmanfi, Mervi Gursoy, Meltem Ozdemir Kabalak, Gokhan Kasnak, Pirkko Pussinen, Floris J. Bikker, Feriha Caglayan, Erhan Firatli, Ulvi Kahraman Gursoy
Summary: The study aimed to localize MCPIP-1 and MALT-1 in gingival tissues and profile their protein expression levels in relation to inflammation, P. gingivalis colonization, and IL-8 levels. The results showed that MCPIP-1 was present in the epithelium and connective tissue, while MALT-1 was observed in all layers of the gingival epithelium and around inflammatory cells. There was no difference in MCPIP-1 and MALT-1 levels based on gingival inflammation severity, but MALT-1 levels were elevated with an increase in P. gingivalis levels and showed an association with IL-8 levels.
CLINICAL ORAL INVESTIGATIONS
(2023)
Letter
Oncology
Ella Brandt, Mutlu Keskin, Taina Tervahartiala, Mustafa Yilmaz, Ilknur Harmankaya, Didem Karacetin, Turgut Ipek, Ulvi Kahraman Gursoy, Shipra Gupta, Ismo T. Raisanen, Jaana Hagstrom, Jaana Rautava, Timo Sorsa
Article
Dentistry, Oral Surgery & Medicine
Neslihan Yilmaz, Recep Polat, Mervi Gursoy, Wendy Kaman, Elif Gul Aydin, Dareen Fteita, Dogukan Yilmaz, Floris Bikker, Ulvi Kahraman Gursoy
Summary: This study aimed to evaluate salivary concentrations of macrophage activation-related chemokines and MAPKK-degrading proteolytic activity in children and adolescents with and without T1DM. The results showed that salivary concentrations of certain chemokines were elevated and others were decreased in the T1DM group, and the proteolytic activity of MAPKK cleavage was also increased.
JOURNAL OF PERIODONTOLOGY
(2023)
Article
Nutrition & Dietetics
Christine Lundtorp Olsen, Laura Massarenti, Vincent Frederik Dahl Vendius, Ulvi Kahraman Gursoy, Annina Van Splunter, Floris J. Bikker, Mervi Gursoy, Christian Damgaard, Merete Markvart, Daniel Belstrom
Summary: The study aimed to test if probiotics can counteract oral dysbiosis and restore oral homeostasis. The findings suggest that consumption of probiotics during short-term sugar stress can have a stabilizing effect on the supragingival microbiota.
Article
Nutrition & Dietetics
Christine Lundtorp Olsen, Laura Massarenti, Vincent Frederik Dahl Vendius, Ulvi Kahraman Gursoy, Annina Van Splunter, Floris J. Bikker, Mervi Gursoy, Christian Damgaard, Merete Markvart, Daniel Belstrom
Summary: The present study aimed to investigate whether probiotics can protect against experimental gingivitis caused by neglecting oral hygiene for 14 days and support the restoration of oral homeostasis afterwards. The results suggest that probiotics play a role in maintaining the resilience of the oral microbiota during the resolution period of gingivitis.
Article
Microbiology
Basar Karaca, Mervi Gursoy, Fadime Kiran, Vuokko Loimaranta, Eva Soderling, Ulvi Kahraman Gursoy
Summary: Postbiotics exhibit antimicrobial activity against pH-adaptive oral bacteria and show no cytotoxicity on human periodontal ligament fibroblast cells at appropriate doses.
MICROBIOLOGY RESEARCH
(2023)