Article
Microbiology
Anna Gasiorek, Ewelina Dobosz, Barbara Potempa, Izabela Ciaston, Mateusz Wilamowski, Zuzanna Oruba, Richard J. Lamont, Jolanta Jura, Jan Potempa, Joanna Koziel
Summary: Periodontal disease is an inflammatory disease of the supporting tissues of the teeth caused by dysbiotic biofilm on the tooth surface. The negative regulator MCPIP-1 plays a key role in controlling inflammatory responses, but its stability can be influenced by periodontal pathogens like Porphyromonas gingivalis. The proteolytic activity of gingipains from these pathogens can lead to rapid degradation of MCPIP-1, exacerbating the inflammatory response. This provides insights into potential new treatment strategies for periodontitis.
Article
Dentistry, Oral Surgery & Medicine
Shuwei Qiao, Baosheng Li, Qing Cai, Zhen Li, Zhaoyi Yin, Jie He, Yuyang Li, Weiyan Meng
Summary: Ferroptosis is involved in the inflammatory processes in HGFs upon P. gingivalis-LPS stimulation. This study found that P. gingivalis-LPS induces ferroptosis in HGFs and that ferroptosis is positively correlated with inflammation levels. Ferroptosis was also observed in the gingival tissue of periodontitis rats.
Article
Immunology
Shuhui Zhou, Yaoting Ji, Hantao Yao, Haiying Guo, Zichen Zhang, Zijun Wang, Minquan Du
Summary: This study found that ginsenoside Rd has inhibitory effects on periodontitis-related bacteria and inflammatory response, as well as the ability to inhibit bone resorption induced by periodontitis. The results provide potential evidence for the development of Rd as a medication for the control and prevention of periodontitis.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2022)
Article
Immunology
Banndith Cheat, Coralie Torrens, Asmaa Foda, Brigitte Baroukh, Jeremy Sadoine, Lotfi Slimani, Veronique Witko-Sarsat, Olivier Huck, Marjolaine Gosset, Jerome Bouchet
Summary: Our study investigates the role of NLRP3 in periodontitis, demonstrating its ambiguous role in neutrophils and its interaction with Porphyromonas gingivalis. The study reveals that NLRP3 is involved in regulatory pathways that limit periodontitis in mouse models, but its protective effect is diminished in the presence of P. gingivalis. Overexpression of NLRP3 in connective tissue leads to increased production of mature IL-1 beta and mobilization of neutrophils, while NLRP3 deficiency results in lower IL-1 beta expression and almost no neutrophil mobilization.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Environmental Sciences
Devaraj Ezhilarasan
Summary: Periodontitis is a prevalent infectious disease linked to various forms of liver disease. Maintaining oral hygiene through scaling and root planning can significantly improve liver damage in patients with periodontitis.
ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY
(2021)
Article
Immunology
Marlies P. Noz, Adelina S. Plachokova, Esther M. M. Smeets, Erik H. J. G. Aarntzen, Siroon Bekkering, Prya Vart, Leo A. B. Joosten, Mihai G. Netea, Niels P. Riksen
Summary: Periodontitis-associated bacteria can induce trained immunity in monocytes, accelerating atherosclerosis development. Patients with severe periodontitis showed signs of increased systemic inflammation and hematopoietic tissue activation, but their circulating monocytes did not exhibit a hyperresponsive phenotype.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Immunology
Jessica Neilands, Bertil Kinnby
Summary: Periodontitis is a chronic inflammatory disease that can lead to tooth-supporting bone destruction. This study found that a bacteria called Porphyromonas gingivalis had strong protease activity and procoagulant activity, which may explain its role in the inflammation process of periodontitis.
MICROBIAL PATHOGENESIS
(2022)
Article
Dentistry, Oral Surgery & Medicine
Chunhua Lan, Shuai Chen, Shan Jiang, Huaxiang Lei, Zhiyu Cai, Xiaojing Huang
Summary: This study found that in human dental pulp stem cells, Escherichia coli lipopolysaccharide (LPS) significantly enhances the expression of inflammatory cytokines, while Porphyromonas gingivalis LPS has no effect on this. Escherichia coli LPS increases the expression of TLR4 in dental pulp stem cells, while Porphyromonas gingivalis LPS has no effect on the expression of TLR2 or TLR4.
Article
Neurosciences
Xueshen Qian, Shuang Zhang, Lian Duan, Fengchun Yang, Kun Zhang, Fuhua Yan, Song Ge
Summary: The study found that periodontitis exacerbated learning and memory impairment in A beta PP/PS1 mice, leading to an increase in A beta and neuroinflammatory responses.
JOURNAL OF ALZHEIMERS DISEASE
(2021)
Article
Immunology
Yingxue Li, Xiaoyue Guan, Yani He, Xiangbin Jia, Lifei Pan, Yuting Wang, Yue Han, Rui Zhao, Jianmin Yang, Tiezhou Hou
Summary: This study aimed to investigate the association and mechanisms between periodontitis and depression. The results showed that periodontitis induced depression-like behaviors in mice, and the proBDNF signaling pathway was involved in this process.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Article
Immunology
Ni Kang, Yong Zhang, Fei Xue, Jinyu Duan, Fan Chen, Yu Cai, Qingxian Luan
Summary: This study found that oral administration of Porphyromonas gingivalis can induce periodontitis and affect the occurrence and development of diabetes. The expression levels of inflammatory cytokines and chemokines changed in the gingiva and blood, leading to alveolar bone loss and inflammatory changes in the liver and adipose tissues. The study also showed a promotion of glucose metabolism disorder in mice.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2022)
Article
Medicine, Research & Experimental
Jing Li, Jing Deng, Shuxian Shang, Guirong Liu, Wenbin Song, Pei Sun, Wenjing Jiang, Keqing Pan
Summary: Periodontitis is an independent risk factor for coronary heart disease, and Porphyromonas gingivalis lipopolysaccharide (Pg-LPS) is considered a major virulence factor. Co-culturing with HPDLCs enhances the calcification effect of Pg-LPS on HUASMCs and significantly increases the expression of specific osteogenic genes.
EXPERIMENTAL AND THERAPEUTIC MEDICINE
(2021)
Article
Cell Biology
Junhong Xiao, Xin Huang, Huiyi Wang, Yan Peng, Heyu Liu, Hantao Huang, Li Ma, Chuan Wang, Xiaoxuan Wang, Zhengguo Cao
Summary: In this study, the levels of CKIP-1 expression and autophagy were shown to increase in periodontal tissues. The knockout of CKIP-1 was found to activate autophagy, and activating autophagy was shown to reduce inflammation in periodontal tissues. These findings demonstrate the important role of CKIP-1 in regulating periodontal tissue inflammation.
Review
Microbiology
William A. Chen, Yuetan Dou, Hansel M. Fletcher, Danilo S. Boskovic
Summary: P. gingivalis is a gram-negative anaerobe that causes periodontitis. It disrupts commensal interactions in the oral cavity to induce a dysbiotic, proinflammatory state. P. gingivalis avoids complete host immunosuppression to take advantage of inflammation-induced tissue damage for robust bacterial growth.
Article
Multidisciplinary Sciences
Gina R. Lewin, Kendall S. Stocke, Richard J. Lamont, Marvin Whiteley
Summary: This study characterizes the behavior and virulence of the periodontal pathogen Porphyromonas gingivalis during human infection. It reveals that P. gingivalis is highly expressed in diseased samples, with genes related to virulence factors and growth/matabolism being actively expressed. The study also shows that the gene expression of P. gingivalis during periodontitis is highly conserved with logarithmic laboratory growth, suggesting that simple test tube growth can be used as a model for studying P. gingivalis biology.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)