Article
Cell Biology
Di Cui, Changxing Chen, Binyan Luo, Fuhua Yan
Summary: Silencing of the PHD2 gene in human periodontal ligament cells (hPDLCs) has been shown to promote cell proliferation and osteogenic differentiation, leading to enhanced new bone formation in vivo. This approach demonstrates the therapeutic potential for highly efficient periodontal regeneration through PHD2 gene interference.
JOURNAL OF LEUKOCYTE BIOLOGY
(2021)
Article
Engineering, Multidisciplinary
Ryoya Iizumi, Michiyo Honda
Summary: This study aimed to investigate the inhibitory effects of Wnt/β-catenin signaling on osteogenic differentiation in human periodontal ligament fibroblasts (HPLFs). The researchers found that Wnt-3a activation of Wnt/β-catenin signaling inhibited the formation of bone nodules and suppressed the expression of osteogenic differentiation-related genes in HPLFs.
Article
Nanoscience & Nanotechnology
Yongxi Liang, Ajay Shakya, Xiaohua Liu
Summary: This study designed and fabricated a bioinspired tubular 3D matrix to guide the migration and growth of human periodontal ligament stem cells (PDLSCs) and form aligned fiber bundles. The tubular matrix controlled cell migration and alignment through inhibiting osteogenic differentiation. Mechanism study revealed involvement of the Yap1/Twist1 signaling pathway.
ACS APPLIED MATERIALS & INTERFACES
(2022)
Article
Cell & Tissue Engineering
Jianjia Li, Zhifa Wang, Xiangyu Huang, Zhaodan Wang, Zehao Chen, Runting Wang, Zhao Chen, Wei Liu, Buling Wu, Fuchun Fang, Wei Qiu
Summary: This study conducted a dynamic proteomic analysis of osteogenic differentiation of hPDLSCs, revealing a regulatory mechanism and potential perspectives for periodontal regeneration research. The results indicated that oxidative phosphorylation and redox-sensitive signaling pathways play important roles in osteogenesis, with SOD2 identified as a key protein in the process.
STEM CELL RESEARCH & THERAPY
(2021)
Article
Multidisciplinary Sciences
Steven Dwi Purbantoro, Thanaphum Osathanon, Sirirat Nantavisai, Chenphop Sawangmake
Summary: The study found that low concentration of osteogenic growth peptide (OGP) enhances osteogenic differentiation of human periodontal ligament stem cells (hPDLSCs) by governing the TGF-beta signaling pathway.
Article
Cell Biology
Rahyza I. F. Assis, Francesca Racca, Rogerio S. Ferreira, Karina G. S. Ruiz, Rodrigo A. da Silva, Samuel J. H. Clokie, Malgorzata Wiench, Denise C. Andia
Summary: Periodontal ligament stem cells (PDLCs) have the potential to be used in cell therapies for bone tissue regeneration, but their heterogeneity in terms of osteoblast differentiation and mineral nodule production makes the therapeutic outcomes unpredictable. This study identified epigenetic, chromatin, and transcriptional differences between PDLCs with low and high osteogenic potential, and suggested that these differences could be used to select PDLCs with a pre-osteoblastic phenotype.
Article
Dentistry, Oral Surgery & Medicine
Yang Zeng, Ji-Jun Deng, Qi-Lan Jiang, Chun-Lian Wang, Li Zhang, Tao Li, Jun Jiang
Summary: The study found that thyrotropin (TSH) inhibited the osteogenic differentiation of periodontal ligament stem cells (PDLSCs), suggesting that adjusting TSH levels in patients with subclinical hypothyroidism may improve orthodontic, implant, and periodontitis outcomes in these patients.
JOURNAL OF PERIODONTAL RESEARCH
(2023)
Article
Dentistry, Oral Surgery & Medicine
Xin Deng, Hirohito Kato, Yoichiro Taguchi, Takaya Nakata, Makoto Umeda
Summary: This study investigated the effects of a low-glucose environment on the proliferation and osteogenic differentiation of periodontal ligament cells (PDLCs). The results showed that a low-glucose environment inhibited the proliferation, migration, and osteogenic differentiation of PDLCs and induced the expression of autophagy-related factors LC3 and p62.
JOURNAL OF PERIODONTAL RESEARCH
(2023)
Article
Cell Biology
Yi Zhao, Qiaoli Zhai, Hong Liu, Xun Xi, Shuai Chen, Dongxu Liu
Summary: TRIM16 plays a crucial role in osteogenic differentiation of human periodontal ligament stem cells by stabilizing the RUNX2 protein levels. It may be a potential target for stem cell-based bone regeneration in periodontal therapies.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Dentistry, Oral Surgery & Medicine
F. Yang, D. Huang, L. Xu, W. Xu, X. Yi, X. Zhou, L. Ye, L. Zhang
Summary: The study investigates the role of sFRP1 in osteogenic differentiation of hPDLCs during inflammation. Results show that P. gingivalis LPS inhibited osteogenic markers and the Wnt/beta-catenin signaling pathway, while sFRP1 inhibitor reversed these effects. Animal experiment confirmed the inhibitory effect of sFRP1 inhibitor on bone loss. Modulation of Wnt signaling through sFRP1 inhibition may provide a new approach for treating chronic apical periodontitis.
INTERNATIONAL ENDODONTIC JOURNAL
(2021)
Article
Biotechnology & Applied Microbiology
Qiang Li, Hangyu Zhou, Chuan Wang, Zhibin Zhu
Summary: This study found that Linc01133 participates in the progression of periodontitis by regulating the expression of miR-30c and BGLAP and promoting the osteogenic differentiation of hPDLSCs.
Article
Dentistry, Oral Surgery & Medicine
Yingzhi Gu, Yuxing Bai
Summary: This study aimed to investigate the effect of crocin on the proliferation and osteogenic differentiation of human periodontal ligament stem cells (PDLSCs) in vitro and in vivo. Crocin treatment significantly promoted PDLSC mRNA levels, protein expression, mineralized nodule formation, and ALP activity. Crocin also enhanced the phosphorylation of beta-catenin and cyclin D1. Inhibition of the Wnt/beta-catenin pathway partially reversed crocin-mediated promotion of PDLSC osteogenic differentiation.
Article
Oncology
Juan Xiang, Ying Bian
Summary: This study investigated the interaction between PWAR6 and miR-106a-5p in hPDLSCs and their effects on osteogenic differentiation. PWAR6 acted as a sponge of miR-106a-5p, promoting osteogenesis, while miR-106a-5p downregulation and PWAR6 overexpression enhanced bone formation and mineralization. These results suggest a positive influence of PWAR6 on the osteogenic differentiation of hPDLSCs, with the PWAR6/miR-106a-5p interaction network potentially serving as a regulatory mechanism for hPDLSCs osteogenesis.
MOLECULAR MEDICINE REPORTS
(2021)
Article
Biochemistry & Molecular Biology
Alexey A. Ivanov, Tamara I. Danilova, Alla V. Kuznetsova, Olga P. Popova, Oleg O. Yanushevich
Summary: The regeneration of periodontal tissues is important for the treatment of periodontitis. This study investigated the osteogenic and odontogenic differentiation of periodontal progenitor and stem cells in decellularized tooth matrix (dTM) and periodontal ligament (dPDL) in both 2D and 3D culture conditions. The results showed that the combination of dTM and dPDL promoted both osteogenic and odontogenic differentiation of periodontal cells.
Article
Dentistry, Oral Surgery & Medicine
Chuan He, Tairan Wang, Yijie Wang, Tongtong Xu, Shuyang Zhao, Haoyu Shi, Rui Zou
Summary: Mechanical memory exists in human periodontal ligament stem cells, and ILK plays a significant role in this process.
Article
Cell Biology
Lin Xiang, Xinyuan Zhang, Hui Yu, Bin Wang, Zhihui Lin, Ping Gong
JOURNAL OF CELLULAR PHYSIOLOGY
(2019)
Letter
Cell Biology
Lin Xiang, Hui Yu, Xinyuan Zhang, Bin Wang, Ying Yuan, Qin Zhang, Ping Gong, Yingying Wu
JOURNAL OF CELLULAR PHYSIOLOGY
(2019)
Article
Dentistry, Oral Surgery & Medicine
Q. Wu, B. Yang, S. Gao, P. Gong, L. Xiang, Y. Man, Y. Qu
INTERNATIONAL JOURNAL OF ORAL AND MAXILLOFACIAL SURGERY
(2019)
Article
Biochemistry & Molecular Biology
Qin Zhang, Yanjun Guo, Huilu Chen, Yixuan Jiang, Haiyang Tang, Ping Gong, Lin Xiang
JOURNAL OF CELLULAR BIOCHEMISTRY
(2019)
Review
Cell Biology
Bo Zhang, Yang Yang, Lin Xiang, Zhihe Zhao, Rui Ye
JOURNAL OF CELLULAR PHYSIOLOGY
(2019)
Article
Dentistry, Oral Surgery & Medicine
Yeyu Liu, Yilin Chen, Chenyu Chu, Yili Qu, Lin Xiang, Yi Man
CLINICAL IMPLANT DENTISTRY AND RELATED RESEARCH
(2020)
Article
Physiology
Ying Yuan, Yixuan Jiang, Bin Wang, Yanjun Guo, Ping Gong, Lin Xiang
FRONTIERS IN PHYSIOLOGY
(2020)
Review
Cell Biology
Jianan Zheng, Hui Yu, Anqi Zhou, Bingfeng Wu, Jiayi Liu, Yinan Jia, Lin Xiang
Review
Cell Biology
Anqi Zhou, Hui Yu, Jiayi Liu, Jianan Zheng, Yinan Jia, Bingfeng Wu, Lin Xiang
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2020)
Article
Biochemistry & Molecular Biology
Qin Zhang, Bingfeng Wu, Ying Yuan, Xinyuan Zhang, Yanjun Guo, Ping Gong, Lin Xiang
Summary: The study suggests that CGRP may play a critical role in bone healing by modulating the biological function of M2 macrophages and influencing osteogenesis. Results indicate that CGRP can affect the secretion of osteogenic factors and have multiple effects on MC3T3 osteogenesis through regulating the osteoimmune environment.
ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS
(2021)
Article
Cell Biology
B. Wang, B. Wu, Y. Jia, Y. Jiang, Y. Yuan, Y. Man, L. Xiang
Summary: The study investigated the effect of the αCGRP-YAP pathway on osteogenesis and angiogenesis around implants during bone healing. Results showed that αCGRP deficiency hampers bone regeneration and vasculature formation, but this can be rescued by overexpressing αCGRP and YAP. In-vivo results suggest that the αCGRP-YAP pathway promotes angiogenesis and osteogenesis, particularly in the early stages of bone healing.
CELLULAR SIGNALLING
(2021)
Review
Cell Biology
Hui Yu, Anqi Zhou, Jiayi Liu, Yufei Tang, Quan Yuan, Yi Man, Lin Xiang
Summary: Dental implants are increasingly popular globally, but systemic disorders and medications may impact success rates. The COVID-19 pandemic poses a challenge, warranting attention to potential systemic risk factors.
JOURNAL OF LEUKOCYTE BIOLOGY
(2021)
Review
Cell Biology
Anqi Zhou, Bingfeng Wu, Hui Yu, Yufei Tang, Jiayi Liu, Yinan Jia, Xiaoyu Yang, Lin Xiang
Summary: This review summarizes the interactions between the skeletal and immune systems, including their co-development and connections at the cellular and molecular levels. Research in osteoimmunology may help uncover the mechanisms of related diseases and provide innovative ideas and solutions.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Review
Nanoscience & Nanotechnology
Bingfeng Wu, Yufei Tang, Kai Wang, Xuemei Zhou, Lin Xiang
Summary: TiO2 nanotube arrays (TiO2 NTAs) on titanium implant surfaces play an important role in osseointegration by manipulating protein adsorption, inflammatory cell adhesion and response, additional relevant cell adhesion, as well as angiogenesis and osteogenesis.
INTERNATIONAL JOURNAL OF NANOMEDICINE
(2022)
Article
Engineering, Biomedical
Li Ma, Lin Xiang, Xiaoni Ma, Shuning Zhang, Ping Gong
JOURNAL OF HARD TISSUE BIOLOGY
(2020)