Article
Medicine, General & Internal
Xuanzhi Zhu, Chao-Jung Chu, Weiyi Pan, Yan Li, Hanyao Huang, Lei Zhao
Summary: The concentrations of cfDNA in GCF, saliva, and plasma are significantly increased in patients with periodontal disease, and there is a positive correlation between cfDNA levels in GCF and saliva and periodontal parameters.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Medicine, General & Internal
Vineet Nair, Vishakha Grover, Suraj Arora, Gotam Das, Irfan Ahmad, Anchal Ohri, Shan Sainudeen, Priyanka Saluja, Arindam Saha
Summary: This study explored the levels of three cytokines (IL-17, 18, and 21) in the gingival crevicular fluid of Indian individuals and found that they were closely associated with the severity of periodontal disease. IL-21 in particular shows promise as a potential biomarker for differentiating between gingivitis and periodontitis.
MEDICINA-LITHUANIA
(2022)
Article
Medicine, General & Internal
Dora Maria Popescu, Dorin Nicolae Gheorghe, Adina Turcu-Stiolica, Andrada Soanca, Alexandra Roman, Claudiu Marinel Ionele, Eduard Mihai Ciuca, Virgil Mihail Boldeanu, Lidia Boldeanu, Allma Pitru, Petra Surlin
Summary: This study analyzed the levels of Pentraxin 3 (PTX3) and Serum amyloid A (SAA) in gingival crevicular fluid (GCF) of patients with periodontal disease and obesity. The results showed significantly higher levels of PTX3 and SAA in patients with obesity and periodontitis compared to patients with either obesity or periodontitis alone. These findings suggest an association between these two markers and the two pathologies.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Dentistry, Oral Surgery & Medicine
Melissa M. Grant, John J. Taylor, Katrin Jaedicke, Andrew Creese, Catherine Gowland, Bernard Burke, Khawla Doudin, Upen Patel, Paul Weston, Michael Milward, Susan M. Bissett, Helen J. Cooper, Gerben Kooijman, Amir Rmaile, Marko de Jager, Philip M. Preshaw, Iain L. C. Chapple
Summary: Differential protein biomarkers in saliva and gingival crevicular fluid can be used to objectively distinguish between periodontal health and disease states.
JOURNAL OF CLINICAL PERIODONTOLOGY
(2022)
Article
Dentistry, Oral Surgery & Medicine
Ayla Ozturk, Sevda Kurt-Bayrakdar, Bahattin Avci
Summary: The levels of hBD-2 in GCF were higher in patients with chronic periodontitis, while levels in serum were lower compared to healthy controls.
Review
Dentistry, Oral Surgery & Medicine
Fatemeh Abdolalian, Mojtaba Bayani, Saeid Afzali, Afrooz Nakhostin, Amir Almasi-Hashiani
Summary: This meta-analysis studied the gingival crevicular fluid (GCF) periostin levels in subjects with periodontal disease and healthy periodontium. The results showed a significant decrease in GCF periostin levels in individuals with chronic periodontitis compared to healthy individuals, while no significant difference was observed between individuals with gingivitis and healthy individuals. Further studies are needed to validate the use of GCF periostin as a diagnostic marker for this disease.
Article
Microbiology
Simran Preet Bhalla, Ann Maria Shaju, Carlos Marcelo da Silva Figueredo, Leticia Algarves Miranda
Summary: C5a levels were significantly increased in both gingival crevicular fluid and saliva of patients with periodontal disease, indicating a potential role of this molecule in the pathogenesis of the disease.
Article
Dentistry, Oral Surgery & Medicine
Nil Yakar, Gulnur Emingil, Asena Turedi, Cagdas Sahi, Timur Kose, Nagihan Bostanci, Angelika Silbereisen
Summary: This study aimed to investigate the association of GCF TREM-1, PGLYRP1, and IL-1 β levels with periodontal health in pre- and postmenopausal women. The results showed that there were no significant differences in GCF levels of TREM-1, PGLYRP1, and IL-1 β between pre- and postmenopausal women. However, higher GCF TREM-1 levels were observed in women with periodontitis, indicating that TREM-1 may be an indicator for periodontitis in both pre- and postmenopausal women.
JOURNAL OF PERIODONTAL RESEARCH
(2023)
Article
Dentistry, Oral Surgery & Medicine
Jie Zhang, Wenjing Li, Hongye Lu, Ruifang Lu, Yalin Zhan, Huanxin Meng
Summary: The level of platelets in the GCF of patients with periodontitis is higher than that of healthy individuals. Platelets can interact with periodontal pathogens and neutrophils, and promote the formation of NETs.
JOURNAL OF CLINICAL PERIODONTOLOGY
(2022)
Article
Dentistry, Oral Surgery & Medicine
Ayaz Enver, Nurdan Ozmeric, Sila Cagri Isler, Murat Toruner, Cigdem Fidan, Gulsah Demirci, Serenay Elgun, Andre Paes B. da Silva
Summary: This study aimed to evaluate the levels of cytokines in saliva and gingival crevicular fluid (GCF) in patients with ulcerative colitis (UC), Crohn disease (CD), and non-IBD, and analyze their associations with periodontal conditions. The study found that UC and CD patients with periodontitis and gingivitis had higher levels of TNF-alpha and lower levels of IL-10 compared to non-IBD patients. Additionally, UC patients with periodontitis had higher scores of bleeding on probing and increased levels of IL-1 beta in saliva and GCF compared to CD patients. The study concluded that in the presence of periodontal diseases, UC and CD patients showed different expression levels of TNF-alpha, IL-1 beta, and IL-10 in oral secretions compared to non-IBD patients.
JOURNAL OF PERIODONTOLOGY
(2022)
Article
Dentistry, Oral Surgery & Medicine
Pasquale Santamaria, Aysegul Sari, Luigi Nibali
Summary: The aim of this study was to assess the differential molecular profiling of gingival crevicular fluid (GCF) from infrabony and suprabony periodontal defects compared with healthy sites. The results showed that 14 biomarkers levels were elevated in GCF from infrabony and suprabony defects compared with healthy sites, while the difference between infrabony and suprabony defects was not significant in biomarker changes.
JOURNAL OF CLINICAL PERIODONTOLOGY
(2023)
Article
Dentistry, Oral Surgery & Medicine
Hiroshi Ito, Yukihiro Numabe, Shuichi Hashimoto, Sunao Uehara, Ya-Hsin Wu, Tomohisa Ogawa
Summary: The study suggests that the presence of hemoglobin in gingival crevicular fluid may indicate slight tissue damage in pre-symptomatic periodontal disease, even in healthy sites without bleeding on probing. Therefore, hemoglobin examination could be a promising candidate marker for early detection of periodontal disease.
CLINICAL ORAL INVESTIGATIONS
(2021)
Article
Multidisciplinary Sciences
Takumi Hiyoshi, Hisanori Domon, Tomoki Maekawa, Hikaru Tamura, Toshihito Isono, Satoru Hirayama, Karin Sasagawa, Fumio Takizawa, Koichi Tabeta, Yutaka Terao
Summary: This study reveals the mechanisms by which neutrophil elastase (NE) exacerbates periodontitis. NE induces increased neutrophil recruitment and activity in the periodontal tissue, leading to worsened periodontal bone loss. Administration of an NE inhibitor reduces NE activity and attenuates periodontal bone loss. NE also promotes bacterial invasion in periodontal tissues by cleaving cell adhesion molecules and disrupting the gingival epithelial barrier.
SCIENTIFIC REPORTS
(2022)
Article
Dentistry, Oral Surgery & Medicine
Hiroshi Ito, Yukihiro Numabe, Shuichi Hashimoto, Satoshi Sekino, Etsuko Murakashi, Hitomi Ishiguro, Daisuke Sasaki, Takashi Yaegashi, Hideki Takai, Masaru Mezawa, Yorimasa Ogata, Hisashi Watanabe, Yuichi Izumi, Jun-Ichi Kido, Yuka Hiroshima, Toshihiko Nagata
Summary: The purpose of this study was to verify the accuracy and utility of clinical and biochemical parameters during the supportive periodontal therapy period. The results showed that all parameters, except plaque index and bleeding on probing, were significantly lower at the second examination than at the first. Adding the haemoglobin test to the bleeding on probing test improved the accuracy of measurement of clinical parameters after periodontal treatment.
Article
Dentistry, Oral Surgery & Medicine
Buket Acar, Ersin Gumus, Selcen Ozcan-Bulut, Cansu Ozsin-Ozler, Meryem Seda Boyraz, Cagman Tan, Ismail Yaz, Begum Ozbek, Deniz Cagdas, Inci Nur Saltik-Temizel, Hulya Demir, Hasan Ozen, Erdem Karabulut, Ilhan Tezcan, Aysel Yuce, Ezel Berker
Summary: The cytokine profile in gingival crevicular fluid and serum of pediatric inflammatory bowel disease (IBD) patients was evaluated, with 50 IBD patients and 21 healthy children enrolled in the study. Patients with IBD were categorized into subgroups based on disease activity and response to treatment, and the levels of pro- and anti-inflammatory cytokines were measured. Results showed that disease activity might impact gingival inflammation in pediatric patients with IBD due to increased cytokine interactions and severity of inflammation.
JOURNAL OF PERIODONTOLOGY
(2022)