Review
Chemistry, Multidisciplinary
Namrata Singh, G. R. Sherin, Govindasamy Mugesh
Summary: Nanozymes, nanomaterials with enzyme-mimicking activity, have attracted significant interest in biomedical applications, particularly in oxidative stress-mediated disorders. The challenge lies in designing nanozymes that can selectively differentiate between physiological oxidative stress and pathological oxidative stress and mediate appropriate redox reactions in cells, tissues, and organs. This review summarizes the advancements in redox-active nanozymes and their therapeutic significance in various disease models, such as cancer, neurodegeneration, and cardiovascular diseases. It also discusses the future prospects and challenges associated with the biomedical applications of nanozymes.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2023)
Review
Biochemistry & Molecular Biology
Yu Ah Hong, Cheol Whee Park
Summary: Reactive oxygen and nitrogen species play crucial roles in kidney injuries, making antioxidant agents, especially catalytic antioxidants that mimic antioxidant enzymes, effective in combating oxidative stress-related kidney diseases. Research has shown the effectiveness of several catalytic antioxidants in treating disease models associated with oxidative stress.
Article
Biochemistry & Molecular Biology
Qi Yan, Jingyan Wei, Junxia Song, Mengna Li, Xin Guan, Jian Song
Summary: This study successfully integrated human GPx and SOD genes into bifunctional fusion proteins, which showed excellent antioxidant and cell protection effects. The results contribute to the development of novel protein therapeutics and provide insights into the synergistic catalytic mechanisms of GPx and SOD.
Review
Biochemistry & Molecular Biology
Mi Yang, Xiaofei Zhou, Xi Tan, Xincheng Huang, Lu Yuan, Zipeng Zhang, Yan Yang, Min Xu, Ying Wan, Zezhi Li
Summary: Alcohol dependence leads to oxidative stress in the body, as evident from the changes observed in the levels of oxidative stress biomarkers. This meta-analysis highlights the decreased activities of superoxide dismutase (SOD) and glutathione peroxidase (GPx) enzymes and lower levels of albumin, along with increased levels of malondialdehyde (MDA), vitamin B12, homocysteine, and bilirubin in patients with alcohol dependence.
Article
Engineering, Marine
Shengjie Zhou, Ninglu Zhang, Zhengyi Fu, Gang Yu, Zhenhua Ma, Lei Zhao
Summary: This study investigated the changes in antioxidation ability of yellowfin tuna under different salinity environments and found that low salinity may influence the antioxidant function of yellowfin tuna. However, yellowfin tuna juveniles have strong adaptability to a salinity of 29 parts per thousand. Nevertheless, excessive stress may deplete the body's reserves and reduce its resistance.
JOURNAL OF MARINE SCIENCE AND ENGINEERING
(2023)
Review
Chemistry, Analytical
Nguyen Thi My Thao, Hoang Dang Khoa Do, Nguyen Nhat Nam, Nguyen Khoi Song Tran, Thach Thi Dan, Kieu The Loan Trinh
Summary: Antioxidant nanozymes have emerged as promising materials to replace natural antioxidant enzymes due to their stability, cost savings, and flexible design. This review discusses the mechanisms and manipulation strategies of antioxidant nanozymes, as well as their potential applications in medicine and healthcare. Overall, this review provides useful information for the further development and application of antioxidant nanozymes.
Article
Food Science & Technology
Aimei Liao, Xing Lyu, Jiarui Ma, Yinchen Hou, Ming Hui, Na Liu, Yi Zhao, Yixiang Cui, Jihong Huang
Summary: Wheat embryo globulin (WEG) has been found to have multiple biological activities, including antioxidative properties and immunomodulatory effects. In this study, the effects of WEG on learning, memory, and antioxidant capacity were examined in an aged mouse model. The results showed that WEG improved learning and memory abilities, enhanced antioxidant capacity, and protected against brain damage in aging mice.
FOOD SCIENCE AND HUMAN WELLNESS
(2023)
Article
Plant Sciences
Bilal Ahmad, Tariq Ahmad Dar, M. Masroor A. Khan, Ajaz Ahmad, Joerg Rinklebe, Yinglong Chen, Parvaiz Ahmad
Summary: This study demonstrates that foliar application of irradiated chitosan (ICn) can effectively alleviate arsenic (As) stress in peppermint plants, promoting growth and production.
FRONTIERS IN PLANT SCIENCE
(2022)
Article
Horticulture
Mohammad Pourebrahimi, Saeid Eshghi, Asghar Ramezanian, Shiva Faghih
Summary: High salinity levels can lead to various adverse effects on plants, including osmotic stress and nutritional disorders. In this study, the combined use of hydrogen sulfide and selenium compounds was found to alleviate the negative effects of salt stress on strawberry yield and enhance the antioxidant and nutritional quality of the fruits.
SCIENTIA HORTICULTURAE
(2023)
Review
Pathology
Amir Tahavvori, Morad Kohandel Gargari, Yalda Yazdani, Alireza Soleimani Mamalo, Elmira Aboutalebi Vand Beilankouhi, Mohammad Valilo
Summary: The etiology of Parkinson's disease is multifactorial, involving both genetic and environmental factors. Exposure to pesticides and the production of reactive oxygen species are the primary environmental risk factors. Oxidative stress triggers a series of reactions that affect cell function and may lead to the development of Parkinson's disease.
PATHOLOGY RESEARCH AND PRACTICE
(2023)
Article
Biochemistry & Molecular Biology
Sahar Golabi, Sheyda Ghasemi, Maryam Adelipour, Reza Bagheri, Katsuhiko Suzuki, Alexei Wong, Maryam Seyedtabib, Mahshid Naghashpour
Summary: This study compared the antioxidant and inflammatory responses between COVID-19 outpatients and healthy individuals, finding higher concentrations of superoxide dismutase (SOD) and glutathione peroxidase (GPx) in COVID-19 patients. These results suggest that targeting oxidative stress in COVID-19 could be a promising therapeutic approach.
Review
Biochemistry & Molecular Biology
Pavlina Hemerkova, Martin Valis
Summary: ALS is a neurodegenerative disease that affects motor neurons and currently has no cure. Free oxygen radicals are known to play a role in the pathogenesis of ALS, while antioxidant enzymes like SOD1 are crucial for antioxidant protection.
Article
Chemistry, Multidisciplinary
Shunlong Meng, Xi Chen, Chao Song, Limin Fan, Liping Qiu, Yao Zheng, Jiazhang Chen, Pao Xu
Summary: The study found that lower concentrations of methomyl had no effect on antioxidant levels in the testis of Nile tilapia, while higher concentrations significantly influenced these antioxidants. Recovery tests showed that oxidative damage caused by lower concentrations of methomyl was reversible, whereas damage from higher concentrations was irreversible within 18 days.
APPLIED SCIENCES-BASEL
(2021)
Article
Cardiac & Cardiovascular Systems
Danilo Menichelli, Roberto Carnevale, Cristina Nocella, Vittoria Cammisotto, Valentina Castellani, Simona Bartimoccia, Giacomo Frati, Pasquale Pignatelli, Daniele Pastori
Summary: The study found that circulating LPS may contribute to impaired antioxidant status in patients with AF. Additionally, patients with high LPS and reduced GPx3 activity showed the highest risk of CVEs.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2021)
Article
Veterinary Sciences
Rejane Santos Sousa, Caroline Santos Sousa, Francisco Leonardo Costa Oliveira, Paulo Ricardo Firmino, Isadora Karolina Freitas Sousa, Valeria Veras Paula, Nohora Mercado Caruso, Enrico Lippi Ortolani, Antonio Humberto Hamad Minervino, Raimundo Alves Barreto-Junior
Summary: Blood loss in sheep can cause clinical, hematological, blood gas, and biochemical alterations, leading to oxidative stress and reduced antioxidant activity.
VETERINARY SCIENCES
(2022)
Article
Dentistry, Oral Surgery & Medicine
Mia Rakic, Alberto Monje, Sandro Radovanovic, Aleksandra Petkovic-Curcin, Danilo Vojvodic, Zoran Tatic
JOURNAL OF PERIODONTOLOGY
(2020)
Article
Dentistry, Oral Surgery & Medicine
Ervin Taso, Vladimir Stefanovic, Alexis Gaudin, Jovan Grujic, Estela Maldonado, Aleksandra Petkovic-Curcin, Danilo Vojvodic, Anton Sculean, Mia Rakic
ARCHIVES OF ORAL BIOLOGY
(2020)
Review
Dentistry, Oral Surgery & Medicine
Luigi Canullo, Maria Menini, Gregorio Santori, Mia Rakic, Anton Sculean, Paolo Pesce
CLINICAL ORAL INVESTIGATIONS
(2020)
Article
Dentistry, Oral Surgery & Medicine
Stefan Fickl, Helena Francisco, Katarzyna Gurzawska-Comis, Iva Milinkovic, Sven Muehlemann, Ignacio Sanz Sanchez, Ferruccio Torsello, Tommie van de Valde
CLINICAL ORAL IMPLANTS RESEARCH
(2020)
Article
Dentistry, Oral Surgery & Medicine
Dragana L. Rakasevic, Iva Z. Milinkovic, Sasa M. Jankovic, Ivan A. Soldatovic, Zoran M. Aleksic, Natasa S. Nikolic-Jakoba
JOURNAL OF ESTHETIC AND RESTORATIVE DENTISTRY
(2020)
Article
Dentistry, Oral Surgery & Medicine
Ana Djinic Krasavcevic, Nadja Nikolic, Iva Mijailovic, Jelena Carkic, Iva Milinkovic, Sasha Jankovic, Zoran Aleksic, Jelena Milasin
Summary: This study analyzed the expression of Notch signaling pathway and periodontitis-related molecules in aggressive and chronic periodontitis patients, finding higher values of PPD in aggressive periodontitis and negative correlations between OPG and CAL/PI in aggressive periodontitis. OPG and Notch 2 were predictors of CAL in aggressive periodontitis, and TNF-alpha and IL-17 were higher in RANKL predominant cases. In RANKL predominant lesions, Notch 1 and Jagged 1 were down-regulated in aggressive periodontitis compared to chronic periodontitis.
JOURNAL OF PERIODONTAL RESEARCH
(2021)
Article
Dentistry, Oral Surgery & Medicine
Natasa Nikolic-Jakoba, Milena Barac, Sasa Jankovic, Zoran Aleksic, Rubens Spin-Neto, Ann Wenzel
Summary: A study compared linear measurements of intrabony defects using different CBCT section thicknesses with intraoperative measurements, and found no statistically significant difference between clinical and radiographic bone level measurements at section thicknesses of 0.25, 1, and 3 mm.
JOURNAL OF PERIODONTOLOGY
(2021)
Article
Dentistry, Oral Surgery & Medicine
Asbjorn Jokstad, Bjarni E. Pjetursson, Sven Muhlemann, Daniel Wismeijer, Stefan Wolfart, Vincent Fehmer, Jan Frederik Gueth, Lucrezia Paterno Holtzman, Christoph H. F. Hammerle, Nikolay Makarov, Henny J. A. Meijer, Iva Milinkovic, Irena Sailer, Frank A. Spitznagel, Stefan Vandeweghe, Tommie Van de Velde, Marcel Zwahlen, Petra C. Giertmuehlen
Summary: The four systematic reviews focused on clinical outcomes of all-ceramic implant-supported crowns, production time and costs of computer-assisted manufacturing, computer-assisted implant planning and surgery time and costs, and patient-reported outcome measures. The reviews varied in terms of language restrictions and inclusion of grey literature, but overall provided comprehensive and reproducible search strategies. The studies highlighted limited evidence on certain aspects, such as the effectiveness of different CAM methods and the time and costs associated with computer-assisted implant planning and surgery.
CLINICAL ORAL IMPLANTS RESEARCH
(2021)
Article
Dentistry, Oral Surgery & Medicine
Iva Milinkovic, Ana Djinic Krasavcevic, Nadja Nikolic, Zoran Aleksic, Jelena Carkic, Marija Jezdic, Sasha Jankovic, Jelena Milasin
Summary: This study aimed to compare the levels of Notch signaling pathway, bone remodeling mediators, and pro-inflammatory cytokines in peri-implantitis patients and healthy implants. The results showed that down-regulation of Notch 1 and increased expression of inflammation modulators in peri-implantitis may lead to increased osteoclast activity and subsequent bone resorption.
CLINICAL ORAL IMPLANTS RESEARCH
(2021)
Article
Dentistry, Oral Surgery & Medicine
Ana Djinic Krasavcevic, Nadja Nikolic, Iva Milinkovic, Jelena Carkic, Marija Jezdic, Sasha Jankovic, Zoran Aleksic, Jelena Milasin
Summary: This research found that upregulation of Notch2 and Hey1 may contribute to alveolar bone resorption and predict the transition from peri-implant mucositis to peri-implantitis. Additionally, overexpression of IL-1 beta and IL-6 may create an osteoclastogenic environment in peri-implantitis with a predominance of RANKL.
JOURNAL OF PERIODONTAL RESEARCH
(2023)
Article
Dentistry, Oral Surgery & Medicine
Iva Milinkovic, Ana Djinic Krasavcevic, Sasha Jankovic, Jelena Sopta, Zoran Aleksic
Summary: This pilot study compared the effects of PEEK and titanium healing abutments on soft tissues through histological and immunohistochemical analyses. The results showed that PEEK abutments triggered a more intense tissue inflammatory response, while titanium abutments resulted in a lower inflammatory reaction.
Article
Dentistry, Oral Surgery & Medicine
Marija Jezdic, Nadja Nikolic, Ana Djinic Krasavcevic, Jelena Milasin, Zoran Aleksic, Jelena Carkic, Sasha Jankovic, Iva Milinkovic
Summary: The study aimed to evaluate the prevalence of specific microbiota and their correlation with clinical parameters, proinflammatory cytokines, Notch signaling pathway molecules, and bone remodeling mediators in different peri-implant conditions. The prevalence of P. gingivalis, Fusobacterium spp., EBV, and C. albicans was assessed in participants' crevicular fluid, and their presence was correlated with markers' expression and clinical data. The results showed a higher prevalence of P. gingivalis and Fusobacterium spp. in peri-implantitis and peri-implant mucositis groups compared to healthy implants, suggesting their potential involvement in osteolysis and disease progression.
CLINICAL ORAL IMPLANTS RESEARCH
(2023)
Article
Dentistry, Oral Surgery & Medicine
Aleksandar Jakovljevic, Nadja Nikolic, Lucrezia Paterno Holtzman, Pierre Tournier, Alexis Gaudin, Luca Cordaro, Iva Milinkovic
Summary: The Notch pathway plays an important role in various vital cell functions and is involved in inflammation regulation, cell differentiation, and bone development. This review focuses on its role in alveolar bone resorption in conditions such as apical periodontitis, periodontal disease, and peri-implantitis. It highlights the potential of targeting the Notch signaling pathway for the treatment of these pathological conditions.
JAPANESE DENTAL SCIENCE REVIEW
(2023)