Article
Oncology
Kelly R. V. Villafuerte, Felipe T. Dantas, Mario Taba, Michel Messora, Francisco J. Candido dos Reis, Helio H. A. Carrara, Cristhiam de Jesus H. Martinez, Thais Gozzo, Daniela Bazan Palioto
Summary: This study found that NSPT can reduce levels of IL-2, TNF-alpha, and TGF-beta in the BC/P group, while in the P group, levels of INF-gamma, IL-2, TNF-alpha decreased and TGF-beta increased. At 180 days, IL-6 in GCF was significantly positively correlated with PD and CAL in the BC/P group, while in the P group, IL-1 beta in GCF was positively correlated with PD and CAL at 45 days.
SUPPORTIVE CARE IN CANCER
(2021)
Review
Dentistry, Oral Surgery & Medicine
Hani Mawardi, Aliyah Alsubhi, Noura Salem, Emad Alhadlaq, Siraj Dakhil, Mohammed Zahran, Lena Elbadawi
Summary: Medication-induced gingival hyperplasia (MIGH) has various treatment options, including surgical and nonsurgical interventions. Persistent or relapsed cases can achieve complete resolution through excision of hyperplastic gingiva, while laser-assisted surgeries combined with intensive plaque control measures show lower risk of recurrence.
ORAL SURGERY ORAL MEDICINE ORAL PATHOLOGY ORAL RADIOLOGY
(2021)
Article
Dentistry, Oral Surgery & Medicine
Hiroshi Ito, Yukihiro Numabe, Shuichi Hashimoto, Sunao Uehara, Ya-Hsin Wu, Tomohisa Ogawa
Summary: The study suggests that the presence of hemoglobin in gingival crevicular fluid may indicate slight tissue damage in pre-symptomatic periodontal disease, even in healthy sites without bleeding on probing. Therefore, hemoglobin examination could be a promising candidate marker for early detection of periodontal disease.
CLINICAL ORAL INVESTIGATIONS
(2021)
Article
Dentistry, Oral Surgery & Medicine
Hiroshi Ito, Yukihiro Numabe, Shuichi Hashimoto, Satoshi Sekino, Etsuko Murakashi, Hitomi Ishiguro, Daisuke Sasaki, Takashi Yaegashi, Hideki Takai, Masaru Mezawa, Yorimasa Ogata, Hisashi Watanabe, Yuichi Izumi, Jun-Ichi Kido, Yuka Hiroshima, Toshihiko Nagata
Summary: The purpose of this study was to verify the accuracy and utility of clinical and biochemical parameters during the supportive periodontal therapy period. The results showed that all parameters, except plaque index and bleeding on probing, were significantly lower at the second examination than at the first. Adding the haemoglobin test to the bleeding on probing test improved the accuracy of measurement of clinical parameters after periodontal treatment.
Review
Cell Biology
Koji Naruishi
Summary: Periodontal diseases, including periodontitis and gingival overgrowth, have different causes. Periodontitis is caused by bacterial infection, while gingival overgrowth is a side effect of specific drugs. Human gingival fibroblasts and human periodontal ligament fibroblasts play crucial roles in the remodeling and homeostasis of periodontal tissue.
Article
Dentistry, Oral Surgery & Medicine
Hyunjin Kim, Fatemeh Momen-Heravi, Steven Chen, Per Hoffmann, Moritz Kebschull, Panos N. Papapanou
Summary: The study investigated differential DNA methylation in gingival tissues in periodontal health, gingivitis, and periodontitis, and its association with differential mRNA expression. The concomitant study of DNA methylation and gene expression patterns may identify genes whose expression is epigenetically regulated in periodontitis.
JOURNAL OF CLINICAL PERIODONTOLOGY
(2021)
Article
Immunology
Katarzyna B. Lagosz-Cwik, Mariia Melnykova, Elwira Nieboga, Aureliusz Schuster, Agnieszka Bysiek, Slawomir Dudek, Weronika Lipska, Malgorzata Kantorowicz, Michal Tyrakowski, Dagmara Darczuk, Tomasz Kaczmarzyk, Marjolijn Gilijamse, Teun J. de Vries, Jan Potempa, Aleksander M. Grabiec
Summary: Interactions between gingival fibroblasts (GFs) and oral pathogens play a role in the development of chronic inflammation in periodontitis. Epigenetic changes in DNA methylation are associated with periodontitis, and DNMT inhibitors have been shown to protect against epithelial barrier disruption and bone resorption. However, the use of DNMT inhibitors may have detrimental effects on GFs, including reduced proliferation, increased inflammation, and enhanced bacterial adherence.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Dentistry, Oral Surgery & Medicine
Ofir Ginesin, Hadar Zigdon-Giladi, Eran Gabay, Eli Eliahu Machtei, Eitan Mijiritsky, Yaniv Mayer
Summary: This study assessed the gingival color in different stages of an active periodontal treatment using digital tools. The results showed that photometric analysis can be used to evaluate gingival color change during periodontal treatment, providing a more objective assessment compared to current subjective indices.
JOURNAL OF DENTISTRY
(2022)
Article
Biochemistry & Molecular Biology
Ondrej Heneberk, Andrea Vernerova, Lenka Kujovska Krcmova, Eliska Wurfelova, Vladimira Radochova
Summary: This study evaluated the impact of periodontitis and nonsurgical periodontal therapy on neopterin concentrations. After periodontal treatment, neopterin concentrations significantly increased in gingival crevicular fluid and oral fluid compared to before treatment. The total amount of gingival crevicular fluid was significantly higher in the study group before treatment than in the control group. There was a significant correlation between neopterin concentrations in serum and oral fluid, suggesting that neopterin in oral fluid likely originates from serum.
Article
Biochemistry & Molecular Biology
Malgorzata Mazurek-Mochol, Magdalena Brzeska, Karol Serwin, Damian Malinowski, Krzysztof Safranow, Edyta Zagrodnik, Iwona Stecewicz, Andrzej Pawlik
Summary: This study examined the association between IL-18 gene polymorphisms and periodontitis. The results showed that these polymorphisms are not significant risk indicators of periodontitis in our population. However, patients with the GG genotype exhibited more severe bleeding and periodontal probing depth compared to those with the TT genotype. Additionally, the expression of IL-18 was significantly decreased in patients with periodontitis and correlated positively with the number of remaining teeth.
Article
Medicine, General & Internal
Ana Maria Ramirez-Pena, Arturo Sanchez-Perez, Matilde Campos-Aranda, Francisco Javier Hidalgo-Tallon
Summary: This study assessed the effectiveness of ozone therapy as an adjunct to mechanical therapy in periodontitis patients. The results showed that ozone treatment significantly reduced the gingival index, improved clinical attachment, reduced mobility, and showed significant differences in subgingival flora. This suggests that ozone therapy is effective and well tolerated in cases of generalized chronic periodontitis.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Dentistry, Oral Surgery & Medicine
Jie Zhang, Wenjing Li, Hongye Lu, Ruifang Lu, Yalin Zhan, Huanxin Meng
Summary: The level of platelets in the GCF of patients with periodontitis is higher than that of healthy individuals. Platelets can interact with periodontal pathogens and neutrophils, and promote the formation of NETs.
JOURNAL OF CLINICAL PERIODONTOLOGY
(2022)
Article
Microbiology
Simran Preet Bhalla, Ann Maria Shaju, Carlos Marcelo da Silva Figueredo, Leticia Algarves Miranda
Summary: C5a levels were significantly increased in both gingival crevicular fluid and saliva of patients with periodontal disease, indicating a potential role of this molecule in the pathogenesis of the disease.
Article
Dentistry, Oral Surgery & Medicine
Hillary N. Wright, Elizabeth T. Mayer, Thomas E. Lallier, Pooja Maney
Summary: This study compared the clinical outcomes of using a periodontal endoscope versus loupes for scaling and root planing. The results showed that the periodontal endoscope was more effective in multirooted sites.
JOURNAL OF PERIODONTOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Agnieszka Drozdzik, Marek Drozdzik
Summary: Drug-induced gingival overgrowth (DIGO) is a side effect of certain therapeutic agents, such as phenytoin, nifedipine, and cyclosporin A. The exact mechanism of DIGO is not fully understood.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)