Review
Immunology
Yang Liu, Yanling Mu, Zhe Li, Voon Wee Yong, Mengzhou Xue
Summary: This review explores the role of EMMPRIN in stroke and its pathological mechanisms. It discusses the regulation of matrix metalloproteinase expression, exacerbation of blood-brain barrier dysfunction and microvascular thrombosis, and promotion of neuroinflammation. Additionally, it summarizes various stroke treatments targeting the EMMPRIN signaling pathway, and suggests the potential of EMMPRIN as a biomarker of stroke injury.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Clinical Neurology
Yang Liu, Lingxiao Qi, Zhe Li, V. Wee Yong, Mengzhou Xue
Summary: Intracerebral hemorrhage (ICH) is a disease caused by cerebrovascular damage, leading to hematoma enlargement, brain edema, and physical injury in the brain parenchyma. Matrix metalloproteinases (MMPs) are a group of endopeptidases that can degrade components of the extracellular matrix and promote neuroinflammation. After ICH, several MMPs are upregulated and may have different functions at different stages. The glycoprotein extracellular matrix metalloproteinase inducer (EMMPRIN, CD147) induces the production of MMPs. The interactions between MMPs and EMMPRIN/CD147 in ICH are complex.
TRANSLATIONAL STROKE RESEARCH
(2023)
Article
Biochemistry & Molecular Biology
Yang Liu, Fei Wang, Zhe Li, Yanling Mu, Voon Wee Yong, Mengzhou Xue
Summary: This study found that chlorogenic acid (CGA) can provide neuroprotection in intracerebral hemorrhage (ICH) by inhibiting the expression of EMMPRIN and MMP-2/9, alleviating neuroinflammation, blood-brain barrier disruption, cell death, and brain injury.
Article
Biochemistry & Molecular Biology
Christian Behm, Michael Nemec, Alice Blufstein, Maria Schubert, Xiaohui Rausch-Fan, Oleh Andrukhov, Erwin Jonke
Summary: The periodontal ligament responds to orthodontic forces by ECM remodeling, influenced by IL-1 beta and aseptic inflammation. IL-1 beta affects the expression of MMPs and TIMPs in hPDL-MSCs under low-magnitude orthodontic forces. FBS suppresses IL-1 beta-induced expression of MMPs and TIMPs, suggesting a complex interplay in the response of hPDL-MSCs to static orthodontic strains.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Biochemistry & Molecular Biology
Christian Behm, Michael Nemec, Fabian Weissinger, Marco Aoqi Rausch, Oleh Andrukhov, Erwin Jonke
Summary: The systematic review revealed that orthodontic forces induce increased expression levels of MMPs and TIMPs in the PDL during orthodontic tooth movement. However, the exact effect may vary depending on intervention and sample parameters as well as subject characteristics.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Nanoscience & Nanotechnology
Yongxi Liang, Ajay Shakya, Xiaohua Liu
Summary: This study designed and fabricated a bioinspired tubular 3D matrix to guide the migration and growth of human periodontal ligament stem cells (PDLSCs) and form aligned fiber bundles. The tubular matrix controlled cell migration and alignment through inhibiting osteogenic differentiation. Mechanism study revealed involvement of the Yap1/Twist1 signaling pathway.
ACS APPLIED MATERIALS & INTERFACES
(2022)
Article
Neurosciences
Yang Liu, Zhe Li, Suliman Khan, Ruiyi Zhang, Ruixue Wei, Yan Zhang, Mengzhou Xue, V. Wee Yong
Summary: The study demonstrates that minocycline plays a protective role in ICH by reducing EMMPRIN and MMP-9 expression, alleviating BBB disruption, inhibiting neuroinflammation, and decreasing neuronal degeneration and death.
NEUROSCIENCE LETTERS
(2021)
Article
Biochemistry & Molecular Biology
Risa Sugiura, Sayuri Hamano, Atsushi Tomokiyo, Daigaku Hasegawa, Shinichiro Yoshida, Hideki Sugii, Shoko Fujino, Orie Adachi, Masataka Kadowaki, Daiki Yamashita, Hidefumi Maeda
Summary: Periodontal ligament stem cells (PDLSCs) play important roles in maintaining, repairing, and regenerating periodontal ligament (PDL) tissue. This study identified the transcription factor PAX9 as a regulator of ECM production in human PDL cells, which plays a crucial role in the differentiation of iNCs into iPDLSCs.
Article
Orthopedics
Masaru Idota, Shinya Ishizuka, Hideki Hiraiwa, Satoshi Yamashita, Hiroki Oba, Yusuke Kawamura, Takefumi Sakaguchi, Takahiro Haga, Takafumi Mizuno, Itaru Kawashima, Kanae Kuriyama, Shiro Imagama
Summary: The study demonstrated that 4-MU effectively suppressed the expression of pro-catabolic factors in ACL cells and altered the dependence on glycolysis in IL-1 beta-activated ACL cells. This suppressive effect was not achieved through the inhibition of hyaluronan synthesis.
JOURNAL OF ORTHOPAEDIC SURGERY AND RESEARCH
(2021)
Article
Cell Biology
Chao Wang, Ziran Wei, Tengbo Yu, Lu Zhang
Summary: This review aims to elucidate the underlying mechanisms of metalloproteinases in the initiation and progression of spinal ligament degeneration. The dysregulation of metalloproteinases and their endogenous inhibitors may affect ligament degeneration by involving several interrelated processes, represented by ECM degradation, fibroblast proliferation, and osteogenic differentiation. Antagonists of the key targets of the processes may in turn ease ligament degeneration.
CONNECTIVE TISSUE RESEARCH
(2023)
Article
Genetics & Heredity
Xuechun Zhao, Zhigang Xie, Nanquan Rao, Shu Zhang, Yunpeng Zhang
Summary: Human periodontal ligament stem cells (hPDLSCs) are potential seed cells for oral bone tissue engineering. Dermatopontin (DPT) has been found to be elevated during the osteogenic differentiation of hPDLSCs. Interfering with DPT expression inhibited the proliferation and osteogenic differentiation ability of hPDLSCs, while exogenous DPT treatment only enhanced the osteogenic differentiation of hPDLSCs in the control group. This study suggests that DPT is an important target for enhancing the osteogenic differentiation of hPDLSCs.
Article
Multidisciplinary Sciences
Braxton Noll, Farah Bahrani Mougeot, Michael T. Brennan, Jean-Luc C. Mougeot
Summary: This study found that the degradation of salivary epithelium in primary Sjogren's syndrome (pSS) patients is initially caused by overexpression of MMP9. The expression of MMP9 and its associated transcription factor ETS1 was assessed in primary salivary gland epithelial cells (SGECs) and potential regulatory mechanisms were investigated in immortalized SGECs. It was found that ETS1 and MMP9 were overexpressed in SGECs of pSS patients. Knocking down ETS1 resulted in reduced mRNA and protein levels of MMP9. ETS1 overexpression affected the expression of markers associated with epithelial-mesenchymal transition (EMT) and progenitor cells.
SCIENTIFIC REPORTS
(2022)
Article
Biochemistry & Molecular Biology
Ivana Okic Dordevic, Tamara Kukolj, Milena Zivanovic, Sanja Momcilovic, Hristina Obradovic, Andelija Petrovic, Slavko Mojsilovic, Drenka Trivanovic, Aleksandra Jaukovic
Summary: Periodontitis is a chronic bacterial disease that can lead to bone resorption and tooth loss. This study found that the antibiotic doxycycline can enhance the migration and osteogenic potential of periodontal ligament mesenchymal stem cells, while reducing the effects of the proinflammatory factor interleukin-17.
Article
Dentistry, Oral Surgery & Medicine
Maythwe Kyawsoewin, Jeeranan Manokawinchoke, Chutimon Termkwanchareon, Hiroshi Egusa, Thanaphum Osathanon, Phoonsuk Limraksasin
Summary: This study examined the role of extracellular adenosine triphosphate (eATP) in the inflammatory responses of human periodontal ligament cells (HPDLCs). The results showed that low concentrations of eATP increased the expression of pro-inflammatory genes, while high concentrations enhanced the expression of anti-inflammatory genes. The study also revealed the underlying mechanism of eATP-induced inflammatory responses in HPDLCs.
JOURNAL OF PERIODONTOLOGY
(2023)
Article
Cell Biology
Alexey A. Ivanov, Alla V. Kuznetsova, Olga P. Popova, Tamara I. Danilova, Andrey V. Latyshev, Oleg O. Yanushevich
Summary: This study evaluated the effect of exogenous components of the extracellular matrix on the differentiation of periodontal ligament stem cells in a 3D collagen hydrogel. The results showed that the cells exhibited characteristics consistent with osteoblast-like and odontoblast-like cells, suggesting potential for periodontal tissue regeneration.
Article
Dentistry, Oral Surgery & Medicine
S. Pan, D. Yang, J. Zhang, Z. Zhang, H. Zhang, X. Liu, C. Li
JOURNAL OF PERIODONTAL RESEARCH
(2018)
Article
Dentistry, Oral Surgery & Medicine
Z. Zhang, X. Yang, H. Zhang, X. Liu, S. Pan, C. Li
JOURNAL OF PERIODONTAL RESEARCH
(2018)
Article
Cell Biology
Liyuan Huang, Hualing Sun, Fangfang Song, Zhengguo Cao, Xinquan Jiang, Lu Zhang, Zhelun Li, Cui Huang
JOURNAL OF CELLULAR PHYSIOLOGY
(2019)
Article
Cell Biology
Mingyuan Du, Yunlong Wang, Zhijian Liu, Leilei Wang, Zhengguo Cao, Chen Zhang, Yunru Hao, Hong He
Article
Cell Biology
Xiaoxuan Wang, Hualing Sun, Huan Liu, Li Ma, Chenxi Jiang, Haiqing Liao, Shihan Xu, Junbo Xiang, Zhengguo Cao
JOURNAL OF CELLULAR PHYSIOLOGY
(2019)
Article
Dentistry, Oral Surgery & Medicine
H. Q. Liao, H. Liu, H. L. Sun, J. B. Xiang, X. X. Wang, C. X. Jiang, L. Ma, Z. G. Cao
JOURNAL OF DENTAL RESEARCH
(2019)
Article
Biochemistry & Molecular Biology
Yingying Hu, Changning Wang, Shanshan Ha, Ningjing Zhu, Zhengguo Cao, Yaling Song
JOURNAL OF CELLULAR BIOCHEMISTRY
(2020)
Review
Cell & Tissue Engineering
Xudong Gao, Zhengguo Cao
CURRENT STEM CELL RESEARCH & THERAPY
(2020)
Article
Dentistry, Oral Surgery & Medicine
Jiaqi Zhu, Yunlong Wang, Zhengguo Cao, Mingyuan Du, Yunru Hao, Jiawen Pan, Hong He
Article
Cell Biology
Shihan Xu, Chenxi Jiang, Huan Liu, Huihui Zhang, Haiqing Liao, Xiaoxuan Wang, Siqi Yao, Li Ma, Yi Guo, Zhengguo Cao
Article
Dentistry, Oral Surgery & Medicine
Jiawen Pan, Mingyuan Du, Zhengguo Cao, Chen Zhang, Yunru Hao, Jiaqi Zhu, Hong He
Review
Biochemistry & Molecular Biology
Xin Huang, Huiyi Wang, Chuan Wang, Zhengguo Cao
Summary: Periodontitis is a chronic infectious disease that can cause damage to periodontal supporting tissues. The treatment of periodontitis aims to control inflammation and achieve regeneration of periodontal tissues. Extracellular vesicles (EVs) are membranous particles secreted by cells and can facilitate communication between cells. Studies have shown that stem cell-derived EVs and immune cell-derived EVs have positive effects on periodontal regeneration. Additionally, bacterial/plant-derived EVs also play a significant role in periodontal homeostasis and regeneration. This review introduces and summarizes the potential therapeutic values of different types of EVs in periodontal regeneration, and discusses the current challenges and prospects for EV-based periodontal regeneration.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Li Ma, Xiaoxuan Wang, Huan Liu, Chenxi Jiang, Haiqing Liao, Shihan Xu, Yi Guo, Zhengguo Cao
INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES
(2019)
Article
Oncology
Chenxi Jiang, Huan Liu, Hualing Sun, Xiaoxuan Wang, Haiqing Liao, Li Ma, Zhengguo Cao
AMERICAN JOURNAL OF TRANSLATIONAL RESEARCH
(2019)
Article
Materials Science, Biomaterials
Jing Zhang, Yang Chen, Jing Xu, Jingjing Wang, Chengzhang Li, Liyan Wang
REGENERATIVE BIOMATERIALS
(2018)