Article
Biochemistry & Molecular Biology
Hiroyoshi Machida, Sumito Inoue, Akira Igarashi, Shinichi Saitoh, Keiko Yamauchi, Michiko Nishiwaki, Takako Nemoto, Yoichiro Otaki, Masamichi Sato, Kento Sato, Hiroshi Nakano, Sujeong Yang, Kodai Furuyama, Hiroaki Murano, Yu Ishibashi, Takahito Ota, Takashi Nakayama, Yoko Shibata, Masafumi Watanabe
Summary: The production of CCL17 by lung epithelial cells upon cigarette smoke exposure contributes to the accumulation of alveolar macrophages and the development of pulmonary emphysema. CCL17-induced production of CCL2 by macrophages plays a role in macrophage accumulation. These findings provide new insights into the pathogenesis of COPD.
AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY
(2022)
Article
Multidisciplinary Sciences
Shatha Bamashmous, Georgios A. Kotsakis, Kristopher A. Kerns, Brian G. Leroux, Camille Zenobia, Dandan Chen, Harsh M. Trivedi, Jeffrey S. McLean, Richard P. Darveau
Summary: Experimental gingivitis can lead to three distinct clinical inflammatory phenotypes (high, low, and slow response groups), each characterized by different levels of host mediators and bacterial composition. Additionally, novel tissue and bone protective responses were observed in all response groups during gingival inflammation, indicating variability in host responses due to differences in host immune profiles and microbial community maturation.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Article
Immunology
Katarzyna B. Lagosz-Cwik, Mariia Melnykova, Elwira Nieboga, Aureliusz Schuster, Agnieszka Bysiek, Slawomir Dudek, Weronika Lipska, Malgorzata Kantorowicz, Michal Tyrakowski, Dagmara Darczuk, Tomasz Kaczmarzyk, Marjolijn Gilijamse, Teun J. de Vries, Jan Potempa, Aleksander M. Grabiec
Summary: Interactions between gingival fibroblasts (GFs) and oral pathogens play a role in the development of chronic inflammation in periodontitis. Epigenetic changes in DNA methylation are associated with periodontitis, and DNMT inhibitors have been shown to protect against epithelial barrier disruption and bone resorption. However, the use of DNMT inhibitors may have detrimental effects on GFs, including reduced proliferation, increased inflammation, and enhanced bacterial adherence.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Gastroenterology & Hepatology
Levar Shamoun, Kalle Landerholm, Amanda Balboa Ramilo, Roland E. Andersson, Jan Dimberg, Dick Wagsater
Summary: This study demonstrated that CCL4 levels in CRC tissue and the CCL4 gene polymorphism rs10491121, particularly in the right colon, are associated with the clinical outcome of CRC patients. High CCL4 expression in CRC tissue was linked to better survival outcomes, while plasma CCL4 levels were elevated in CRC patients compared to healthy controls. The analysis also highlighted differences in CCL4 gene polymorphism between localized and disseminated disease, with potential implications for prognosis.
WORLD JOURNAL OF GASTROENTEROLOGY
(2021)
Article
Fisheries
Ling-Ling Zhang, Chang-Hong Li, Jiong Chen
Summary: In this study, the CCL25 gene in Japanese sea bass was found to play a crucial role in the response to Vibrio harveyi infection by promoting the migration of monocytes/macrophages, leading to increased survival rates in infected fish.
FISH & SHELLFISH IMMUNOLOGY
(2021)
Article
Dentistry, Oral Surgery & Medicine
Chiaki Morimoto, Masahide Takedachi, Kohsuke Kawasaki, Junpei Shimomura, Mari Murata, Asae Hirai, Kazuma Kawakami, Keigo Sawada, Tomoaki Iwayama, Shinya Murakami
Summary: The study demonstrated that hypoxia stimulates type I collagen production in HGFs and HPDLs through upregulation of hydroxylases P4HA1 and PLOD2 in an HIF-1 alpha-dependent manner.
JOURNAL OF PERIODONTOLOGY
(2021)
Article
Medicine, General & Internal
Takatoshi Nagano, Takao Yamaguchi, Sohtaro Kajiyama, Takuma Suzuki, Yuji Matsushima, Akihiro Yashima, Satoshi Shirakawa, Kazuhiro Gomi
Summary: Previous reports have shown that azithromycin affects collagen synthesis and cytokine production in human gingival fibroblasts. Little is known about its effect on human periodontal ligament fibroblasts. The study found that azithromycin specifically influences human gingival fibroblasts by increasing expression of IL-6 and IL-8 under LPS stimulation, modifying the inflammatory response and promoting connective tissue remodeling.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Pharmacology & Pharmacy
Shan Liu, Xiao-Bing Lan, Miao-Miao Tian, Chun-Hao Zhu, Lin Ma, Jia-Mei Yang, Juan Du, Ping Zheng, Jian-Qiang Yu, Ning Liu
Summary: Chronic pain poses a significant public health challenge, impacting patients' physical and psychological health as well as their quality of life. Current drug treatments for chronic pain often have limited efficacy and come with numerous side effects. The chemokine system, specifically the CCL2/CCR2 axis, plays a crucial role in the development and maintenance of chronic pain. Targeting this system through various approaches, such as siRNA, blocking antibodies, or small molecule antagonists, holds promise for managing chronic pain.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2023)
Article
Dentistry, Oral Surgery & Medicine
Devy F. Garna, Francis J. Hughes, Mandeep S. Ghuman
Summary: Periodontal ligament cells stimulate the expression and osteogenic capacity of gingival fibroblasts through paracrine signaling, which can be partially inhibited by the Wnt antagonist, Dkk1.
JOURNAL OF PERIODONTAL RESEARCH
(2022)
Article
Biochemical Research Methods
Katherine E. Rogers, Okhil K. Nag, Michael H. Stewart, Kimihiro Susumu, Eunkeu Oh, James B. Delehanty
Summary: In mammalian cells, growth factor-induced intracellular signaling and protein synthesis are crucial for cellular physiology and homeostasis. Researchers have developed a method using semiconductor quantum dots to enhance the expression of AQPN-4 in human astrocytes, resulting in improved water transport and increased signaling activity. This study demonstrates the potential of nanoparticle bioconjugates for modulating cellular signaling and understanding glymphatic system function.
BIOCONJUGATE CHEMISTRY
(2023)
Article
Pharmacology & Pharmacy
Libao Liu, Jordi Doijen, Thomas D'huys, Yenthel Verhaegen, Wim Dehaen, Steven De Jonghe, Dominique Schols, Tom Van Loy
Summary: Our study on CCR8 ligands in in vitro cell-based assays revealed differences in signaling pathways and cell migration induced by different ligands. Human CCL1 most efficiently induced cell migration and required Gll-γ signaling, while other CCR8 ligands did not depend on Gll-γ signaling for cell migration. Despite all tested CCR8 agonists being full agonists for calcium mobilization, significant contributions of Gll-γ signaling were only observed in human and viral CCL1.
BIOCHEMICAL PHARMACOLOGY
(2021)
Article
Cell & Tissue Engineering
Hardik Makkar, Srividya Atkuru, Yi Ling Tang, Tanya Sethi, Chwee Teck Lim, Kai Soo Tan, Gopu Sriram
Summary: Gingival and periodontal connective tissue equivalents (CTEs) exhibit differential responses to different bacteria, providing insights into the importance of tissue topography and fibroblast heterogeneity in immune response to early biofilm colonizers.
JOURNAL OF TISSUE ENGINEERING
(2022)
Article
Urology & Nephrology
Hiroko Beppu, Tatsuya Fukuda, Naoya Otsubo, Tomoko Kawanishi, Toshie Ogawa, Yasutomo Abe, Mariko Endo, Tomohide Hanawa, Chise Sugita, Yoshiaki Kikkawa, Shuji Hatakeyama, Tetsuya Yamada, Sachiko Wakai
Summary: CCL17 levels can predict the risk of developing severe COVID-19 in maintenance haemodialysis patients with mild or moderate COVID-19.
Review
Rheumatology
Yuchen Zhang, Di Liu, Djandan Tadum Arthur Vithran, Bosomtwe Richmond Kwabena, Wenfeng Xiao, Yusheng Li
Summary: Osteoarthritis is a degenerative disease that involves inflammation and immune responses. CC chemokine ligands and their receptors play a crucial role in the pathogenesis and treatment of osteoarthritis.
ARTHRITIS RESEARCH & THERAPY
(2023)
Article
Fisheries
Shoucong Zhao, Yuqing Li, Min Cao, Ning Yang, Jie Hu, Ting Xue, Chao Li, Qiang Fu
Summary: Chemokines play a crucial role in cell mobilization for development, immunity, and homeostasis. The study identified multiple CC and CXC chemokine receptors in the turbot genome, with evolutionary analyses revealing mechanisms for the expansion of these receptors. Furthermore, the expression of turbot chemokine receptors was found to be significantly affected by infection and interacted with immune-related genes.
DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY
(2021)