Journal
JOURNAL OF PERINATOLOGY
Volume 34, Issue 10, Pages 767-773Publisher
SPRINGERNATURE
DOI: 10.1038/jp.2014.91
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Funding
- American Academy of Pediatrics-Perinatal Section
- Departments of Clinical Pathology, Pediatrics & Child Health and Obstetrics & Gynecology at Howard University Hospital
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OBJECTIVE: We investigated risk for comorbidities and preeclampsia at low vitamin D levels in ethnic minorities. STUDY DESIGN: Umbilical cord vitamin D (25(OH)D) concentration was determined in urban minorities: 80.9% African American and 17% Hispanic mothers-baby pairs. To identify the correlation between vitamin D levels and high-risk comorbidities which result in preeclampsia, multivariate logistic regression analyses were performed. RESULT: Below the Institute of Medicine threshold of 25(OH)D for pregnant women (25 ng ml(-1)), obesity (P=0.055) and pregestational diabetes (odds ratio (OR) = 2.056) were observed. The study median was 16 ng ml(-1) ( < 25th percentile), at which gestational hypertension (P=0.042), chronic hypertension (OR= 4.842) and pregestational diabetes (OR= 3.45) became relevant. The risk for preeclampsia increased 12-fold with gestational hypertension (P=0.003) and 14-fold with combined chronic and gestational hypertension (P=0.001). CONCLUSION: Pregnant women of ethnic minority had lower median vitamin D levels which may contribute to a potential risk for preeclampsia.
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