Journal
JOURNAL OF PERINATOLOGY
Volume 30, Issue 1, Pages 11-16Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/jp.2009.170
Keywords
cord clamping; motor outcomes; very low birth weight infants; randomized controlled trial; gender
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Funding
- National Institute of Health, National Institute for Nursing Research [K23 NR00078]
- NATIONAL INSTITUTE OF NURSING RESEARCH [K23NR008027] Funding Source: NIH RePORTER
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Objective: The results from our previous trial revealed that infants with delayed cord clamping (DCC) had significantly lesser intraventricular hemorrhage (IVH) and late-onset sepsis (LOS) than infants with immediate cord clamping (ICC). A priori, we hypothesized that infants with DCC would have better motor function by 7 months corrected age. Study Design: Infants between 24 and 31 weeks were randomized to ICC or DCC and follow-up evaluation was completed at 7 months corrected age. Result: We found no differences in the Bayley Scales of Infant Development (BSID) scores between the DCC and ICC groups. However, a regression model of effects of DCC on motor scores controlling for gestational age, IVH, bronchopulmonary dysplasia, sepsis and male gender suggested higher motor scores of male infants with DCC. Conclusion: DCC at birth seems to be protective of very low birth weight male infants against motor disability at 7 months corrected age. Journal of Perinatology (2010) 30, 11-16; doi: 10.1038/jp.2009.170; published online 22 October 2009
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