Review
Biochemistry & Molecular Biology
Anna Kajdy, Dorota Sys, Jan Modzelewski, Joanna Boguslawska, Aneta Cymbaluk-Ploska, Ewa Kwiatkowska, Magdalena Bednarek-Jedrzejek, Dariusz Borowski, Katarzyna Stefanska, Michal Rabijewski, Arkadiusz Baran, Andrzej Torbe, Stepan Feduniw, Sebastian Kwiatkowski
Summary: During pregnancy, the placenta naturally undergoes an aging process, but an abnormally accelerated and premature placental aging may lead to health issues. Placental senescence is associated with obstetric complications such as abnormal fetal growth, preeclampsia, preterm birth, and stillbirth. However, there is limited evidence on the role of placental aging in late small for gestational age (SGA), fetal growth restriction (FGR), and stillbirth. Future research should follow guidelines for planning and reporting and include clear differentiation between early and late SGA and FGR, and only include stillbirths with no other known cause.
Article
Obstetrics & Gynecology
H. Valgeirsdottir, T. Kunovac Kallak, I. Sundstrom Poromaa, M. Jonsson, N. Roos, L. Lindstrom, A-K Wikstrom
Summary: A nationwide register-based cohort study in Sweden found that women with polycystic ovary syndrome (PCOS) have an increased risk of stillbirth, particularly in late pregnancy. Compared to women without PCOS, women with PCOS had a 50% higher risk of stillbirth. However, women with PCOS and a severe hyperandrogenic profile did not show a stronger association with stillbirth compared to those without this profile.
BJOG-AN INTERNATIONAL JOURNAL OF OBSTETRICS AND GYNAECOLOGY
(2021)
Article
Immunology
Salome Maswime, Caroline Pule, Zama Mtshali, Richard Chawana, Mushi Matjila
Summary: Africa has the highest number of pregnant women with HIV, which is associated with adverse perinatal outcomes. The use of antiretroviral therapy has helped reduce transmission and adverse fetal outcomes, but further research is needed to understand the placental mechanisms and fetal immune responses to maternal HIV infection.
JOURNAL OF INFECTIOUS DISEASES
(2021)
Review
Medicine, General & Internal
Olivera Iordache, Doru Mihai Anastasiu, Manaswini Kakarla, Ayesha Ali, Felix Bratosin, Radu Neamtu, Catalin Dumitru, Flavius Olaru, Izabella Erdelean, Angelica Gherman, Cecilia Roberta Avram, Lavinia Stelea
Summary: This systematic review examined the relationship between antiphospholipid antibody-associated thrombophilia and adverse pregnancy outcomes, such as preterm birth and impaired fetal development. It found that multiple aPL antibody positivity is associated with a higher risk of preterm birth. Additionally, treatment during pregnancy can significantly reduce the risk of preterm birth.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Peripheral Vascular Disease
Kelsey McLaughlin, John W. Snelgrove, Melanie C. Audette, Atif Syed, Sebastian R. Hobson, Rory C. Windrim, Nir Melamed, Sergio Carmona, John C. Kingdom
Summary: This study evaluated the association between maternal PlGF levels and pregnancy outcomes in high-risk pregnancies, finding a strong correlation between low PlGF levels and adverse outcomes such as preterm birth, early-onset preeclampsia, and stillbirth.
Review
Medicine, Research & Experimental
Yang Liu, Jing Cao, Xingli Gao, Songwei Gao, Yu Song, Yongran Guo
Summary: Pregnancy complications have a significant impact on millions of women each year, but there is currently no safe and effective treatment available. Placenta-specific therapy, which targets abnormal placental development using biomolecules and signaling pathways, shows promise as a safe and effective therapeutic strategy. This review provides a detailed explanation of the physiological structure and characteristics of the placenta, as well as the mechanisms of biomolecules and signaling pathways involved in normal and abnormal placental development. It also discusses how these biomolecules can be used as therapeutic targets and explores the potential of nanodelivery systems in placenta-specific therapy.
MOLECULAR PHARMACEUTICS
(2022)
Review
Medicine, General & Internal
Anastasija Arechvo, Despoina A. Nikolaidi, Maria M. Gil, Valeria Rolle, Argyro Syngelaki, Ranjit Akolekar, Kypros H. Nicolaides
Summary: This study found that the independent predictor of stillbirth is higher for black women compared to other racial groups, with the risk being about two times higher than that for white women. This suggests that closer surveillance should be provided for black women.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Obstetrics & Gynecology
Beatrix Thompson, Parker Holzer, Harvey Kliman
Summary: There are approximately 5 million pregnancies per year in the USA, with 1 million ending in miscarriage and over 20,000 ending in stillbirth. As many as 50% of these losses are unexplained. The study aimed to evaluate the effect of expanding placental pathology diagnostic categories in examining previously unexplained losses and found that dysmorphic chorionic villi and small placenta were common pathologic features associated with these losses.
REPRODUCTIVE SCIENCES
(2023)
Review
Public, Environmental & Occupational Health
Shashi B. Singh, Bijaya K. Padhi, Aravind P. Gandhi, Pallavi Lohani, Nisha Kumari, Geetu Singh, Prakasini Satapathy, Keerti Bhusan Pradhan, Sarvesh Rustagi, Alaa Hamza Hermis, Arkadiusz Dziedzic, Ranjit Sah
Summary: This study aims to estimate the global burden of stillbirths among pregnant women with COVID-19 vaccination. The systematic review and meta-analysis found a low prevalence of stillbirths among pregnant women vaccinated against COVID-19 infection.
TRAVEL MEDICINE AND INFECTIOUS DISEASE
(2023)
Article
Biochemistry & Molecular Biology
Edgar Ontsouka, Alessandra Epstein, Sampada Kallol, Jonas Zaugg, Marc Baumann, Henning Schneider, Christiane Albrecht
Summary: The study found significant alterations in placental SLCO3A1 (OATP3A1) gene expression in patients with intrahepatic cholestasis of pregnancy (ICP), while the expression levels of the other 20 genes were comparable between healthy and ICP placentae. Additionally, certain genes in ICP placentae showed positive correlations with BA concentrations and maternal body mass index.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Letter
Medicine, General & Internal
Peilin Zhang, Sylvia Dygulski, Farah Al-Sayyed, Beata Dygulska, Sanford Lederman
Summary: This study compared the prevalence of common pregnancy complications and placental pathologies by race and ethnicity among individuals treated at a community hospital in New York City.
Article
Obstetrics & Gynecology
Sarah Gower, Justice Luddington, Deep Khosa, Abhinand Thaivalappil, Andrew Papadopoulos
Summary: This study explores the lived experiences and the most important aspects of person-centred care for Canadian families experiencing a pregnancy after a stillbirth. The findings indicate that these families desire attention, listening, and specialized clinical care in their subsequent pregnancy, as well as psychological support and connections with others who have similar experiences.
BMC PREGNANCY AND CHILDBIRTH
(2023)
Article
Medicine, General & Internal
Zhenyu Wang, Jia Chen, Tuhong Long, Lixuan Liang, Caijuan Zhong, Yingtao Li
Summary: We analyzed the clinical characteristics of patients with diabetes in pregnancy (DIP) associated with stillbirth and found that hypertensive disorders, placenta previa, placental abruption, fetal malformation, high plasma glucose levels, and polyhydramnios were associated with higher incidences of stillbirth in DIP. Antenatal plasma glucose levels and HbA1c were significantly associated with stillbirth in DIP. Age, hypertensive disorders, body mass index, preeclampsia, and diabetic ketoacidosis were positively correlated with the occurrence of stillbirth in DIP. Controlling perinatal plasma glucose, managing comorbidities/complications, and timely termination of pregnancy can reduce the incidence of stillbirths associated with DIP.
Article
Obstetrics & Gynecology
Sukainah Al Khalaf, Karolina Kublickiene, Marius Kublickas, Ali S. Khashan, Alexander E. P. Heazell
Summary: The study found that women with a history of stillbirth in the first two pregnancies have an increased risk of stillbirth or other adverse outcomes in the third pregnancy. Additional surveillance is recommended for these women.
ACTA OBSTETRICIA ET GYNECOLOGICA SCANDINAVICA
(2023)
Article
Obstetrics & Gynecology
Ulla Sovio, Francesca Gaccioli, Emma Cook, D. Stephen Charnock-Jones, Gordon C. S. Smith
Summary: This study aimed to determine the inter-relationships between five first-trimester biomarkers and a range of adverse pregnancy outcomes. The results showed that these biomarkers were associated with fetal growth restriction, preterm birth, and preeclampsia, indicating heterogeneity in the underlying pathophysiological pathways for different types of adverse pregnancy outcomes.
BJOG-AN INTERNATIONAL JOURNAL OF OBSTETRICS AND GYNAECOLOGY
(2023)
Article
Psychiatry
Inbal Shlomi Polachek, Mordechai Dulitzky, Lilia Margolis-Dorfman, Michal J. Simchen
ARCHIVES OF WOMENS MENTAL HEALTH
(2016)
Article
Obstetrics & Gynecology
Michal Dviri, Michal J. Simchen, Anat Kalter, Shali Mazaki Tovi, Orit Moran, Eyal Schiff, Eyal Sivan, Israel Hendler
JOURNAL OF PERINATAL MEDICINE
(2015)
Article
Developmental Biology
Y. Yinon, E. Ben Meir, L. Margolis, S. Lipitz, E. Schiff, S. Mazaki-Tovi, M. J. Simchen
Article
Medicine, Research & Experimental
Alina Weissmann-Brenner, Michal J. Simchen, Eran Zilberberg, Anat Kalter, Mordechai Dulitzky
MEDICAL SCIENCE MONITOR
(2015)
Article
Obstetrics & Gynecology
Michal J. Simchen, Avital L. Okrent Smolar, Mordechai Dulitzky, Eyal Sivan, Iris Morag
JOURNAL OF PERINATAL MEDICINE
(2016)
Article
Obstetrics & Gynecology
Keren Ofir, Liat Lerner-Geva, Valentina Boyko, Eran Zilberberg, Eyal Schiff, Michal J. Simchen
EUROPEAN JOURNAL OF OBSTETRICS & GYNECOLOGY AND REPRODUCTIVE BIOLOGY
(2013)
Article
Obstetrics & Gynecology
Michal J. Simchen, Boaz Weisz, Eran Zilberberg, Iris Morag, Alina Weissmann-Brenner, Eyal Sivan, Mordechai Dulitzki
JOURNAL OF MATERNAL-FETAL & NEONATAL MEDICINE
(2014)
Article
Obstetrics & Gynecology
Iris Morag, Avital L. Okrent, Tzipora Strauss, Orna Staretz-Chacham, Jacob Kuint, Michal J. Simchen, Amir Kugelman
JOURNAL OF MATERNAL-FETAL & NEONATAL MEDICINE
(2015)
Article
Obstetrics & Gynecology
Hagit Shani, Rafael Kuperstein, Alla Berlin, Michael Arad, Ilan Goldenberg, Michal J. Simchen
JOURNAL OF PERINATAL MEDICINE
(2015)
Article
Rheumatology
Y. Berkun, M. J. Simchen, T. Strauss, S. Menashcu, S. Padeh, G. Kenet
Meeting Abstract
Obstetrics & Gynecology
Keren Ofir, Liat Lerner-Geva, Valentina Boyko, Eran Zilberberg, Eyal Schiff, Michal J. Simchen
OBSTETRICAL & GYNECOLOGICAL SURVEY
(2014)
Article
Oncology
Ayala Maayan-Metzger, Aaron Lubetsky, Jacob Kuint, Nurit Rosenberg, Michal J. Simchen, Amir Kuperman, Tzipora Strauss, Ben-Ami Sela, Gili Kenet
PEDIATRIC BLOOD & CANCER
(2013)
Article
Medicine, General & Internal
Itai Gat, Mordechai Dulitzki, Eyal Schiff, Eyal Sivan, Michal J. Simchen
ISRAEL MEDICAL ASSOCIATION JOURNAL
(2014)
Article
Psychology, Developmental
Iris Morag, Orit Bart, Raanan Raz, Shira Shayevitz, Michal J. Simchen, Tzipora Strauss, Samuel Zangen, Jacob Kuint, Lidia Gabis
INFANT BEHAVIOR & DEVELOPMENT
(2013)