Article
Biology
Kengo Inada, Kazoku Tsujimoto, Masahide Yoshida, Katsuhiko Nishimori, Kazunari Miyamichi
Summary: Studies have shown that oxytocin signaling in the arcuate nucleus suppresses excessive food intake, playing an important role in body weight homeostasis and appetite regulation.
Article
Biochemistry & Molecular Biology
Shruti Mohan, Andrew G. McCloskey, Aine M. McKillop, Peter R. Flatt, Nigel Irwin, R. Charlotte Moffett
Summary: Research on peptide-based oxytocin analogues shows potential for improving obesity and type 2 diabetes. These analogues have demonstrated antidiabetic effects in high fat fed mice after extensive characterization, suggesting therapeutic potential for long-acting oxytocin-based agents.
BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS
(2021)
Article
Obstetrics & Gynecology
Ruth M. Wei, Mark Bounthavong, Meghan G. Hill
Summary: This study aimed to assess whether women with obesity benefited from higher doses of oxytocin for induction of labor. The results showed no difference in time to delivery between low-dose and high-dose oxytocin protocols. However, there was a trend towards a lower rate of cesarean delivery in both lean women and women with obesity when high-dose oxytocin was used.
AMERICAN JOURNAL OF OBSTETRICS & GYNECOLOGY MFM
(2022)
Review
Obstetrics & Gynecology
Xiaoqing He, Xiaojing Zeng, James Troendle, Maria Ahlberg, Ellen L. Tilden, Joao Paulo Souza, Stine Bernitz, Tao Duan, Olufemi T. Oladapo, William Fraser, Jun Zhang
Summary: The past 20 years have seen a resurgence in research on labor progression and a shift in thinking about normal labor. New evidence and advanced statistical methods are being used to analyze labor progression. There is a growing consensus that the definition of abnormal labor may not be tied to an ideal or average labor curve due to variations in the onset and pattern of labor progression.
AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY
(2023)
Article
Chemistry, Multidisciplinary
Yi Zhang, Yangyang Zhu, Jinghui Wang, Li Jin, Mingwei Guo, Liwei Chen, Lina Zhang, Yangyang Li, Baocheng Wan, Rong Zhang, Weiping Jia, Cheng Hu
Summary: Nrg4 is an adipose tissue-enriched factor that regulates glucose and lipid metabolism and is closely associated with obesity. It acts on ErbB4 in the hypothalamus, excites PVN neurons, and influences energy balance. Its effects on reducing obesity are mediated through ErbB4-mediated excitation of Oxt release from Oxt neurons.
Article
Obstetrics & Gynecology
Cecilia Bruggemann, Sara Carlhall, Hanna Grundstrom, Marie Blomberg
Summary: The study found that oxytocin augmentation at cervical dilatation <= 5 cm increased the risk of cesarean section, while no increased risk of operative birth was found at 6-10 cm of cervical dilatation. Additionally, a decreased risk of operative birth was observed at full cervical dilatation, with a high rate of negative birthing experience across all groups.
BMC PREGNANCY AND CHILDBIRTH
(2022)
Article
Obstetrics & Gynecology
Melese Gezahegn Tesemma, Demisew Amenu Sori, Desta Hiko Gemeda
Summary: The study found that pregnant mothers who received high dose oxytocin for labor induction had higher rates of adverse perinatal outcomes compared to those who received low dose oxytocin. Risk factors associated with adverse perinatal outcomes included high dose oxytocin use, caesarean birth, instrumental birth, and antepartum hemorrhage. The study recommended the use of low dose oxytocin for better perinatal outcomes.
BMC PREGNANCY AND CHILDBIRTH
(2021)
Article
Clinical Neurology
Yusuke Kunimi, Marina Minami, Sifa Marie Joelle Muchanga, Masamitsu Eitoku, Kazutoshi Hayashi, Mikiya Fujieda, Narufumi Suganuma, Nagamasa Maeda
Summary: This study found no significant association between the use of exogenous oxytocin for labor induction and adverse maternal-infant bonding. The results suggest that exogenous oxytocin is a safe and important drug for labor induction.
JOURNAL OF AFFECTIVE DISORDERS
(2022)
Article
Obstetrics & Gynecology
Aviad Sapir, Lior Friedrich, Roni Gat, Offer Erez
Summary: This study found that cesarean section during the second stage of labor is associated with an increased risk for preterm birth and/or cervical insufficiency in the subsequent pregnancy. Maternal and neonatal risk factors for long-term complications following cesarean section due to prolonged second stage of labor were also identified.
JOURNAL OF MATERNAL-FETAL & NEONATAL MEDICINE
(2023)
Article
Obstetrics & Gynecology
Li Wang, Xuyuan Ma, Le Chen, Fangfang Jiang, Jie Zhou
Summary: Neuraxial analgesia affects the circadian rhythm of labor, changing the cosine rhythm of spontaneous vaginal delivery, which is aggravated by the use of induction, oxytocin, and operative delivery.
BMC PREGNANCY AND CHILDBIRTH
(2022)
Article
Integrative & Complementary Medicine
Dongjing Sun
Summary: This study aimed to investigate the effect of carbetocin on intraoperative blood loss and thickness of myometrium during cesarean section with a scarred uterus. The clinical data of pregnant women who underwent cesarean section were retrospectively analyzed. The results showed that carbetocin was effective in reducing operation time, intraoperative blood loss, and promoting uterine recovery.
EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE
(2022)
Article
Multidisciplinary Sciences
Yun Zhou, Wenwen Liu, Yang Xu, Xiaoyan Zhang, Yiqun Miao, Aihua Wang, Yuanyuan Zhang
Summary: This study explored the effect of synthetic oxytocin on neonatal instinctive breastfeeding behavior. The results showed that with an increase in the dose of synthetic oxytocin, the effect on breast seeking activity and breast attachment was more significant. Additionally, there were differences in exclusive breastfeeding sessions within the first few days after birth, but no statistical difference in exclusive breastfeeding rate at 3 months.
SCIENTIFIC REPORTS
(2022)
Article
Obstetrics & Gynecology
Lotta Selin, Marie Berg, Ulla-Britt Wennerholm, Anna Dencker
Summary: The study aimed to compare childbirth experiences and labor pain in primiparous women who received high- vs low-dose oxytocin for delayed labor. Results showed that oxytocin dosage did not impact women's childbirth experiences or pain assessment 1 month after birth.
ACTA OBSTETRICIA ET GYNECOLOGICA SCANDINAVICA
(2021)
Article
Biochemistry & Molecular Biology
Imen Becetti, Vibha Singhal, Supritha Nimmala, Hang Lee, Elizabeth A. A. Lawson, Miriam A. A. Bredella, Madhusmita Misra
Summary: A study compared young individuals with severe obesity who underwent sleeve gastrectomy with non-surgical controls, and found that decreases in hormone OXT levels were associated with reductions in lean mass but not with decreases in fat mass or bone density. This suggests that OXT pathways may be targeted to prevent loss of lean mass following weight loss surgery.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Obstetrics & Gynecology
Adeniyi K. Akiseku, Olusoji E. Jagun, Adebayo A. Akadri, John O. Imaralu, Adetola O. Olatunji, Adewale O. Sule-Odu
Summary: This study assessed the effectiveness of Butylbromide on the duration of the first stage of labor among nulliparous women. The results showed that Butylbromide significantly reduced the duration of labor and increased the rate of cervical dilation in comparison to the control group, without any significant differences in fetal heart rate, maternal vital signs, or Apgar scores.
INTERNATIONAL JOURNAL OF GYNECOLOGY & OBSTETRICS
(2021)