Article
Biophysics
Dirk Hoyer, Alexander Schmidt, Adelina Pytlik, Lukas Viehofer, Hernani Goncalves, Celia Amorim-Costa, Joao Bernardes, Diogo Ayres-de-Campos, Silvia M. Lobmaier, Uwe Schneider
Summary: This study investigates the transferability of established electrophysiological HRV indices to CTG recordings during the fetal maturation period. The results show that CTG can provide indices related to long-term regulation and models using HRV indices calculated from CTG allow for the identification of maturational age and discriminate fetal growth restriction (FGR) with almost similar precision as electrophysiological means. Further validation is needed to confirm the diagnostic potential of these CTG-specific HRV indices in monitoring fetal developmental disturbances.
PHYSIOLOGICAL MEASUREMENT
(2021)
Article
Cardiac & Cardiovascular Systems
Annette Wacker-Gussmann, Janette F. Strasburger, Ronald T. Wakai
Summary: The study found that fMCG contributes significantly to the accuracy and precision of fetal arrhythmia diagnosis and risk assessment, leading to changes in management. Additional findings beyond the referring echocardiogram or alternative diagnoses were seen in a large portion of cases in categories such as tachycardia, bradycardia/AV block, and familial long QT syndrome.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2022)
Article
Engineering, Biomedical
Fabian Beutel, Chris Van Hoof, Xavier Rottenberg, Koen Reesink, Evelien Hermeling
Summary: This study demonstrates a novel method for pulse arrival time (PAT) segmentation into cardiac isovolumic contraction (IVC) and vascular pulse transit time to approximate central pulse wave velocity (PWV). Central PWV was found to explain twice the variability in Bramwell-Hill PWV compared to peripheral PWV. The method provides unbiased vascular pulse transit time estimates and has potential to improve cardiovascular risk assessment in clinical routines.
IEEE TRANSACTIONS ON BIOMEDICAL ENGINEERING
(2021)
Article
Medicine, General & Internal
David Wurm, Peter Ewert, Peter Fierlinger, Ronald T. Wakai, Verena Wallner, Lena Wunderl, Annette Wacker-Gussmann
Summary: Fetal magnetocardiography (fMCG) is the best technique for diagnosing fetal arrhythmia, providing a more comprehensive evaluation of fetal cardiac rhythm compared to other methods. This study demonstrated a practical fMCG system based on optically pumped magnetometers (OPMs), which is consistent with previous studies using superconducting quantum interference device (SQUID) fMCG systems. This is an important step towards widespread accessibility of the method.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Medicine, General & Internal
Gabriela P. P. Tardelli, Tan Phan, Janette Strasburger, Oswaldo Baffa, Ronald Wakai
Summary: Fetal magnetocardiography (fMCG) is a valuable tool for prenatal monitoring, but the high cost of equipment limits its use in routine clinical practice. This study aimed to reduce environmental magnetic interference in fMCG signals by using a small ferrite shield. The results showed that the ferrite shield reduced interference and significantly improved signal-to-noise ratio and waveform resolution, especially in the axial direction. This is particularly beneficial for triaxial optically pumped magnetometers (OPMs).
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Acoustics
Keooudone Thammavong, Suchaya Luewan, Theera Tongsong
Summary: The study aimed to establish reference intervals for the cardiac volume of normal fetuses between 14 to 40 weeks of pregnancy. The models based on parameters like gestational age, biparietal diameter, head circumference, and estimated fetal weight were used to calculate the reference intervals. This information will be useful for detecting cardiac abnormalities, particularly those associated with cardiomegaly.
JOURNAL OF ULTRASOUND IN MEDICINE
(2022)
Article
Computer Science, Interdisciplinary Applications
Manuel Goncalves da Silva Neto, Joao Paulo do Vale Madeiro, Danielo G. Gomes
Summary: Through a systematic mapping study, recent research on the building blocks that compose biosignal-based fetal state assessment systems was identified and synthesized. The majority of studies lack validation, CTU-UHB is the most common dataset, and the need for validation studies in a clinical environment was highlighted.
COMPUTER METHODS AND PROGRAMS IN BIOMEDICINE
(2022)
Article
Computer Science, Interdisciplinary Applications
Caridad Mireles, Misael Sanchez, David Cruz-Ortiz, Ivan Salgado, Isaac Chairez
Summary: This study presents the development of a nursing mobile robotic device that can monitor vital signals in home-cared patients and provide assistance in the gait cycle. The robot's structural components were 3D-printed, and it is equipped with electronic embedded devices and sensors for measuring physiological data and tracking the patient's position. It has been tested with positive results, demonstrating its effectiveness in primary health care.
MEDICAL & BIOLOGICAL ENGINEERING & COMPUTING
(2023)
Article
Physiology
Zeynep Melike Isilay Zeybek, Vittorio Racca, Antonio Pezzano, Monica Tavanelli, Marco Di Rienzo
Summary: Cardiac mechanics can be derived from cardiac time intervals, traditionally estimated by ultrasound techniques. However, specific fiducial points in the waveform of the seismocardiogram can also be used for assessment. This study found that not every cardiac patient has an SCG waveform suitable for CTI estimation, thus a preliminary check is advisable before using SCG-based monitoring.
FRONTIERS IN PHYSIOLOGY
(2022)
Article
Chemistry, Analytical
Keren Zhu, Asimina Kiourti
Summary: We demonstrate a real-time magnetocardiography (MCG) sensor that operates in non-shielded environments without an accompanying device for cardiac cycle identification. The sensor integrates optimized coils into an array to convert magnetic flux from the heart to voltage. By leveraging digital signal processing, MCG can be retrieved in real-time. The results confirm the feasibility of real-time R-peak detection and provide insights for the development of accessible, miniaturized, safe, and low-cost MCG tools.
Article
Engineering, Aerospace
Barbara Le Roy, Charlotte Aufauvre-Poupon, Agathe Ferragu, Alexandre Vannier, Charles Martin-Krumm, Marion Trousselard
Summary: This study evaluated the negative impact of submarine patrol on submariners' psychological and sensory performances using heart rate variability (HRV). It found that submariners with higher parasympathetic activity (HPa) had better interoceptive and exteroceptive functioning during the patrol and at recovery compared to those with lower parasympathetic activity (LPa). Emotional health did not show significant differences between the two groups.
Article
Engineering, Biomedical
Zhiwen Zheng, Qingshan Wang, Dazhu Deng, Qi Wang, Wei Huang
Summary: Gesture is a diverse form of human-computer interaction, and the biosignal-based continuous gesture recognition system CG-Recognizer effectively addresses the issues of deformation and length diversity, achieving high accuracy.
BIOMEDICAL SIGNAL PROCESSING AND CONTROL
(2022)
Article
Engineering, Electrical & Electronic
Vikas R. Bhat, S. Sengottuvel, Pragyna P. Swain, H. Anitha, K. Gireesan
Summary: This paper attempts to simulate and compare spatio-temporal VCG and VMCG derived from epicardial potentials. By comparing the orientations of EHV and MHV, the usefulness of these spatiotemporal vectors in tracing the cardiac current flow inside the thorax for a healthy heart is demonstrated. Clinically relevant information could be obtained if the present analysis is extended to highly complex and irregular cardiac activation sequences that could be seen in arrhythmia and myocardial infarction.
IETE JOURNAL OF RESEARCH
(2023)
Article
Nanoscience & Nanotechnology
Sarnab Bhattacharya, Mohammad Nikbakht, Alec Alden, Philip Tan, Jieting Wang, Taha A. Alhalimi, Sangjun Kim, Pulin Wang, Hirofumi Tanaka, Animesh Tandon, Edward F. Coyle, Omer T. Inan, Nanshu Lu
Summary: Cardiovascular diseases are responsible for the majority of deaths worldwide. This study introduces a thin, stretchable, lightweight, wireless, and low-power cardiac monitoring device, known as an e-tattoo, which adheres to the human chest like a temporary tattoo sticker. It allows continuous monitoring of cardiac signals, enabling early detection and prevention of cardiac complications.
ADVANCED ELECTRONIC MATERIALS
(2023)
Article
Geochemistry & Geophysics
Yongwen Zhang, Yosef Ashkenazy, Shlomo Havlin
Summary: This study focuses on the asymmetry of interevent time series in earthquake catalogs, finding that there is a significant crossover from high to low asymmetry as lag index increases. Different earthquake triggering processes are associated with the two distinct regimes of asymmetry, and a new generalized ETAS model better reproduces the observed asymmetry compared to the standard ETAS model.
JOURNAL OF GEOPHYSICAL RESEARCH-SOLID EARTH
(2021)
Article
Endocrinology & Metabolism
Ralf Veit, Lisa Horstman, Maike A. Hege, Martin Heni, Peter J. Rogers, Jeffrey M. Brunstrom, Andreas Fritsche, Hubert Preissl, Stephanie Kullmann
INTERNATIONAL JOURNAL OF OBESITY
(2020)
Article
Endocrinology & Metabolism
Martin Heni, Robert Wagner, Caroline Willmann, Benjamin Assad Jaghutriz, Andreas Vosseler, Christian Kuebler, Verena Hund, Klaus Scheffler, Andreas Peter, Hans-Ulrich Haering, Hubert Preissl, Stephanie Kullmann, Andreas Fritsche
NEUROENDOCRINOLOGY
(2020)
Article
Endocrinology & Metabolism
Haliza Mat Husin, Franziska Schleger, Ilena Bauer, Ellen Fehlert, Isabelle Kiefer-Schmidt, Magdalene Weiss, Karl Oliver Kagan, Sara Brucker, Jan Pauluschke-Froehlich, Hari Eswaran, Hans-Ulrich Haering, Andreas Fritsche, Hubert Preissl
Article
Developmental Biology
Hari Eswaran, Chrystal Lau, Pam Murphy, Eric R. Siegel, Hubert Preissl, Curtis Lowery
Summary: This study tracked the development trajectory of fetal auditory and visual evoked responses in high-risk pregnancies, showing a decrease in latency with gestational age progression. There was a significant difference in detection rates between male and female fetuses, but this difference was not reflected in latency values or sensory modality. Factors affecting response detectability included intervening layers of adipose tissue and an increase in maternal body mass index.
DEVELOPMENTAL PSYCHOBIOLOGY
(2021)
Meeting Abstract
Endocrinology & Metabolism
Robert Wagner, Benedikt Dietz, Juergen Machann, Patrick Schwab, Julia K. Dienes, Steffen Reichert, Andreas L. Birkenfeld, Hans-Ulrich Haering, Fritz Schick, Norbert Stefan, Martin Heni, Hubert Preissl, Bernhard Schoelkopf, Stefan Bauer, Andreas Fritsche
Article
Medicine, Research & Experimental
Joe J. Simon, Marion A. Stopyra, Esther Monning, Sebastian Sailer, Nora Lavandier, Lars P. Kihm, Martin Bendszus, Hubert Preissl, Wolfgang Herzog, Hans-Christoph Friederich
JOURNAL OF CLINICAL INVESTIGATION
(2020)
Article
Multidisciplinary Sciences
Dorothea Niepel, Bhargavi Krishna, Eric R. Siegel, Rossitza Draganova, Hubert Preissl, Rathinaswamy B. Govindan, Hari Eswaran
Article
Clinical Neurology
Katharina Zinke, Vanessa Lehnert, Andreas Fritsche, Hubert Preissl, Manfred Hallschmid
Summary: The study investigated the effects of pregnancy on memory during sleep, finding that subjective sleep quality was impaired in pregnant women, but objective memory consolidation was similar between pregnant and non-pregnant women.
JOURNAL OF SLEEP RESEARCH
(2021)
Article
Endocrinology & Metabolism
Stephanie Kullmann, Dominik Blum, Benjamin Assad Jaghutriz, Christoph Gassenmaier, Benjamin Bender, Hans-Ulrich Haering, Gerald Reischl, Hubert Preissl, Christian la Fougere, Andreas Fritsche, Matthias Reimold, Martin Heni
Summary: This study demonstrates that central administration of insulin can impact dopaminergic activity in the striatum, which in turn affects regional brain activity and connectivity. The interaction between insulin and dopamine and the regulation of whole-body metabolism through a complex network are further elucidated by our findings.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2021)
Article
Endocrinology & Metabolism
Louise Fritsche, Martin Heni, Sabine S. Eckstein, Julia Hummel, Anette Schurmann, Hans-Ulrich Haring, Hubert Preissl, Andreas L. Birkenfeld, Andreas Peter, Andreas Fritsche, Robert Wagner
Summary: This study aimed to investigate the incretin response during an oral glucose tolerance test (OGTT) in pregnant women. The results showed that insulin secretion was lower in women with gestational diabetes mellitus (GDM), but the increase in GLP-1 was only associated with insulin secretion in GDM women. Additionally, postprandial GLP-1 levels were negatively associated with birth weight.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2022)
Article
Endocrinology & Metabolism
Lore Wagner, Ralf Veit, Louise Fritsche, Hans-Ulrich Haring, Andreas Fritsche, Andreas L. Birkenfeld, Martin Heni, Hubert Preissl, Stephanie Kullmann
Summary: This study found that obesity and sex influence the central insulin-mediated neural response to visual food cues in the brain. These findings reveal that central insulin action regulates food response differently in men and women, which may have consequences for metabolism and eating behavior.
INTERNATIONAL JOURNAL OF OBESITY
(2022)
Article
Neurosciences
Stephanie Kullmann, Ralf Veit, Daniel R. Crabtree, William Buosi, Odysseas Androutsos, Alexandra M. Johnstone, Yannis Manios, Hubert Preissl, Paul A. M. Smeets
Summary: This study investigated the effect of hunger state on the hypothalamus network using functional magnetic resonance imaging, and found that the hypothalamus showed higher functional connectivity with other brain regions in the sated state. Differences in hypothalamus to dorsolateral prefrontal cortex connectivity between individuals with obesity and normal weight were also observed in the fasted state.
HUMAN BRAIN MAPPING
(2023)
Article
Endocrinology & Metabolism
Lore Wagner, Ralf Veit, Christian Kuebler, Andreas L. Birkenfeld, Hans-Ulrich Haering, Andreas L. Birkenfeld, Martin Heni, Hubert Preissl, Stephanie Kullmann
Summary: This study investigated the relationship between brain insulin responsiveness, age, and peripheral insulin sensitivity. The results showed significant negative associations between age and insulin action in the hippocampus and caudate nucleus, as well as between peripheral insulin sensitivity and insulin action in the amygdala. The study also found that the association between age and hippocampal insulin action was strongest in women, while the association between peripheral insulin sensitivity and age in reward-related brain regions was strongest in men.
DIABETES OBESITY & METABOLISM
(2023)
Article
Physiology
Luis Mercado, Diana Escalona-Vargas, Sarah Blossom, Eric R. Siegel, Julie R. Whittington, Hubert Preissl, Kaitlyn Walden, Hari Eswaran
Summary: The study found that maternal pregestational diabetes has an effect on the fetal autonomic nervous system (ANS), which can be assessed using non-invasive fetal magnetocardiography. There were differences in the frequency domain of fetal heart rate variability (fHRV) and heart rate-movement coupling in fetuses of pregestational diabetic mothers compared to non-diabetics. However, the effect on fHRV related to fetal ANS and sympathovagal balance was not as conclusive as observed in neonates of pregestational diabetic mothers.
PHYSIOLOGICAL REPORTS
(2023)
Article
Endocrinology & Metabolism
Julia Hummel, Charlotte Benkendorff, Louise Fritsche, Katsiaryna Prystupa, Andreas Vosseler, Sofiya Gancheva, Sandra Trenkamp, Andreas L. Birkenfeld, Hubert Preissl, Michael Roden, Hans-Ulrich Haering, Andreas Fritsche, Andreas Peter, Robert Wagner, Stephanie Kullmann, Martin Heni
Summary: This study found that brain insulin action improves peripheral insulin sensitivity in women, but only during the follicular phase of the menstrual cycle. The study also found different effects of insulin on hypothalamic sensitivity depending on the menstrual cycle phase.