Article
Microbiology
Jane Wairimu Maina, Frank Gekara Onyambu, Peter Shikuku Kibet, Abednego Moki Musyoki
Summary: The study revealed a high prevalence of multidrug-resistant Gram-negative bacteria infections in ICU patients, predominantly urinary tract infections. Factors associated with these infections included a history of antibiotic use, nasogastric tube use, and respiratory and cardiovascular conditions. Most of the isolates were multidrug-resistant, mainly Escherichia coli, Klebsiella pneumoniae, and Pseudomonas aeruginosa.
ANNALS OF CLINICAL MICROBIOLOGY AND ANTIMICROBIALS
(2023)
Review
Medicine, Research & Experimental
Matteo Bassetti, Antonio Vena, Daniele Roberto Giacobbe, Nadia Castaldo
Summary: The article discusses the global increase in isolation of multidrug-resistant Gram-negative bacteria and the challenges in providing effective therapy using old antibiotics. It emphasizes the importance of establishing appropriate clinical and therapeutic recommendations for the antibiotic treatment of these pathogens.
ARCHIVES OF MEDICAL RESEARCH
(2021)
Review
Infectious Diseases
Souha S. Kanj, Matteo Bassetti, Pattarachai Kiratisin, Camilla Rodrigues, Maria Virginia Villegas, Yunsong Yu, David van Duin
Summary: Multidrug-resistant Gram-negative bacteria pose a critical threat to healthcare. New antibiotics and combination therapies, including ceftazidime-avibactam, meropenem-vaborbactam, and ceftolozane-tazobactam, have shown effectiveness in treating these infections.
INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS
(2022)
Article
Microbiology
Yuan Liu, Kangni Yang, Yuqian Jia, Jingru Shi, Ziwen Tong, Zhiqiang Wang
Summary: The study showed that thymine can effectively enhance the bactericidal activity of antibiotics against Gram-negative pathogens by activating bacterial metabolism and restoring susceptibility to antibiotics. This finding provides a universal strategy to overcome Gram-negative pathogens.
FRONTIERS IN MICROBIOLOGY
(2021)
Review
Microbiology
Claire Maher, Karl A. Hassan
Summary: Gram-negative bacteria are resistant to antibiotics due to their cell envelope's permeability barrier. Understanding the role of different components in the envelope is crucial for developing new broad-spectrum antibiotics.
Article
Agriculture, Dairy & Animal Science
Francesca Paola Nocera, Monica Ambrosio, Filomena Fiorito, Laura Cortese, Luisa De Martino
Summary: The study found that Staphylococcus and Gram-negative bacteria are the most common pathogens in skin infections of small animals, and the increasing prevalence of multi-drug-resistant strains is a concerning trend. This spread is not only significant in veterinary medicine but also has implications for zoonotic diseases.
Article
Infectious Diseases
Francesco Cogliati Dezza, Gabriele Arcari, Federica Alessi, Serena Valeri, Ambrogio Curtolo, Federica Sacco, Giancarlo Ceccarelli, Giammarco Raponi, Francesco Alessandri, Claudio Maria Mastroianni, Mario Venditti, Alessandra Oliva
Summary: This study evaluates the impact of COVID-19 on MDR-GN bloodstream infections in an ICU setting. The study finds that COVID-19 patients have a higher incidence of MDR-GN infections and experience more severe conditions and higher mortality rates.
Article
Medical Laboratory Technology
Zhenli Peng, Yanxin Wang, Lijuan Jia, Yao Jiang, Xiang Li
Summary: This paper investigated the composition and antibiotic resistance of pathogens isolated from blood cultures of patients with bloodstream infection in the ICU. The study found that Gram-positive bacteria were the dominant pathogens and showed high susceptibility to vancomycin, linezolid, and teicoplanin. The antibiotic susceptibility of Gram-negative bacteria varied greatly.
CLINICAL LABORATORY
(2022)
Article
Public, Environmental & Occupational Health
Yijie Liu, Ting Sun, Ying Cai, Tianshu Zhai, Linna Huang, Qi Zhang, Chunlei Wang, He Chen, Xu Huang, Min Li, Jingen Xia, Sichao Gu, Lingxi Guo, Bin Yang, Xiaojing Wu, Binghuai Lu, Qingyuan Zhan
Summary: This study aimed to investigate the clinical and prognostic characteristics of pneumonia-related bloodstream infections (PRBSI) in the intensive care unit (ICU). The study found that patients with PRBSI had higher mortality rates, longer duration of mechanical ventilation and ICU stay compared to non-PRBSI patients. PRBSI patients showed extensive consolidation lesions on chest radiographs and the most common causative organisms were carbapenem-resistant gram-negative bacteria.
FRONTIERS IN PUBLIC HEALTH
(2023)
Article
Multidisciplinary Sciences
Btissam Arhoune, Samira El Fakir, Sara Himri, Kaoutar Moutaouakkil, Salma El Hassouni, Moussa Benboubker, Fouzia Hmami, Bouchra Oumokhtar
Summary: The study revealed a high colonization rate of ESBL and CPE in neonates during their hospitalization in NICU. Risk factors significantly associated with MDR enterobacteria colonization included admission from the maternity of the university hospital and neurological distress. High rates of colonization and presence of resistance genes indicate possible cross-transmission in the NICU, emphasizing the need for active strategies to control the spread of MDR enterobacteria.
Article
Public, Environmental & Occupational Health
Dharm Raj Bhatta, Supram Hosuru Subramanya, Deependra Hamal, Rajani Shrestha, Eva Gauchan, Sahisnuta Basnet, Niranjan Nayak, Shishir Gokhale
Summary: This study found a high level of bacterial contamination of objects/instruments in the NICU. Common potential pathogens isolated were Escherichia coli, Klebsiella species, and Staphylococcus aureus. Most bacterial isolates were susceptible to gentamicin and amikacin.
ANTIMICROBIAL RESISTANCE AND INFECTION CONTROL
(2021)
Article
Infectious Diseases
Eric S. Donkor, Khitam Muhsen, Sherry A. M. Johnson, Fleischer C. N. Kotey, Nicholas T. K. D. Dayie, Patience B. Tetteh-Quarcoo, Edem M. A. Tette, Mary-Magdalene Osei, Beverly Egyir, Nicholas I. Nii-Trebi, Godfred Owusu-Okyere, Alex Owusu-Ofori, Yonatan Amir, Saritte Perlman, Perdita Hilary Lopes, Adjo Mfodwo, Nicola C. Gordon, Louise Gresham, Mark Smolinski, Dani Cohen
Summary: This study aimed to determine the distribution and antimicrobial resistance patterns of Gram-negative bacteria causing bloodstream infections in Ghana. The results showed high resistance and multidrug resistance to various antibiotics, including cephalosporins, fluoroquinolones, and penicillins, indicating limited effectiveness of these antibiotics in BSI treatment in the country.
Article
Microbiology
Jaime E. Zlamal, Semen A. Leyn, Mallika Iyer, Marinela L. Elane, Nicholas A. Wong, James W. Wamsley, Maarten Vercruysse, Fernando Garcia-Alcalde, Andrei L. Osterman
Summary: Resistance to the broad-spectrum antibiotic ciprofloxacin is detected at high rates in various bacterial pathogens, with early resistance primarily caused by single mutations in DNA gyrase target genes. Further genetic alterations influence drug efflux mechanisms and secondary target genes, leading to increased resistance levels. The study highlights shared and unique evolutionary aspects across different species, providing insights for the development of novel antibiotics with reduced resistance tendencies.
Review
Microbiology
Manon Lang, Andre Carvalho, Zeynep Baharoglu, Didier Mazel
Summary: This review aims to consolidate existing and recent knowledge about the uptake of aminoglycosides (AGs), explore the connection between AG-dependent bacterial stress and drug uptake, and present new strategies to enhance AG uptake for more efficient antibiotic therapies, with a focus on the connection between sugar transport and AG potentiation.
MICROBIOLOGY AND MOLECULAR BIOLOGY REVIEWS
(2023)
Article
Infectious Diseases
Mandira Chakraborty, Sayani Sardar, Rituparna De, Malabika Biswas, Maria Teresa Mascellino, Maria Claudia Miele, Silpak Biswas, Anita Nandi Mitra
Summary: Nosocomial infections caused by multidrug-resistant bacteria are a major concern in ICUs, and the resistance patterns of these pathogens were examined in a tertiary care hospital in Kolkata, India. The study found that multidrug-resistant bacteria were prevalent in both adult and pediatric ICUs and showed high resistance against multiple antibiotics.
