Article
Obstetrics & Gynecology
Amelie Tetu, Paul Guerby, Fabien Rallu, Louise Duperron, Valerie Morin, Emmanuel Bujold
Summary: This study found no cases of mid-trimester MIAC in low-risk asymptomatic pregnant women using a combination of Mycoplasma-specific PCR and culture techniques. More sensitive and broad-range microbiologic techniques, such as 16S DNA detection by PCR, may need further evaluation.
JOURNAL OF MATERNAL-FETAL & NEONATAL MEDICINE
(2022)
Article
Immunology
Kyong-No Lee, Kyo Hoon Park, Kwanghee Ahn, Eun Mi Im, Eunji Oh, Iseop Cho
Summary: This study aimed to investigate the association between the levels of various extracellular matrix (ECM)-related and serine protease proteins in amniotic fluid (AF) and spontaneous preterm birth (SPTB) and intra-amniotic inflammation/microbial invasion in women with preterm labor (PTL). The study included 252 women with singleton pregnancies who underwent amniocentesis. The levels of kallistatin, lumican, MMP-2, SPARC, TGFBI, and uPA in AF were measured. The results showed that altered levels of these proteins were significantly associated with the occurrence of SPTB and intra-amniotic inflammation/microbial invasion.
AMERICAN JOURNAL OF REPRODUCTIVE IMMUNOLOGY
(2023)
Article
Biology
Jeong-Won Sohn, Eun-Saem Choi, Chan-Wook Park, Kyung-Chul Moon, Joong-Shin Park, Jong-Kwan Jun
Summary: The study reveals that patients with PTL and preterm-PROM at lower gestational ages are more likely to have IAI, especially severe IAI, leading to a shorter latency to delivery.
Article
Immunology
Kyong-No Lee, Iseop Cho, Eun Mi Im, Eunji Oh, Kyo Hoon Park
Summary: This study found that IGFBP-1, Fas, kallistatin, and P-selectin are associated with acute HCA and microbial-associated HCA in women with PTL. Their combined use can significantly improve the diagnostic ability for the detection of microbial-associated HCA.
AMERICAN JOURNAL OF REPRODUCTIVE IMMUNOLOGY
(2023)
Article
Pediatrics
Noah H. Hillman, Matthew W. Kemp, Erin Fee, Judith Rittenschober-Boehm, Emily Royse, Leenah Abugisisa, Fabrizio Salomone, Gabrielle C. Musk, Alan H. Jobe
Summary: The addition of budesonide to surfactant in preterm lambs exposed to intra-amniotic LPS improved physiology and markers of lung and systemic inflammation, showing potential for decreasing lung inflammation in preterm infants with chorioamnionitis.
PEDIATRIC RESEARCH
(2021)
Article
Infectious Diseases
Piya Chaemsaithong, Waranyu Lertrut, Threebhorn Kamlungkuea, Pitak Santanirand, Arunee Singsaneh, Adithep Jaovisidha, Sasikarn Pakdeeto, Paninee Mongkolsuk, Pisut Pongchaikul
Summary: This case report demonstrates maternal septicemia and intra-amniotic infection caused by S. mitis which might be attributed to periodontitis in women presenting with preterm PROM. Oral cavity examination should be included in the prenatal care to ensure good dental hygiene.
BMC INFECTIOUS DISEASES
(2022)
Article
Medicine, General & Internal
Eunwook Joo, Kyo Hoon Park, Yu Mi Kim, Kwanghee Ahn, Subeen Hong
Summary: The study found that elevated levels of LBP in plasma and amniotic fluid were associated with increased risks of MIAC, IAI, and microbial-associated IAI. Elevated levels of PTX3 and resistin in amniotic fluid were independently associated with these risks as well, while decreased levels of IGFBP-3 in plasma were only associated with IAI.
JOURNAL OF KOREAN MEDICAL SCIENCE
(2021)
Article
Obstetrics & Gynecology
Ibrahim H. Polat, Silvia Marin, Jose Rios, Marta Larroya, Ana B. Sanchez-Garcia, Clara Murillo, Claudia Rueda, Marta Cascante, Eduard Gratacos, Teresa Cobo
Summary: The study found signs of microbial invasion of the amniotic cavity in the vaginal metabolome expression of women with preterm labor, which may lead to the development of noninvasive diagnostic tools.
AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY
(2021)
Article
Obstetrics & Gynecology
Hassendrini N. Peiris, Roberto Romero, Kanchan Vaswani, Sarah Reed, Nardhy Gomez-Lopez, Adi L. Tarca, Dereje W. Gudicha, Offer Erez, Eli Maymon, Murray D. Mitchell
Summary: The study found that amniotic fluid concentrations of prostaglandins were higher in patients with intra-amniotic infection, with PGE(2) and PGF(2 alpha) concentrations being greater in cases with infection compared to sterile intra-amniotic inflammation. Mass spectrometric analysis can differentiate between intra-amniotic infection and sterile intra-amniotic inflammation based on amniotic fluid concentrations of PGE(2) and PGF(2 alpha).
JOURNAL OF MATERNAL-FETAL & NEONATAL MEDICINE
(2021)
Article
Immunology
Kenichiro Motomura, Roberto Romero, Jose Galaz, Adi L. Tarca, Bogdan Done, Yi Xu, Yaozhu Leng, Valeria Garcia-Flores, Marcia Arenas-Hernandez, Kevin R. Theis, Meyer Gershater, Eunjung Jung, Chaur-Dong Hsu, Nardhy Gomez-Lopez
Summary: The study identified significant differences in immune responses to inflammation and infection in fetal tissues, shedding light on the immunobiology of preterm labor and birth.
INFECTION AND IMMUNITY
(2021)
Article
Obstetrics & Gynecology
Emma S. Ryan, Megan Varvoutis, Jeffrey A. Kuller, Sarah Dotters-Katz
Summary: Intra-amniotic infection (IAI) is a common condition with serious maternal and neonatal complications. There are numerous risk factors for IAI, some of which can be modified. Antibiotics are the main treatment option, but there is no consensus on the best antimicrobial agents and duration of therapy. Monitoring, proper treatment, and communication with the pediatric team are essential for preventing complications of IAI. More research is needed to determine optimal treatment regimens.
OBSTETRICAL & GYNECOLOGICAL SURVEY
(2021)
Article
Immunology
Nardhy Gomez-Lopez, Roberto Romero, Aneesha Varrey, Yaozhu Leng, Derek Miller, Bogdan Done, Yi Xu, Gaurav Bhatti, Kenichiro Motomura, Meyer Gershater, Roger Pique-Regi, Adi L. Tarca
Summary: The study found significant transcriptomic differences between amniotic fluid neutrophils and monocytes/macrophages in women with intra-amniotic infection, suggesting distinct roles for these cells. Transcriptome of fetal and maternal immune cells in the amniotic fluid varies, and immune cells from preterm deliveries exhibit enhanced transcriptional activity compared to those from term deliveries.
JOURNAL OF INNATE IMMUNITY
(2021)
Article
Obstetrics & Gynecology
Masazumi Ikeda, Yuko Oshima, Keisuke Tsumura, Kanako Gondo, Takeshi Ono, Yutaka Kozuma, Yukiko Nakura, Itaru Yanagihara, Makoto Nomiyama, Masatoshi Yokoyama
Summary: Intravenous administration of azithromycin significantly decreases IL-6 levels in the amniotic fluid of patients with preterm premature rupture of membranes (PPROM) and intra-amniotic infection. The efficacy of azithromycin in these patients needs to be further confirmed through randomized controlled studies.
JOURNAL OF MATERNAL-FETAL & NEONATAL MEDICINE
(2023)
Article
Obstetrics & Gynecology
Yohei Maki, Seishi Furukawa, Tetsuo Nakayama, Masanao Oohashi, Nozomi Shiiba, Ken Furuta, Shuuichi Tokunaga, Hiroshi Sameshima
Summary: The conventional clinical chorioamnionitis criteria have low sensitivity for predicting intra-amniotic infection in pregnant women with preterm labor and/or preterm prelabor rupture of membranes.
JOURNAL OF MATERNAL-FETAL & NEONATAL MEDICINE
(2022)
Article
Developmental Biology
Alexandra Berezowsky, Asaf Romano, Alyssa Hochberg, Eyal Krispin, Hadas Zafrir Danieli, Amir Krencel, Eran Hadar
Summary: This study investigated the correlation between histologically proven chorioamnionitis and placental bacteriologic infection in preterm births. The results showed a low correlation between histologic and bacteriologic placental findings, which could be due to the early stage of bacterial infection, hard-to-cultivate bacterial species, noninfectious conditions, or contamination of the placental surfaces during passage through the vaginal tract.
Editorial Material
Obstetrics & Gynecology
Piya Chaemsaithong, Roberto Romero, Waranyu Lertrut, Arunee Singsaneh, Pisut Pongchaikul
AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY
(2023)
Article
Obstetrics & Gynecology
Dahiana M. Gallo, Roberto Romero, Mariachiara Bosco, Tinnakorn Chaiworapongsa, Nardhy Gomez-Lopez, Marcia Arenas-Hernandez, Eunjung Jung, Manaphat Suksai, Francesca Gotsch, Offer Erez, Adi L. Tarca
Summary: The study found that pregnant women with severe PPH had higher median maternal plasma concentrations of IL-16, IL-6, IL-12/IL-23p40, MCP-1, and IL-1 beta than patients without PPH. These cytokines could serve as biomarkers or therapeutic targets.
JOURNAL OF PERINATAL MEDICINE
(2023)
Article
Obstetrics & Gynecology
Maria Teresa Gervasi, Roberto Romero, Elisa Cainelli, Paola Veronese, Maria Rosa Tran, Eunjung Jung, Manaphat Suksai, Mariachiara Bosco, Francesca Gotsch
Summary: This study suggests that asymptomatic intra-amniotic inflammation in the mid-trimester of pregnancy can increase the risk of neurodevelopmental disorders in children. Early recognition and treatment of maternal immune activation may be a strategy for preventing such disorders in offspring.
JOURNAL OF PERINATAL MEDICINE
(2023)
Article
Obstetrics & Gynecology
Nandor Gabor Than, Roberto Romero, Daniel Gyorffy, Mate Posta, Gaurav Bhatti, Bogdan Done, Piya Chaemsaithong, Eunjung Jung, Manaphat Suksai, Francesca Gotsch, Dahiana M. Gallo, Mariachiara Bosco, Bomi Kim, Yeon Mee Kim, Tinnakorn Chaiworapongsa, Simona W. Rossi, Andras Szilagyi, Offer Erez, Adi L. Tarca, Zoltan Papp
Summary: This study identified different molecular subclasses of preeclampsia through longitudinal proteomic profiling, laying the foundation for the development of new diagnostic and personalized tools for prevention.
JOURNAL OF PERINATAL MEDICINE
(2023)
Article
Obstetrics & Gynecology
Tinnakorn Chaiworapongsa, Roberto Romero, Francesca Gotsch, Manaphat Suksai, Dahiana M. Gallo, Eunjung Jung, Arthur Krieger, Piya Chaemsaithong, Offer Erez, Adi L. Tarca
Summary: This study aimed to determine the prevalence, characteristics, and clinical significance of angiogenic/antiangiogenic factor abnormalities in women with preeclampsia stratified according to gestational age at delivery. The results showed that patients with early preeclampsia had an abnormal angiogenic profile in virtually all cases, whereas only 50% of women with preeclampsia at term had such abnormalities. These findings have implications for future clinical care and research.
AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY
(2023)
Letter
Obstetrics & Gynecology
Bo Hyun Yoon, Roberto Romero, Kyung Joon Oh, Hyeon Ji Kim, Eunjung Jung, Francesca Gotsch
AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY
(2023)
Article
Obstetrics & Gynecology
Roberto Romero
AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY
(2023)
Article
Obstetrics & Gynecology
Tomi Kanninen, Eunjung Jung, Dahiana M. Gallo, Ramiro Diaz-Primera, Roberto Romero, Francesca Gotsch, Manaphat Suksai, Mariachiara Bosco, Tinnakorn Chaiworapongsa
Summary: Preeclampsia and fetal growth disorders are pregnancy-specific conditions that share common pathophysiological mechanisms. This study suggests that the severity of the maternal inflammatory response is highest in patients with preeclampsia, while patients with an SGA fetus also show elevated inflammatory response.
JOURNAL OF MATERNAL-FETAL & NEONATAL MEDICINE
(2023)
Review
Obstetrics & Gynecology
Agustin Conde-Agudelo, Roberto Romero
Summary: This review examines the efficacy of vaginal progesterone (VP) in preventing preterm birth (PTB) in different subsets of high-risk women. The evidence suggests that VP is effective in reducing the risk of PTB and improving perinatal outcomes in certain groups, such as singleton gestations with a short cervix. However, further research is needed to determine its efficacy in other high-risk groups.
JOURNAL OF PERINATAL MEDICINE
(2023)
Review
Obstetrics & Gynecology
Dahiana M. Gallo, Roberto Romero, Mariachiara Bosco, Francesca Gotsch, Sunil Jaiman, Eunjung Jung, Manaphat Suksai, Carlos Lopez Ramon y Cajal, Bo Hyun Yoon, Tinnakorn Chaiworapongsa
Summary: Green-stained amniotic fluid, also known as meconium-stained amniotic fluid, is a common obstetric hazard. It can be caused by the passage of fetal colonic content or intraamniotic bleeding. Birth with green-stained amniotic fluid is associated with fetal acidemia and potential complications like respiratory distress and seizures. Infection/inflammation inside the amniotic fluid plays a role in the development of meconium-stained amniotic fluid and can lead to clinical chorioamnionitis and neonatal sepsis.
AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY
(2023)
Review
Obstetrics & Gynecology
Agustin Conde-Agudelo, Roberto Romero, Anoop Rehal, Maria L. Brizot, Vicente Serra, Eduardo Da Fonseca, Elcin Cetingoz, Argyro Syngelaki, Alfredo Perales, Sonia S. Hassan, Kypros H. Nicolaides
Summary: This study evaluated the efficacy of vaginal progesterone for preventing preterm birth and adverse perinatal outcomes in twin pregnancies. The results showed that vaginal progesterone did not prevent preterm birth or improve perinatal outcomes in unselected twin pregnancies. However, it appeared to reduce the risk of preterm birth and neonatal morbidity and mortality in twin pregnancies with a sonographic short cervix.
AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY
(2023)
Review
Microbiology
Jonathan J. Panzer, Roberto Romero, Jonathan M. Greenberg, Andrew D. Winters, Jose Galaz, Nardhy Gomez-Lopez, Kevin R. Theis
Summary: The existence of a microbiota in the human placenta is still debated. Recent DNA sequencing investigations reported the presence of a microbiota in typical human term placentas, but it could be background DNA or contamination. Re-analysis of publicly available 16S rRNA gene datasets showed that Lactobacillus, a vaginal bacterium, was highly abundant in placentas but disappeared after applying DNA contaminant removal. Furthermore, bacterial profiles of placental samples clustered primarily by study origin and mode of delivery, suggesting that placentas delivered at term are unlikely to be the original source of observed bacterial DNA signals.
Letter
Obstetrics & Gynecology
Piya Chaemsaithong, Piroon Jenjaroenpun, Pisut Pongchaikul, Arunee Singsaneh, Iyarit Thaipisuttikul, Roberto Romero, Thidathip Wongsurawat
AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY
(2023)
Article
Obstetrics & Gynecology
Priya Prasad, Roberto Romero, Tinnakorn Chaiworapongsa, Nardhy Gomez-Lopez, Anderson Lo, Jose Galaz, Andreea B. B. Taran, Eunjung Jung, Francesca Gotsch, Nandor Gabor Than, Adi L. L. Tarca
Summary: Approximately 47% of women with preterm labor deliver at term, but their infants are at higher risk for being small for gestational age and having neurodevelopmental disorders. This study tested the involvement of components of the insulin-like growth factor system in preterm labor and found higher levels of certain components in women with a history of preterm labor.
FETAL DIAGNOSIS AND THERAPY
(2023)
Article
Medicine, Research & Experimental
Nardhy Gomez-Lopez, Roberto Romero, Maria Fernanda Escobar, Javier Andres Carvajal, Maria Paula Echavarria, Ludwig L. Albornoz, Daniela Nasner, Derek Miller, Dahiana M. Gallo, Jose Galaz, Marcia Arenas-Hernandez, Gaurav Bhatti, Bogdan Done, Maria Andrea Zambrano, Isabella Ramos, Paula Andrea Fernandez, Leandro Posada, Tinnakorn Chaiworapongsa, Eunjung Jung, Valeria Garcia-Flores, Manaphat Suksai, Francesca Gotsch, Mariachiara Bosco, Nandor Gabor Than, Adi L. Tarca
Summary: In this study, the plasma proteome of pregnant and non-pregnant COVID-19 patients and controls was characterized. The findings revealed shared and pregnancy-specific proteomic changes in COVID-19 patients compared to controls, and the plasma proteome accurately identifies COVID-19 patients, even when they are asymptomatic. This study provides insight into the pathogenesis of COVID-19 and explains the more severe outcomes observed in pregnant women.
COMMUNICATIONS MEDICINE
(2023)