Journal
JOURNAL OF PEPTIDE SCIENCE
Volume 16, Issue 1, Pages 1-5Publisher
WILEY
DOI: 10.1002/psc.1197
Keywords
amidation reactions; bioconjugation; chemoselectivity; 'sulfo-click'; thio acids/sulfonyl azides
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The 'sulfo-click' reaction, which is a chemoselective amidation reaction involving the reaction of an aminoethane sulfonyl azide with a thio acid, encompasses a new approach for ligation and conjugation. Detailed protocols are provided for decorating biologically active peptides or dendrimers with biophysical tags, fluorescent probes, metal chelators, and small peptides by using this reaction as a novel, metal-free 'sulfo-click' approach. Copyright (C) 2009 European Peptide Society and John Wiley & Sons, Ltd.
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