Article
Gastroenterology & Hepatology
Caecilie Crawley, Nadia Savino, Cecilie Halby, Stine Dydensborg Sander, Anne-Marie Nybo Andersen, Manimozhiyan Arumugam, Joseph Murray, Robin Christensen, Steffen Husby
Summary: This study investigated whether gluten induces gastrointestinal symptoms and mental health symptoms in adolescents. The results showed that compared with placebo, adding gluten to the diet did not induce gastrointestinal symptoms or worsened mental health.
ALIMENTARY PHARMACOLOGY & THERAPEUTICS
(2022)
Article
Gastroenterology & Hepatology
Keerthivasan Seetharaman, Sadhna Bhasin Lal, Kaushal Kishor Prasad, Yashwant Kumar, Alka Bhatia, Sunita Malhotra
Summary: This study compared different modalities for assessing adherence to a gluten-free diet (GFD) and predicting persistent mucosal damage in children with celiac disease (CD). The study found that none of the existing methods accurately predicted persistent mucosal damage, but the detection of gluten immunogenic peptide (GIP) in feces may be sensitive in identifying individual dietary transgressions.
DIGESTIVE DISEASES AND SCIENCES
(2023)
Article
Nutrition & Dietetics
Stephanie M. Moleski, Apeksha Shah, Philip Durney, Michael Matthews, Gagan Kaushal, Colin Smith, Katelyn C. Koons, Emily Rubin, Patrick Casey, Robin Miller, Cynthia Miller, Mahreema Jawairia, Ahmed Hasan, Anthony J. DiMarino
Summary: The study found that there was no significant difference in symptom severity within the NCGS group whether they received placebo or gluten. Patients with NCGS were more adherent to the GFD based on stool and urine GIP results, and had increased symptom severity at baseline compared with healthy controls. Neither group had significantly increased symptoms after ingestion of gluten.
Article
Obstetrics & Gynecology
Connie D. Cao, Molly A. Amero, Katrina A. Marcinkowski, Norman G. Rosenblum, Joanna S. Y. Chan, Scott D. Richard
Summary: The study describes the clinical characteristics of transmasculine individuals undergoing hysterectomy, including demographics, insurance status, mental health conditions, and surgical pathology findings such as cervical abnormalities, endometrial or cervical atrophy, and ovarian cysts. It highlights the importance of considering these factors when providing care for this unique patient population.
OBSTETRICS AND GYNECOLOGY
(2021)
Article
Rheumatology
Miriam Almirall, Francesc Casellas, Joan Dot, Ines de Torres, Hegoi Segurola, Sara Marsal
Summary: The prevalence of non-coeliac gluten sensitivity (NCGS) in fibromyalgia patients is low, and a gluten-free diet (GFD) can improve their intestinal symptoms. However, not all patients meet the diagnostic criteria, and diarrhea, intraepithelial lymphocytosis, and lower levels of anxiety are associated with diet response.
Article
Nutrition & Dietetics
Roberta Mandile, Mariantonia Maglio, Caterina Mosca, Antonella Marano, Valentina Discepolo, Riccardo Troncone, Renata Auricchio
Summary: Considerable heterogeneity exists in the recovery of intestinal mucosa in celiac patients on a gluten-free diet. This study investigated histological and immunohistochemical features in celiac patients on a long-term gluten-free diet and their correlation with diet duration. The results showed that a gluten-free diet can restore a normal villous to crypt ratio and reduce inflammation, but some characteristics of the disorder still persist in the epithelial cells regardless of the duration of the diet.
Article
Nutrition & Dietetics
Valentina Ponzo, Ilario Ferrocino, Ilaria Goitre, Marianna Pellegrini, Mauro Bruno, Marco Astegiano, Gianni Cadario, Eleonora Castellana, Fabio Bioletto, Maria Rita Corvaglia, Patrizia Malfa, Luca Cocolin, Ezio Ghigo, Simona Bo
Summary: By conducting a double-blind placebo-controlled gluten challenge test, this study found that almost half of individuals suspected of gluten sensitivity reported symptoms even with the placebo. These individuals showed lower mental health scores, increased risk for eating disorders, and a different gut microbiota composition compared to placebo-responsive participants.
Article
Health Care Sciences & Services
Aurelio Seidita, Pasquale Mansueto, Stella Compagnoni, Daniele Castellucci, Maurizio Soresi, Giorgio Chiarello, Giorgia Cavallo, Gabriele De Carlo, Alessia Nigro, Marta Chiavetta, Francesca Mandreucci, Alessandra Giuliano, Rosaria Disclafani, Antonio Carroccio
Summary: This study assessed the frequency, severity, morphologic features, and pathogenic factors of anemia in patients with Celiac Disease (CD) and found that iron deficiency anemia (IDA) is common, especially in women. The study also showed that some women with CD continue to have IDA despite following a strict gluten-free diet, and low body mass index and menstrual abnormalities might contribute to the persistence of anemia.
JOURNAL OF PERSONALIZED MEDICINE
(2022)
Article
Pathology
Ozlem Kulak, Bhaskar Gurram, Elizabeth A. Montgomery, Jason Y. Park
Summary: Autoimmune gastritis is a rare condition in children, with most patients being female and often having extragastric immune disorders. Histologic features of autoimmune gastritis in pediatric patients include enterochromaffin-like cell hyperplasia, atrophy, and chronic injury in gastric body mucosa.
Article
Nutrition & Dietetics
Noe Ontiveros, Raul Emilio Real-Delor, Jose Antonio Mora-Melgem, Carlos Eduardo Beltran-Cardenas, Oscar Gerardo Figueroa-Salcido, Marcela de Jesus Vergara-Jimenez, Feliznando Isidro Cardenas-Torres, Lilian Karem Flores-Mendoza, Jesus Gilberto Aramburo-Galvez, Francisco Cabrera-Chavez
Summary: The study found that a significant number of Paraguayan adults suffer from gluten-related disorders, with a higher prevalence among women than men. Most individuals adhering to a gluten-free diet do so based on recommendations from healthcare professionals.
Article
Nutrition & Dietetics
Sylvie Tagliati, Simona Barni, Mattia Giovannini, Giulia Liccioli, Lucrezia Sarti, Tatiana Alicandro, Erika Paladini, Giancarlo Perferi, Chiara Azzari, Elio Novembre, Francesca Mori
Summary: Nut allergies are increasingly common in Italian children, with hazelnuts and walnuts being common allergens. Clinical manifestations include anaphylaxis and gastrointestinal symptoms, with a majority of patients having a family history of allergy or concomitant allergic disorders.
Article
Food Science & Technology
Maria Purificacion Gonzalez, Catalina Ballestero-Fernandez, Violeta Fajardo, Maria Achon, Angela Garcia-Gonzalez, Elena Alonso-Aperte, Natalia Ubeda
Summary: The study assessed the contribution of GFP to the diets of children and adolescents with CD, finding that GFP accounted for a high percentage of total energy, carbohydrates, fiber, and salt intake, but a lower percentage of fat, sugar, and protein intake. It is important to reduce fat, saturated fat, and salt intake, and increase fiber content in processed GFP.
Review
Gastroenterology & Hepatology
Frances Onyimba, Sheila E. Crowe, Sarah Johnson, John Leung
Summary: This article provides an overview of food allergy, including classification, evaluation, and management, key differentiating features from other adverse food reactions, roles and limitations of various food allergy testing, and promising areas of emerging research. Case studies are used to highlight important clinical points in diagnosing and managing food-related diseases.
CLINICAL GASTROENTEROLOGY AND HEPATOLOGY
(2021)
Article
Clinical Neurology
Shailee Shah, Rocio Vazquez Do Campo, Neeraj Kumar, Andrew McKeon, Eoin P. Flanagan, Christopher Klein, Sean J. Pittock, Divyanshu Dubey
Summary: This study retrospectively reviewed the clinical, radiologic, and serologic features of 32 patients with paraneoplastic myeloneuropathy, finding common symptoms including asymmetric paresthesias, neuropathic pain, subacute onset, sensory ataxia, bladder dysfunction, and unintentional weight loss.
Article
Multidisciplinary Sciences
Wei Zhou, Shoulin Li, Hao Wang, Guanglun Zhou, Jianguo Wen
Summary: This study aimed to explore the value of ultrasound in the preoperative diagnosis of NPT in children. The results showed that ultrasound had a high consistency rate when compared with surgical exploration and pathological results, especially in identifying EAT and IAT with normal testicular morphology.
SCIENTIFIC REPORTS
(2022)
Article
Gastroenterology & Hepatology
Fernanda Cristofori, Mariaelena Tripaldi, Giusi Lorusso, Flavia Indrio, Vincenzo Rutigliano, Domenico Piscitelli, Stefania Castellaneta, Vincenzo Bentivoglio, Ruggiero Francavilla
Summary: A study on children with celiac disease on a strict gluten-free diet found a higher prevalence of functional abdominal pain disorders, particularly irritable bowel syndrome and functional constipation, compared to controls. Younger age and higher levels of anti-transglutaminase IgA at diagnosis were associated with these disorders.
CLINICAL GASTROENTEROLOGY AND HEPATOLOGY
(2021)
Article
Nutrition & Dietetics
Maurizio Delvecchio, Francesca Bizzoco, Rosa Lapolla, Antonia Gentile, Cinzia Carrozza, Michele Barone, Simonetta Simonetti, Paola Giordano, Vanessa Nadia Dargenio, Fernanda Cristofori, Ruggiero Francavilla
Summary: The study found that iodine absorption in children with celiac disease is impaired compared to the general population, and while it slightly increases during the gluten-free diet, the increase is not significant. Regular reinforcement of the need for proper iodine intake in celiac disease patients is necessary to reduce the risk of iodine deficiency.
Review
Gastroenterology & Hepatology
Giulia Concas, Michele Barone, Ruggiero Francavilla, Fernanda Cristofori, Vanessa Nadia Dargenio, Rossella Giorgio, Costantino Dargenio, Vassilios Fanos, Maria Antonietta Marcialis
Summary: This review provides a practical reference for physicians dealing with patients with chronic gastrointestinal diseases during the COVID-19 pandemic. It summarizes the origin and pathogenetic mechanism of SARS-CoV-2, clinical manifestations of GI involvement, recent guidelines for GI procedures, and special conditions such as faecal-oral transmission and gut microbiota.
DIGESTIVE DISEASES AND SCIENCES
(2022)
Article
Nutrition & Dietetics
Margherita Caroli, Andrea Vania, Maria Carmen Verga, Giuseppe Di Mauro, Marcello Bergamini, Barbara Cuomo, Rosaria D'Anna, Giuseppe D'Antonio, Iride Dello Iacono, Angelica Dessi, Mattia Doria, Vassilios Fanos, Michele Fiore, Ruggiero Francavilla, Simonetta Genovesi, Marco Giussani, Antonella Gritti, Dario Iafusco, Lucia Leonardi, Vito Leonardo Miniello, Emanuele Miraglia Del Giudice, Filomena Palma, Francesco Pastore, Immacolata Scotese, Giovanni Simeone, Marco Squicciarini, Giovanna Tezza, Ersilia Troiano, Giuseppina Rosa Umano
Summary: Adequate and balanced nutrition is crucial for child growth and health. The introduction of complementary feeding (CF) is a controversial process influenced by socio-cultural choices and family traditions. Italian medical associations have developed evidence-based recommendations for CF to guide developed countries in selecting the appropriate timing and methods, as well as understanding the link between CF and the development of non-communicable diseases.
Article
Biochemistry & Molecular Biology
Cristina Piras, Michele Mussap, Antonio Noto, Andrea De Giacomo, Fernanda Cristofori, Martina Spada, Vassilios Fanos, Luigi Atzori, Ruggiero Francavilla
Summary: Metabolomics-based studies suggest that autistic subjects may have metabolic abnormalities and alterations in gut microbiota and gut mucosal permeability. This study aimed to explore the relevant metabolic perturbations in autistic children and investigate the relationship between increased intestinal permeability and specific metabolic changes.
Review
Microbiology
V. N. Dargenio, F. Cristofori, C. Dargenio, P. Giordano, F. Indrio, G. Celano, R. Francavilla
Summary: This study reviewed the evidence on Limosilactobacillus reuteri DSM 17938 (LR DSM 17938), which secretes reuterin and other substances to inhibit pathogen growth and restore intestinal homeostasis. LR DSM 17938 has been shown to have beneficial effects in functional gastrointestinal disorders and in the treatment of acute diarrhea, acute gastroenteritis, and Helicobacter pylori infection. The correct dosage, frequency of administration, and therapy duration need to be further investigated.
BENEFICIAL MICROBES
(2022)
Review
Nutrition & Dietetics
Michele Barone, Andrea Iannone, Fernanda Cristofori, Vanessa Nadia Dargenio, Flavia Indrio, Elvira Verduci, Alfredo Di Leo, Ruggiero Francavilla
Summary: Most celiac patients have a normal BMI at presentation, and a gluten-free diet does not increase the risk of overweight or obesity, especially in children.
Review
Nutrition & Dietetics
Elisabetta Di Profio, Vittoria Carlotta Magenes, Giulia Fiore, Marta Agostinelli, Alice La Mendola, Miriam Acunzo, Ruggiero Francavilla, Flavia Indrio, Alessandra Bosetti, Enza D'Auria, Elisa Borghi, Gianvincenzo Zuccotti, Elvira Verduci
Summary: The gut microbiota, influenced by multiple factors, plays a crucial role in the development of infants and children. Breastfeeding, complementary feeding, and dietary patterns during infancy and toddlerhood are important for the proper development of the gut microbiota. Dysbiosis can have long-lasting effects, leading to an increased risk of non-communicable diseases, weakened immune system, and alterations in the gut-brain axis. Children with specific diseases require special formulas and diets to exclude certain foods or nutrients. This review aims to examine the impact of special formulas and diets on the gut microbiota and their potential health implications in children.
Article
Nutrition & Dietetics
Angelo Antignani, Ruggiero Francavilla, Andrea Vania, Lucia Leonardi, Cristina Di Mauro, Giovanna Tezza, Fernanda Cristofori, Vanessa Nadia Dargenio, Immacolata Scotese, Filomena Palma, Margherita Caroli
Summary: Adequate complementary feeding practices are crucial for child health, but there are concerns about the nutritional composition of commercial baby foods (CBFs) available in the Italian market. Issues include inappropriate recommended timeframes, high levels of fats and sugars, unnecessary salt content, and inappropriate texture for infant development.
Article
Gastroenterology & Hepatology
Francesco Valitutti, Maureen M. Leonard, Victoria Kenyon, Monica Montuori, Pasqua Piemontese, Ruggiero Francavilla, Basilio Malamisura, Lorenzo Norsa, Angela Calvi, Maria Elena Lionetti, Mariella Baldassarre, Chiara Maria Trovato, Michela Perrone, Tiziana Passaro, Naire Sansotta, Marco Crocco, Annalisa Morelli, Lidia Celeste Raguseo, Federica Malerba, Luca Elli, Fernanda Cristofori, Carlo Catassi, Alessio Fasano, CD-GEMM Team
Summary: The purpose of this study was to identify potential serum biomarkers predicting the onset of celiac disease (CD) in at-risk children. The results showed that 73.6% of the children had an increase in anti-deamidated gliadin peptides (DGPs) IgG levels before their first seroconversion of anti-tissue transglutaminase (anti-tTG) IgA antibodies, indicating that anti-DGPs IgG may serve as an early preclinical biomarker predicting CD onset in children.
AMERICAN JOURNAL OF GASTROENTEROLOGY
(2023)
Review
Nutrition & Dietetics
Flavia Indrio, Vanessa Nadia Dargenio, Ruggiero Francavilla, Hania Szajewska, Yvan Vandenplas
Summary: About 25% of infants experience prolonged crying or colic during the first three months of life, and there is limited understanding of its long-term consequences. Literature suggests an association between infant colic and the development of gastrointestinal disorders, headaches, and behavioral problems later in life. However, the current evidence is based on correlations, and a causal relationship has not been established.
Review
Nutrition & Dietetics
Flavia Indrio, Pedro Gutierrez Castrellon, Yvan Vandenplas, Ener Cagri Dinleyici, Ruggiero Francavilla, Massimo Pettoello Mantovani, Assunta Grillo, Isadora Beghetti, Luigi Corvaglia, Arianna Aceti
Summary: Through a systematic review and network meta-analysis, it was found that infant formula supplemented with probiotics or synbiotics may have certain effects on reducing colic, fever days, and antibiotic use in healthy infants and 36-month-old toddlers. However, there is considerable heterogeneity which reduces the certainty of these effects, and no significant effects were observed on weight, height, and changes in fecal bacteria proportions.
Article
Multidisciplinary Sciences
Maureen Leonard, Victoria Kenyon, Francesco Valitutti, Rita Pennacchio-Harrington, Pasqua Piemontese, Ruggiero Francavilla, Lorenzo Norsa, Tiziana Passaro, Marco Crocco, Mariella Baldassarre, Chiara Maria Trovato, Alessio Fasano
Summary: The CDGEMM study is an international birth cohort study focusing on children at-risk of developing celiac disease (CD) and utilizing a multi-omic approach to predict CD onset. Participants are required to have a first-degree family member with biopsy diagnosed CD and be enrolled before solid food introduction. Longitudinal collection of blood, stool samples, and questionnaires related to participant, family, and environment has been ongoing since 2014. With a total of 554 participants and an average age of 56.4 months, the study has identified microbial strains, pathways, and metabolites associated with CD development. Ongoing analysis includes expanding metagenomic and metabolomic analyses, evaluating environmental risk factors, and investigating the role of microbiome and metabolites in CD development.
Review
Nutrition & Dietetics
Vito Leonardo Miniello, Andrea Miniello, Laura Ficele, Aleksandra Skublewska-D'Elia, Vanessa Nadia Dargenio, Fernanda Cristofori, Ruggiero Francavilla
Summary: The human gastrointestinal tract houses a complex and dynamic community of microorganisms, known as the gut microbiota, which interact with the host organism through molecular communication to maintain a symbiotic relationship. The balance and diversity of the gut microbiota are essential for the host's immune and metabolic homeostasis and protection against pathogens. Dysregulation of the microbiota composition, called dysbiosis, has been linked to the development of various diseases. Dietary manipulation of the gut microbiota using biomodulators such as prebiotics, probiotics, symbionts, and postbiotics has emerged as a promising strategy to restore and maintain a healthy microbiota. Recent advancements in the production of infant formulas have included the addition of prebiotics, probiotics, and postbiotics to create formulas that closely resemble the nutritional and biological composition of human milk.
Review
Nutrition & Dietetics
Vanessa Nadia Dargenio, Costantino Dargenio, Stefania Castellaneta, Andrea De Giacomo, Marianna Laguardia, Federico Schettini, Ruggiero Francavilla, Fernanda Cristofori
Summary: Autism spectrum disorder (ASD) is a complex neurodevelopmental disorder characterized by impairment in communication, social interactions, and skills. Dysbiosis of gut microbiota plays a key role in the pathogenesis of ASD, influencing central nervous system development and homeostasis. Although probiotics have shown promise in modulating the microbiota and improving symptoms in ASD, concrete evidence is still lacking due to study heterogeneity.
Article
Pediatrics
Tarun Aurora, Audrey Cole, Parul Rai, Paul Lavoie, Carrie Mcivor, Lisa M. Klesges, Guolian Kang, Janaka S. S. Liyanage, Heather M. Brandt, Jane S. Hankins
Summary: This study evaluated the effectiveness of a vaccine strategy bundle in increasing HPV vaccine initiation and completion rates in a specialty clinic setting. By implementing the bundle, which included staff education, provider incentives, offering vaccines in clinics, and verifying vaccine completion, the clinic successfully improved HPV vaccine initiation and completion rates among sickle cell disease patients.
JOURNAL OF PEDIATRICS
(2024)
Article
Pediatrics
Nienke M. Halbmeijer, Wes Onland, Jeroen Dudink, Filip Cools, Anne Debeer, Anton H. van Kaam, Manon J. N. L. Benders, Niek E. van der Aa
Summary: In ventilated infants born preterm, high dose systemic hydrocortisone initiated between 7 and 14 days after birth did not have a significant impact on brain development.
JOURNAL OF PEDIATRICS
(2024)
Article
Pediatrics
Katherine Melton, Jianfang Liu, Hossein Sadeghi, Maureen George, Arlene Smaldone
Summary: This study aims to identify predictors of change in lung function and body weight during health care transition in cystic fibrosis (CF) patients. The study findings highlight the importance of CF RISE program engagement and reducing gaps in care for improving the transition of adolescents and young adults with CF.
JOURNAL OF PEDIATRICS
(2024)
Article
Pediatrics
Laura A. Duckworth, Kimberly A. Sutton, Nurmohammad Shaikh, Jinli Wang, Carla Hall-Moore, Lori R. Holtz, Phillip I. Tarr, Ronald C. Rubenstein
Summary: The study tested the usefulness of various biomarkers as indicators of gut dysfunction in cystic fibrosis (CF) and investigated the repeatability of these measures in individuals over short periods and their correlation with clinical outcomes. The results showed that elevated levels of fLcn2 in individuals with CF may predict worsened pulmonary function.
JOURNAL OF PEDIATRICS
(2024)
Article
Pediatrics
Lindsey Haack, Nikkan Das, Arvind Hoskoppal, Mark Debrunner, Tarek Alsaied, Gaurav Arora
Summary: RAE on ECG has a low positive predictive value for RAE on echocardiogram in previously healthy young patients. The highest yield for RAE on echocardiogram was observed in patients who were <1 year of age, had RAE in the anterior precordial leads, or displayed right ventricular hypertrophy on ECG.
JOURNAL OF PEDIATRICS
(2024)
Article
Pediatrics
Michael A. Padula, Khatija Naing, Tara L. Wenger, Irfan Ahmad, Carl H. Coghill, K. Taylor Wild, S. Alex Rottgers, Cory M. Resnick, Jeffrey Goldstein, Zarmina Ehsan, Donna Watkins, Nicole Deptula, Kuan-Chi Lai, Janet Lioy, Semsa Gogcu, Christopher M. Cielo
Summary: This study describes the spectrum of disease and burden of care in infants with congenital micrognathia. The results show that these infants commonly require surgical intervention and tube feedings, and disparities based on race and among centers were identified.
JOURNAL OF PEDIATRICS
(2024)
Article
Pediatrics
Michael P. Fundora, Manvitha Kalicheti, Guantao Zhao, Kevin O. Maher, Nicoleta Serban
Summary: This study investigated the variation of outpatient opioid prescribing in postoperative pediatric cardiac patients across the US. The results showed that there were significant differences in opioid prescribing by race, ethnicity, sex, and region.
JOURNAL OF PEDIATRICS
(2024)
Article
Pediatrics
Jia Guo, Brooklyn J. Fraser, Leigh Blizzard, Michael D. Schmidt, Terence Dwyer, Alison J. Venn, Costan G. Magnussen
Summary: There is a correlation between childhood and adulthood cardiorespiratory fitness.
JOURNAL OF PEDIATRICS
(2024)
Article
Pediatrics
Nianzhou Xiao, Michelle Starr, Adrienne Stolfi, Gilad Hamdani, Shireen Hashmat, Stefan G. Kiessling, Christina Sethna, Mahmoud Kallash, Robyn Matloff, Robert Woroniecki, Keia Sanderson, Ikuyo Yamaguchi, Stephen D. Cha, Michael G. Semanik, Rahul Chanchlani, Joseph T. Flynn, Mark Mitsnefes
Summary: This multicenter study reports that most infants diagnosed with idiopathic hypertension in the NICU will discontinue antihypertensive treatment within 2 years of discharge. Antenatal steroid treatment is associated with a decreased likelihood of needing antihypertensive therapy for more than 1 year.
JOURNAL OF PEDIATRICS
(2024)
Editorial Material
Pediatrics
Kanwaljit Singh, John Concato, Jonathan M. Davis
JOURNAL OF PEDIATRICS
(2024)
Article
Pediatrics
Yaxing Meng, Harri Niinikoski, Suvi P. Rovio, Brooklyn J. Fraser, Feitong Wu, Antti Jula, Tapani Ronnemaa, Jorma S. A. Viikari, Olli T. Raitakari, Katja Pahkala, Costan G. Magnussen
Summary: This 26-year study shows a correlation between early-life non-HDL-C levels and future levels. Early dietary counseling can reduce the risk of high pediatric non-HDL-C, emphasizing the importance of early interventions in preventing cardiovascular risks.
JOURNAL OF PEDIATRICS
(2024)
Article
Pediatrics
Kelsey A. B. Gastineau, Rebecca Bell, Allison Hanes, Sandra Mckay, Eric Sigel, Filoteia Popescu, Evan C. Sommer, Shari Barkin
Summary: This study aimed to assess the self-reported counseling outcomes for a firearm safe storage counseling training program provided by the American Academy of Pediatrics. The results demonstrated significant improvement in counseling self-efficacy and frequency one month after the training.
JOURNAL OF PEDIATRICS
(2024)
Article
Pediatrics
Kathryn E. K. Berlin, William Scott, Sara Dawson, David Brousseau, Joanne M. Lagatta
Summary: This prospective cohort study aimed to investigate the impact of bronchopulmonary dysplasia (BPD) on the health-related quality of life (HRQL) of infants from NICU hospitalization to one year post-discharge. The study found that lower HRQL during NICU stay was associated with earlier gestational age, postnatal corticosteroid usage, outborn status, and gastrostomy tube placement. Lower HRQL at 3 and 12 months post-discharge was associated with readmissions, home oxygen use, parent-reported difficulty breathing, lower developmental scores, and not playing with other children. Most parents reported similar or improved HRQL after discharge, but parents of infants with respiratory symptoms experienced less improvement. Efforts to improve parent HRQL should focus on respiratory symptoms and social isolation.
JOURNAL OF PEDIATRICS
(2024)
Article
Pediatrics
Garett J. Griffith, Alan P. Wang, Robert I. Liem, Michael R. Carr, Tyler Corson, Kendra Ward
Summary: This study developed reference values for cardiorespiratory fitness in children aged 6-18 years without underlying heart disease, measured by peak oxygen uptake and treadmill time. Fitness levels increased with age in males but not females. Males generally exhibited higher fitness levels compared to females in the same age groups.
JOURNAL OF PEDIATRICS
(2024)
Article
Pediatrics
David S. Liu, Patricia Miller, Anna Rothenberg, Carley Vuillermin, Peter M. Waters, Andrea S. Bauer
Summary: This study aims to determine if children with elbow flexion contracture (EFC) caused by brachial plexus birth injury (BPBI) are more likely to develop shoulder contracture and undergo surgical treatment. A retrospective review was conducted on children under 2 years old with BPBI who presented to a single children's hospital. The results showed that patients with EFC had reduced shoulder range of motion and higher odds of shoulder contracture and surgical treatment. Prompt referral to a BPBI specialty clinic is recommended for evaluation and potential surgery.
JOURNAL OF PEDIATRICS
(2024)
