4.6 Article

Candidate Gene Analysis: Severe Intraventricular Hemorrhage in Inborn Preterm Neonates

Journal

JOURNAL OF PEDIATRICS
Volume 163, Issue 5, Pages 1503-+

Publisher

MOSBY-ELSEVIER
DOI: 10.1016/j.jpeds.2013.06.025

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Funding

  1. National Institutes of Health [NS053865, R01 DA016750-09]

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Intraventricular hemorrhage (IVH) is a disorder of complex etiology. We analyzed genotypes for 7 genes from 224 inborn preterm neonates treated with antenatal steroids and grade 3-4 IVH and 389 matched controls. Only methylenetetrahydrofolate reductase was more prevalent in cases of IVH, emphasizing the need for more comprehensive genetic strategies.

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