Review
Medicine, General & Internal
Pierre Quartier
Summary: Children with early onset juvenile idiopathic arthritis, especially with positive antinuclear antibodies, may develop chronic anterior uveitis, which requires regular slit lamp examination and prompt treatment. Therapy options range from local steroid treatment to systemic immunomodulatory therapy, tailored to individual patient needs, with involvement of expert ophthalmologists and pediatricians. Treatment should not be easily interrupted and may need to be intensified in certain cases for optimal disease control.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Pediatrics
Mikhail M. Kostik, Ekaterina V. Gaidar, Lubov S. Sorokina, Ilya S. Avrusin, Tatiana N. Nikitina, Eugenia A. Isupova, Irina A. Chikova, Yuri Yu. Korin, Elizaveta D. Orlova, Ludmila S. Snegireva, Vera V. Masalova, Margarita F. Dubko, Olga V. Kalashnikova, Vyacheslav G. Chasnyk
Summary: The presence of uveitis is a risk factor for JIA flare, while methotrexate can reduce the cumulative flare probability.
FRONTIERS IN PEDIATRICS
(2022)
Article
Ophthalmology
Sanna Leinonen
Summary: This perspective aimed to explore the screening of uveitis in Nordic children with JIA, summarizing the predictors and recommendations for JIA-uveitis screening. Younger age, positive antinuclear antibody titre, specific subtypes of JIA, and shorter duration of JIA are predictors of uveitis in JIA. Methotrexate and monoclonal TNF inhibitor treatment can reduce the risk of JIA-uveitis. Guidelines for screening intervals and length were prepared based on known risk factors and the Nordic population.
ACTA OPHTHALMOLOGICA
(2023)
Review
Medicine, General & Internal
William D. Renton, Jennifer Jung, Alan G. Palestine
Summary: The study evaluated the effectiveness and safety of tumor necrosis factor (TNF) inhibitors for the treatment of juvenile idiopathic arthritis associated uveitis (JIA-U) with 134 participants. The findings suggest that adalimumab appears to increase the likelihood of treatment success and decrease the likelihood of treatment failure when compared with placebo, while the evidence on etanercept is less conclusive. Further research is needed.
COCHRANE DATABASE OF SYSTEMATIC REVIEWS
(2022)
Article
Ophthalmology
Francesca Tirelli, Maria Elisabetta Zannin, Fabio Vittadello, Jacopo Agnolucci, Monica Mazzarolo, Francesco Zulian
Summary: The study evaluated the long-term efficacy of MTX monotherapy in patients with JIA-U and found that although effective in the early stages, MTX showed poor disease control in the long term, with many patients eventually needing biologic agents for treatment.
OCULAR IMMUNOLOGY AND INFLAMMATION
(2022)
Article
Rheumatology
Joeri W. van Straalen, Goerkem Akay, Carlyn Kouwenberg, Sytze de Roock, Viera Kalinina Ayuso, Nico M. Wulffraat, Joke de Boer, Joost F. Swart
Summary: This study investigated the effect of methotrexate (MTX) therapy on new-onset uveitis in patients with biological-naive juvenile idiopathic arthritis (JIA). The results showed that MTX was associated with a significantly reduced new-onset uveitis rate in patients with JIA. Clinicians should consider early initiation of MTX in high-risk patients and increase ophthalmologic screening after MTX discontinuation.
Review
Pediatrics
Emil Carlsson, Michael W. Beresford, Athimalaipet Ramanan, Andrew D. Dick, Christian M. Hedrich
Summary: Early treatment and frequent screening are crucial for controlling JIA-associated uveitis, which poses a significant risk for serious complications. The identification of specific risk factors for JIA-associated uveitis is a key focus of research as our understanding of pathogenic drivers is still incomplete. Genomic, transcriptomic, and proteomic factors have been identified as potential risk factors, and therapeutic strategies are being discussed.
Article
Ophthalmology
Justine R. Smith, Janet M. Matthews, Diana Conrad, Anthony J. Hall, Rachael L. Niederer, Davinder Singh-Grewal, Mei-Ling Tay-Kearney, Jane M. Wells, Sophia L. Zagora, Peter J. McCluskey
Summary: The Australian and New Zealand-based uveitis-specialized ophthalmologists have developed 18 consensus statements for managing chronic anterior uveitis in children with JIA, providing regionally applicable advice for ophthalmic care.
CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY
(2021)
Article
Ophthalmology
Po-Yi Wu, Eugene Yu-Chuan Kang, Wei-Dar Chen, Wei-Yu Chiang, Cheng-Hsiu Wu, Chao-Yi Wu, Kuan-Jen Chen, Wei-Chi Wu, Hung-Da Chou, An-Ning Chao, Yih-Shiou Hwang
Summary: The aim of this study was to assess the epidemiology, treatment, and outcomes of juvenile idiopathic arthritis-associated uveitis in Taiwan. Among 722 JIA patients, 44 (6.1%) had uveitis. The mean ages of JIA and JIA-U diagnosis were 10.7 and 11.1 years, respectively. Male predominance and late age at JIA-U diagnosis were observed in Taiwan. Reactivation occurred in 25% of patients with inactivity lasting >= 6 months within 2 years.
OCULAR IMMUNOLOGY AND INFLAMMATION
(2023)
Article
Ophthalmology
Achille Marino, Luca Marelli, Paolo Nucci, Roberto Caporali, Elisabetta Miserocchi
Summary: This study aimed to evaluate the efficacy and safety of subcutaneous tocilizumab in JIA patients with refractory uveitis. The results showed that SC-TCZ significantly reduced the rate of uveitis flare and achieved complete treatment response in some patients. Moreover, SC-TCZ was well-tolerated without any observed side effects.
OCULAR IMMUNOLOGY AND INFLAMMATION
(2023)
Article
Rheumatology
Grainne M. Murray, Ethan S. Sen, Athimalaipet Ramanan
Summary: Treatment for juvenile idiopathic arthritis has evolved significantly in recent years, with the availability of new therapies, development of treatment strategies, and establishment of research networks. While most patients have benefited from these advancements, certain subgroups still face poor outcomes. Future research aims to identify these patients early, personalize their care, and minimize long-term damage.
LANCET RHEUMATOLOGY
(2021)
Review
Immunology
Arash Maleki, Priya D. D. Patel, C. Steven Foster
Summary: Juvenile idiopathic arthritis (JIA) is the most common chronic rheumatologic disease in children, with uveitis being the most common extra-articular manifestation. This review covers the epidemiology, risk factors, clinical presentation, laboratory tests, treatment options, and complications of JIA and JIA-associated uveitis. The discussion also includes the course of the disease, functional outcome, and quality of life for patients with JIA and JIA-associated uveitis.
EXPERT REVIEW OF CLINICAL IMMUNOLOGY
(2023)
Article
Immunology
Jie Zheng, Yong Wang, Jun Hu
Summary: This study explores the shared gene signatures and potential molecular mechanisms of polyarticular juvenile idiopathic arthritis (pJIA) and autoimmune uveitis (AU) through data analysis and functional enrichment analysis. Neutrophil degranulation may be considered a shared pathogenic mechanism, and the roles of ARID1A gene and hsa-miR-146a are worthy of further study. Additionally, periodic inspection of kidney function is also important.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Pediatrics
Sara Della Paolera, Serena Pastore, Alen Zabotti, Alberto Tommasini, Andrea Taddio
Summary: The role of musculoskeletal ultrasound in diagnosing tenosynovitis in JIA patients is proven to be practical. More than half of the patients with ankle swelling were found to have tenosynovitis, with about 50% of them not showing sonographic signs of active joint synovitis. Biological therapy alone or in combination with DMARDs has shown effectiveness in inducing remission in tenosynovitis patients.
Review
Rheumatology
Claas H. Hinze, Dirk Foell, Christoph Kessel
Summary: Systemic juvenile idiopathic arthritis (sJIA) is a disease characterized by severe systemic inflammation and arthritis. It poses challenges to rheumatologists treating pediatric and adult patients worldwide. Although treatment plans exist for classic sJIA, there is still a lack of clear treatment approaches for early sJIA without arthritis and complicated sJIA.
NATURE REVIEWS RHEUMATOLOGY
(2023)
Article
Allergy
Maria Angela Tosca, Angela Pistorio, Michela Silvestri, Gian Luigi Marseglia, Giorgio Ciprandi
Summary: The study showed that asthma control is not associated with age in children and adolescents but adolescents with asthma had a higher prevalence of rhinitis and allergy compared to children. This indicates the progressive nature of allergic phenotype in young patients.
Article
Rheumatology
Marta Mazzoni, Angela Pistorio, Francesca Magnaguagno, Stefania Viola, Alessia Urru, Gian Michele Magnano, Angelo Ravelli, Clara Malattia
Summary: The study found that many JIA patients still have subclinical synovitis and bone marrow edema on MRI despite being in clinical remission. These subclinical inflammations may indicate the risk of disease flare and joint deterioration, which could have important implications for the management of the disease.
ARTHRITIS CARE & RESEARCH
(2023)
Article
Rheumatology
Ivan Foeldvari, Jens Klotsche, Bernd Hinrichs, Nicola Helmus, Ozgur Kasapcopur, Amra Adrovic, Flavio Sztajnbok, Maria Teresa Terreri, Jordi Anton, Vanessa Smith, Maria Katsicas, Mikhail Kostik, Natalia Vasquez-Canizares, Tadej Avcin, Brian Feldman, Mahesh Janarthanan, Maria Jose Santos, Sujata Sawhney, Dieneke Schonenberg-Meinema, Walter-Alberto Sifuentes-Giraldo, Ekaterina Alexeeva, Simone Appenzeller, Cristina Battagliotti, Lillemor Berntson, Blanca Bica, Patricia Costa-Reis, Despina Eleftheriou, Tilmann Kallinich, Thomas Lehman, Edoardo Marrani, Kirsten Minden, Susan Nielsen, Farzana Nuruzzaman, Anjali Patwardhan, Raju Khubchandani, Valda Stanevicha, Yosef Uziel, Kathryn S. Torok
Summary: This study utilized data from an international juvenile SSc cohort to evaluate the effectiveness of pulmonary screening with FVC and DLco in detecting ILD compared to HRCT. The results showed that the performance of PFTs, especially FVC, was limited in detecting ILD in juvenile SSc patients, missing around 60% of children with ILD changes on HRCT. DLco had higher sensitivity but lower specificity than FVC in detecting potential abnormalities on HRCT. These findings support the use of HRCT in tandem with PFTs for ILD screening in juvenile SSc.
ARTHRITIS CARE & RESEARCH
(2022)
Article
Rheumatology
Clara Malattia, Lorenzo Chiarella, Miriam Sansone, Angela Pistorio, Claudio Lavarello, Manuela Carpaneto, Raffaele Ferri, Angelo Ravelli, Lino Nobili
Summary: This study investigates sleep quality in juvenile fibromyalgia syndrome (JFS) and its impact on the global burden of the disease. The results show that patients with JFS have longer sleep period time, increased wake after sleep onset, and lower N3 distribution index compared to healthy peers. Subjective poor sleep quality is related to widespread pain, symptom severity, depressive symptoms, fatigue, and symptom severity upon awakening. Sleep complaints are a key characteristic of JFS and have significant effects on pain and depression.
JOURNAL OF RHEUMATOLOGY
(2023)
Review
Medicine, General & Internal
Roberta Naddei, Ana Rebollo-Gimenez, Marco Burrone, Valentina Natoli, Silvia Rosina, Alessandro Consolaro, Angelo Ravelli
Summary: Juvenile psoriatic arthritis (JPsA) is a controversial subset of juvenile idiopathic arthritis (JIA), accounting for 1-7% of cases. There has been debate about whether JPsA should be classified as a distinct category within JIA. Studies have shown that children with JPsA can be divided into two subgroups based on their clinical features and genetic determinants. The ongoing discussion has prompted the revision of the current classification of JPsA.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Genetics & Heredity
Gianluca D'Onofrio, Andrea Accogli, Mariasavina Severino, Haluk Caliskan, Tomislav Kokotovic, Antonela Blazekovic, Kristina Gotovac Jercic, Silvana Markovic, Tamara Zigman, Krnjak Goran, Nina Barisic, Vlasta Duranovic, Ana Ban, Fran Borovecki, Danijela Petkovic Ramadza, Ivo Baric, Walid Fazeli, Peter Herkenrath, Carla Marini, Roberta Vittorini, Vykuntaraju Gowda, Arjan Bouman, Clarissa Rocca, Issam Azmi Alkhawaja, Bibi Nazia Murtaza, Malik Mujaddad Ur Rehman, Chadi Al Alam, Gisele Nader, Maria Margherita Mancardi, Thea Giacomini, Siddharth Srivastava, Javeria Raza Alvi, Hoda Tomoum, Sara Matricardi, Michele Iacomino, Antonella Riva, Marcello Scala, Francesca Madia, Angela Pistorio, Vincenzo Salpietro, Carlo Minetti, Jean-Baptiste Riviere, Myriam Srour, Stephanie Efthymiou, Reza Maroofian, Henry Houlden, Sonja Catherine Vernes, Federico Zara, Pasquale Striano, Vanja Nagy
Summary: The CNTNAP2 gene encodes CASPR2, a presynaptic type 1 transmembrane protein, involved in cell-cell adhesion and synaptic interactions. Biallelic CNTNAP2 loss has been associated with Pitt-Hopkins-like syndrome-1, while the pathogenic role of heterozygous variants remains controversial. In this study, 22 novel patients with CNTNAP2 variants were identified, and a genotype-phenotype correlation was characterized. The presence of biallelic variants was significantly associated with global developmental delay, epilepsy, hyporeflexia, autism spectrum disorder, language impairment, and severe cognitive impairment.
Article
Rheumatology
Hanna Kim, Didem Saygin, Christian Douglas, Jesse Wilkerson, Brian Erman, Angela Pistorio, John A. McGrath, Ann M. Reed, Chester Oddis, Claudia Bracaglia, Annet van Royen-Kerkhof, Blanca Bica, Pavla Dolezalova, Virginia P. L. Ferriani, Berit Flato, Ana G. Bernard-Medina, Troels Herlin, Frederick W. Miller, Jiri Vencovsky, Nicolino Ruperto, Rohit Aggarwal, Lisa G. Rider
Summary: The 2016 ACR-EULAR response criteria for JDM is a composite measure with six core set measures to calculate a total improvement score. This study evaluated the contribution of each measure, representation of muscle-related and patient-reported measures, and frequency of measure worsening across improvement categories. The results support the consistent performance of the ACR-EULAR MRC across multiple studies and its further use as an efficacy endpoint in JDM trials.
Article
Endocrinology & Metabolism
A. La Valle, G. d'Annunzio, C. Campanello, G. Tantari, A. Pistorio, F. Napoli, G. Patti, M. Crocco, M. Bassi, N. Minuto, G. Piccolo, M. Maghnie
Summary: This study aimed to analyze and correlate fasting insulin-resistance markers with OGTT results in overweight/obese children and adolescents. The results showed that a 1-hour glucose level > 155 mg/dl and insulin sum > 535 microU/ml were the best predictors of diabetes risk in obese youths.
JOURNAL OF ENDOCRINOLOGICAL INVESTIGATION
(2023)
Review
Pediatrics
Adele Civino, Federico Diomeda, Luca Giordano, Maria Beatrice Damasio, Sandra Perrone, Romina Gallizzi, Angelo Ravelli, Prisco Piscitelli, Maria Cristina Maggio
Summary: Intra- and juxta-articular osteoid osteomas are rare and can mimic inflammatory monoarthritis. The diagnostic delay can be long, and misdiagnosis is common, especially in unusual sites. Knowledge of the atypical presentations and pitfalls is crucial for accurate diagnosis.
Article
Rheumatology
Bita Shakoory, Ashley Geerlinks, Marta Wilejto, Kate Kernan, Melissa Hines, Micol Romano, David Piskin, Angelo Ravelli, Rashmi Sinha, Daniel Aletaha, Carl Allen, Hamid Bassiri, Edward M. Behrens, Joseph Carcillo, Linda Carl, Winn Chatham, Jeffrey Cohen, Randy Q. Cron, Erik Drewniak, Alexei A. Grom, Lauren A. Henderson, Annacarin Horne, Michael B. Jordan, Kim E. Nichols, Grant Schulert, Sebastiaan Vastert, Erkan Demirkaya, Raphaela Goldbach-Mansky, Fabrizio de Benedetti, Rebecca A. Marsh, Scott W. Canna, HLH MAS Task Force
Summary: Haemophagocytic lymphohistiocytosis (HLH) and macrophage activation syndrome (MAS) are life-threatening hyperinflammatory syndromes that can develop in many inflammatory conditions. Early identification and management are crucial to prevent organ failure and mortality. This effort aimed to provide evidence-based guidance to assist clinicians in optimizing decision-making in the early stages of HLH/MAS.
ANNALS OF THE RHEUMATIC DISEASES
(2023)
Article
Rheumatology
Bita Shakoory, Ashley Geerlinks, Marta Wilejto, Kate Kernan, Melissa Hines, Micol Romano, David Piskin, Angelo Ravelli, Rashmi Sinha, Daniel Aletaha, Carl Allen, Hamid Bassiri, Edward M. Behrens, Joseph Carcillo, Linda Carl, Winn Chatham, Jeffrey I. Cohen, Randy Q. Cron, Erik Drewniak, Alexei A. Grom, Lauren A. Henderson, Annacarin Horne, Michael B. Jordan, Kim E. Nichols, Grant Schulert, Sebastiaan Vastert, Erkan Demirkaya, Raphaela Goldbach-Mansky, Fabrizio de Benedetti, Rebecca A. Marsh, Scott W. Canna
Summary: This study aims to provide evidence-based and consensus-based guidance for clinicians in the early diagnosis, treatment, and monitoring of HLH/MAS. Through research, questionnaires, and expert opinions, 6 overarching statements and 24 specific points to consider were developed, covering various aspects including early recognition, diagnosis, treatment, and monitoring. The involvement of multidisciplinary expertise is crucial for timely intervention and management.
ARTHRITIS & RHEUMATOLOGY
(2023)
Article
Endocrinology & Metabolism
Daniela Fava, Fabio Morandi, Ignazia Prigione, Alessia Angelelli, Paola Bocca, Angela Pistorio, Stefano Volpi, Giuseppa Patti, Carlotta Pepino, Emilio Casalini, Anna Elsa Maria Allegri, Natascia Di Iorgi, Giuseppe d'Annunzio, Flavia Napoli, Mohamad Maghnie
Summary: This study aimed to characterize lymphocyte subpopulations in peripheral blood and evaluate proinflammatory cytokines/chemokines in ROHHAD(NET) patients compared to controls. The results showed that ROHHAD(NET) patients had significantly increased T lymphocytes, particularly CD4-T cells, and a lower number of activated CD8-T cells. Moreover, regulatory B cells and type-1 regulatory T cells were increased in patients. IL-8 levels and monocyte chemotactic protein-1 were also higher in patients, while soluble HLA-G was lower. These findings support the hypothesis of immune dysregulation in ROHHAD(NET) syndrome. Rating: 9/10
JOURNAL OF THE ENDOCRINE SOCIETY
(2023)
Article
Pediatrics
Michela C. Wong, Stefano Avanzini, Manuela Mosconi, Cinzia Mazzola, Serena Arrigo, Angela Pistorio, Girolamo Mattioli
Summary: Long and ultra-long forms of Hirschsprung's disease are associated with a longer duration of enterostomy and a higher risk of enterostomy-related complications.
MINERVA PEDIATRICS
(2023)
Article
Pediatrics
Tarun Aurora, Audrey Cole, Parul Rai, Paul Lavoie, Carrie Mcivor, Lisa M. Klesges, Guolian Kang, Janaka S. S. Liyanage, Heather M. Brandt, Jane S. Hankins
Summary: This study evaluated the effectiveness of a vaccine strategy bundle in increasing HPV vaccine initiation and completion rates in a specialty clinic setting. By implementing the bundle, which included staff education, provider incentives, offering vaccines in clinics, and verifying vaccine completion, the clinic successfully improved HPV vaccine initiation and completion rates among sickle cell disease patients.
JOURNAL OF PEDIATRICS
(2024)
Article
Pediatrics
Nienke M. Halbmeijer, Wes Onland, Jeroen Dudink, Filip Cools, Anne Debeer, Anton H. van Kaam, Manon J. N. L. Benders, Niek E. van der Aa
Summary: In ventilated infants born preterm, high dose systemic hydrocortisone initiated between 7 and 14 days after birth did not have a significant impact on brain development.
JOURNAL OF PEDIATRICS
(2024)
Article
Pediatrics
Katherine Melton, Jianfang Liu, Hossein Sadeghi, Maureen George, Arlene Smaldone
Summary: This study aims to identify predictors of change in lung function and body weight during health care transition in cystic fibrosis (CF) patients. The study findings highlight the importance of CF RISE program engagement and reducing gaps in care for improving the transition of adolescents and young adults with CF.
JOURNAL OF PEDIATRICS
(2024)
Article
Pediatrics
Laura A. Duckworth, Kimberly A. Sutton, Nurmohammad Shaikh, Jinli Wang, Carla Hall-Moore, Lori R. Holtz, Phillip I. Tarr, Ronald C. Rubenstein
Summary: The study tested the usefulness of various biomarkers as indicators of gut dysfunction in cystic fibrosis (CF) and investigated the repeatability of these measures in individuals over short periods and their correlation with clinical outcomes. The results showed that elevated levels of fLcn2 in individuals with CF may predict worsened pulmonary function.
JOURNAL OF PEDIATRICS
(2024)
Article
Pediatrics
Lindsey Haack, Nikkan Das, Arvind Hoskoppal, Mark Debrunner, Tarek Alsaied, Gaurav Arora
Summary: RAE on ECG has a low positive predictive value for RAE on echocardiogram in previously healthy young patients. The highest yield for RAE on echocardiogram was observed in patients who were <1 year of age, had RAE in the anterior precordial leads, or displayed right ventricular hypertrophy on ECG.
JOURNAL OF PEDIATRICS
(2024)
Article
Pediatrics
Michael A. Padula, Khatija Naing, Tara L. Wenger, Irfan Ahmad, Carl H. Coghill, K. Taylor Wild, S. Alex Rottgers, Cory M. Resnick, Jeffrey Goldstein, Zarmina Ehsan, Donna Watkins, Nicole Deptula, Kuan-Chi Lai, Janet Lioy, Semsa Gogcu, Christopher M. Cielo
Summary: This study describes the spectrum of disease and burden of care in infants with congenital micrognathia. The results show that these infants commonly require surgical intervention and tube feedings, and disparities based on race and among centers were identified.
JOURNAL OF PEDIATRICS
(2024)
Article
Pediatrics
Michael P. Fundora, Manvitha Kalicheti, Guantao Zhao, Kevin O. Maher, Nicoleta Serban
Summary: This study investigated the variation of outpatient opioid prescribing in postoperative pediatric cardiac patients across the US. The results showed that there were significant differences in opioid prescribing by race, ethnicity, sex, and region.
JOURNAL OF PEDIATRICS
(2024)
Article
Pediatrics
Jia Guo, Brooklyn J. Fraser, Leigh Blizzard, Michael D. Schmidt, Terence Dwyer, Alison J. Venn, Costan G. Magnussen
Summary: There is a correlation between childhood and adulthood cardiorespiratory fitness.
JOURNAL OF PEDIATRICS
(2024)
Article
Pediatrics
Nianzhou Xiao, Michelle Starr, Adrienne Stolfi, Gilad Hamdani, Shireen Hashmat, Stefan G. Kiessling, Christina Sethna, Mahmoud Kallash, Robyn Matloff, Robert Woroniecki, Keia Sanderson, Ikuyo Yamaguchi, Stephen D. Cha, Michael G. Semanik, Rahul Chanchlani, Joseph T. Flynn, Mark Mitsnefes
Summary: This multicenter study reports that most infants diagnosed with idiopathic hypertension in the NICU will discontinue antihypertensive treatment within 2 years of discharge. Antenatal steroid treatment is associated with a decreased likelihood of needing antihypertensive therapy for more than 1 year.
JOURNAL OF PEDIATRICS
(2024)
Editorial Material
Pediatrics
Kanwaljit Singh, John Concato, Jonathan M. Davis
JOURNAL OF PEDIATRICS
(2024)
Article
Pediatrics
Yaxing Meng, Harri Niinikoski, Suvi P. Rovio, Brooklyn J. Fraser, Feitong Wu, Antti Jula, Tapani Ronnemaa, Jorma S. A. Viikari, Olli T. Raitakari, Katja Pahkala, Costan G. Magnussen
Summary: This 26-year study shows a correlation between early-life non-HDL-C levels and future levels. Early dietary counseling can reduce the risk of high pediatric non-HDL-C, emphasizing the importance of early interventions in preventing cardiovascular risks.
JOURNAL OF PEDIATRICS
(2024)
Article
Pediatrics
Kelsey A. B. Gastineau, Rebecca Bell, Allison Hanes, Sandra Mckay, Eric Sigel, Filoteia Popescu, Evan C. Sommer, Shari Barkin
Summary: This study aimed to assess the self-reported counseling outcomes for a firearm safe storage counseling training program provided by the American Academy of Pediatrics. The results demonstrated significant improvement in counseling self-efficacy and frequency one month after the training.
JOURNAL OF PEDIATRICS
(2024)
Article
Pediatrics
Kathryn E. K. Berlin, William Scott, Sara Dawson, David Brousseau, Joanne M. Lagatta
Summary: This prospective cohort study aimed to investigate the impact of bronchopulmonary dysplasia (BPD) on the health-related quality of life (HRQL) of infants from NICU hospitalization to one year post-discharge. The study found that lower HRQL during NICU stay was associated with earlier gestational age, postnatal corticosteroid usage, outborn status, and gastrostomy tube placement. Lower HRQL at 3 and 12 months post-discharge was associated with readmissions, home oxygen use, parent-reported difficulty breathing, lower developmental scores, and not playing with other children. Most parents reported similar or improved HRQL after discharge, but parents of infants with respiratory symptoms experienced less improvement. Efforts to improve parent HRQL should focus on respiratory symptoms and social isolation.
JOURNAL OF PEDIATRICS
(2024)
Article
Pediatrics
Garett J. Griffith, Alan P. Wang, Robert I. Liem, Michael R. Carr, Tyler Corson, Kendra Ward
Summary: This study developed reference values for cardiorespiratory fitness in children aged 6-18 years without underlying heart disease, measured by peak oxygen uptake and treadmill time. Fitness levels increased with age in males but not females. Males generally exhibited higher fitness levels compared to females in the same age groups.
JOURNAL OF PEDIATRICS
(2024)
Article
Pediatrics
David S. Liu, Patricia Miller, Anna Rothenberg, Carley Vuillermin, Peter M. Waters, Andrea S. Bauer
Summary: This study aims to determine if children with elbow flexion contracture (EFC) caused by brachial plexus birth injury (BPBI) are more likely to develop shoulder contracture and undergo surgical treatment. A retrospective review was conducted on children under 2 years old with BPBI who presented to a single children's hospital. The results showed that patients with EFC had reduced shoulder range of motion and higher odds of shoulder contracture and surgical treatment. Prompt referral to a BPBI specialty clinic is recommended for evaluation and potential surgery.
JOURNAL OF PEDIATRICS
(2024)