Article
Microbiology
Shuang Qu, Yinghui Zheng, Yichun Huang, Yicheng Feng, Kunyao Xu, Wei Zhang, Yawen Wang, Kaili Nie, Meng Qin
Summary: Disorders in the gut microbiota can damage the intestinal barrier, leading to intestinal disease. In this study, we investigated the effect of excess colonization of Akkermansia muciniphila (A. muciniphila) on the intestinal barrier using a mouse model. The over-colonization of A. muciniphila resulted in decreased intestinal mucin content and reduced expression of tight junction proteins, ultimately damaging the intestinal barrier and exacerbating colitis and colorectal cancer development. These findings have important implications for the safety of A. muciniphila as a probiotic.
FRONTIERS IN MICROBIOLOGY
(2023)
Article
Pediatrics
Alexandra Adam-Darque, Lorena Freitas, Frederic Grouiller, Julien Sauser, Francois Lazeyras, Dimitri Van de Ville, Philippe Pollien, Clara L. Garcia-Rodenas, Gabriela Bergonzelli, Petra S. Hueppi, Russia Ha-Vinh Leuchter
Summary: The study investigates the neural mechanisms of infant colic by examining newborns' brain responses to sensory stimuli, finding that infants who develop colic exhibit distinct brain activation patterns compared to non-colicky infants. This early sensitivity to stimuli explains a significant portion of subsequent crying behavior. The findings have implications for understanding and potentially advising families with colicky infants.
PEDIATRIC RESEARCH
(2021)
Article
Microbiology
Xiaolong Zhang, Muhammad Akhtar, Yan Chen, Ziyu Ma, Yuyun Liang, Deshi Shi, Ranran Cheng, Lei Cui, Yafang Hu, Abdallah A. Nafady, Abdur Rahman Ansari, El-Sayed M. Abdel-Kafy, Huazhen Liu
Summary: This study found that jejunal microbiota can affect chicken growth performance by alleviating intestinal inflammation. Gram-positive bacteria were predominant in high body weight chickens, while Gram-negative bacteria were abundant in low body weight chickens. Low body weight chickens had higher levels of serum lipopolysaccharide and upregulated expression of inflammatory cytokines in the jejunum.
Article
Immunology
Linglian Kong, Zhenhua Wang, Chuanpi Xiao, Qidong Zhu, Zhigang Song
Summary: The study demonstrated that appropriate doses of glycerol monolaurate (GML) enhanced growth performance and immunity, improved intestinal morphology and barrier function in broiler chicks, and modulated the composition of cecal microbiota.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Cell Biology
Qian Ji, Shengqiao Fu, Hao Zuo, Yumeng Huang, Liangmei Chu, Yanyan Zhu, Jing Hu, Yuting Wu, Shuangwei Chen, Yue Wang, Yongfei Ren, Xi Pu, Na Liu, Rongkun Li, Xu Wang, Chunhua Dai
Summary: Lipid peroxidation-induced ferroptosis is a newly recognized type of programmed cell death. In this study, it was found that irradiation increased the expression of ferroptosis promotive genes and decreased the expression of ferroptosis suppressive genes in murine intestine tissues. Further experiments showed that ACSL4 is an important component for ferroptosis execution and its expression was upregulated in irradiated intestine tissues. Additionally, the ACSL4 inhibitor troglitazone was able to suppress lipid peroxidation and protect against tissue damage after irradiation.
CELL DEATH DISCOVERY
(2022)
Article
Biochemistry & Molecular Biology
Xiaobin Wen, Fan Wan, You Wu, Lei Liu, Yueping Liu, Ruqing Zhong, Liang Chen, Hongfu Zhang
Summary: During weaning, piglets are susceptible to intestinal injuries caused by infections. Caffeic acid (CA) shows potential as a dietary supplement for enhancing intestinal health, but limited information is available regarding its benefits for piglets. A 28-day study was conducted to examine the effectiveness of CA supplementation in protecting against intestinal injury induced by LPS injection in piglets.
Article
Pharmacology & Pharmacy
Lea Gnatzy, George Ismailos, Maria Vertzoni, Christos Reppas
Summary: Intestinal dysbiosis refers to changes in the intestinal microbiota that are associated with the development and worsening of diseases in humans. This review briefly presents the clinical effects of drug-induced intestinal dysbiosis and critically reviews methodologies for managing it based on clinical data. A pharmacokinetically-based approach is proposed for mitigating the impact of antimicrobial therapy on intestinal dysbiosis, but further optimization and confirmation of effectiveness to the general population are needed.
EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES
(2023)
Review
Oncology
Wenjie Zhang, Jie Zhang, Tian Liu, Juan Xing, Huan Zhang, Daorong Wang, Dong Tang
Summary: The interaction between intestinal microbiota and antibiotics plays a key role in the treatment of colorectal cancer, enhancing the treatment outcomes. However, the use of antibiotics may affect the effectiveness of the treatment, so caution should be exercised.
JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Fan Deng, Ze-Bin Lin, Qi-Shun Sun, Yue Min, Yue Zhang, Yu Chen, Wen-Ting Chen, Jing-Juan Hu, Ke-Xuan Liu
Summary: Intestinal ischemia/reperfusion (I/R) is a common pathological process in severely ill patients, and the impact of intestinal I/R injury on the overall systemic state of the patient is greater than that of primary intestinal injury. Recent evidence suggests that intestinal microbiota and its metabolites play a crucial role in the occurrence, development, diagnosis, and treatment of intestinal I/R injury. Targeting the intestinal microbiota and its metabolites may be an effective therapy for treating intestinal I/R injury and associated extraintestinal organ injuries.
INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES
(2022)
Article
Nutrition & Dietetics
Ting Zheng, Haining Hao, Qiqi Liu, Jiankun Li, Yukun Yao, Yisuo Liu, Tai Zhang, Zhe Zhang, Huaxi Yi
Summary: Akkermansia muciniphila-derived extracellular vesicles (Akk EVs) have the potential to regulate immune responses, protect intestinal barriers, and modulate the gut microbiota, showing promise in preventing and alleviating inflammatory bowel disease.
Article
Food Science & Technology
Wanzhong Liao, Huafeng Wu, Liangcheng Pang, Bizuan He, Jianjun Tong, Jiuyun Qin, Liang Li, Wei Liu, Xianqiang Zhou, Sihua Huang, Weizhe Jiang, Shujie Fu
Summary: The Hylocereus undatus flower (HUF) has significant anti-inflammatory and immunomodulatory activity. It alleviates colitis by restoring the integrity of the intestinal barrier, reducing the inflammatory response, and regulating gut and lung microbiota.
JOURNAL OF FUNCTIONAL FOODS
(2023)
Article
Agriculture, Multidisciplinary
Xingtao Zhou, Duoduo Zhang, Wucheng Qi, Tao Hong, Tao Xiong, Tingqin Wu, Fang Geng, Mingyong Xie, Shaoping Nie
Summary: EPS116 promotes intestinal epithelial regeneration by increasing the number of intestinal stem cells and modulating the gut microbiota profile, thereby maintaining intestinal barrier and homeostasis.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2021)
Article
Microbiology
Chengrui Zhang, Tingyi Hou, Qingyuan Yu, Jihong Wang, Miao Ni, Yunfei Zi, Hangshu Xin, Yonggen Zhang, Yukun Sun
Summary: The study demonstrates that dietary supplementation with Clostridium butyricum significantly increases the expression of the Claudin-4 gene in the jejunal mucosa of goats and has a regulatory effect on the gut microbiota, thereby improving the intestinal epithelial barrier.
FRONTIERS IN MICROBIOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Mengfan Luo, Qiaoyue Yuan, Mingzhen Liu, Xingye Song, Yingjie Xu, Tao Zhang, Xiaoqun Zeng, Zhen Wu, Daodong Pan, Yuxing Guo
Summary: This study aimed to develop a novel astaxanthin nanoparticle using gum arabic (GA) and whey protein powder enriched with milk fat globule membranes (MFGM-WPI) as carriers and investigated its effect and alleviation mechanism on colitis in mice. Results showed that MFGM-GA-astaxanthin effectively improved bioaccessibility of astaxanthin, reduced oxidative stress, alleviated colitis symptoms, repaired intestinal barrier function, and restored abnormalities of gut flora. This study provides a promising therapeutic approach for colon diseases using astaxanthin nanoparticles.
Article
Biochemistry & Molecular Biology
Mengfan Luo, Qiaoyue Yuan, Mingzhen Liu, Xingye Song, Yingjie Xu, Tao Zhang, Xiaoqun Zeng, Zhen Wu, Daodong Pan, Yuxing Guo
Summary: This study aimed to develop a novel astaxanthin nanoparticle using gum arabic and whey protein powder enriched with milk fat globule membranes as carriers, and investigate its effect and alleviation mechanism on colitis in mice. The study demonstrated that the nanoparticle could improve astaxanthin bioaccessibility and cope with oxidative stress more effectively. In vivo studies showed that the nanoparticle alleviated colitis symptoms, repaired intestinal barrier function, and restored the abnormalities of flora caused by dextran sulfate sodium. This study provides a basis for the therapeutic effect of astaxanthin nanoparticles on colon diseases.
Article
Pediatrics
Tarun Aurora, Audrey Cole, Parul Rai, Paul Lavoie, Carrie Mcivor, Lisa M. Klesges, Guolian Kang, Janaka S. S. Liyanage, Heather M. Brandt, Jane S. Hankins
Summary: This study evaluated the effectiveness of a vaccine strategy bundle in increasing HPV vaccine initiation and completion rates in a specialty clinic setting. By implementing the bundle, which included staff education, provider incentives, offering vaccines in clinics, and verifying vaccine completion, the clinic successfully improved HPV vaccine initiation and completion rates among sickle cell disease patients.
JOURNAL OF PEDIATRICS
(2024)
Article
Pediatrics
Nienke M. Halbmeijer, Wes Onland, Jeroen Dudink, Filip Cools, Anne Debeer, Anton H. van Kaam, Manon J. N. L. Benders, Niek E. van der Aa
Summary: In ventilated infants born preterm, high dose systemic hydrocortisone initiated between 7 and 14 days after birth did not have a significant impact on brain development.
JOURNAL OF PEDIATRICS
(2024)
Article
Pediatrics
Katherine Melton, Jianfang Liu, Hossein Sadeghi, Maureen George, Arlene Smaldone
Summary: This study aims to identify predictors of change in lung function and body weight during health care transition in cystic fibrosis (CF) patients. The study findings highlight the importance of CF RISE program engagement and reducing gaps in care for improving the transition of adolescents and young adults with CF.
JOURNAL OF PEDIATRICS
(2024)
Article
Pediatrics
Laura A. Duckworth, Kimberly A. Sutton, Nurmohammad Shaikh, Jinli Wang, Carla Hall-Moore, Lori R. Holtz, Phillip I. Tarr, Ronald C. Rubenstein
Summary: The study tested the usefulness of various biomarkers as indicators of gut dysfunction in cystic fibrosis (CF) and investigated the repeatability of these measures in individuals over short periods and their correlation with clinical outcomes. The results showed that elevated levels of fLcn2 in individuals with CF may predict worsened pulmonary function.
JOURNAL OF PEDIATRICS
(2024)
Article
Pediatrics
Lindsey Haack, Nikkan Das, Arvind Hoskoppal, Mark Debrunner, Tarek Alsaied, Gaurav Arora
Summary: RAE on ECG has a low positive predictive value for RAE on echocardiogram in previously healthy young patients. The highest yield for RAE on echocardiogram was observed in patients who were <1 year of age, had RAE in the anterior precordial leads, or displayed right ventricular hypertrophy on ECG.
JOURNAL OF PEDIATRICS
(2024)
Article
Pediatrics
Michael A. Padula, Khatija Naing, Tara L. Wenger, Irfan Ahmad, Carl H. Coghill, K. Taylor Wild, S. Alex Rottgers, Cory M. Resnick, Jeffrey Goldstein, Zarmina Ehsan, Donna Watkins, Nicole Deptula, Kuan-Chi Lai, Janet Lioy, Semsa Gogcu, Christopher M. Cielo
Summary: This study describes the spectrum of disease and burden of care in infants with congenital micrognathia. The results show that these infants commonly require surgical intervention and tube feedings, and disparities based on race and among centers were identified.
JOURNAL OF PEDIATRICS
(2024)
Article
Pediatrics
Michael P. Fundora, Manvitha Kalicheti, Guantao Zhao, Kevin O. Maher, Nicoleta Serban
Summary: This study investigated the variation of outpatient opioid prescribing in postoperative pediatric cardiac patients across the US. The results showed that there were significant differences in opioid prescribing by race, ethnicity, sex, and region.
JOURNAL OF PEDIATRICS
(2024)
Article
Pediatrics
Jia Guo, Brooklyn J. Fraser, Leigh Blizzard, Michael D. Schmidt, Terence Dwyer, Alison J. Venn, Costan G. Magnussen
Summary: There is a correlation between childhood and adulthood cardiorespiratory fitness.
JOURNAL OF PEDIATRICS
(2024)
Article
Pediatrics
Nianzhou Xiao, Michelle Starr, Adrienne Stolfi, Gilad Hamdani, Shireen Hashmat, Stefan G. Kiessling, Christina Sethna, Mahmoud Kallash, Robyn Matloff, Robert Woroniecki, Keia Sanderson, Ikuyo Yamaguchi, Stephen D. Cha, Michael G. Semanik, Rahul Chanchlani, Joseph T. Flynn, Mark Mitsnefes
Summary: This multicenter study reports that most infants diagnosed with idiopathic hypertension in the NICU will discontinue antihypertensive treatment within 2 years of discharge. Antenatal steroid treatment is associated with a decreased likelihood of needing antihypertensive therapy for more than 1 year.
JOURNAL OF PEDIATRICS
(2024)
Editorial Material
Pediatrics
Kanwaljit Singh, John Concato, Jonathan M. Davis
JOURNAL OF PEDIATRICS
(2024)
Article
Pediatrics
Yaxing Meng, Harri Niinikoski, Suvi P. Rovio, Brooklyn J. Fraser, Feitong Wu, Antti Jula, Tapani Ronnemaa, Jorma S. A. Viikari, Olli T. Raitakari, Katja Pahkala, Costan G. Magnussen
Summary: This 26-year study shows a correlation between early-life non-HDL-C levels and future levels. Early dietary counseling can reduce the risk of high pediatric non-HDL-C, emphasizing the importance of early interventions in preventing cardiovascular risks.
JOURNAL OF PEDIATRICS
(2024)
Article
Pediatrics
Kelsey A. B. Gastineau, Rebecca Bell, Allison Hanes, Sandra Mckay, Eric Sigel, Filoteia Popescu, Evan C. Sommer, Shari Barkin
Summary: This study aimed to assess the self-reported counseling outcomes for a firearm safe storage counseling training program provided by the American Academy of Pediatrics. The results demonstrated significant improvement in counseling self-efficacy and frequency one month after the training.
JOURNAL OF PEDIATRICS
(2024)
Article
Pediatrics
Kathryn E. K. Berlin, William Scott, Sara Dawson, David Brousseau, Joanne M. Lagatta
Summary: This prospective cohort study aimed to investigate the impact of bronchopulmonary dysplasia (BPD) on the health-related quality of life (HRQL) of infants from NICU hospitalization to one year post-discharge. The study found that lower HRQL during NICU stay was associated with earlier gestational age, postnatal corticosteroid usage, outborn status, and gastrostomy tube placement. Lower HRQL at 3 and 12 months post-discharge was associated with readmissions, home oxygen use, parent-reported difficulty breathing, lower developmental scores, and not playing with other children. Most parents reported similar or improved HRQL after discharge, but parents of infants with respiratory symptoms experienced less improvement. Efforts to improve parent HRQL should focus on respiratory symptoms and social isolation.
JOURNAL OF PEDIATRICS
(2024)
Article
Pediatrics
Garett J. Griffith, Alan P. Wang, Robert I. Liem, Michael R. Carr, Tyler Corson, Kendra Ward
Summary: This study developed reference values for cardiorespiratory fitness in children aged 6-18 years without underlying heart disease, measured by peak oxygen uptake and treadmill time. Fitness levels increased with age in males but not females. Males generally exhibited higher fitness levels compared to females in the same age groups.
JOURNAL OF PEDIATRICS
(2024)
Article
Pediatrics
David S. Liu, Patricia Miller, Anna Rothenberg, Carley Vuillermin, Peter M. Waters, Andrea S. Bauer
Summary: This study aims to determine if children with elbow flexion contracture (EFC) caused by brachial plexus birth injury (BPBI) are more likely to develop shoulder contracture and undergo surgical treatment. A retrospective review was conducted on children under 2 years old with BPBI who presented to a single children's hospital. The results showed that patients with EFC had reduced shoulder range of motion and higher odds of shoulder contracture and surgical treatment. Prompt referral to a BPBI specialty clinic is recommended for evaluation and potential surgery.
JOURNAL OF PEDIATRICS
(2024)