Journal
JOURNAL OF PEDIATRICS
Volume 162, Issue 5, Pages 918-U63Publisher
MOSBY-ELSEVIER
DOI: 10.1016/j.jpeds.2012.10.062
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Funding
- Academy of Finland [126925, 121584, 124282, 129378, 117797, 41071]
- Social Insurance Institution of Finland, Kuopio, Tampere
- Turku University Hospital Medical Funds
- Juho Vainio Foundation
- Paavo Nurmi Foundation
- Finnish Foundation of Cardiovascular Research
- Finnish Cultural Foundation
- Sigrid Juselius Foundation
- Orion-Farmos Research Foundation
- Tampere Tuberculosis Foundation
- Emil Aaltonen Foundation
- National Health and Medical Research Council [APP1012201]
- National Health and Medical Research Council Early Career Fellowship [APP1037559]
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Objectives To investigate whether the body mass index (BMI) of a child's mother is associated with an increased future risk of type 2 diabetes, independent of genetic risk or childhood metabolic, behavioral, and environmental factors. Study design The analyses were based on the Cardiovascular Risk in Young Finns Study including 1835 individuals aged 3-18 years at baseline with data on maternal BMI, childhood metabolic factors, as well as 34 newly identified type 2 diabetes susceptibility alleles. These subjects were then followed-up over 21-27 years. Results Maternal BMI (OR for 1-SD increase 1.54 [95% CI 1.12-2.11], P = .008) and child's systolic blood pressure (1.54 [1.01-2.35], P = .04) were significantly associated with increased odds for later type 2 diabetes, in a multivariable analysis adjusted for age, sex, type 2 diabetes genetic risk score, childhood BMI, insulin, lipids, dietary factors, socioeconomic status, and mother's age, and history of type 2 diabetes. A risk prediction model, which included maternal BMI status outperformed one which utilized only child's BMI data (area under the receiver operating characteristic curve 0.720 vs 0.623, P = .02). The inclusion of genetic risk score and other baseline risk variables did not additionally improve prediction (area under the receiver operating characteristic curve 0.720 vs 0.745, P = .40). Conclusions Maternal BMI is a useful variable in determining offspring risk of developing type 2 diabetes. (J Pediatr 2013;162:918-23).
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