Article
Immunology
Gaayathri Ariyakumar, Sarah Gee, Abhishek Das, Shraddha Kamdar, Rachel M. Tribe, Deena L. Gibbons
Summary: This study reveals rapid changes in immune cell populations within hours of birth, indicating immediate mobilization of the immune system post birth. Therefore, blood sampling should begin as soon after birth as possible to study the trajectory of immune development.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Pharmacology & Pharmacy
Dinko Rekic, Susanne Johansson, Jacob Leander
Summary: This study investigated the potential covariates for febuxostat pharmacokinetics, with a special focus on Asian race and bodyweight. The results showed that Asians have a 1.64-fold higher febuxostat exposure compared to Caucasians, independent of bodyweight or other investigated covariates. These findings may be important for selecting starting febuxostat doses in Asian patients.
CLINICAL PHARMACOKINETICS
(2021)
Article
Pediatrics
Hailing Shao, Yehui Lan, Yiyu Qian, Ruyang Chen, Lingli Peng, Ying Hua, Xiaomei Wang
Summary: Later cord clamping of >= 30 s resulted in a tendency towards metabolic acidosis of umbilical arterial blood in neonates of diabetic mothers and non-diabetic mothers. Umbilical arterial blood gas parameters at birth were similar in neonates of diabetic mothers and non-diabetic mothers.
Review
Immunology
Daisuke Tokuhara, Norikatsu Hikita
Summary: Neonates and infants are more susceptible to infections with severe outcomes. The weak vaccine-induced immunity in infants may be due to their immature innate immune response. Developing vaccines for these children requires an understanding of their uniquely immature innate immunity.
Article
Environmental Sciences
Meizi Wang, Jianhua Ying, Ukadike Chris Ugbolue, Duncan S. Buchan, Yaodong Gu, Julien S. Baker
Summary: Significant correlations were found between measures of fatness and metabolic risk in Scottish South Asian adolescents, while no positive relationships were seen in the Caucasian group.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
(2021)
Article
Biochemistry & Molecular Biology
Dana Mihaela Ciobanu, Cornelia Bala, Adriana Rusu, Gabriel Cismaru, Gabriela Roman
Summary: This study found that elevated serum E-selectin is associated with increased ambulatory diastolic blood pressure variability in patients with type 2 diabetes.
Article
Endocrinology & Metabolism
Yoshifumi Kasuga, Tomoko Kawai, Kei Miyakoshi, Yoshifumi Saisho, Masumi Tamagawa, Keita Hasegawa, Satoru Ikenoue, Daigo Ochiai, Mariko Hida, Mamoru Tanaka, Kenichiro Hata
Summary: This study revealed an association between gestational diabetes mellitus and neonatal plasma glucose level at 1 hour after birth as well as DNA methylation changes at the alternative transcription start site of ZNF696 in cord blood cells.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Article
Cell Biology
Alexander K. Grevsen, Claus V. B. Hviid, Anne K. Hansen, Anne-Mette Hvas
Summary: Platelet function in term neonatal umbilical cord blood is similar to that in peripheral blood in terms of count and surface GP expression, but differ in terms of activation and aggregation.
Article
Neurosciences
Chaohua Yang, Tao He, Qing Wang, Gaoju Wang, Jingjin Ma, Zhiyu Chen, Qiaochu Li, Linbang Wang, Zhengxue Quan
Summary: Elevated intraspinal pressure (ISP) following traumatic spinal cord injury (tSCI) may lead to secondary SCI, exacerbating tissue damage and functional deficits. This study investigated the dynamic changes in ISP after different degrees of acute compression SCI in rabbits and found that ISP significantly increased after compression injuries and exhibited different dynamic patterns. Elevated ISP was associated with spinal cord perfusion, edema progression, and secondary lesion enlargement.
EXPERIMENTAL NEUROLOGY
(2022)
Article
Pediatrics
Chaitra Angadi, Poonam Singh, Yash Shrivastava, Mayank Priyadarshi, Suman Chaurasia, Jaya Chaturvedi, Sriparna Basu
Summary: Recommendations for umbilical cord management in intrauterine growth-restricted (IUGR) neonates are lacking. A randomized controlled trial compared hemodynamic effects of umbilical cord milking (UCM) with delayed cord clamping (DCC) in 170 IUGR neonates, and the results showed that UCM significantly increases SVC flow, venous hematocrit, and CrSO2 compared to DCC, without significant differences in other hemodynamic parameters and incidences of polycythemia and jaundice requiring phototherapy. However, the need for non-invasive respiratory support was higher with UCM.
EUROPEAN JOURNAL OF PEDIATRICS
(2023)
Article
Endocrinology & Metabolism
K. M. Venkat Narayan, Dimple Kondal, Sayuko Kobes, Lisa R. Staimez, Deepa Mohan, Unjali P. Gujral, Shivani A. Patel, Ranjit Mohan Anjana, Roopa Shivashankar, Mohammed K. Ali, Howard H. Chang, Masood Kadir, Dorairaj Prabhakaran, Natalie Daya, Elizabeth Selvin, Nikhil Tandon, Robert Hanson, Viswanathan Mohan
Summary: South Asians and Pima Indians have different diabetes incidence rates, with South Asians having a lower rate than Pima Indians at comparable BMI levels. However, among men with BMI <25, the risk of diabetes is five times higher in South Asians compared to Pima Indians.
BMJ OPEN DIABETES RESEARCH & CARE
(2021)
Article
Obstetrics & Gynecology
Ryan M. McAdams, Satyan Lakshminrusimha
Summary: This review summarizes the high-quality evidence supporting delayed umbilical cord clamping as a strategy to promote placental transfusion to both preterm and term neonates. It highlights the potential benefits of delayed cord clamping in reducing mortality and the need for blood transfusions for preterm neonates. The review also discusses various clinical scenarios and topics related to cord management strategies, including delivery mode, twin gestations, maternal comorbidities, and neonatal complications.
OBSTETRICS AND GYNECOLOGY
(2022)
Article
Pediatrics
Alma Sulaj, Marina Tsaousi, Eleni Karapati, Abraham Pouliakis, Zoi Iliodromiti, Theodora Boutsikou, Serena Valsami, Nicoletta Iacovidou, Marianna Politou, Rozeta Sokou
Summary: This study establishes reference ranges for ROTEM assay in healthy term neonates, providing a reference group for future studies of neonates with underlying pathology.
Article
Endocrinology & Metabolism
Genya Aharon-Hananel, Nimrod Dori-Dayan, Roni Zemet, Lihi Bakal, Amna Jabarin, Keren Levi, Rina Hemi, Ehud Barhod, Oshrit Kordi-Patimer, Shali Mazaki-Tovi, Tali Cukierman-Yaffe, Rakefet Yoeli-Ullman
Summary: This study explores the association between the glucose control during pregnancy and the occurrence of hypoglycaemia in newborns of individuals with type 1 diabetes. The results show that higher cord-blood c-peptide levels are an independent risk factor for clinically significant neonatal hypoglycaemia.
DIABETES-METABOLISM RESEARCH AND REVIEWS
(2023)
Review
Cell Biology
Chao-Hua Yang, Zheng-Xue Quan, Gao-Ju Wang, Tao He, Zhi-Yu Chen, Qiao-Chu Li, Jin Yang, Qing Wang
Summary: The current recommended management for acute traumatic spinal cord injury aims to reduce secondary injury incidence and promote functional recovery. Elevated ISP, mainly caused by hemorrhage, edema, and blood-spinal cord barrier destruction, peaks at 3 days after traumatic spinal cord injury. Promising treatments for reducing ISP within this time window include duraplasty and hypertonic saline.
NEURAL REGENERATION RESEARCH
(2022)
Article
Obstetrics & Gynecology
C. A. Vollgraff Heidweiller-Schreurs, I. R. van Osch, M. W. Heymans, W. Ganzevoort, L. J. Schoonmade, C. J. Box, B. W. J. Mol, C. J. M. de Groot, P. M. M. Bossuyt, M. A. de Boer
Summary: This study found that in evaluating singleton pregnancies, the cerebroplacental ratio did not add predictive value for adverse perinatal outcomes beyond using umbilical artery pulsatility index alone.
BJOG-AN INTERNATIONAL JOURNAL OF OBSTETRICS AND GYNAECOLOGY
(2021)
Article
Endocrinology & Metabolism
Maurice B. Bizino, Ingrid M. Jazet, Huub J. van Eyk, Patrick C. N. Rensen, Petronella H. Geelhoed-Duijvestijn, Aan Kharagjitsingh, Elisabeth H. M. Paiman, Johannes W. Smit, Hildebrandus J. Lamb
Summary: The study found that liraglutide treatment resulted in more participants reaching target HbA1c compared to placebo. In participants using MDI regimens, liraglutide was significantly more effective than placebo. There was no significant difference in liraglutide efficacy between Western European and South Asian populations.
ACTA DIABETOLOGICA
(2021)
Article
Cardiac & Cardiovascular Systems
Mark Trinder, Yanan Wang, Christian M. Madsen, Tatjana Ponomarev, Lubos Bohunek, Brendan A. Daisely, HyeJin Julia Kong, Lisanne L. Blauw, Borge G. Nordestgaard, Anne Tybjaerg-Hansen, Mark M. Wurfel, James A. Russell, Keith R. Walley, Patrick C. N. Rensen, John H. Boyd, Liam R. Brunham
Summary: Clinical genetics and humanized mouse models suggest that inhibiting CETP may preserve high-density lipoprotein levels and improve outcomes for individuals with sepsis.
Article
Hematology
Enchen Zhou, Zhuang Li, Hiroyuki Nakashima, Cong Liu, Zhixiong Ying, Amanda C. Foks, Jimmy F. P. Berbee, Ko Willems van Dijk, Patrick C. N. Rensen, Yanan Wang
Summary: Brown fat activation attenuates atherosclerosis development by accelerating triglyceride-rich lipoprotein turnover and stimulating reverse cholesterol transport via SRB1. Knockdown of hepatic SRB1 not only increases HDL-cholesterol levels but also reduces plasma triglyceride and non-HDL-cholesterol levels, which explains the reduction in atherosclerosis development. This study suggests that brown fat activation combined with SRB1 modulation could be a potential strategy to treat cardiovascular disease.
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
(2021)
Article
Cardiac & Cardiovascular Systems
Cong Liu, Milena Schonke, Enchen Zhou, Zhuang Li, Sander Kooijman, Mariette R. Boon, Mikael Larsson, Kristina Wallenius, Niek Dekker, Louise Barlind, Xiao-Rong Peng, Yanan Wang, Patrick C. N. Rensen
Summary: FGF21 plays a role in regulating lipoprotein metabolism, improving hypercholesterolemia and atherosclerotic lesions. It accelerates the metabolism of triglyceride-rich lipoproteins by activating BAT and inducing browning of WAT, leading to decreased levels of non-HDL cholesterol and severity of hepatic steatosis.
CARDIOVASCULAR RESEARCH
(2022)
Article
Obstetrics & Gynecology
J. Klumper, B. M. Kazemier, J. Been, K. W. M. Bloemenkamp, M. A. de Boer, J. J. H. M. Erwich, W. Heidema, F. J. C. M. Klumper, S. W. A. Nij Bijvank, S. G. Oei, M. A. Oudijk, S. Schoenmakers, A. S. van Teeffelen, C. J. M. de Groot
Summary: The study in the Netherlands found a significant decrease in iatrogenic preterm births in singletons during the initial COVID-19 lockdown, while an increase in preterm births was observed in multiple pregnancies. Future studies should focus on understanding the mechanism behind these changes and their effects on perinatal outcome.
BMC PREGNANCY AND CHILDBIRTH
(2021)
Article
Medicine, General & Internal
Anadeijda J. E. M. C. Landman, Marjon A. de Boer, Laura Visser, Tobias A. J. Nijman, Marieke A. C. Hemels, Christiana N. Naaktgeboren, Marijke C. van der Weide, Ben W. Mol, Judith O. E. H. van Laar, Dimitri N. M. Papatsonis, Mireille N. Bekker, Joris van Drongelen, Marielle G. van Pampus, Marieke Sueters, David P. van der Ham, J. Marko Sikkema, Joost J. Zwart, Anjoke J. M. Huisjes, Marloes E. van Huizen, Gunilla Kleiverda, Janine Boon, Maureen T. M. Franssen, Wietske Hermes, Harry Visser, Christianne J. M. de Groot, Martijn A. Oudijk
Summary: The study aimed to evaluate the effectiveness of low-dose aspirin compared to placebo in preventing preterm birth in women with a previous spontaneous preterm birth. The results showed that low-dose aspirin did not significantly reduce the preterm birth rate. However, a modest reduction in preterm birth with aspirin cannot be ruled out. Further research is needed to determine the potential benefits of low-dose aspirin in women with a previous spontaneous preterm birth.
Article
Immunology
Hannah G. Juncker, Sien J. Mulleners, Marit J. van Gils, Tom P. L. Bijl, Christianne J. M. de Groot, Dasja Pajkrt, Aniko Korosi, Johannes B. van Goudoever, Britt J. van Keulen
Summary: This study found that the levels of SARS-CoV-2-specific antibodies in breast milk were similar after vaccination or infection. There was higher variability in IgA levels in breast milk following infection compared to vaccination.
Article
Obstetrics & Gynecology
Petra M. van Baar, Sophie M. Welters, Anita C. J. Ravelli, Marjon A. de Boer, Christianne J. M. de Groot
Summary: This study aimed to describe the cardiovascular mortality (CVM) risk in women after twin versus singleton pregnancies complicated by hypertensive disorders of pregnancy (HDP). The findings showed that women after both twin and singleton pregnancies complicated by HDP are at a similarly increased risk of CVM later in life.
PREGNANCY HYPERTENSION-AN INTERNATIONAL JOURNAL OF WOMENS CARDIOVASCULAR HEALTH
(2022)
Article
Public, Environmental & Occupational Health
Hanna M. Heller, Annemijn V. R. de Vries, Adriaan W. Hoogendoorn, Fedde Scheele, Willem J. Kop, Christianne J. M. de Groot, Adriaan Honig, Birit F. P. Broekman
Summary: In a country with free healthcare access, women with a migrant background did not differ from native Dutch women in terms of pregnancy complications and healthcare consumption, except for diabetes. However, women with a migrant background experienced more depressive symptoms and had an increased risk of hospital admission when depressed.
MATERNAL AND CHILD HEALTH JOURNAL
(2022)
Article
Obstetrics & Gynecology
Renee J. Burger, Ben W. W. Mol, Wessel Ganzevoort, Sanne J. J. Gordijn, Eva Pajkrt, Joris A. M. Van Der Post, Christianne J. M. De Groot, Anita C. J. Ravelli
Summary: This study examined the impact of labor induction at each week of gestation from 37 to 42 weeks on offspring's school performance at age 12. The results showed that induction of labor was associated with decreased school performance scores and a lower proportion of children reaching higher secondary school level. These long-term effects should be taken into account in counseling and decision making.
ACTA OBSTETRICIA ET GYNECOLOGICA SCANDINAVICA
(2023)
Article
Public, Environmental & Occupational Health
Renee J. Burger, Tessa J. Roseboom, Wessel Ganzevoort, Sanne J. Gordijn, Eva Pajkrt, Ameen Abu-Hanna, Martine Eskes, Aleid G. Leemhuis, Ben W. Mol, Christianne J. M. de Groot, Anita C. J. Ravelli
Summary: This study investigates the association between gestational age, sociodemographic characteristics, and school performance at the age of 12. Results show that longer gestational age is associated with better school performance, regardless of socio-demographic factors. Factors such as maternal education, maternal age, and ethnicity also influence school performance. Preterm children and those from socially or economically disadvantaged backgrounds are more vulnerable to the negative impact of preterm birth on school performance. Caution is needed in interpreting the results due to differential loss to follow-up.
PAEDIATRIC AND PERINATAL EPIDEMIOLOGY
(2023)
Meeting Abstract
Cardiac & Cardiovascular Systems
M. Schonke, Z. Ying, W. In Het Panhuis, S. Kooijman, P. C. N. Rensen
Meeting Abstract
Cardiac & Cardiovascular Systems
A. Borup, I. Donkin, M. R. Boon, M. Frydland, B. Martinez-Tellez, A. Loft, S. H. Keller, A. Kjaer, J. Kjaergaard, C. Hassager, R. Barres, P. C. N. Rensen, C. Christoffersen
Meeting Abstract
Cardiac & Cardiovascular Systems
M. M. Bos, N. J. Goulding, M. Lee, A. Hofman, M. Bot, R. Pool, L. Vijfhuizen, X. Zhang, C. Li, R. Mustafa, M. J. Neville, R. Li-Gao, S. Trompet, M. Beekman, N. R. Biermasz, D. I. Boomsma, I. De Boer, C. Christodoulides, A. Dehghan, K. Willems Van Dijk, I. Ford, M. Ghanbari, B. T. Heijmans, M. A. Ikram, J. W. Jukema, D. O. Mook-Kanamori, F. Karpe, A. I. Luik, L. Lumey, A. M. Van Den Maagdenberg, S. P. Mooijaart, R. De Mutsert, B. W. J. H. Penninx, P. C. N. Rensen, R. C. Richmond, F. R. Rosendaal, N. Sattar, R. Schoevers, P. E. Slagboom, G. M. Terwindt, C. S. Thesing, K. Wade, C. A. Wijsman, G. Willemsen, A. Zinderman, G. C. Verwoert, R. Noordam, D. A. Lawlor
Article
Pediatrics
Tarun Aurora, Audrey Cole, Parul Rai, Paul Lavoie, Carrie Mcivor, Lisa M. Klesges, Guolian Kang, Janaka S. S. Liyanage, Heather M. Brandt, Jane S. Hankins
Summary: This study evaluated the effectiveness of a vaccine strategy bundle in increasing HPV vaccine initiation and completion rates in a specialty clinic setting. By implementing the bundle, which included staff education, provider incentives, offering vaccines in clinics, and verifying vaccine completion, the clinic successfully improved HPV vaccine initiation and completion rates among sickle cell disease patients.
JOURNAL OF PEDIATRICS
(2024)
Article
Pediatrics
Nienke M. Halbmeijer, Wes Onland, Jeroen Dudink, Filip Cools, Anne Debeer, Anton H. van Kaam, Manon J. N. L. Benders, Niek E. van der Aa
Summary: In ventilated infants born preterm, high dose systemic hydrocortisone initiated between 7 and 14 days after birth did not have a significant impact on brain development.
JOURNAL OF PEDIATRICS
(2024)
Article
Pediatrics
Katherine Melton, Jianfang Liu, Hossein Sadeghi, Maureen George, Arlene Smaldone
Summary: This study aims to identify predictors of change in lung function and body weight during health care transition in cystic fibrosis (CF) patients. The study findings highlight the importance of CF RISE program engagement and reducing gaps in care for improving the transition of adolescents and young adults with CF.
JOURNAL OF PEDIATRICS
(2024)
Article
Pediatrics
Laura A. Duckworth, Kimberly A. Sutton, Nurmohammad Shaikh, Jinli Wang, Carla Hall-Moore, Lori R. Holtz, Phillip I. Tarr, Ronald C. Rubenstein
Summary: The study tested the usefulness of various biomarkers as indicators of gut dysfunction in cystic fibrosis (CF) and investigated the repeatability of these measures in individuals over short periods and their correlation with clinical outcomes. The results showed that elevated levels of fLcn2 in individuals with CF may predict worsened pulmonary function.
JOURNAL OF PEDIATRICS
(2024)
Article
Pediatrics
Lindsey Haack, Nikkan Das, Arvind Hoskoppal, Mark Debrunner, Tarek Alsaied, Gaurav Arora
Summary: RAE on ECG has a low positive predictive value for RAE on echocardiogram in previously healthy young patients. The highest yield for RAE on echocardiogram was observed in patients who were <1 year of age, had RAE in the anterior precordial leads, or displayed right ventricular hypertrophy on ECG.
JOURNAL OF PEDIATRICS
(2024)
Article
Pediatrics
Michael A. Padula, Khatija Naing, Tara L. Wenger, Irfan Ahmad, Carl H. Coghill, K. Taylor Wild, S. Alex Rottgers, Cory M. Resnick, Jeffrey Goldstein, Zarmina Ehsan, Donna Watkins, Nicole Deptula, Kuan-Chi Lai, Janet Lioy, Semsa Gogcu, Christopher M. Cielo
Summary: This study describes the spectrum of disease and burden of care in infants with congenital micrognathia. The results show that these infants commonly require surgical intervention and tube feedings, and disparities based on race and among centers were identified.
JOURNAL OF PEDIATRICS
(2024)
Article
Pediatrics
Michael P. Fundora, Manvitha Kalicheti, Guantao Zhao, Kevin O. Maher, Nicoleta Serban
Summary: This study investigated the variation of outpatient opioid prescribing in postoperative pediatric cardiac patients across the US. The results showed that there were significant differences in opioid prescribing by race, ethnicity, sex, and region.
JOURNAL OF PEDIATRICS
(2024)
Article
Pediatrics
Jia Guo, Brooklyn J. Fraser, Leigh Blizzard, Michael D. Schmidt, Terence Dwyer, Alison J. Venn, Costan G. Magnussen
Summary: There is a correlation between childhood and adulthood cardiorespiratory fitness.
JOURNAL OF PEDIATRICS
(2024)
Article
Pediatrics
Nianzhou Xiao, Michelle Starr, Adrienne Stolfi, Gilad Hamdani, Shireen Hashmat, Stefan G. Kiessling, Christina Sethna, Mahmoud Kallash, Robyn Matloff, Robert Woroniecki, Keia Sanderson, Ikuyo Yamaguchi, Stephen D. Cha, Michael G. Semanik, Rahul Chanchlani, Joseph T. Flynn, Mark Mitsnefes
Summary: This multicenter study reports that most infants diagnosed with idiopathic hypertension in the NICU will discontinue antihypertensive treatment within 2 years of discharge. Antenatal steroid treatment is associated with a decreased likelihood of needing antihypertensive therapy for more than 1 year.
JOURNAL OF PEDIATRICS
(2024)
Editorial Material
Pediatrics
Kanwaljit Singh, John Concato, Jonathan M. Davis
JOURNAL OF PEDIATRICS
(2024)
Article
Pediatrics
Yaxing Meng, Harri Niinikoski, Suvi P. Rovio, Brooklyn J. Fraser, Feitong Wu, Antti Jula, Tapani Ronnemaa, Jorma S. A. Viikari, Olli T. Raitakari, Katja Pahkala, Costan G. Magnussen
Summary: This 26-year study shows a correlation between early-life non-HDL-C levels and future levels. Early dietary counseling can reduce the risk of high pediatric non-HDL-C, emphasizing the importance of early interventions in preventing cardiovascular risks.
JOURNAL OF PEDIATRICS
(2024)
Article
Pediatrics
Kelsey A. B. Gastineau, Rebecca Bell, Allison Hanes, Sandra Mckay, Eric Sigel, Filoteia Popescu, Evan C. Sommer, Shari Barkin
Summary: This study aimed to assess the self-reported counseling outcomes for a firearm safe storage counseling training program provided by the American Academy of Pediatrics. The results demonstrated significant improvement in counseling self-efficacy and frequency one month after the training.
JOURNAL OF PEDIATRICS
(2024)
Article
Pediatrics
Kathryn E. K. Berlin, William Scott, Sara Dawson, David Brousseau, Joanne M. Lagatta
Summary: This prospective cohort study aimed to investigate the impact of bronchopulmonary dysplasia (BPD) on the health-related quality of life (HRQL) of infants from NICU hospitalization to one year post-discharge. The study found that lower HRQL during NICU stay was associated with earlier gestational age, postnatal corticosteroid usage, outborn status, and gastrostomy tube placement. Lower HRQL at 3 and 12 months post-discharge was associated with readmissions, home oxygen use, parent-reported difficulty breathing, lower developmental scores, and not playing with other children. Most parents reported similar or improved HRQL after discharge, but parents of infants with respiratory symptoms experienced less improvement. Efforts to improve parent HRQL should focus on respiratory symptoms and social isolation.
JOURNAL OF PEDIATRICS
(2024)
Article
Pediatrics
Garett J. Griffith, Alan P. Wang, Robert I. Liem, Michael R. Carr, Tyler Corson, Kendra Ward
Summary: This study developed reference values for cardiorespiratory fitness in children aged 6-18 years without underlying heart disease, measured by peak oxygen uptake and treadmill time. Fitness levels increased with age in males but not females. Males generally exhibited higher fitness levels compared to females in the same age groups.
JOURNAL OF PEDIATRICS
(2024)
Article
Pediatrics
David S. Liu, Patricia Miller, Anna Rothenberg, Carley Vuillermin, Peter M. Waters, Andrea S. Bauer
Summary: This study aims to determine if children with elbow flexion contracture (EFC) caused by brachial plexus birth injury (BPBI) are more likely to develop shoulder contracture and undergo surgical treatment. A retrospective review was conducted on children under 2 years old with BPBI who presented to a single children's hospital. The results showed that patients with EFC had reduced shoulder range of motion and higher odds of shoulder contracture and surgical treatment. Prompt referral to a BPBI specialty clinic is recommended for evaluation and potential surgery.
JOURNAL OF PEDIATRICS
(2024)