Article
Multidisciplinary Sciences
Maren Leiz, Melanie Knorr, Kilson Moon, Luisa Tischler, Jan de Laffolie, Neeltje van den Berg
Summary: The incidence and prevalence of pediatric-onset inflammatory bowel disease (PIBD) are increasing globally. This study found that the diagnostic delay for PIBD is higher in Crohn's disease (CD) compared to ulcerative colitis (UC), and factors such as abdominal pain at night and video capsule endoscopy may influence the delay. Participating centers have improved the diagnostic delay over the years, but awareness for common symptoms like abdominal pain still needs to be high.
SCIENTIFIC REPORTS
(2022)
Article
Medicine, General & Internal
Nicolas Schneider, Keywan Sohrabi, Henning Schneider, Klaus-Peter Zimmer, Patrick Fischer, Jan de Laffolie
Summary: This study evaluated the performance of algorithms based on promptly available data in diagnosing pediatric inflammatory bowel diseases (PIBD). The optimized neural network achieved an accuracy of up to 90.57%, outperforming other methods.
FRONTIERS IN MEDICINE
(2021)
Article
Immunology
Judith Kelsen, Noor Dawany, Maire Conrad, Trusha Patel, Marcella Devoto, Kelly Maurer, Kathleen E. Sullivan
Summary: The genetic causes of very early onset inflammatory bowel disease are diverse, ranging from pure epithelial defects to classic T cell defects. Genetic testing is currently the most reliable method for identifying monogenic cases of very early onset IBD.
CLINICAL IMMUNOLOGY
(2022)
Review
Medicine, General & Internal
Andreea Salcudean, Andreea Georgiana Nan, Cristina Raluca Bodo, Marius Catalin Cosma, Elena Gabriela Strete, Maria Melania Lica
Summary: Inflammatory bowel disease (IBD) is a chronic, immune-mediated condition of the gastrointestinal tract, which significantly reduces quality of life in pediatric populations. Physical symptoms such as abdominal pain and fatigue are accompanied by mental and emotional distress, leading to poor body image and low self-esteem. Diagnosis and treatment of mental health problems in pediatric IBD patients can improve adherence to treatment and reduce long-term morbidity and mortality.
Article
Pediatrics
Merle Classen, Jan de Laffolie, Martin Classen, Alexander Schnell, Keywan Sohrabi, Andre Hoerning
Summary: Biological agents, like anti-TNF-alpha drugs, have shown efficacy in pediatric patients with inflammatory bowel disease. Early initiation of anti-TNF-alpha therapy can significantly reduce treatment failure risk and decrease extraintestinal manifestations.
FRONTIERS IN PEDIATRICS
(2022)
Article
Health Care Sciences & Services
M. Leiz, M. Knorr, K. Moon, L. Tischler, K. Sohrabi, S. Cantez, J. Daebritz, J. de Laffolie, N. van den Berg
Summary: This study aimed to analyze whether the diagnostic process of pediatric-onset inflammatory bowel disease (PIBD) in German and Austrian region is in line with the international guidelines ('Porto criteria'). The results showed that the registry reflects the guideline's recommendations, but the proportion of documented diagnostic examinations varies between different diagnoses.
BMC HEALTH SERVICES RESEARCH
(2023)
Article
Public, Environmental & Occupational Health
Natalia Mouratidou, Petter Malmborg, Jacob Jaras, Vignir Sigurdsson, Olof Sandstrom, Ulrika L. Fagerberg, Gabriella Broms, Jonas F. Ludvigsson, Ola Olen
Summary: The validity of register-based definitions of childhood-onset inflammatory bowel disease (IBD) in the Swedish National Patient Register (NPR) is high and can be used to identify patients in observational research.
CLINICAL EPIDEMIOLOGY
(2022)
Article
Pediatrics
Andrea Taddio, Gabriele Cont, Eva Da Dalt, Patrizia Salierno, Egidio Barbi, Marcella Montico, Luca Ronfani, Matteo Bramuzzo, Alessandro Ventura
Summary: This study evaluated the final height in patients with pediatric-onset IBD and identified factors influencing long-term growth. The results showed that most CD and UC patients achieved the target final height, with disease severity and low height at diagnosis being predictive factors for low final height.
MINERVA PEDIATRICS
(2023)
Review
Pharmacology & Pharmacy
Anne. E. E. Levine, Dominique Mark, Laila Smith, Hengqi. B. B. Zheng, David. L. L. Suskind
Summary: Inflammatory bowel disease (IBD) is a condition treated with various immunomodulating and immunosuppressive therapies, but targeted treatments for specific disease phenotypes are lacking. However, monogenic IBD with identifiable genetic defects offers the potential for precision therapeutics. The advent of genetic sequencing platforms has led to an increased identification of monogenic immunodeficiencies that cause IBD, particularly a subpopulation called very early onset inflammatory bowel disease (VEO-IBD) with an onset age of less than six years old. This review discusses the current state of disease-specific targeted therapies and empiric treatment for undifferentiated causes of VEO-IBD.
Article
Immunology
Eliana Shaul, Maire A. Conrad, Noor Dawany, Trusha Patel, Megan C. Canavan, Alyssa Baccarella, Sarah Weinbrom, Daniel Aleynick, Kathleen E. Sullivan, Judith R. Kelsen
Summary: This study evaluated the clinical response to canakinumab in children with refractory very early onset inflammatory bowel disease (VEO-IBD). The results suggest that canakinumab may be an effective and safe treatment for VEO-IBD patients.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Medicine, General & Internal
Pojsakorn Danpanichkul, Kanokphong Suparan, Suchapa Arayakarnkul, Aunchalee Jaroenlapnopparat, Natchaya Polpichai, Panisara Fangsaard, Siwanart Kongarin, Karan Srisurapanont, Banthoon Sukphutanan, Wasuwit Wanchaitanawong, Yatawee Kanjanakot, Jakrapun Pupaibool, Kwanjit Duangsonk, Gursimran Singh Kochhar, Karn Wijarnpreecha
Summary: There is an increasing incidence of inflammatory bowel disease (IBD), especially in elderly-onset IBD and among males. The Western Pacific region has the highest incidence rates, while America and high-SDI countries bear the greatest burden. Although mortality and disability-adjusted life years (DALYs) are decreasing in most regions, the overall burden of IBD remains highest in America and high-SDI countries.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Pediatrics
Alex Krauthammer, Ilana Weintraub, Ron Shaoul, Raffi Lev-Tzion, Efrat Broide, Michael Wilschanski, Aaron Lerner, Baruch Yerushalmi, Dror S. Shouval, Hussein Shamaly, Yael Haberman-Ziv, Batia Weiss
Summary: This study retrospectively evaluated the presentation and long-term outcomes of infants with early-onset inflammatory bowel disease (IO-IBD). The majority of patients had a severe disease presentation at diagnosis, but most achieved long-term remission. However, the surgery rate was high, mainly in the first few months after diagnosis.
FRONTIERS IN PEDIATRICS
(2023)
Article
Gastroenterology & Hepatology
Azusa Akiya, Ken Takahashi, Satoshi Akimoto, Yu Hosono, Mayumi Ifuku, Takeshi Iso, Kana Yazaki, Sachie Shigemitsu, Keisuke Jimbo, Takahiro Kudo, Yoshikazu Ohtsuka, Toshiaki Shimizu
Summary: This study aimed to assess left ventricular function in patients with childhood-onset inflammatory bowel disease (IBD) using layer-specific strain analysis and to identify early indicators of cardiac dysfunction. The results showed that children and young adults with childhood-onset IBD already have reduced myocardial deformability. Layer-specific strain analysis could be useful in identifying indicators of cardiac dysfunction in patients with IBD.
INFLAMMATORY BOWEL DISEASES
(2023)
Editorial Material
Gastroenterology & Hepatology
Jodie Ouahed
Summary: Research has identified over 70 genes associated with very early onset inflammatory bowel disease (VEOIBD), with some mutations leading to the disease. This provides valuable insights for the treatment of patients with VEOIBD.
INFLAMMATORY BOWEL DISEASES
(2021)
Article
Gastroenterology & Hepatology
Kuan-Yi Sung, Bing Zhang, Hohui E. Wang, Ya-Mei Bai, Shih-Jen Tsai, Tung-Ping Su, Tzeng-Ji Chen, Ming-Chih Hou, Ching-Liang Lu, Yen-Po Wang, Mu-Hong Chen
Summary: This population-based cohort study found a significant association between schizophrenia and subsequent development of IBD. Patients with schizophrenia develop IBD at a younger age, and the risk increases when schizophrenia is inadequately controlled. Understanding this correlation can improve the diagnosis and management of IBD in this vulnerable patient population.
ALIMENTARY PHARMACOLOGY & THERAPEUTICS
(2022)
Article
Urology & Nephrology
Caroline Kempf, Johannes Holle, Susanne Berns, Stephan Henning, Philip Bufler, Dominik Mueller
Summary: The safety of PEG insertion in pediatric PD patients can be improved by implementing a prophylactic antibiotic and antifungal regimen as well as modifying the PD program, which may help reduce the risk of peritonitis.
PERITONEAL DIALYSIS INTERNATIONAL
(2022)
Article
Gastroenterology & Hepatology
Jutta Keller, Thilo Wedel, Holger Seidl, Martin E. Kreis, Ivo van der Voort, Maximilian Gebhard, Jost Langhorst, Petra Lynen Jansen, Oliver Schwandner, Martin Storr, Pia van Leeuwen, Viola Andresen, Jan C. PreiSS, Peter Layer, H. Allescher, T. Andus, S. C. Bischoff, S. Buderus, M. Classen, U. Ehlert, S. Elsenbruch, M. Engel, A. Enninger, W. Fischbach, M. Freitag, T. Frieling, A. Gillessen, M. Goebel-Stengel, J. Gschossmann, F. Gundling, S. Haag, W. Haeuser, U. Helwig, S. Hollerbach, G. Holtmann, M. Karaus, M. Katschinski, H. Krammer, W. Kruis, R. Kuhlbusch-Zicklam, P. Lynen Jansen, A. Madisch, H. Matthes, S. Miehlke, H. Monnikes, S. Muller-Lissner, B. Niesler, C. Pehl, D. Pohl, C. Posovszky, M. Raithel, G. Roehrig-Herzog, R. Schafert, M. Schemann, A. Schmidt-Choudhury, S. Schmiedel, A. Schweinlin, J. Schwille-Kiuntke, A. Stengel, J. Tesarz, W. Voderholzer, G. von Boyen, J. von Schonfeld
ZEITSCHRIFT FUR GASTROENTEROLOGIE
(2022)
Article
Medicine, General & Internal
Simon Moosburner, Leke Wiering, Safak Guel-Klein, Paul Ritschl, Tomasz Dziodzio, Nathanael Raschzok, Christian Witzel, Alexander Gratopp, Stephan Henning, Philip Bufler, Moritz Schmelzle, Georg Lurje, Wenzel Schoening, Johann Pratschke, Brigitta Globke, Robert oellinger
Summary: This study analyzed the short- and long-term outcomes of pediatric liver transplantation over a 30-year period. The results showed excellent long-term survival rates in pediatric patients undergoing liver transplantation. The improvement in patient survival can be attributed to advancements in surgical techniques, improved interdisciplinary collaboration, and better management of perioperative complications.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Gastroenterology & Hepatology
Lucas Griessmair, Laura Pirringer, Steffeni Mountford, Andrea Sendelhofert, Marie-Christine Makeschin, Sibylle Koletzko, Doris Mayr, Philip Bufler
Summary: This study characterized the hepatic inflammatory infiltrate and expression of IL-37 in children with autoimmune liver diseases. IL-37 expression correlated positively with liver inflammation and fibrosis, the number of infiltrating immune cells, and serum markers for hepatic inflammation. IL-37 was mainly expressed in hepatocytes, cholangiocytes, and infiltrating immune cells. Additionally, IL-37 colocalized with intranuclear pSmad3L in areas of liver inflammation. These findings suggest that IL-37 may play a modulating role to limit hepatic inflammation and fibrosis in pediatric autoimmune liver diseases.
JOURNAL OF PEDIATRIC GASTROENTEROLOGY AND NUTRITION
(2022)
Article
Gastroenterology & Hepatology
Maria Zernickel, Andreas Krahl, Stephan Buderus, Sascha Hach, Ralph Melchior, Slim Saadi, Soehnke Dammann, Martin Classen, Carsten Posovszky
Summary: There is a deficit in both outpatient and inpatient care for children and adolescents with chronic gastrointestinal, pancreatic and liver diseases in Germany. This is mainly due to economic conditions and a lack of personnel. Well-trained specialists in pediatric and adolescent gastroenterology are still needed nationwide to provide qualified care.
ZEITSCHRIFT FUR GASTROENTEROLOGIE
(2022)
Article
Multidisciplinary Sciences
Maryam Ghalandary, Yue Li, Thomas Frohlich, Thomas Magg, Yanshan Liu, Meino Rohlfs, Sebastian Hollizeck, Raffaele Conca, Tobias Schwerd, Holm H. Uhlig, Philip Bufler, Sibylle Koletzko, Aleixo M. Muise, Scott B. Snapper, Fabian Hauck, Christoph Klein, Daniel Kotlarz
Summary: NOD2 polymorphisms may affect the perception of bacterial MDP and trigger inflammatory responses. A rare homozygous missense mutation in the first CARD domain of NOD2 was found in a patient with immunodeficiency and enteropathy. The mutation impaired NOD2-dependent signaling and proinflammatory cytokine production. The study also discovered that VCP is a novel interaction partner of NOD2, and VCP-mediated inflammatory responses upon ER stress are NOD2-dependent.
SCIENTIFIC REPORTS
(2022)
Article
Pediatrics
Susanne Greber-Platzer, Melanie Gsoellpointner, Nadja Haiden, Almuth Christine Hauer, Roland Lanzersdorfer, Beate Pietschnig, Anna-Maria Schneider, Sabine Scholl-Buergi, Wolfgang Sperl, Helga Christine Stenzel, Daniel Weghuber, Christoph Buehrer, Regina Ensenauer, Frank Jochum, Hermann Kalhoff, Berthold Koletzko, Antje Koerner, Burkhard Lawrenz, Walter Mihatsch, Carsten Posovszky, Silvia Rudloff, Christian Braegger, Celine J. Fischer-Fumeaux, Roger Lauener, Leatitia-Marie Petit
Summary: Foods for special medical purposes (FSMP) are used for treating infants with specific medical and nutritional needs. These products should only be used under medical supervision and not solely based on marketing or over the counter sales. There is a lack of clinical evidence supporting the use of special nutrient solutions for healthy neonates or special dietary products for infants with colic and constipation.
MONATSSCHRIFT KINDERHEILKUNDE
(2022)
Correction
Multidisciplinary Sciences
Eva Goncalves Serra, Tobias Schwerd, Loukas Moutsianas, Athena Cavounidis, Laura Fachal, Sumeet Pandey, Jochen Kammermeier, Nicholas M. Croft, Carsten Posovszky, Astor Rodrigues, Richard K. Russell, Farah Barakat, Marcus K. H. Auth, Robert Heuschkel, Matthias Zilbauer, Krzysztof Fyderek, Christian Braegger, Simon P. Travis, Jack Satsangi, Miles Parkes, Nikhil Thapar, Helen Ferry, Julie C. Matte, Kimberly C. Gilmour, Andrzej Wedrychowicz, Peter Sullivan, Carmel Moore, Jennifer Sambrook, Willem Ouwehand, David Roberts, John Danesh, Toni A. Baeumler, Tudor A. Fulga, Eli M. Carrami, Ahmed Ahmed, Rachel Wilson, Jeffrey C. Barrett, Abdul Elkadri, Anne M. Griffiths, Scott B. Snapper, Neil Shah, Aleixo M. Muise, David C. Wilson, Holm H. Uhlig, Carl A. Anderson
NATURE COMMUNICATIONS
(2022)
Article
Gastroenterology & Hepatology
Aline Azabdaftari, Henrike L. L. Sczakiel, Magdalena Danyel, Benno Kohlmaier, Christoph J. J. Mache, Amelie Stalke, Eva-Doreen Pfister, Julia Thumfart, Stephan Henning, A. S. Knisely, Philip Bufler
Summary: Neonatal sclerosing cholangitis (NSC) is a liver disease associated with biliary fibrosis that often requires liver transplantation in childhood. Recent studies have discovered variants in the DCDC2 gene, which is involved in syndromic disease and NSC. This report presents four patients with hepatobiliary disease associated with novel variants in the DCDC2 gene, expanding the phenotypic spectrum of this disease. Testing for DCDC2 expression and variants should be considered in the evaluation of unknown cholangiopathy in childhood.
LIVER INTERNATIONAL
(2023)
Editorial Material
Pediatrics
Frank Jochum
MONATSSCHRIFT KINDERHEILKUNDE
(2023)
Article
Medicine, General & Internal
Alexander Seipp, Andreas Klausen, Antje Timmer, Teresa Grimm, Martin Gross, Oliver Summ, Fabian Otto-Sobotka
Summary: This study aims to investigate the effect of mechanical insufflation-exsufflation (MI-E) intervention on the duration of mechanical ventilation and other outcomes. One hundred adult patients with neurological or neurosurgical disease will be recruited in a randomized controlled trial, with half receiving MI-E and half receiving best standard care. The primary endpoint is the duration of mechanical ventilation until successful weaning. The findings of this study will be disseminated in a peer-reviewed journal.
Article
Pediatrics
Norman Junge, Hanna Hentschel, Dorothee Krebs-Schmitt, Amelie Stalke, Eva-Doreen Pfister, Bjoern Hartleben, Martin Classen, Alexander Querfurt, Veronika Muench, Philip Bufler, Jun Oh, Enke Grabhorn
Summary: A study found that patients with mild Crigler-Najjar Syndrome (CNS) carrying the c.115C>G variant have a higher risk of progressive liver disease, despite having a very mild CNS phenotype. Currently, there are no identifiable predictors or causes for disease progression, but close follow-up can help identify patients with progressive liver disease at an early stage.
Article
Health Care Sciences & Services
Mike-Andrew Westhoff, Carsten Posovszky, Klaus-Michael Debatin
Summary: Vaccines are highly effective in saving lives, but unfortunately they are often met with more controversy than their safety profile justifies. The anti-vaccine movement has evolved through three generations, with the current generation being closely associated with the broader anti-COVID movement and promoting individualism over community health. It is crucial to provide better science education to the young and the general public to improve overall science literacy, and strategies to achieve this are suggested.
INQUIRY-THE JOURNAL OF HEALTH CARE ORGANIZATION PROVISION AND FINANCING
(2023)
Article
Gastroenterology & Hepatology
Alicia Brenig, Ilse Broekaert, Patrick Gerner, Carsten Posovszky, Christoph Huenseler, Alexander Joachim
Summary: The purpose of this study was to assess the current attitude and status quo towards the use of microbiome analysis and fecal microbiota transfer (FMT) in pediatric patients in German-speaking pediatric gastroenterology centers. The results showed that 31.0% of the centers use diagnostic microbiome analysis, but only a few perform it frequently (2.8%) or regularly (1.4%). 15.5% of the centers have performed FMT as a therapeutic approach. Most of these centers use individual in-house donor screening programs (61.5%). Guidelines and standardized procedures are necessary to improve patient-centered care in pediatric gastroenterology. Rating: 8 out of 10.
INTERNATIONAL JOURNAL OF COLORECTAL DISEASE
(2023)
Article
Immunology
Laura Kroehn, Aline Azabdaftari, Julian Heuberger, Christian Hudert, Matthias Zilbauer, Tilman Breiderhoff, Philip Bufler
Summary: IL-37 plays its anti-inflammatory role in the intestines mainly by protecting the intestinal epithelial integrity through lamina propria immune cells.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Pediatrics
Tarun Aurora, Audrey Cole, Parul Rai, Paul Lavoie, Carrie Mcivor, Lisa M. Klesges, Guolian Kang, Janaka S. S. Liyanage, Heather M. Brandt, Jane S. Hankins
Summary: This study evaluated the effectiveness of a vaccine strategy bundle in increasing HPV vaccine initiation and completion rates in a specialty clinic setting. By implementing the bundle, which included staff education, provider incentives, offering vaccines in clinics, and verifying vaccine completion, the clinic successfully improved HPV vaccine initiation and completion rates among sickle cell disease patients.
JOURNAL OF PEDIATRICS
(2024)
Article
Pediatrics
Nienke M. Halbmeijer, Wes Onland, Jeroen Dudink, Filip Cools, Anne Debeer, Anton H. van Kaam, Manon J. N. L. Benders, Niek E. van der Aa
Summary: In ventilated infants born preterm, high dose systemic hydrocortisone initiated between 7 and 14 days after birth did not have a significant impact on brain development.
JOURNAL OF PEDIATRICS
(2024)
Article
Pediatrics
Katherine Melton, Jianfang Liu, Hossein Sadeghi, Maureen George, Arlene Smaldone
Summary: This study aims to identify predictors of change in lung function and body weight during health care transition in cystic fibrosis (CF) patients. The study findings highlight the importance of CF RISE program engagement and reducing gaps in care for improving the transition of adolescents and young adults with CF.
JOURNAL OF PEDIATRICS
(2024)
Article
Pediatrics
Laura A. Duckworth, Kimberly A. Sutton, Nurmohammad Shaikh, Jinli Wang, Carla Hall-Moore, Lori R. Holtz, Phillip I. Tarr, Ronald C. Rubenstein
Summary: The study tested the usefulness of various biomarkers as indicators of gut dysfunction in cystic fibrosis (CF) and investigated the repeatability of these measures in individuals over short periods and their correlation with clinical outcomes. The results showed that elevated levels of fLcn2 in individuals with CF may predict worsened pulmonary function.
JOURNAL OF PEDIATRICS
(2024)
Article
Pediatrics
Lindsey Haack, Nikkan Das, Arvind Hoskoppal, Mark Debrunner, Tarek Alsaied, Gaurav Arora
Summary: RAE on ECG has a low positive predictive value for RAE on echocardiogram in previously healthy young patients. The highest yield for RAE on echocardiogram was observed in patients who were <1 year of age, had RAE in the anterior precordial leads, or displayed right ventricular hypertrophy on ECG.
JOURNAL OF PEDIATRICS
(2024)
Article
Pediatrics
Michael A. Padula, Khatija Naing, Tara L. Wenger, Irfan Ahmad, Carl H. Coghill, K. Taylor Wild, S. Alex Rottgers, Cory M. Resnick, Jeffrey Goldstein, Zarmina Ehsan, Donna Watkins, Nicole Deptula, Kuan-Chi Lai, Janet Lioy, Semsa Gogcu, Christopher M. Cielo
Summary: This study describes the spectrum of disease and burden of care in infants with congenital micrognathia. The results show that these infants commonly require surgical intervention and tube feedings, and disparities based on race and among centers were identified.
JOURNAL OF PEDIATRICS
(2024)
Article
Pediatrics
Michael P. Fundora, Manvitha Kalicheti, Guantao Zhao, Kevin O. Maher, Nicoleta Serban
Summary: This study investigated the variation of outpatient opioid prescribing in postoperative pediatric cardiac patients across the US. The results showed that there were significant differences in opioid prescribing by race, ethnicity, sex, and region.
JOURNAL OF PEDIATRICS
(2024)
Article
Pediatrics
Jia Guo, Brooklyn J. Fraser, Leigh Blizzard, Michael D. Schmidt, Terence Dwyer, Alison J. Venn, Costan G. Magnussen
Summary: There is a correlation between childhood and adulthood cardiorespiratory fitness.
JOURNAL OF PEDIATRICS
(2024)
Article
Pediatrics
Nianzhou Xiao, Michelle Starr, Adrienne Stolfi, Gilad Hamdani, Shireen Hashmat, Stefan G. Kiessling, Christina Sethna, Mahmoud Kallash, Robyn Matloff, Robert Woroniecki, Keia Sanderson, Ikuyo Yamaguchi, Stephen D. Cha, Michael G. Semanik, Rahul Chanchlani, Joseph T. Flynn, Mark Mitsnefes
Summary: This multicenter study reports that most infants diagnosed with idiopathic hypertension in the NICU will discontinue antihypertensive treatment within 2 years of discharge. Antenatal steroid treatment is associated with a decreased likelihood of needing antihypertensive therapy for more than 1 year.
JOURNAL OF PEDIATRICS
(2024)
Editorial Material
Pediatrics
Kanwaljit Singh, John Concato, Jonathan M. Davis
JOURNAL OF PEDIATRICS
(2024)
Article
Pediatrics
Yaxing Meng, Harri Niinikoski, Suvi P. Rovio, Brooklyn J. Fraser, Feitong Wu, Antti Jula, Tapani Ronnemaa, Jorma S. A. Viikari, Olli T. Raitakari, Katja Pahkala, Costan G. Magnussen
Summary: This 26-year study shows a correlation between early-life non-HDL-C levels and future levels. Early dietary counseling can reduce the risk of high pediatric non-HDL-C, emphasizing the importance of early interventions in preventing cardiovascular risks.
JOURNAL OF PEDIATRICS
(2024)
Article
Pediatrics
Kelsey A. B. Gastineau, Rebecca Bell, Allison Hanes, Sandra Mckay, Eric Sigel, Filoteia Popescu, Evan C. Sommer, Shari Barkin
Summary: This study aimed to assess the self-reported counseling outcomes for a firearm safe storage counseling training program provided by the American Academy of Pediatrics. The results demonstrated significant improvement in counseling self-efficacy and frequency one month after the training.
JOURNAL OF PEDIATRICS
(2024)
Article
Pediatrics
Kathryn E. K. Berlin, William Scott, Sara Dawson, David Brousseau, Joanne M. Lagatta
Summary: This prospective cohort study aimed to investigate the impact of bronchopulmonary dysplasia (BPD) on the health-related quality of life (HRQL) of infants from NICU hospitalization to one year post-discharge. The study found that lower HRQL during NICU stay was associated with earlier gestational age, postnatal corticosteroid usage, outborn status, and gastrostomy tube placement. Lower HRQL at 3 and 12 months post-discharge was associated with readmissions, home oxygen use, parent-reported difficulty breathing, lower developmental scores, and not playing with other children. Most parents reported similar or improved HRQL after discharge, but parents of infants with respiratory symptoms experienced less improvement. Efforts to improve parent HRQL should focus on respiratory symptoms and social isolation.
JOURNAL OF PEDIATRICS
(2024)
Article
Pediatrics
Garett J. Griffith, Alan P. Wang, Robert I. Liem, Michael R. Carr, Tyler Corson, Kendra Ward
Summary: This study developed reference values for cardiorespiratory fitness in children aged 6-18 years without underlying heart disease, measured by peak oxygen uptake and treadmill time. Fitness levels increased with age in males but not females. Males generally exhibited higher fitness levels compared to females in the same age groups.
JOURNAL OF PEDIATRICS
(2024)
Article
Pediatrics
David S. Liu, Patricia Miller, Anna Rothenberg, Carley Vuillermin, Peter M. Waters, Andrea S. Bauer
Summary: This study aims to determine if children with elbow flexion contracture (EFC) caused by brachial plexus birth injury (BPBI) are more likely to develop shoulder contracture and undergo surgical treatment. A retrospective review was conducted on children under 2 years old with BPBI who presented to a single children's hospital. The results showed that patients with EFC had reduced shoulder range of motion and higher odds of shoulder contracture and surgical treatment. Prompt referral to a BPBI specialty clinic is recommended for evaluation and potential surgery.
JOURNAL OF PEDIATRICS
(2024)