Review
Dermatology
Anant Patil, Jun Lu, Martin Kassir, Mahsa Babaei, Mohamad Goldust
Summary: Dermatomyositis is a rare autoimmune inflammatory condition affecting skin and muscles. This review article provides comprehensive information about the treatment options for dermatomyositis, including traditional immunosuppressive agents, immunomodulatory therapy, and biological agents. Although several treatment options are available, there are still unanswered questions about the optimal treatment for dermatomyositis.
JOURNAL OF COSMETIC DERMATOLOGY
(2023)
Article
Pediatrics
Amir B. Orandi, Lampros Fotis, Jamie Lai, Hallie Morris, Andrew J. White, Anthony R. French, Kevin W. Baszis
Summary: The study retrospectively reviewed patients diagnosed with Juvenile Dermatomyositis at a single tertiary-care children's hospital between 2000 and 2014, finding that treatment with reduced glucocorticoid dosing and duration can achieve favorable outcomes in Juvenile Dermatomyositis patients.
PEDIATRIC RHEUMATOLOGY
(2021)
Article
Medicine, General & Internal
Christopher Costin, Amer Khojah, Elisa Ochfeld, Gabrielle Morgan, Saravanan Subramanian, Marisa Klein-Gitelman, Xiao-Di Tan, Lauren M. Pachman
Summary: This study aimed to determine if B lymphocytosis can be used as a biomarker for disease activity in JDM. Children with untreated JDM were divided into two groups based on B cell percentage: normal group and high B cell group. The high B cell group had higher disease activity scores and neopterin levels. Secondary analysis showed that B cell values increased after 3-6 months of therapy and decreased after completion of therapy, while JM patients had higher BAFF levels than controls. This study supports the use of B cell lymphocytosis as a biomarker and suggests B cell-directed therapies for JDM.
Article
Allergy
Yochai Adir, Marc Humbert, Walid Saliba
Summary: The study found that biologics approved for asthma and systemic corticosteroids do not increase the risk of SARS-CoV-2 infection. However, systemic corticosteroids are associated with worse COVID-19 severity and higher all-cause mortality.
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
(2021)
Article
Biology
Laura Amado-Rodriguez, Estefania Salgado Del Riego, Juan Gomez de Ona, Ines Lopez Alonso, Helena Gil-Pena, Cecilia Lopez-Martinez, Paula Martin-Vicente, Antonio Lopez-Vazquez, Adrian Gonzalez Lopez, Elias Cuesta-Llavona, Raquel Rodriguez-Garcia, Jose Antonio Boga, Marta Elena Alvarez-Arguelles, Juan Mayordomo-Colunga, Jose Ramon Vidal-Castineira, Irene Crespo, Margarita Fernandez, Loreto Criado, Victoria Salvadores, Francisco Jose Jimeno-Demuth, Lluis Blanch, Belen Prieto, Alejandra Fernandez-Fernandez, Carlos Lopez-Larrea, Eliecer Coto, Guillermo M. Albaiceta
Summary: Patients with the IFIH1 rs1990760 TT variant show an attenuated inflammatory response and better outcomes. Dexamethasone may reverse this anti-inflammatory phenotype.
Editorial Material
Hematology
Sophie Lanzkron, Lydia Pecker
Summary: This article investigates the association between corticosteroid exposure and subsequent hospitalization for vaso-occlusive episodes (VOEs) in individuals with sickle cell disease (SCD).
Article
Rheumatology
Gulnara Mamyrova, Erica McBride, Lawrence Yao, Joseph A. Shrader, Minal Jain, Jianhua Yao, Rodolfo Curiel, Frederick W. Miller, Michael O. Harris-Love, Lisa G. Rider
Summary: The study found that muscle ultrasound parameters in patients with JDM were positively correlated with disease activity measures and MRI, suggesting that MUS may be a valuable imaging modality to assess JDM disease activity and damage.
Article
Rheumatology
K. El-Garf, A. El-Garf, S. Salah, H. Marzouk, Y. Farag, N. Mostafa
Summary: This study retrospectively analyzed Egyptian children with juvenile dermatomyositis (JDM), and found some differences in demographic, clinical and management aspects compared to other regions, possibly due to ethnic and environmental disparities.
CLINICAL AND EXPERIMENTAL RHEUMATOLOGY
(2022)
Article
Rheumatology
Erdal Sag, Selcan Demir, Yelda Bilginer, Beril Talim, Goknur Haliloglu, Haluk Topaloglu, Seza Ozen
Summary: The study analyzed the clinical features, laboratory tests, treatment response, and long-term outcomes of 58 patients with JDM. Dermatological manifestations and muscle weakness were key diagnostic elements, while calcinosis was the most common long-term complication. The presence of TIF1g and NXP2 may indicate a severe disease course.
SEMINARS IN ARTHRITIS AND RHEUMATISM
(2021)
Editorial Material
Critical Care Medicine
Laura H. Kim, Julie Duncan, Connie L. Yang
Summary: A previously healthy 17-year-old Taiwanese girl presented with symptoms consistent with juvenile dermatomyositis, including weakness, polyarthritis, and heliotrope rash. Diagnosis was confirmed based on elevated creatine phosphokinase level and diffuse myositis on lower limb MRI.
Article
Agriculture, Dairy & Animal Science
Jose Ignacio Cristobal, Francisco Javier Duque, Jesus Maria Uson-Casaus, Patricia Ruiz, Esther Lopez Nieto, Eva Maria Perez-Merino
Summary: The study evaluated the feasibility and effects of combined application of stem cells and prednisone in dogs with IBD for the first time. Results demonstrated that stem cell transplantation significantly and safely improved the disease condition in dogs with IBD, irrespective of prednisone treatment. The beneficial effects of the therapy were stable and long lasting, and allowed for a reduction or elimination of steroid dosage.
Article
Pediatrics
Avinash Sharma, Dharmagat Bhattarai, Anju Gupta, Sandesh Guleria, Amit Rawat, Pandiarajan Vignesh, Ravinder Garg, Surjit Singh
Summary: The study found that eight patients with JDM tested positive for at least one MSA or MAA, with varying presence of SRP, MDA-5, Mi-2, and SSA/Ro52 antibodies.
INDIAN JOURNAL OF PEDIATRICS
(2021)
Article
Immunology
Andrea Abbona, Vincenzo Ricci, Matteo Paccagnella, Cristina Granetto, Fiorella Ruatta, Carolina Cauchi, Danilo Galizia, Michele Ghidini, Nerina Denaro, Marco Carlo Merlano, Ornella Garrone
Summary: A study examined the levels of 18 cytokines in the blood samples of 25 metastatic colorectal cancer patients treated with regorafenib. Eight cytokines were found to be associated with progression-free survival, and a signature based on these cytokines was created to predict patient outcomes.
Article
Microbiology
Miguel Alejandro Pinzon, Doris Cardona Arango, Juan Felipe Betancur, Santiago Ortiz, Hector Holguin, Carolina Arias Arias, Bernardo J. Munoz Palacio, Michael Amarillo, Juan Felipe Llano, Pablo Montoya
Summary: This study aimed to describe the clinical manifestations and outcomes of patients with severe Covid-19 Pneumonia treated with corticosteroids and colchicine. The results showed that treatment with these medications was associated with lower mortality at the hospital level. However, further randomized, placebo-controlled studies are needed to evaluate the effects of corticosteroids and colchicine on complications or death from Covid-19.
ANNALS OF CLINICAL MICROBIOLOGY AND ANTIMICROBIALS
(2021)
Article
Oncology
Neta Bar-Hai, Guy Ben-Betzalel, Ronen Stoff, Shirly Grynberg, Jacob Schachter, Ronnie Shapira-Frommer, Nethanel Asher
Summary: In the era of immunotherapy, advanced melanoma patients have higher survival rates, but the use of steroids may affect treatment efficacy. This study analyzed 415 immunotherapy patients and found that steroid exposure increased progression-free survival (PFS), but early initiation of steroids resulted in a shorter PFS compared to late or no exposure. Caution should be taken in using steroids during the initial stages of treatment.
Article
Rheumatology
Watchareewan Sontichai, Fangming Liao, Daniela Dominguez, Deborah M. Levy, Muna Al Mutairi, Lawrence Ng, Frank Silverio, Earl D. Silverman, Jonathan D. Wasserman, Linda T. Hiraki
Summary: This study aimed to evaluate the impact of timing of childhood-onset systemic lupus erythematosus (SLE) diagnosis on the final height of female patients. The results showed that patients diagnosed after menarche achieved a taller final height, even after adjusting for ethnicity and disease severity.
ARTHRITIS CARE & RESEARCH
(2022)
Article
Rheumatology
Jennifer J. Y. Lee, Ronald M. Laxer, Brian M. Feldman, Claire E. H. Barber, Michelle Batthish, Roberta Berard, Lori B. Tucker, Deborah M. Levy
Summary: This study examines the Canadian pediatric rheumatology workforce and care processes. The findings reveal a national deficit of pediatric rheumatologists at the recommended benchmark, with a regional maldistribution of these specialists. Most rheumatologists work in multidisciplinary teams, but there may be inadequate support for allied health professionals (AHPs).
JOURNAL OF RHEUMATOLOGY
(2022)
Article
Rheumatology
Nathalie E. Chalhoub, Scott E. Wenderfer, Deborah M. Levy, Kelly Rouster-Stevens, Amita Aggarwal, Sonia Savani, Natasha M. Ruth, Thaschawee Arkachaisri, Tingting Qiu, Angela Merritt, Karen Onel, Beatrice Goilav, Raju P. Khubchandani, Jianghong Deng, Adriana R. Fonseca, Stacy P. Ardoin, Coziana Ciurtin, Ozgur Kasapcopur, Marija Jelusic, Adam M. Huber, Seza Ozen, Marisa S. Klein-Gitelman, Simone Appenzeller, Andre Cavalcanti, Lampros Fotis, Sern Chin Lim, Rodrigo M. Silva, Julia Ramirez-Miramontes, Natalie L. Rosenwasser, Claudia Saad-Magalhaes, Dieneke Schonenberg-Meinema, Christiaan Scott, Clovis A. Silva, Sandra Enciso, Maria T. Terreri, Alfonso-Ragnar Torres-Jimenez, Maria Trachana, Sulaiman M. Al-Mayouf, Prasad Devarajan, Bin Huang, Hermine Brunner
Summary: This study aimed to develop a standardized steroid dosing regimen for physicians treating childhood-onset systemic lupus erythematosus complicated by lupus nephritis. By evaluating patient course and various parameters, a consensus-based dosing regimen was developed and validated.
ARTHRITIS & RHEUMATOLOGY
(2022)
Article
Allergy
Natalie T. Deuitch, Dan Yang, Pui Y. Lee, Xiaomin Yu, Natalia Sampaio Moura, Oskar Schnappauf, Amanda K. Ombrello, Deborah Stone, Hye Sun Kuehn, Sergio D. Rosenzweig, Patrycja Hoffmann, Cornelia Cudrici, Deborah M. Levy, Elizabeth Kessler, Jennifer B. Soep, Arielle D. Hay, Austin Dalrymple, Yu Zhang, Li Sun, Qiuye Zhang, Xuemei Tang, Yuan Wu, Koneti Rao, Haibo Li, Hong Luo, Yao Zhang, Jon M. Burnham, Manfred Boehm, Karyl Barron, Daniel L. Kastner, Ivona Aksentijevich, Qing Zhou
Summary: This study investigates the cellular mechanisms underlying the response to TNF inhibitor therapy in patients with DADA2 and identifies the pathological features associated with treatment response. TNFi treatment reduces inflammation, corrects skewed macrophage differentiation, and restores endothelial cell integrity.
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
(2022)
Article
Rheumatology
Ana C. Ulloa, Fangming Liao, Raffaella L. Carlomagno, Talia Diaz, Daniela Dominguez, Deborah M. Levy, Lawrence Ng, Andrea M. Knight, Linda T. Hiraki
Summary: The association between schizophrenia genetic susceptibility loci and NPSLE features in multiethnic childhood-onset SLE patients was examined. The results suggested that there was no significant association between schizophrenia risk loci and NPSLE in this cohort.
JOURNAL OF RHEUMATOLOGY
(2022)
Article
Pediatrics
Brian R. Stotter, Ellen Cody, Hongjie Gu, Ankana Daga, Larry A. Greenbaum, Minh Dien Duong, Alexandra Mazo, Beatrice Goilav, Alexis Boneparth, Mahmoud Kallash, Ahmed Zeid, Wacharee Seeherunvong, Rebecca R. Scobell, Issa Alhamoud, Caitlin E. Carter, Siddharth Shah, Caroline E. Straatmann, Bradley P. Dixon, Jennifer C. Cooper, Raoul D. Nelson, Deborah M. Levy, Hermine Brunner, Priya S. Verghese, Scott E. Wenderfer
Summary: Children with lupus nephritis and stage 3 acute kidney injury have a high long-term risk of kidney failure. The severity of tubular atrophy and interstitial fibrosis at the time of acute kidney injury predicts kidney disease progression.
PEDIATRIC NEPHROLOGY
(2023)
Article
Rheumatology
Melissa C. Misztal, Fangming Liao, Madeline Couse, Jingjing Cao, Daniela Dominguez, Lynette Lau, Christian R. Marshall, Sergey Naumenko, Andrea M. Knight, Deborah M. Levy, Linda T. Hiraki
Summary: This study conducted genome-wide sequencing in children suspected of having monogenic lupus, and found that 13% of patients carried rare predicted damaging variants for monogenic lupus. Further studies are needed to validate these findings.
JOURNAL OF RHEUMATOLOGY
(2023)
Letter
Rheumatology
Jennifer J. Y. Lee, Roberta Berard, Deborah M. Levy, Vicki Ling, Jodi M. Gatley, Jessica Widdifield
JOURNAL OF RHEUMATOLOGY
(2023)
Meeting Abstract
Rheumatology
Tala El Tal, Avery Longmore, Abdulaziz el Mutairi, Amani Al Bijadi, Audrea Chen, Holly Convery, Dinah Finkelstein, Linda Hiraki, Chetana Kulkarni, Justine Ledochowski, Neely Lerman, Karen Leslie, Deborah Levy, Sharon Lorber, Jayne MacMahon, Jeanine McColl, Sarah Mossad, Oscar Mwizerwa, Lawrence Ng, Luana Flores Pereira, Vandana Rawal, Alaa Shehab, Evelyn Smith, Alene Toulany, Andrea Knight
ARTHRITIS & RHEUMATOLOGY
(2022)
Meeting Abstract
Rheumatology
Tala El Tal, Santiago Arciniegas, Sarah Mossad, Ibrahim Mohamed, Victoria Lishak, Stephanie Fevrier, Lawrence Ng, Paris Moaf, Joanna Law, Ashley Danguecan, Linda Hiraki, Deborah Levy, Andrea Knight
ARTHRITIS & RHEUMATOLOGY
(2022)
Meeting Abstract
Rheumatology
Nicholas Gold, Fangming Liao, JingJing Cao, Daniela Dominguez, Andrea Knight, Deborah Levy, Linda Hiraki
ARTHRITIS & RHEUMATOLOGY
(2022)
Meeting Abstract
Rheumatology
Santiago Arciniegas, Sarah Mossad, Tala El Tal, Lawrence Ng, Paris Moaf, Helen Branson, Adrienne Davis, Linda Hiraki, Deborah Levy, Ashley Danguecan, George Ibrahim, Andrea Knight
JOURNAL OF RHEUMATOLOGY
(2022)
Meeting Abstract
Rheumatology
Chelsea DeCoste, Paris Moaf, Lawrence Ng, Dragana Ostojic-Aitkens, Fatima Faruq, Bryan Maguire, Deborah Levy, Linda Hiraki, Alene Toulany, Andrea Knight
JOURNAL OF RHEUMATOLOGY
(2022)
Meeting Abstract
Rheumatology
Ibrahim Mohamed, Chelsea DeCoste, Lawrence Ng, Paris Moaf, Hardil Bhatt, Dragana Ostojic-Aitkens, Bryan Maguire, Linda Hiraki, Deborah Levy, Alene Toulany, Andrea Knight
JOURNAL OF RHEUMATOLOGY
(2022)
Meeting Abstract
Rheumatology
Sarah Mossad, Santiago Arciniegas, Tala El Tal, Lawrence Ng, Paris Moaf, Helen Branson, Adrienne Davis, Linda Hiraki, Deborah Levy, Ashley Danguecan, George Ibrahim, Andrea Knight
JOURNAL OF RHEUMATOLOGY
(2022)
Article
Pediatrics
Tarun Aurora, Audrey Cole, Parul Rai, Paul Lavoie, Carrie Mcivor, Lisa M. Klesges, Guolian Kang, Janaka S. S. Liyanage, Heather M. Brandt, Jane S. Hankins
Summary: This study evaluated the effectiveness of a vaccine strategy bundle in increasing HPV vaccine initiation and completion rates in a specialty clinic setting. By implementing the bundle, which included staff education, provider incentives, offering vaccines in clinics, and verifying vaccine completion, the clinic successfully improved HPV vaccine initiation and completion rates among sickle cell disease patients.
JOURNAL OF PEDIATRICS
(2024)
Article
Pediatrics
Nienke M. Halbmeijer, Wes Onland, Jeroen Dudink, Filip Cools, Anne Debeer, Anton H. van Kaam, Manon J. N. L. Benders, Niek E. van der Aa
Summary: In ventilated infants born preterm, high dose systemic hydrocortisone initiated between 7 and 14 days after birth did not have a significant impact on brain development.
JOURNAL OF PEDIATRICS
(2024)
Article
Pediatrics
Katherine Melton, Jianfang Liu, Hossein Sadeghi, Maureen George, Arlene Smaldone
Summary: This study aims to identify predictors of change in lung function and body weight during health care transition in cystic fibrosis (CF) patients. The study findings highlight the importance of CF RISE program engagement and reducing gaps in care for improving the transition of adolescents and young adults with CF.
JOURNAL OF PEDIATRICS
(2024)
Article
Pediatrics
Laura A. Duckworth, Kimberly A. Sutton, Nurmohammad Shaikh, Jinli Wang, Carla Hall-Moore, Lori R. Holtz, Phillip I. Tarr, Ronald C. Rubenstein
Summary: The study tested the usefulness of various biomarkers as indicators of gut dysfunction in cystic fibrosis (CF) and investigated the repeatability of these measures in individuals over short periods and their correlation with clinical outcomes. The results showed that elevated levels of fLcn2 in individuals with CF may predict worsened pulmonary function.
JOURNAL OF PEDIATRICS
(2024)
Article
Pediatrics
Lindsey Haack, Nikkan Das, Arvind Hoskoppal, Mark Debrunner, Tarek Alsaied, Gaurav Arora
Summary: RAE on ECG has a low positive predictive value for RAE on echocardiogram in previously healthy young patients. The highest yield for RAE on echocardiogram was observed in patients who were <1 year of age, had RAE in the anterior precordial leads, or displayed right ventricular hypertrophy on ECG.
JOURNAL OF PEDIATRICS
(2024)
Article
Pediatrics
Michael A. Padula, Khatija Naing, Tara L. Wenger, Irfan Ahmad, Carl H. Coghill, K. Taylor Wild, S. Alex Rottgers, Cory M. Resnick, Jeffrey Goldstein, Zarmina Ehsan, Donna Watkins, Nicole Deptula, Kuan-Chi Lai, Janet Lioy, Semsa Gogcu, Christopher M. Cielo
Summary: This study describes the spectrum of disease and burden of care in infants with congenital micrognathia. The results show that these infants commonly require surgical intervention and tube feedings, and disparities based on race and among centers were identified.
JOURNAL OF PEDIATRICS
(2024)
Article
Pediatrics
Michael P. Fundora, Manvitha Kalicheti, Guantao Zhao, Kevin O. Maher, Nicoleta Serban
Summary: This study investigated the variation of outpatient opioid prescribing in postoperative pediatric cardiac patients across the US. The results showed that there were significant differences in opioid prescribing by race, ethnicity, sex, and region.
JOURNAL OF PEDIATRICS
(2024)
Article
Pediatrics
Jia Guo, Brooklyn J. Fraser, Leigh Blizzard, Michael D. Schmidt, Terence Dwyer, Alison J. Venn, Costan G. Magnussen
Summary: There is a correlation between childhood and adulthood cardiorespiratory fitness.
JOURNAL OF PEDIATRICS
(2024)
Article
Pediatrics
Nianzhou Xiao, Michelle Starr, Adrienne Stolfi, Gilad Hamdani, Shireen Hashmat, Stefan G. Kiessling, Christina Sethna, Mahmoud Kallash, Robyn Matloff, Robert Woroniecki, Keia Sanderson, Ikuyo Yamaguchi, Stephen D. Cha, Michael G. Semanik, Rahul Chanchlani, Joseph T. Flynn, Mark Mitsnefes
Summary: This multicenter study reports that most infants diagnosed with idiopathic hypertension in the NICU will discontinue antihypertensive treatment within 2 years of discharge. Antenatal steroid treatment is associated with a decreased likelihood of needing antihypertensive therapy for more than 1 year.
JOURNAL OF PEDIATRICS
(2024)
Editorial Material
Pediatrics
Kanwaljit Singh, John Concato, Jonathan M. Davis
JOURNAL OF PEDIATRICS
(2024)
Article
Pediatrics
Yaxing Meng, Harri Niinikoski, Suvi P. Rovio, Brooklyn J. Fraser, Feitong Wu, Antti Jula, Tapani Ronnemaa, Jorma S. A. Viikari, Olli T. Raitakari, Katja Pahkala, Costan G. Magnussen
Summary: This 26-year study shows a correlation between early-life non-HDL-C levels and future levels. Early dietary counseling can reduce the risk of high pediatric non-HDL-C, emphasizing the importance of early interventions in preventing cardiovascular risks.
JOURNAL OF PEDIATRICS
(2024)
Article
Pediatrics
Kelsey A. B. Gastineau, Rebecca Bell, Allison Hanes, Sandra Mckay, Eric Sigel, Filoteia Popescu, Evan C. Sommer, Shari Barkin
Summary: This study aimed to assess the self-reported counseling outcomes for a firearm safe storage counseling training program provided by the American Academy of Pediatrics. The results demonstrated significant improvement in counseling self-efficacy and frequency one month after the training.
JOURNAL OF PEDIATRICS
(2024)
Article
Pediatrics
Kathryn E. K. Berlin, William Scott, Sara Dawson, David Brousseau, Joanne M. Lagatta
Summary: This prospective cohort study aimed to investigate the impact of bronchopulmonary dysplasia (BPD) on the health-related quality of life (HRQL) of infants from NICU hospitalization to one year post-discharge. The study found that lower HRQL during NICU stay was associated with earlier gestational age, postnatal corticosteroid usage, outborn status, and gastrostomy tube placement. Lower HRQL at 3 and 12 months post-discharge was associated with readmissions, home oxygen use, parent-reported difficulty breathing, lower developmental scores, and not playing with other children. Most parents reported similar or improved HRQL after discharge, but parents of infants with respiratory symptoms experienced less improvement. Efforts to improve parent HRQL should focus on respiratory symptoms and social isolation.
JOURNAL OF PEDIATRICS
(2024)
Article
Pediatrics
Garett J. Griffith, Alan P. Wang, Robert I. Liem, Michael R. Carr, Tyler Corson, Kendra Ward
Summary: This study developed reference values for cardiorespiratory fitness in children aged 6-18 years without underlying heart disease, measured by peak oxygen uptake and treadmill time. Fitness levels increased with age in males but not females. Males generally exhibited higher fitness levels compared to females in the same age groups.
JOURNAL OF PEDIATRICS
(2024)
Article
Pediatrics
David S. Liu, Patricia Miller, Anna Rothenberg, Carley Vuillermin, Peter M. Waters, Andrea S. Bauer
Summary: This study aims to determine if children with elbow flexion contracture (EFC) caused by brachial plexus birth injury (BPBI) are more likely to develop shoulder contracture and undergo surgical treatment. A retrospective review was conducted on children under 2 years old with BPBI who presented to a single children's hospital. The results showed that patients with EFC had reduced shoulder range of motion and higher odds of shoulder contracture and surgical treatment. Prompt referral to a BPBI specialty clinic is recommended for evaluation and potential surgery.
JOURNAL OF PEDIATRICS
(2024)