Review
Endocrinology & Metabolism
Marie-Odile Soyer-Gobillard, Laura Gaspari, Philippe Courtet, Charles Sultan
Summary: Synthetic endocrine disruptors such as diethylstilbestrol (DES) may affect neurodevelopment and psychiatric disorders in children exposed in utero, particularly Autism Spectrum Disorders (ASD). Limited studies have reported severe depression, bipolar disorders, schizophrenia, and other psychiatric disorders in in-utero exposed children. Molecular studies suggest transgenerational effects and epigenetic changes on genes related to neurodevelopment.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Psychiatry
Hongling Zeng, Shuo Liu, Run Huang, Yi Zhou, Jun Tang, Jun Xie, Pan Chen, Bing Xiang Yang
Summary: The study showed that TEACCH-based group rehabilitation training effectively improved the development of children with ASD. This intervention provided enhanced rehabilitation strategies that helped children with ASD in areas such as expressive language, affective expression, social reciprocity, problem behavior, and personal self-care.
JOURNAL OF PSYCHIATRIC RESEARCH
(2021)
Article
Nutrition & Dietetics
Julio Plaza-Diaz, Katherine Flores-Rojas, Maria Jose de la Torre-Aguilar, Antonio Rafael Gomez-Fernandez, Pilar Martin-Borreguero, Juan Luis Perez-Navero, Angel Gil, Mercedes Gil-Campos
Summary: Children with ASD exhibit dietary patterns characterized by high energy and fat intake, low intake of vegetables and fruits, and frequent consumption of processed foods with poor nutritional quality, such as beverages, sweets, snacks, and bakery products. Their meat and dairy intake is associated with increased consumption of fish, grains, and pasta. Nutrient adequacy comparisons show higher intake for energy, saturated fat, calcium, and vitamin C, but lower intake for iron, iodine, and B group vitamins in children with ASD compared to control children. This study emphasizes the importance of assessing dietary patterns and nutrient intake in children with ASD to address nutritional deficiencies and prevent potential health issues.
Review
Environmental Sciences
Haixia Liu, Liu Ding, Guangbo Qu, Xianwei Guo, MingMing Liang, Shaodi Ma, Yehuan Sun
Summary: This meta-analysis aims to clarify the relationship between particulate matter (PM) and autism spectrum disorder (ASD). The results suggest that PM2.5 is associated with an increased risk of ASD, while PM10 is not. Different types of PM have varying effects on the risk of ASD.
SCIENCE OF THE TOTAL ENVIRONMENT
(2023)
Article
Pediatrics
Giulia Purpura, Francesco Cerroni, Marco Carotenuto, Renata Nacinovich, Luca Tagliabue
Summary: This study explores the clinical expression of sensory processing disorders (SPDs) and their correlation with behavioral aspects in children with autism spectrum disorder (ASD) and isolated SPD. The results show that both ASD and SPD children exhibit sensory-related behavioral symptoms, with ASD children being more impaired in all areas. Significant correlations are found between sensory processing difficulties and repetitive behaviors, with a specific relationship between body awareness and ritualistic/sameness behavior in the SPD group. In conclusion, sensory-motor skills play a key role in the early diagnosis and intervention for children at risk of neurodevelopmental disorders.
Article
Clinical Neurology
Duoxi Duan, Lin He, Hong Chen, Ying Lei, Wei Wu, Tao Li
Summary: The objective of this study is to assess the clinical effectiveness of auricular plaster therapy (APT) in treating sleep disorders in children with autism spectrum disorders (ASDs). A total of 44 preschool children with sleep disorders and ASD will be included in a randomized controlled trial. The primary outcome is the Children's Sleep Habits Questionnaire (CSHQ), while secondary outcomes include the Autism Behavior Checklist (ABC) and polysomnography (PSG) for sleep time, latency, duration, and structures. This study may provide evidence of the efficacy of APT and offer new alternatives for the treatment of sleep disorders in children with ASD.
FRONTIERS IN NEUROLOGY
(2022)
Article
Psychology, Developmental
Katharine E. Zuckerman, Sarabeth Broder-Fingert, R. Christopher Sheldrick
Summary: The American Academy of Pediatrics recommends autism spectrum disorder screening at 18- and 24-month well-child visits, but many low-income and minority children are not diagnosed until school age. Offering screening at preschool well-child visits may help reduce disparities and improve early diagnosis of autism spectrum disorder.
Article
Hematology
Christian A. Di Buduo, Silvia Giannini, Vittorio Abbonante, Vittorio Rosti, Karin M. Hoffmeister, Alessandra Balduini
Summary: Aberrant megakaryopoiesis in MPNs is characterized by increased TPO levels and LacNAc expression in platelets, along with elevated B4GALT1 gene expression in megakaryocytes. This altered gene expression may lead to the production of platelets with aberrant galactosylation, promoting hepatic TPO synthesis. Targeting b4GalT1 could be a potential therapeutic strategy for MPNs.
Article
Neurosciences
Zhihong Lan, Shoujun Xu, Xiangrong Yu, Zhenjie Yu, Meng Li, Feng Chen, Yu Liu, Tianyue Wang, Yunfan Wu, Yungen Gan, Guihua Jiang
Summary: This study investigates the functional connectivity in single-sex children with autism spectrum disorders (ASDs) through resting-state functional magnetic resonance imaging (rs-fMRI), revealing enhanced connectivity in specific brain regions. The study suggests a possible relationship between atypical visual attention and poor learning ability in subjects with ASD.
FRONTIERS IN NEUROSCIENCE
(2022)
Article
Behavioral Sciences
William J. Chopik, Jeewon Oh, Amy K. Nuttall, Katharine N. Thakkar, Brooke Ingersoll
Summary: Past research has focused on refining the broader autism phenotype (BAP) and its correlates, while neglecting how the BAP differs by socio-demographic characteristics, like age. This study found that total BAP scores were higher in younger adults and lower in older adults, particularly for pragmatic language difficulties. Aloofness also decreased with age, while rigidity did not show a significant association. These results suggest a decrease in BAP traits across the lifespan and have implications for clinical interventions.
Review
Pediatrics
Taynara Amancio de Lima, Patricia Aparecida Zuanetti, Marina Estima Neiva Nunes, Ana Paula Andrade Hamad
Summary: This review discusses the clinical features of differential diagnoses for ASD in preschoolers, focusing on similarities and disparities. Proper ranking and characterization of symptoms are essential for accurate diagnosis and intervention.
WORLD JOURNAL OF PEDIATRICS
(2023)
Article
Immunology
Xin-Jie Xu, Ji-Dong Lang, Jun Yang, Bo Long, Xu-Dong Liu, Xiao-Feng Zeng, Geng Tian, Xin You
Summary: This study found altered immune function and gut microbiota in children with Autism Spectrum Disorders (ASD), and the severity of autistic symptoms was higher in the high IFN-gamma group. Analysis of gut microbiota revealed overrepresentation of certain bacterial species and underrepresentation of others in the high IFN-gamma group. The results suggest that IFN-gamma level could serve as a potential biomarker to subtype ASD individuals and understanding the associations among immune function, gut microbiota, and metabolism abnormalities could lead to personalized biomedical treatment for ASD.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Pediatrics
Yun Zhang, Bin Qin, Longlun Wang, Jie Chen, Jinhua Cai, Tingyu Li
Summary: This study investigates the potential sex differences in language ability in children with autism spectrum disorder (ASD) and explores whether these differences might be attributed to developmental imbalances in the anatomical structures of Broca and Wernicke areas. The findings reveal that males have better language abilities compared to females, particularly in terms of verbal development quotient (DQ) scores. Furthermore, there is a positive correlation between Broca thickness and verbal DQ scores.
FRONTIERS IN PEDIATRICS
(2022)
Article
Neurosciences
Zhihong Lan, Shoujun Xu, Yunfan Wu, Likun Xia, Kelei Hua, Meng Li, Mengchen Liu, Yi Yin, Chunlong Li, Shumei Huang, Ying Feng, Guihua Jiang, Tianyue Wang
Summary: The study aimed to investigate alterations in local spontaneous brain activity in preschool boys with ASD. The results showed changes in spontaneous activity in multiple brain regions of the ASD group, especially in visual and language-related areas, without correlation with CARS, ABC, or age.
FRONTIERS IN NEUROSCIENCE
(2021)
Article
Engineering, Environmental
Yongwei Guo, Wei Shi, Zhiwei Liu, Xian Sun, Yuping Wu
Summary: The global surge in disinfection practices during the COVID-19 response has raised concerns about marine exposure to hazardous ingredients in disinfectant products, such as triclosan and triclocarban. Limited studies have focused on the response of marine triclosan and triclocarban loading to the pandemic. This study used cetaceans as bio-indicators and found increased concentrations of triclosan in certain dolphin species and fish after the pandemic, suggesting a profound impact on marine ecosystems.
JOURNAL OF HAZARDOUS MATERIALS
(2023)
Article
Nursing
Jen-Chan Cheng, Tzu-Ting Chang, Ling-Wei Wang, Shu-Yuan Liang, Shu-Chen Hsu, Shu-Fang Wu, Tsae-Jyy Wang, Chieh-Yu Liu
Summary: The study aimed to develop and evaluate the psychometric properties of the Caregiver Caregiving Self-Efficacy Scale-Oral Cancer (CSES-OC). The results showed that the scale had appropriate reliability and validity for assessing caregiver caregiving self-efficacy for family members with oral cancer.
INTERNATIONAL JOURNAL OF NURSING PRACTICE
(2022)
Article
Health Care Sciences & Services
Yu-Chi Chen, Christina Cheng, Richard H. Osborne, Lars Kayser, Chieh-Yu Liu, Li-Chun Chang
Summary: This study translated and culturally adapted the eHealth Literacy Questionnaire (eHLQ) for Mandarin-speaking people with chronic diseases in Taiwan. The validity testing showed satisfactory-to-strong psychometric properties of the eHLQ. The 7 scales of the tool are likely to be useful for evaluating digital health interventions and developing health technology products that suit diverse users' needs.
JOURNAL OF MEDICAL INTERNET RESEARCH
(2022)
Article
Nursing
Pei-Yi Chao, Wen Ling Hsieh, Shin Ting Yeh, Chia Jung Hsieh, Chieh-Yu Liu, Wen- Liu
Summary: This study investigates the factors associated with personal recovery among psychiatric nursing home residents and finds that empowerment, social support, and global function are the main predictive factors. Strengthening empowerment in mental health nursing may contribute more to the personal recovery of psychiatric nursing home residents.
JOURNAL OF PSYCHIATRIC AND MENTAL HEALTH NURSING
(2022)
Article
Nursing
Mei-Feng Hsu, Yew-Wha Whu, I-Chen Lin, Chieh-Yu Liu, Fei-Chen Lai, Pei-Ching Liu, Chi-Wen Chen
Summary: This study demonstrates that an interactive virtual reality (VR) play intervention, including instructional play and emotional catharsis play sessions, effectively reduces children's pain and fear during intravenous placement.
ASIAN NURSING RESEARCH
(2022)
Article
Health Care Sciences & Services
Pei-Shan Li, Chia-Jung Hsieh, Eva Berthy Tallutondok, Ya-Ling Shih, Chieh-Yu Liu
Summary: The study confirmed the high consistency reliability and good construct validity of LSI-SF, indicating its reliability in measuring satisfaction with elderly life. There was a significant correlation between LSI-SF and WHO-5 Well-Being Index, and a negative association between frailty status and life satisfaction.
JOURNAL OF PERSONALIZED MEDICINE
(2022)
Article
Environmental Sciences
Ru-Yu Huang, Ting-Ting Lee, Yi-Hsien Lin, Chieh-Yu Liu, Hsiu-Chun Wu, Shu-He Huang
Summary: This study investigated the influencing factors of family caregivers' readiness for discharge in advanced cancer patients. The findings showed that family caregivers' readiness for discharge affects patients' ability to be discharged home. Factors influencing readiness included the patient's physical activity performance status and expressed discharge willingness, the presence of someone to assist with home care, and the difficulties of providing in-home care.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
(2022)
Article
Environmental Sciences
Ya-Ling Shih, Chia-Jung Hsieh, Tso-Ying Lee, Pei-Hung Liao, Hao-Ting Wu, Chieh-Yu Liu
Summary: This study investigated the association between phthalate exposure and metabolic syndrome in adults. The findings suggest that there are differential associations between certain phthalate metabolites and metabolic syndrome based on sex, age, and menopausal status.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
(2022)
Article
Geriatrics & Gerontology
Chia-Hui Lin, Chieh-Yu Liu, Chun-Ching Huang, Jiin-Ru Rong
Summary: This study examined the mediating effects of daily physical activity and healthy life self-efficacy on the relationship between frailty and quality of life in older adults. The findings suggest that daily physical activity and healthy life self-efficacy partially mediate the relationship between frailty and quality of life. Additionally, serial mediation analysis showed that the association between frailty and quality of life is partially mediated by daily physical activity and healthy life self-efficacy in a sequential manner.
Article
Nursing
Pei-Yu Lu, Hsiao-Ying Wu, Li-Huan Chen, Chieh-Yu Liu, Ai-Fu Chiou
Summary: This randomized controlled trial investigated the effects of aromatherapy on pain and sleep quality among rheumatoid arthritis patients. The study found that aromatherapy massage has positive effects on improving sleep quality in patients, but the improvement in pain levels is not significant.
PAIN MANAGEMENT NURSING
(2023)
Article
Geriatrics & Gerontology
Pei-Shan Li, Chia-Jung Hsieh, Ya-Ling Shih, Ya-Ting Lin, Chieh-Yu Liu
Summary: This study aimed to explore the impact of frailty in middle-aged and older adults on life satisfaction under the simultaneous occurrence and correlation of physical disability and physical activity status. The results showed that physical disability and physical activity partially mediated the relationship between frailty status and life satisfaction. Frailty led to increased physical disability, which in turn affected physical activity and led to lower life satisfaction. Stratifications by age significantly increased the mediating effect of physical activity but did not reduce the mediating effect of physical disability.
Article
Health Care Sciences & Services
Thi Thuy Nga Nguyen, Shu-Yuan Liang, Chieh-Yu Liu, Huu Dung Nguyen
Summary: Self-care and self-efficacy are important factors for predicting the quality of life in hemodialysis patients. However, there is currently a lack of a Vietnamese instrument for assessing these factors. This study aimed to validate and assess the reliability of the Vietnamese version of the Strategies Used by People to Promote Health questionnaire. The questionnaire showed good content validity and reliability, indicating its usefulness for measuring self-care and self-efficacy in hemodialysis patients.
Article
Nursing
Chi-Wei Lin, Huei-Mei Liu, Chieh-Yu Liu, Yen-Hung Chu, Shou-Tzu Wang, Chi-Wen Chen
Summary: Both maternal and paternal voices can alleviate pain during heel puncture procedures among high-risk newborns. The acoustic characteristics and speech rate of parents are related to pain reduction.
NURSING IN CRITICAL CARE
(2023)
Article
Nutrition & Dietetics
Wan-Chun Liao, Tsae-Jyy Wang, Chieh-Yu Liu, Tsang-Pai Liu, Shu-Yuan Liang, Ko-Shih Chang
Summary: Sleeve gastrectomy achieves significant weight loss but also carries the risk of gastrointestinal symptoms and malnutrition. A retrospective study in Taiwan found that patients who underwent sleeve gastrectomy experienced a strong weight loss effect, but also an increased risk of nutritional deficiency, particularly among women and those with constipation or diarrhea.
Article
Health Care Sciences & Services
Huey-Yeu Yan, Chieh-Yu Liu, Mei-Chih Meg Tseng, Tzu-Ying Lee, Pei-Fan Mu, Hung-Ru Lin
Summary: The aim of this study was to investigate binge eating behavior among overweight college students in Taiwan and its associated factors. The study found that nearly one-fifth of the participants exhibited moderate to severe levels of binge eating behaviors, and these were significantly correlated with sex and external environmental stress. The study suggests early intervention from campus psychological health personnel to provide proper therapy.
Article
Nursing
Chia-Chi Chang, Hua-Shan Wu, Chen-Jee Hong, Chieh-Yu Liu, Chi-Wen Chen, Chiu-Yueh Yang
Summary: This study explored the effects of group cognitive stimulation training (GCST) on cognitive function and social function in people with schizophrenia. The results showed that GCST positively impacted overall cognitive and social functions, but not higher-order cognitive functions.
JOURNAL OF NURSING RESEARCH
(2023)
Article
Pediatrics
Tarun Aurora, Audrey Cole, Parul Rai, Paul Lavoie, Carrie Mcivor, Lisa M. Klesges, Guolian Kang, Janaka S. S. Liyanage, Heather M. Brandt, Jane S. Hankins
Summary: This study evaluated the effectiveness of a vaccine strategy bundle in increasing HPV vaccine initiation and completion rates in a specialty clinic setting. By implementing the bundle, which included staff education, provider incentives, offering vaccines in clinics, and verifying vaccine completion, the clinic successfully improved HPV vaccine initiation and completion rates among sickle cell disease patients.
JOURNAL OF PEDIATRICS
(2024)
Article
Pediatrics
Nienke M. Halbmeijer, Wes Onland, Jeroen Dudink, Filip Cools, Anne Debeer, Anton H. van Kaam, Manon J. N. L. Benders, Niek E. van der Aa
Summary: In ventilated infants born preterm, high dose systemic hydrocortisone initiated between 7 and 14 days after birth did not have a significant impact on brain development.
JOURNAL OF PEDIATRICS
(2024)
Article
Pediatrics
Katherine Melton, Jianfang Liu, Hossein Sadeghi, Maureen George, Arlene Smaldone
Summary: This study aims to identify predictors of change in lung function and body weight during health care transition in cystic fibrosis (CF) patients. The study findings highlight the importance of CF RISE program engagement and reducing gaps in care for improving the transition of adolescents and young adults with CF.
JOURNAL OF PEDIATRICS
(2024)
Article
Pediatrics
Laura A. Duckworth, Kimberly A. Sutton, Nurmohammad Shaikh, Jinli Wang, Carla Hall-Moore, Lori R. Holtz, Phillip I. Tarr, Ronald C. Rubenstein
Summary: The study tested the usefulness of various biomarkers as indicators of gut dysfunction in cystic fibrosis (CF) and investigated the repeatability of these measures in individuals over short periods and their correlation with clinical outcomes. The results showed that elevated levels of fLcn2 in individuals with CF may predict worsened pulmonary function.
JOURNAL OF PEDIATRICS
(2024)
Article
Pediatrics
Lindsey Haack, Nikkan Das, Arvind Hoskoppal, Mark Debrunner, Tarek Alsaied, Gaurav Arora
Summary: RAE on ECG has a low positive predictive value for RAE on echocardiogram in previously healthy young patients. The highest yield for RAE on echocardiogram was observed in patients who were <1 year of age, had RAE in the anterior precordial leads, or displayed right ventricular hypertrophy on ECG.
JOURNAL OF PEDIATRICS
(2024)
Article
Pediatrics
Michael A. Padula, Khatija Naing, Tara L. Wenger, Irfan Ahmad, Carl H. Coghill, K. Taylor Wild, S. Alex Rottgers, Cory M. Resnick, Jeffrey Goldstein, Zarmina Ehsan, Donna Watkins, Nicole Deptula, Kuan-Chi Lai, Janet Lioy, Semsa Gogcu, Christopher M. Cielo
Summary: This study describes the spectrum of disease and burden of care in infants with congenital micrognathia. The results show that these infants commonly require surgical intervention and tube feedings, and disparities based on race and among centers were identified.
JOURNAL OF PEDIATRICS
(2024)
Article
Pediatrics
Michael P. Fundora, Manvitha Kalicheti, Guantao Zhao, Kevin O. Maher, Nicoleta Serban
Summary: This study investigated the variation of outpatient opioid prescribing in postoperative pediatric cardiac patients across the US. The results showed that there were significant differences in opioid prescribing by race, ethnicity, sex, and region.
JOURNAL OF PEDIATRICS
(2024)
Article
Pediatrics
Jia Guo, Brooklyn J. Fraser, Leigh Blizzard, Michael D. Schmidt, Terence Dwyer, Alison J. Venn, Costan G. Magnussen
Summary: There is a correlation between childhood and adulthood cardiorespiratory fitness.
JOURNAL OF PEDIATRICS
(2024)
Article
Pediatrics
Nianzhou Xiao, Michelle Starr, Adrienne Stolfi, Gilad Hamdani, Shireen Hashmat, Stefan G. Kiessling, Christina Sethna, Mahmoud Kallash, Robyn Matloff, Robert Woroniecki, Keia Sanderson, Ikuyo Yamaguchi, Stephen D. Cha, Michael G. Semanik, Rahul Chanchlani, Joseph T. Flynn, Mark Mitsnefes
Summary: This multicenter study reports that most infants diagnosed with idiopathic hypertension in the NICU will discontinue antihypertensive treatment within 2 years of discharge. Antenatal steroid treatment is associated with a decreased likelihood of needing antihypertensive therapy for more than 1 year.
JOURNAL OF PEDIATRICS
(2024)
Editorial Material
Pediatrics
Kanwaljit Singh, John Concato, Jonathan M. Davis
JOURNAL OF PEDIATRICS
(2024)
Article
Pediatrics
Yaxing Meng, Harri Niinikoski, Suvi P. Rovio, Brooklyn J. Fraser, Feitong Wu, Antti Jula, Tapani Ronnemaa, Jorma S. A. Viikari, Olli T. Raitakari, Katja Pahkala, Costan G. Magnussen
Summary: This 26-year study shows a correlation between early-life non-HDL-C levels and future levels. Early dietary counseling can reduce the risk of high pediatric non-HDL-C, emphasizing the importance of early interventions in preventing cardiovascular risks.
JOURNAL OF PEDIATRICS
(2024)
Article
Pediatrics
Kelsey A. B. Gastineau, Rebecca Bell, Allison Hanes, Sandra Mckay, Eric Sigel, Filoteia Popescu, Evan C. Sommer, Shari Barkin
Summary: This study aimed to assess the self-reported counseling outcomes for a firearm safe storage counseling training program provided by the American Academy of Pediatrics. The results demonstrated significant improvement in counseling self-efficacy and frequency one month after the training.
JOURNAL OF PEDIATRICS
(2024)
Article
Pediatrics
Kathryn E. K. Berlin, William Scott, Sara Dawson, David Brousseau, Joanne M. Lagatta
Summary: This prospective cohort study aimed to investigate the impact of bronchopulmonary dysplasia (BPD) on the health-related quality of life (HRQL) of infants from NICU hospitalization to one year post-discharge. The study found that lower HRQL during NICU stay was associated with earlier gestational age, postnatal corticosteroid usage, outborn status, and gastrostomy tube placement. Lower HRQL at 3 and 12 months post-discharge was associated with readmissions, home oxygen use, parent-reported difficulty breathing, lower developmental scores, and not playing with other children. Most parents reported similar or improved HRQL after discharge, but parents of infants with respiratory symptoms experienced less improvement. Efforts to improve parent HRQL should focus on respiratory symptoms and social isolation.
JOURNAL OF PEDIATRICS
(2024)
Article
Pediatrics
Garett J. Griffith, Alan P. Wang, Robert I. Liem, Michael R. Carr, Tyler Corson, Kendra Ward
Summary: This study developed reference values for cardiorespiratory fitness in children aged 6-18 years without underlying heart disease, measured by peak oxygen uptake and treadmill time. Fitness levels increased with age in males but not females. Males generally exhibited higher fitness levels compared to females in the same age groups.
JOURNAL OF PEDIATRICS
(2024)
Article
Pediatrics
David S. Liu, Patricia Miller, Anna Rothenberg, Carley Vuillermin, Peter M. Waters, Andrea S. Bauer
Summary: This study aims to determine if children with elbow flexion contracture (EFC) caused by brachial plexus birth injury (BPBI) are more likely to develop shoulder contracture and undergo surgical treatment. A retrospective review was conducted on children under 2 years old with BPBI who presented to a single children's hospital. The results showed that patients with EFC had reduced shoulder range of motion and higher odds of shoulder contracture and surgical treatment. Prompt referral to a BPBI specialty clinic is recommended for evaluation and potential surgery.
JOURNAL OF PEDIATRICS
(2024)
