Article
Nutrition & Dietetics
Anna T. Reischl-Hajiabadi, Sven F. Garbade, Patrik Feyh, Karl Heinz Weiss, Ulrike Muetze, Stefan Koelker, Georg F. Hoffmann, Gwendolyn Gramer
Summary: This study assesses the characteristics of maternal vitamin B-12 deficiency detected by newborn screening, finding that the cause of deficiency is often unknown and there is low adherence to vitamin supplementation. Maternal vitamin B-12, folic acid, and homocysteine levels are significantly correlated with child's blood levels.
Review
Medicine, General & Internal
Thura Win Htut, Kyaw Zin Thein, Thein Hlaing Oo
Summary: Pernicious anemia is the most common cause of vitamin B12 deficiency anemia worldwide, characterized by autoimmune chronic atrophic gastritis and cobalamin deficiency. Patients may lack anemic symptoms, necessitating vigilance, while diagnostic challenges arise from the lack of reliable cobalamin assays.
JOURNAL OF EVIDENCE BASED MEDICINE
(2021)
Review
Biochemistry & Molecular Biology
Magdolna Kosa, Zsolt Galla, Istvan Lenart, Akos Barath, Nora Grecso, Gabor Racz, Csaba Bereczki, Peter Monostori
Summary: Compared to the incidence of inherited diseases in newborn screening, acquired vitamin B12 deficiency is relatively frequent in newborns. Infants may present anemia and/or neurologic symptoms before 6 months of age if not diagnosed in an asymptomatic state. Newborn screening can also help identify vitamin deficient mothers during pregnancy and breastfeeding. Vitamin supplementation is widely available and easy to administer. However, vitamin B12 deficiency is often not included in national screening programs. Optimized screening requires second-tier testing or analysis of new urine and blood samples, along with multiple clinical and laboratory follow ups.
Review
Nutrition & Dietetics
Alessandra Vincenti, Laura Bertuzzo, Antonio Limitone, Giuseppe D'Antona, Hellas Cena
Summary: Vitamin B12 is essential and obtained exclusively from diet, with certain population groups at risk of subclinical deficiency. Poor intake of animal products and age-related decrease in intestinal B12 uptake contribute to the risk of deficiency in elderly population.
Article
Medicine, General & Internal
Nehemias A. Guevara, Esmirna Perez, Jorge Sanchez, Flor Rosado, Harry G. Sequeira Gross, Ilmana Fulger
Summary: Anemia, the most common hematological disorder, often occurs as a manifestation of an underlying disease. It has multifactorial causes, including nutritional deficiencies, chronic conditions, inflammatory processes, medications, malignancy, renal dysfunction, hereditary diseases, and bone marrow disorders. Here we present a case of anemia related to cold agglutin disease and severe B12 deficiency secondary to pernicious anemia.
CUREUS JOURNAL OF MEDICAL SCIENCE
(2023)
Article
Oncology
Sin Hye Park, Sang Soo Eom, Hyewon Lee, Bang Wool Eom, Hong Man Yoon, Young-Woo Kim, Keun Won Ryu
Summary: This study aimed to evaluate the effect of vitamin B12 replacement intervals on the clinical characteristics of patients after total gastrectomy. The results showed that regular replacement led to higher vitamin B12 levels, but no significant changes were observed in hemoglobin levels. There was also no significant difference in symptoms between the regular replacement group and the lab-based replacement group.
Article
Nutrition & Dietetics
Patricia Lipari Pinto, Cristina Florindo, Patricia Janeiro, Rita Loureiro Santos, Sandra Mexia, Hugo Rocha, Isabel Tavares de Almeida, Laura Vilarinho, Ana Gaspar
Summary: Early diagnosis and intervention in vitamin B12 deficiency in exclusively breastfed infants by mothers with low vitamin B12 are crucial in preventing irreversible neurologic damage, megaloblastic anemia, and failure to thrive. Monitoring serum vitamin B12 levels during pregnancy is important. Acquired B12 deficiency should be ruled out before proceeding in a differential diagnosis of cobalamin metabolism deficits, methylmalonic acidemia, and homocystinuria.
Article
Emergency Medicine
Andrew D. Yocum, Mili Patel, Bradley Palocko, Erin L. Simon
Summary: Vitamin B12 is essential for metabolic function and its absorption is dependent on intrinsic factor secreted by parietal cells. Pernicious anemia, caused by intrinsic factor deficiency or autoantibodies, leads to megaloblastic anemia. Early suspicion and detection of pernicious anemia can prevent serious complications and the development of autoimmune disorders.
JOURNAL OF EMERGENCY MEDICINE
(2023)
Article
Nutrition & Dietetics
Josue Cruz-Rodriguez, Andres Diaz-Lopez, Josefa Canals-Sans, Victoria Arija
Summary: This prospective cohort study examined the association between maternal vitamin B12 status and neurodevelopmental outcomes of infants at 40 days postpartum. The study found that medium maternal vitamin B12 levels in the first trimester were associated with better motor, language, and cognitive skills in infants.
Article
Medicine, General & Internal
Yi-Pang Lee, Ching-Hui Loh, Ming-Jay Hwang, Chun-Pin Lin
Summary: LVs have significantly higher frequencies of microcytosis, macrocytosis, blood Hb, RBC, and serum vitamin B12 deficiencies than HCSs. Normocytic and microcytic anemias are the two most common types of anemia in LVs.
JOURNAL OF THE FORMOSAN MEDICAL ASSOCIATION
(2021)
Article
Endocrinology & Metabolism
Evgeniya Babacheva, Dimitrios Rallis, Helen Christou, George Mitsiakos, Themistoklis Mikos, Kalliopi Dampala, Christos Tsakalidis, Anna Kioumi, Dimitrios G. Goulis, Vasiliki Soubasi
Summary: This study aimed to evaluate the effects of maternal diabetes on neonatal iron status and examine the association between neonatal MCHr, red cell indices, and ferritin. The results showed that infants of mothers with diabetes had significantly lower MCHr levels and were correlated with maternal hypochromia and neonatal MCV. Neonatal MCHr was significantly associated with maternal diabetes and preeclampsia.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Review
Medical Laboratory Technology
Li Zhou, Xiaosong Song, Jiani Wang, Yongjun Tan, Qin Yang
Summary: Vitamin B12 deficiency is associated with ischemic stroke, with mechanisms including disorder of methylation metabolism, accumulation of toxic metabolites, immune dysfunction, affecting gut microbial composition and gut-brain immune homeostasis, and toxic stress responses to the brain. Vitamin B12 deficiency may lead to cerebral artery atherosclerosis, change myelination, influence the metabolism and transmission between nerve tissue, and ultimately causes the occurrence and development of ischemic stroke.
CLINICAL BIOCHEMISTRY
(2023)
Article
Medicine, General & Internal
Giulia Costanzo, Giada Sambugaro, Giulia Mandis, Sofia Vassallo, Angelo Scuteri
Summary: This article identifies vitamin B12 deficiency as a leading cause of pancytopenia among adults through a case study of four patients with megaloblastic anemia. It is found that all patients had documented deficiency of vitamin B12. Although there was no correlation between the severity of anemia and deficiency of the vitamin, the study highlights the importance of recognizing vitamin B12 deficiency as a primary cause of pancytopenia in adults.
JOURNAL OF CLINICAL MEDICINE
(2023)
Review
Food Science & Technology
Zebenay Workneh Bitew, Teshager Worku, Ayinalem Alemu
Summary: Vitamin D deficiency is prevalent among neonates, especially those with sepsis. Low maternal and cord blood levels of vitamin D are significantly associated with an increased risk of neonatal sepsis. Supplementing pregnant women and newborns with vitamin D could help decrease the incidence of neonatal sepsis.
FOOD SCIENCE & NUTRITION
(2021)
Article
Nutrition & Dietetics
Odunayo Ifeoluwa Sobowale, Moududur Rahman Khan, Anjan Kumar Roy, Rubhana Raqib, Faruk Ahmed
Summary: This study examines the deficiency of vitamin B-12 in pregnant rural Bangladeshi women and found that the proportions of vitamin B-12 deficiency and marginal deficiency increased as their pregnancies progressed. Gestational age, housing situation, and the frequency of consuming red or organ meat were identified as independent risk factors for vitamin B-12 deficiency in this population.
Article
Pediatrics
Tarun Aurora, Audrey Cole, Parul Rai, Paul Lavoie, Carrie Mcivor, Lisa M. Klesges, Guolian Kang, Janaka S. S. Liyanage, Heather M. Brandt, Jane S. Hankins
Summary: This study evaluated the effectiveness of a vaccine strategy bundle in increasing HPV vaccine initiation and completion rates in a specialty clinic setting. By implementing the bundle, which included staff education, provider incentives, offering vaccines in clinics, and verifying vaccine completion, the clinic successfully improved HPV vaccine initiation and completion rates among sickle cell disease patients.
JOURNAL OF PEDIATRICS
(2024)
Article
Pediatrics
Nienke M. Halbmeijer, Wes Onland, Jeroen Dudink, Filip Cools, Anne Debeer, Anton H. van Kaam, Manon J. N. L. Benders, Niek E. van der Aa
Summary: In ventilated infants born preterm, high dose systemic hydrocortisone initiated between 7 and 14 days after birth did not have a significant impact on brain development.
JOURNAL OF PEDIATRICS
(2024)
Article
Pediatrics
Katherine Melton, Jianfang Liu, Hossein Sadeghi, Maureen George, Arlene Smaldone
Summary: This study aims to identify predictors of change in lung function and body weight during health care transition in cystic fibrosis (CF) patients. The study findings highlight the importance of CF RISE program engagement and reducing gaps in care for improving the transition of adolescents and young adults with CF.
JOURNAL OF PEDIATRICS
(2024)
Article
Pediatrics
Laura A. Duckworth, Kimberly A. Sutton, Nurmohammad Shaikh, Jinli Wang, Carla Hall-Moore, Lori R. Holtz, Phillip I. Tarr, Ronald C. Rubenstein
Summary: The study tested the usefulness of various biomarkers as indicators of gut dysfunction in cystic fibrosis (CF) and investigated the repeatability of these measures in individuals over short periods and their correlation with clinical outcomes. The results showed that elevated levels of fLcn2 in individuals with CF may predict worsened pulmonary function.
JOURNAL OF PEDIATRICS
(2024)
Article
Pediatrics
Lindsey Haack, Nikkan Das, Arvind Hoskoppal, Mark Debrunner, Tarek Alsaied, Gaurav Arora
Summary: RAE on ECG has a low positive predictive value for RAE on echocardiogram in previously healthy young patients. The highest yield for RAE on echocardiogram was observed in patients who were <1 year of age, had RAE in the anterior precordial leads, or displayed right ventricular hypertrophy on ECG.
JOURNAL OF PEDIATRICS
(2024)
Article
Pediatrics
Michael A. Padula, Khatija Naing, Tara L. Wenger, Irfan Ahmad, Carl H. Coghill, K. Taylor Wild, S. Alex Rottgers, Cory M. Resnick, Jeffrey Goldstein, Zarmina Ehsan, Donna Watkins, Nicole Deptula, Kuan-Chi Lai, Janet Lioy, Semsa Gogcu, Christopher M. Cielo
Summary: This study describes the spectrum of disease and burden of care in infants with congenital micrognathia. The results show that these infants commonly require surgical intervention and tube feedings, and disparities based on race and among centers were identified.
JOURNAL OF PEDIATRICS
(2024)
Article
Pediatrics
Michael P. Fundora, Manvitha Kalicheti, Guantao Zhao, Kevin O. Maher, Nicoleta Serban
Summary: This study investigated the variation of outpatient opioid prescribing in postoperative pediatric cardiac patients across the US. The results showed that there were significant differences in opioid prescribing by race, ethnicity, sex, and region.
JOURNAL OF PEDIATRICS
(2024)
Article
Pediatrics
Jia Guo, Brooklyn J. Fraser, Leigh Blizzard, Michael D. Schmidt, Terence Dwyer, Alison J. Venn, Costan G. Magnussen
Summary: There is a correlation between childhood and adulthood cardiorespiratory fitness.
JOURNAL OF PEDIATRICS
(2024)
Article
Pediatrics
Nianzhou Xiao, Michelle Starr, Adrienne Stolfi, Gilad Hamdani, Shireen Hashmat, Stefan G. Kiessling, Christina Sethna, Mahmoud Kallash, Robyn Matloff, Robert Woroniecki, Keia Sanderson, Ikuyo Yamaguchi, Stephen D. Cha, Michael G. Semanik, Rahul Chanchlani, Joseph T. Flynn, Mark Mitsnefes
Summary: This multicenter study reports that most infants diagnosed with idiopathic hypertension in the NICU will discontinue antihypertensive treatment within 2 years of discharge. Antenatal steroid treatment is associated with a decreased likelihood of needing antihypertensive therapy for more than 1 year.
JOURNAL OF PEDIATRICS
(2024)
Editorial Material
Pediatrics
Kanwaljit Singh, John Concato, Jonathan M. Davis
JOURNAL OF PEDIATRICS
(2024)
Article
Pediatrics
Yaxing Meng, Harri Niinikoski, Suvi P. Rovio, Brooklyn J. Fraser, Feitong Wu, Antti Jula, Tapani Ronnemaa, Jorma S. A. Viikari, Olli T. Raitakari, Katja Pahkala, Costan G. Magnussen
Summary: This 26-year study shows a correlation between early-life non-HDL-C levels and future levels. Early dietary counseling can reduce the risk of high pediatric non-HDL-C, emphasizing the importance of early interventions in preventing cardiovascular risks.
JOURNAL OF PEDIATRICS
(2024)
Article
Pediatrics
Kelsey A. B. Gastineau, Rebecca Bell, Allison Hanes, Sandra Mckay, Eric Sigel, Filoteia Popescu, Evan C. Sommer, Shari Barkin
Summary: This study aimed to assess the self-reported counseling outcomes for a firearm safe storage counseling training program provided by the American Academy of Pediatrics. The results demonstrated significant improvement in counseling self-efficacy and frequency one month after the training.
JOURNAL OF PEDIATRICS
(2024)
Article
Pediatrics
Kathryn E. K. Berlin, William Scott, Sara Dawson, David Brousseau, Joanne M. Lagatta
Summary: This prospective cohort study aimed to investigate the impact of bronchopulmonary dysplasia (BPD) on the health-related quality of life (HRQL) of infants from NICU hospitalization to one year post-discharge. The study found that lower HRQL during NICU stay was associated with earlier gestational age, postnatal corticosteroid usage, outborn status, and gastrostomy tube placement. Lower HRQL at 3 and 12 months post-discharge was associated with readmissions, home oxygen use, parent-reported difficulty breathing, lower developmental scores, and not playing with other children. Most parents reported similar or improved HRQL after discharge, but parents of infants with respiratory symptoms experienced less improvement. Efforts to improve parent HRQL should focus on respiratory symptoms and social isolation.
JOURNAL OF PEDIATRICS
(2024)
Article
Pediatrics
Garett J. Griffith, Alan P. Wang, Robert I. Liem, Michael R. Carr, Tyler Corson, Kendra Ward
Summary: This study developed reference values for cardiorespiratory fitness in children aged 6-18 years without underlying heart disease, measured by peak oxygen uptake and treadmill time. Fitness levels increased with age in males but not females. Males generally exhibited higher fitness levels compared to females in the same age groups.
JOURNAL OF PEDIATRICS
(2024)
Article
Pediatrics
David S. Liu, Patricia Miller, Anna Rothenberg, Carley Vuillermin, Peter M. Waters, Andrea S. Bauer
Summary: This study aims to determine if children with elbow flexion contracture (EFC) caused by brachial plexus birth injury (BPBI) are more likely to develop shoulder contracture and undergo surgical treatment. A retrospective review was conducted on children under 2 years old with BPBI who presented to a single children's hospital. The results showed that patients with EFC had reduced shoulder range of motion and higher odds of shoulder contracture and surgical treatment. Prompt referral to a BPBI specialty clinic is recommended for evaluation and potential surgery.
JOURNAL OF PEDIATRICS
(2024)