Article
Oncology
Luke Paters, Patrick Melchior, Christian Ruebe, Benjamin T. Cooper, Mary Fran McAleer, John A. Kalapurakal, Arnold C. Paulino
Summary: The objectives of the treatment of Wilms tumor by COG and SIOP focus on improving cure rates and minimizing toxicity by limiting the use of radiation and doxorubicin. Different strategies are employed by COG and SIOP, but both achieve the same survival rates. Future research will explore the prognostic significance of biological markers and the impact of radiation techniques on clinical outcomes. Collaboration between COG and SIOP may further research and enhance clinical outcomes for children with Wilms tumor.
PEDIATRIC BLOOD & CANCER
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Michalis Mazonakis, Efrosyni Lyraraki, Maria Tolia, John Damilakis
Summary: This study compares the dosimetric parameters and radiogenic risks of three different irradiation techniques (3D-CRT, IMRT, and VMAT) for pediatric Wilms tumor flank irradiation. IMRT and VMAT showed better organ sparing and superior planning parameters compared to 3D-CRT. The risks of developing secondary malignancies were also higher with the intensity modulated techniques.
PHYSICA MEDICA-EUROPEAN JOURNAL OF MEDICAL PHYSICS
(2022)
Article
Oncology
Juan Wang, Lian Zhang, Lanying Guo, Yi Que, Yu Zhang, Feifei Sun, Jia Zhu, Suying Lu, Junting Huang, Liuhong Wu, Ruiqing Cai, Zijun Zhen, Sihui Zeng, Yizhuo Zhang, Xiaofei Sun
Summary: The combination of irinotecan and doxorubicin hydrochloride liposome regimens shows positive efficacy and well-tolerated toxicity in treating relapsed or refractory pediatric Wilms tumor. Further prospective clinical trials are warranted to validate these findings.
FRONTIERS IN ONCOLOGY
(2021)
Article
Pediatrics
James K. Moon, Rosa Hwang, Frank M. Balis, Peter Mattei
Summary: The use of an ERAS protocol in children undergoing nephrectomy for Wilms tumor is safe and results in rapid return to regular diet. It also leads to shorter postoperative hospital stay without increased complications or return to the emergency department or operating room.
JOURNAL OF PEDIATRIC SURGERY
(2022)
Article
Oncology
Daniel J. Benedetti, Carly R. Varela, Lindsay A. Renfro, Brett Tornwall, David B. Dix, Peter F. Ehrlich, Richard D. Glick, John Kalapurakal, Elizabeth Perlman, Eric Gratias, Nita L. Seibel, James I. Geller, Geetika Khanna, Marcio Malogolowkin, Paul Grundy, Conrad V. Fernandez, Jeffrey S. Dome, Elizabeth A. Mullen
Summary: Pooled outcomes across three studies of patients with favorable histology Wilms tumor and extrapulmonary metastases revealed 4-year event-free survival of 77.3% and overall survival of 88.9%, with no statistical differences seen between patients on AREN0533 compared with those on NWTS-5. Missing details on local management of metastatic sites informs a critical need for better data capture in future studies to optimize local control strategies and chemotherapy regimens for this higher-risk favorable histology Wilms tumor patient group.
Review
Urology & Nephrology
Adree Khondker, Anshika Jain, Michael L. Groff, Jack Brzezinski, Armando J. Lorenzo, Michael Zappitelli
Summary: Based on the study findings, nephron-sparing surgery in Wilms tumor patients may be associated with better preservation of kidney function and blood pressure control. Further research is recommended to investigate sources of heterogeneity.
JOURNAL OF UROLOGY
(2022)
Article
Chemistry, Organic
Wanzhu Zhao, Guangfei Wang, Lin Guo, Jingmin Wang, Congcong Jing, Ben Liu, Feng Zhao, Shumin Zhang, Zeping Xie
Summary: Three novel actinomycins, actimomycin S (1), neo-actinomycins C and D (2 and 3), and one new benzo[d]oxazole alkaloid (4) were isolated from the Streptomyces sp. strain S22. The structures of the new products were determined by spectroscopic methods, and the absolute configuration of amino acid residues was determined by Marfey's analysis. Actinomycins 1-3 exhibited antimicrobial activity against multiple resistant ESKAPE pathogens and showed potent cytotoxic activities against the HepG2 liver carcinoma cell line.
ORGANIC & BIOMOLECULAR CHEMISTRY
(2023)
Article
Chemistry, Analytical
Xiao-Jie Lu, Na Du, Bing Zhang, Xiao-Xue Zhou, Xiao-Fan Li, Jian-Hua Ju, Zhang-Li Hu, Li-Yan Wang
Summary: This study successfully utilized supercritical fluid chromatography (SFC) for the purification of Actinomycin X-2 and actinomycin D from a marine derived Streptomyces sp. DQS-5, providing a green alternative for their separation. The study also demonstrated the development of a simple and rapid method for the separation of natural products based on SFC.
JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS
(2021)
Review
Oncology
Bo Hong, Rui Dong
Summary: Wilms tumor is a common pediatric abdominal solid tumor, with current treatment mainly focusing on multi-modal therapy. While targeted therapy and immunotherapy show potential in clinical trials, they are less commonly used in Wilms tumor treatment. There are dozens of clinical trials worldwide researching these new therapeutic approaches.
TRANSLATIONAL CANCER RESEARCH
(2021)
Article
Nanoscience & Nanotechnology
Qiyang Zhou, Jingliang Wu, Bo Lian, Bo Zhang, Pingping Zhang, Ruiyan Pan
Summary: This study demonstrated the potential of glycyrrhetinic acid-modified sulfated hyaluronic acid nanoparticles for co-delivery of doxorubicin and magnolol. The nanoparticles showed effective anti-proliferation and anti-migration effects on cancer-associated fibroblasts (CAFs) and tumor cells. Furthermore, in vivo studies confirmed that the nanoparticles reduced the side effects of doxorubicin and inhibited CAFs activation, tumor angiogenesis, proliferation, and lung metastasis, leading to enhanced antitumor effects.
ACS APPLIED NANO MATERIALS
(2022)
Article
Oncology
Adrienne B. Shannon, Richard J. Straker, Michael J. Carr, James Sun, Karenia Landa, Kirsten Baecher, Kevin Lynch, Harrison G. Bartels, Robyn Panchaud, Luke J. Keele, Michael C. Lowe, Craig L. Slingluff, Mark J. Jameson, Kenneth Y. Tsai, Mark B. Faries, Georgia M. Beasley, Vernon K. Sondak, Giorgos C. Karakousis, Jonathan S. Zager, John T. Miura
Summary: A risk-score model incorporating patient and tumor factors improves prognostic assessment of Merkel cell carcinoma patients. Factors such as age, sex, immune compromise, microsatellites, and nodal involvement are associated with disease-specific survival. The model can help inform surveillance strategies and patient selection for adjuvant therapy trials.
ANNALS OF SURGICAL ONCOLOGY
(2022)
Article
Chemistry, Multidisciplinary
Astgik Petrosyan, Valentina Villani, Paola Aguiari, Matthew E. Thornton, Yizhou Wang, Alex Rajewski, Shengmei Zhou, Paolo Cravedi, Brendan H. Grubbs, Roger E. De Filippo, Sargis Sedrakyan, Kevin V. Lemley, Marie Csete, Stefano Da Sacco, Laura Perin
Summary: A nephrogenic progenitor cell (NP) with cancer stem cell characteristics driving Wilms tumor (WT) is identified and characterized using spatial transcriptomics, bulk and single cell RNA sequencing, and complementary in vitro and transplantation experiments. Comparative analysis between NP from WT samples and NP from the developing human kidney reveals that cells expressing SIX2 and CITED1 fulfill cancer stem cell criteria by reliably recapitulating WT in transplantation studies. The interplay between integrins ITG beta 1 and ITG beta 4 regulates self-renewal versus differentiation in SIX2+CITED1+ cells. Spatial transcriptomic analysis defines gene expression maps and identifies interactive gene networks involved in WT development, pointing to the renal developmental transcriptome changes as a possible driver in regulating WT formation and progression.
Article
Engineering, Environmental
Xinru Kong, Zhijing He, Yu Zhang, Yuelin Fang, Dongzhu Liu, Hang Wu, Jianbo Ji, Yanwei Xi, Lei Ye, Xiaoye Yang, Guangxi Zhai
Summary: This study developed a tumor-specific nanoplatform, p-LDM, for the delivery of doxorubicin (DOX) and activation of combined ferroptosis and apoptosis. The nanoplatform was constructed by coating a ferric metal-organic framework (MOF) with liposomes, which were further modified with targeting peptides and enzyme-activatiable cell-penetrating peptides (CPPs) for tumor-specific penetration. The MOF components, Fe3+ and terephthalic acid (H2BDC), triggered ferroptosis of tumor cells. Combining DOX and ferroptosis activation, p-LDM showed potent direct killing effect, immune cell death, T cell activation, and dendritic cell maturation promotion. Moreover, the combination with CD47-SIRPα blockade therapy further enhanced ferroptosis and remodeled the tumor immune microenvironment, resulting in superior inhibition of tumor growth, metastasis, and recurrence.
CHEMICAL ENGINEERING JOURNAL
(2023)
Article
Oncology
Janna A. Hol, Marjolijn C. J. Jongmans, Helene Sudour-Bonnange, Gema L. Ramirez-Villar, Tanzina Chowdhury, Catherine Rechnitzer, Niklas Pal, Gudrun Schleiermacher, Axel Karow, Roland P. Kuiper, Beatriz de Camargo, Simona Avcin, Danka Redzic, Antonio Wachtel, Heidi Segers, Gordan M. Vujanic, Harm van Tinteren, Christophe Bergeron, Kathy Pritchard-Jones, Norbert Graf, Marry M. van den Heuvel-Eibrink
Summary: WAGR syndrome is a rare genetic condition with an increased risk of developing Wilms tumor. Patients with WAGR and Wilms tumor can be treated according to existing protocols, but monitoring of treatment complications and surveillance of the remaining kidney(s) are advised for optimal outcomes.
Article
Oncology
Amrita K. Cheema, Yaoxiang Li, Mary Ventimiglia, Keith Kowalczyk, Ryan Hankins, Gaurav Bandi, Einsley-Marie Janowski, Scott Grindrod, Alejandro Villagra, Anatoly Dritschilo
Summary: Radiotherapy is an effective treatment for cancers, which can be used alone or in combination with surgery and chemotherapy. It can cause DNA damage and activate innate immune response, leading to cell cycle arrest, cell death, and immune stimulation.
CLINICAL CANCER RESEARCH
(2023)
