Review
Pharmacology & Pharmacy
Demis Ferreira de Melo, Gabryella Garcia Guedes, Livia Maria Coelho de Carvalho Moreira, Joao Augusto Oshiro-Junior, Bolivar Ponciano Goulart de Lima Damasceno
Summary: The use of antimicrobial agents in wound treatment is crucial for patient management, and silver sulfadiazine (AgSD) has been considered the gold standard due to its mechanism of action, efficacy, and safety. The combination of AgSD with polymers for curative formulations has been explored, and the evaluation of physical-chemical properties using analytical techniques is essential for determining their activities and detecting any incompatibilities. This review discusses the main physicochemical characterization techniques used in evaluating AgSD-containing systems, providing parameters for ensuring efficacy and safety.
CURRENT PHARMACEUTICAL DESIGN
(2023)
Article
Biochemistry & Molecular Biology
Brian Michael Cartwright, Sean James Fox, Mary Jane Underdown, William Andrew Clark, Joseph Andrew Molnar
Summary: Current treatments for deep tissue burns are limited, often relying on slow natural processes for wound healing. Infections, which can disrupt the healing process, are a major concern. This study introduces ARAG, an antioxidant-rich antimicrobial gel, which can effectively suppress the growth of bacteria commonly found in burn infections. The findings also demonstrate that ARAG promotes enhanced wound healing compared to the current standard of care, Mepilex-Ag, likely due to increased wound debridement and reduced inflammation.
Article
Polymer Science
Jakub Staniczek, Zaneta Jastrzebska-Stojko, Rafal Stojko
Summary: The study evaluated the pharmacological efficacy of ointments containing 1% propolis and nanosilver in treating burn wounds. Results showed that 1% propolis ointment has broad-spectrum antibacterial action, accelerates wound healing, improves scar appearance, and has no side effects; 1% nanosilver ointment reduces free radicals, but there is no synergism between propolis and nanosilver.
Article
Critical Care Medicine
Matilda Karlsson, Ingrid Steinvall, Moustafa Elmasry
Summary: This retrospective study compared the efficacy of two different dressings, Suprathel (R) and Mepilex (R) Ag, for the treatment of partial-thickness scalds in children. The results showed no significant differences in healing time, burn wound infection, need for operations, and number of dressing changes between the two groups.
Article
Pediatrics
Yunfei Chi, Huinan Yin, Xin Chen, Quan Hu, Wei Liu, Lil Feng, Jiake Chai
Summary: The study found that precise partial scab removal can shorten the wound-healing time, reduce fever duration, lower antibiotic use frequency, and decrease the number of dressing changes on the wound in children with deep partial-thickness burn wounds.
TRANSLATIONAL PEDIATRICS
(2021)
Article
Dermatology
Jennifer Lynn Schiefer, Janine Andreae, Mahsa Bagheri, Paul Christian Fuchs, Rolf Lefering, Wolfram Heitzmann, Alexandra Schulz
Summary: The study compared the effectiveness of Suprathel and Dressilk in treating burn wounds, finding that both dressings led to safe wound healing and reduced pain during the healing process. However, Dressilk, being significantly cheaper, proved to be a good option for the treatment of superficial burns.
INTERNATIONAL WOUND JOURNAL
(2022)
Article
Critical Care Medicine
Silvia Silva Moreira, Mayara Costa de Camargo, Rosangela Caetano, Maira Ramos Alves, Alexander Itria, Tiago Veiga Pereira, Luciane Cruz Lopes
Summary: The study found no significant difference in efficacy and safety outcomes between nanocrystalline silver dressings and 1% silver sulfadiazine dressings. Although nanocrystalline silver dressings reduced the number of dressing changes, they incurred higher total costs, requiring further cost-effectiveness studies.
Article
Cell Biology
Mehrdad Abdullahzadeh, Saeed Shafiee
Summary: The study found that sea buckthorn cream was more effective in healing second-degree burns compared to 1% SSD, with a shorter healing time. Using sea buckthorn dressing can shorten the treatment course of second-degree burns and reduce the burden of care in healthcare services.
WOUND REPAIR AND REGENERATION
(2021)
Article
Dermatology
Annika Resch, Clement Staud, Christine Radtke
Summary: The use of nanocellulose-based dressing in treating burn wounds in children can achieve complete re-epithelialisation in a short period of time, reduce the frequency of dressing changes, and provide a more flexible and acceptable treatment option for patients and their parents.
INTERNATIONAL WOUND JOURNAL
(2021)
Article
Biochemistry & Molecular Biology
Shahia Khattak, Xiao-Tong Qin, Long-Hui Huang, Yan-Yan Xie, Shi-Ru Jia, Cheng Zhong
Summary: The study prepared a hydrogel based on bacterial cellulose and chitosan, with the addition of silver sulfadiazine and crosslinked with glutaraldehyde. The incorporation of SSd significantly improved the mechanical and antibacterial properties of the hydrogel. The hydrogel showed higher toxicity to S. aureus than to E. coli.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2021)
Article
Mathematical & Computational Biology
Zhiwei Li, Jie Huang, Xirui Tong, Chenbei Zhang, Jianyu Lu, Wei Zhang, Anping Song, Shizhao Ji
Summary: Burns are common injuries that cause pain to patients. To improve the accuracy and automation of burn depth classification, a deep learning method using U-Net for segmentation and a fusion model called GL-FusionNet were introduced. The proposed method achieved the best results in both segmentation and classification tasks, with high accuracy, recall, precision, and F1-score.
MATHEMATICAL BIOSCIENCES AND ENGINEERING
(2023)
Article
Chemistry, Physical
Sirui He, Jia Liu, Shu He, An Liu, Wei Shao
Summary: In this study, a double crosslinking strategy was used to fabricate novel PGA sponges. The morphology and chemical composition of the sponges were characterized, and their antibacterial activity was evaluated. The results showed that the PGA sponges exhibited excellent antibacterial performance due to the release of silver sulfadiazine, and the release of sulfadiazine was diffusion controlled. These prepared PGA sponges showed improved mechanical properties and excellent antibacterial effects.
COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS
(2022)
Article
Chemistry, Physical
Qian Dong, Fengling Yang, Feng Liang, Yan Zhang, Dehua Xia, Wei Zhao, Li Wu, Xueping Liu, Zhongfeng Jiang, Cheng Sun
Summary: Decahedral BiVO4 was successfully prepared at low temperature, forming BiVO4 nanosheet (S-BiVO4) through morphological changes in surfactant addition, which was then used to fabricate a series of Ag/S-BiVO4 plasmonic photocatalysts. Among them, Ag/4S-BiVO4 showed the highest photocatalytic performance, attributed to the SPR effect induced by silver nanoparticles.
JOURNAL OF MOLECULAR LIQUIDS
(2021)
Article
Biotechnology & Applied Microbiology
Shahia Khattak, Xiao-Tong Qin, Fazli Wahid, Long-Hui Huang, Yan-Yan Xie, Shi-Ru Jia, Cheng Zhong
Summary: Surface oxidation of bacterial cellulose was carried out using the TEMPO-mediated oxidation mechanism, followed by impregnation with silver sulfadiazine to create nanocomposite membranes. Analysis using FTIR and XRD determined the presence of functional groups and crystallinity, while FESEM analysis showed the impregnation of nanoparticles and increased antibacterial activity with higher TOBC and AgSD content. This method retains and enhances the reactivity of BC, making it a promising option for biomedical applications such as wound dressing and tissue engineering.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2021)
Review
Medicine, General & Internal
Nicole J. Levin, Young Erben, Yupeng Li, Tara J. Brigham, Alison J. Bruce
Summary: This study evaluated the healing time of second-and third-degree burn wounds between silver sulfadiazine (SSD) and Aloe vera (AV). The meta-analysis demonstrated that the mean time to wound healing favored AV, indicating that the use of AV may accelerate the healing process for burn wounds. Therefore, greater attention should be given to the use of AV as an adjunct for burn wound healing.
CUREUS JOURNAL OF MEDICAL SCIENCE
(2022)
Article
Pediatrics
Ashwini Suresh Poola, Amy L. Pierce, Beth A. Orrick, Shawn David St Peter, Charles L. Snyder, David Juang, Pablo Aguayo, Jason D. Fraser, George W. Holcomb
EUROPEAN JOURNAL OF PEDIATRIC SURGERY
(2018)
Article
Critical Care Medicine
Bindi J. Naik-Mathuria, Eric H. Rosenfeld, Ankush Gosain, Randall Burd, Richard A. Falcone, Rajan Thakkar, Barbara Gaines, David Mooney, Mauricio Escobar, Mubeen Jafri, Anthony Stallion, Denise B. Klinkner, Robert Russell, Brendan Campbell, Rita V. Burke, Jeffrey Upperman, David Juang, Shawn St. Peter, Stephon J. Fenton, Marianne Beaudin, Hale Wills, Adam Vogel, Stephanie Polites, Adam Pattyn, Christine Leeper, Laura V. Veras, Ilan Maizlin, Shefali Thaker, Alexis Smith, Megan Waddell, Joseph Drews, James Gilmore, Lindsey Armstrong, Alexis Sandler, Suzanne Moody, Brandon Behrens, Laurence Carmant
JOURNAL OF TRAUMA AND ACUTE CARE SURGERY
(2017)
Article
Critical Care Medicine
Richard Sola, Valerie A. Waddell, Shawn D. St. Peter, Pablo Aguayo, David Juang
INJURY-INTERNATIONAL JOURNAL OF THE CARE OF THE INJURED
(2018)
Article
Surgery
Hanna Alemayehu, Richard Sola, Nhatrang H. Le, David Juang, Pablo Aguayo, Jason D. Fraser, Shawn D. St Peter
JOURNAL OF LAPAROENDOSCOPIC & ADVANCED SURGICAL TECHNIQUES
(2018)
Article
Pediatrics
Eric H. Rosenfeld, Adam M. Vogel, Denise B. Klinkner, Mauricio Escobar, Barbara Gaines, Robert Russell, Brendan Campbell, Hale Wills, Anthony Stallion, David Juang, Rajan K. Thakkar, Jeffrey Upperman, Mubeen Jafri, Randall Burd, Bindi J. Naik-Mathuria
JOURNAL OF PEDIATRIC SURGERY
(2018)
Article
Pediatrics
Shawn D. St Peter, Ashwini Poola, Obinna Adibe, David Juang, Jason D. Fraser, Pablo Aguayo, G. W. Holcomb
JOURNAL OF PEDIATRIC SURGERY
(2018)
Article
Pediatrics
Eric H. Rosenfeld, Adam Vogel, Robert T. Russell, Ilan Maizlin, Denise B. Klinkner, Stephanie Polites, Barbara Gaines, Christine Leeper, Stallion Anthony, Megan Waddell, Shawn St Peter, David Juang, Rajan Thakkar, Joseph Drews, Brandon Behrens, Mubeen Jahri, Randall S. Burd, Marianne Beaudin, Laurence Carmant, Richard A. Falcone, Suzanne Moody, Bindi J. Naik-Mathuria
PEDIATRIC SURGERY INTERNATIONAL
(2018)
Article
Pediatrics
Charlene Dekonenko, Robert M. Dorman, Yara Duran, David Juang, Pablo Aguayo, Jason D. Fraser, Tolulope A. Oyetunji, Charles L. Snyder, George W. Holcomb, Daniel L. Millspaugh, Shawn D. St. Peter
JOURNAL OF PEDIATRIC SURGERY
(2020)
Article
Pediatrics
Pamela M. Choi, Charlene Dekonenko, Pablo Aguayo, David Juang
JOURNAL OF PEDIATRIC SURGERY
(2020)
Article
Pediatrics
Obiyo Osuchukwu, Joseph Lopez, Katrina L. Weaver, Valerie A. Waddell, Pablo Aguayo, Shawn D. St Peter, David Juang
Summary: In pediatric patients, CT is not necessary for all asymptomatic non-occult pneumothoraces (ANOPTX) from blunt chest trauma (BCT), and observation has been found to be safe and cost-effective. Patients who underwent CT placement had longer hospital stays, higher hospital expenses, and more imaging performed compared to those who were observed.
JOURNAL OF PEDIATRIC SURGERY
(2021)
Article
Pediatrics
Wendy Jo Svetanoff, James A. Fraser, Kayla B. Briggs, Jessica K. Staszak, Charlene Dekonenko, Rebecca M. Rentea, David Juang, Pablo Aguayo, Jason D. Fraser, Charles L. Snyder, Richard J. Hendrickson, Shawn D. St Peter, Tolulope Oyetunji
Summary: A retrospective study found that using percutaneous internal ring suturing technique for laparoscopic repair of inguinal hernias in children is safe and effective, with low rates of postoperative complications and recurrence.
JOURNAL OF PEDIATRIC SURGERY
(2021)
Article
Surgery
Shai Stewart, Kayla B. Briggs, James A. Fraser, Charlene Dekonenko, Wendy Jo Svetanoff, Rebecca M. Rentea, Pablo Aguayo, David Juang, Richard J. Hendrickson, Charles L. Snyder, Shawn D. St Peter, Tolulope A. Oyetunji, Jason D. Fraser
Summary: This study reviewed patients who underwent open abdominal surgery with concurrent laparoscopic gastrostomy from January 2010 to June 2020. The results showed that laparoscopic gastrostomy can be safely performed during an open abdominal procedure, with favorable outcomes in terms of operative time and complications.
JOURNAL OF LAPAROENDOSCOPIC & ADVANCED SURGICAL TECHNIQUES
(2022)
Article
Pediatrics
Shai Stewart, James A. Fraser, Rebecca M. Rentea, Pablo Aguayo, David Juang, Jason D. Fraser, Charles L. Snyder, Richard J. Hendrickson, Tolulope A. Oyetunji, Shawn D. St. Peter
Summary: This study analyzed the outcomes of pediatric patients with primary spontaneous pneumothorax (PSP) who were managed with a protocol involving simple aspiration and, if necessary, Video-Assisted Thoracoscopic Surgery (VATS). The results showed that 33% of patients were successfully treated with aspiration alone, while 66% required VATS. Simple aspiration is a safe and effective initial management for children with PSP, but VATS may be necessary in most cases.
JOURNAL OF PEDIATRIC SURGERY
(2023)
Article
Surgery
Nelimar Cruz-Centeno, Shai Stewart, Derek R. Marlor, Pablo Aguayo, Rebecca M. Rentea, Richard J. Hendrickson, David Juang, Charles L. Snyder, Jason D. Fraser, Shawn D. St Peter, Tolulope A. Oyetunji
Summary: This study compared the effects of different surgical approaches and techniques of anastomosis on the repair of duodenal atresia. The findings suggest that the choice of surgical approach does not significantly impact the outcomes or complications.
Article
Pediatrics
Joseph Sujka, Richard Sola, David Juang
JOURNAL OF PEDIATRIC SURGERY CASE REPORTS
(2018)